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All Journal Jurnal Ilmu Kimia Universitas Brawijaya KOVALEN: Jurnal Riset Kimia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST CHEESA: Chemical Engineering Research Articles JOPS (Journal Of Pharmacy and Science) Jurnal Surya Masyarakat Klinikal Sains (Jurnal Analis Kesehatan) Surya Abdimas Jurnal Biomedika INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Ilmiah Farmako Bahari Medicra (Journal of Medical Laboratory Science/Technology) Jurnal Surya Masyarakat Indonesian Journal of Cultural and Community Development Borneo Journal Of Pharmascientech Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Sains dan Praktis SWARNA Journal of Pharmacy Science and Technology
Ersalina Nidianti
Universitas Nahdlatul Ulama Surabaya, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Journal : Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan

 1 
UJI TOKSISITAS DENGAN METODE BSLT PADA NANOPARTIKEL KOMBINASI OBAT CISPLATIN, BOVINE SERUM ALBUMIN DAN ASAM FOLAT Ersalina Nidianti; Ary Andini
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (246.575 KB) | DOI: 10.36387/jiis.v6i1.609

Abstract

Cancer is a non-communicable disease that causes morbidity and mortality in all regions of the world. Cancer treatment is important in reducing the high number of deaths (mortality) due to cancer sufferers. One of the cancer treatments is using chemotherapy drug cisplatin. However, cisplatin drug has side effects, namely nephrotoxicity, ototoxicity, neurotoxicity, hemotoxicity, cardiotoxicity, and hepatotoxicity. Therefore, the combination of cisplatin in albumin nanoparticles and modification of the bond using folic acid as an alternative solution minimizes the resulting toxic effects. This study aimed to determine the toxicity effect of the cisplatin drug formulation with a combination of bovine serum albumin (BSA) nanoparticles and folic acid through the Brine Shrimp Lethality Test (BSLT) method. The research methods used were BSA nanoparticle synthesis (NP-BSA), NP-BSA Synthesis with Cisplatin Drug (CP-NP-BSA), Folic Acid Synthesis with CP-NP-BSA Combination (As-CP-NP-BSA). Then, a toxicity test was carried out using the BSLT method to determine the toxicity level of BSA nanoparticles and the effect of adding folic acid in the cisplatin drug in the nanoparticles. The results showed that the absorbance of the 358 nm As-CP-NP-BSA UV-Vis spectrophotometer was 0.86. The toxicity level of the NP-BSA with the LC50 value was 69.23 ppm while the As-CP-NP-BSA LC50 toxicity level was 56.56 ppm. Nanoparticles consisting of a combination of bovine serum albumin, cisplatin and folic acid can be used as candidates for anticancer drugs
Co-Authors Adinda Priyanti Dewi Aini, Fadlilah Nur Aisah Humairoh Andreas Putro Ragil Santoso Ary Andini Ary Andini Aulia, Ilmiah Alvi Nisa Chika Nur Azizah Dea Ayu Rahmawati Desi Susanti Devyana Dyah Wulandari Devyana Dyah Wulandari Endah Prayekti Endah Prayekti Fadlilah Nur Aini Farah Nuriannisa Gilang Nugraha Halimah Prisilia Herliani Rahmania Sari Himawan, Toto Ilmiah Alvi Nisa Aulia Kartika Yuliani Mubarokator Rizkiyah Muhammad Fifin Kombih Muhammad Taufiq Hidayat Ngiluhtara Aditiya Putri Nia Kurniaty Rukman Nila Dwi Utami Nisrina Salsabila Firdaus Nurul Hidayatih Rahmawati Fitri Awalia Rizka Amalia Rizka Amalia Rizma Defva Santoso Salfa Salsabilah Zain Salfa Salsabilah Zain Sari, Herliani Rahmania Saumia Khoirunnisa Syadzila Siti Basiroh Sri Surya Suciati Suciati, Sri Surya Sunaryo, Merry Syadzila, Saumia Khoirunnisa Utami, Nila Dwi Utomo, Edi Priyo Wardah Rohmah Wieke Sri Wulan Wieke Sri Wulan Yauwan Tobing Lukiyono Yuni Nur Malita Sari