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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 11 Documents

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Search results for , issue "Vol. 5 No. 2 (2021): Bioscientia Medicina: Journal of Biomedicine " : 11 Documents clear

Cancer Progression : Focus on Platelet Erty Sundarita; Mediarty
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 2 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i2.197

Platelets are an important component in the process of hemostasis and coagulation. It’snow known that high platelets count closely related to poor prognosis of patients withcancer, due to their role in the hematogenous spread of cancer cells. Platelet can beactivated by cancer cells into tumor educated platelet and then cause thrombosis throughtumor induced platelet aggregation. Platelet also protect cancer cells in the blood circulationfrom natural killer cells and help the transition of cancer cells from epithelial tomesenchymal and vice versa, resulting in the process of metastasis. In the next stage ofmetastasis, platelets trigger extravasation of cancer cells from primary cancer and helpadhesion of cancer cells to distant organs.

The Concordance of Recursive Partitioning Analysis (RPA) Class Stratification with Survival of Brain Metastases Patients in Mohammad Hoesin Hospital, Palembang, Indonesia: The concordance of RPA, Diansari et al Yunni Diansari; Selly Marisdina; Afriani; Dya Anggraeni; Hediaty Syafiera
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 2 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i2.202

A B S T R A C TIntroduction: Recursive Partitioning Analysis is one of prognostic scores, has beenvalidated to any different setting. Objective: To identify the concordance of RecursivePartitioning Analysis stratification in survival with brain metastases patients.Methods: Retrospective study was performed on brain metastases patients fromJanuary 2017 until Desember 2019 based on medical record. The follow up timestarted from the first diagnosis of brain metastases to death or last follow up. TheKaplan Meier was used to plot survival curves and the log-rank test was used toanalyse differences between groups Results: Mean overall survival time was 4,67months with 1,14 months for median survival for all patients. According to scoring,mostly (80,8%) patients were in group 3. The median survival time was 7 monthsand 2 months for group 2 and 3. Conclusion: It has shown relatively congruitysurvival in BM patients with stratification of Recursive Partitioning Analysis in ourinstitution.

The Efficacy of Cinnamon Extract ( Cinnamomum burmannii ) on Reducing Staging Acute Kidney Injury in Ischemia Reperfusion (IR) Model Evi Lusiana; Nia Savitri Tamzil; Desi Oktarina
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 2 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i1.203

A B S T R A C TIntroduction. Acute kidney injury (AKI) is defined as sudden decline in theglomerular filtration rate, resulting in the retention of nitrogenous wastes, such asurea and creatinine in plasma. Cinnamomum burmannii is known as a anti-inflammatory renoprotective agent, although the precise mechanism is not wellunderstood. This study aimed to elucidate the effectiveness of Cinnamomumburmannii extract in decreasing creatinine level of acute kidney injury Ischemiareperfusion (IR) model. Method. We performed Ischemia reperfusion (IR) in maleWistar rat to induce acute kidney injury. The rat (n=30) were divided into six groups:IR, 1 group treated with methylprednisolone as a control (IR+M), 3 groups treatedwith different oral Cinnamomum burmannii extract doses (50mg/kg (IR+EKM1),100mg/kg (IR+EKM2), and 200 mg/kg (IR+EKM3), and a Sham operation (SO)group. AKI stage reduction based on serum creatinine levels, before and aftermodeling, before and after the cinnamon extract intervention. Creatinine levels werequntified by spectrophotometry and analyzed by SPSS. Result. Cinnamomumburmannii extract lowers creatinine levels; significant (P <0.05). 200 mg / kgbb isthe effective dose of lowering creatinine levels in the IR model. Conclusion.Cinnamomum burmannii extract reduced serum creatinine levels associated withdecreased acute renal staging in the IR model.

Vascular and Cardiorespiratory Factors are Associated with Functional Capacity in Patient with Type 2 Diabetes Mellitus Ni Made Elva Mayasari; Raden Ayu Tanzila; Namira Amanda; Woro Nurul Sandra Anindhita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 2 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i1.204

A B S T R A C TIntroduction Diabetes mellitus is a degenerative disease that has globally increasedprevalence annually 1 . Impaired functional capacity due to poor blood sugar controland presence of cardiovascular autonomic dysfunction. Six minute walk test is amethod that is widely used in the assessment of functional capacity in patients withType 2 Diabetes Mellitus.ObjectiveTo evaluate factors that are associated withfunctional capacity in Type 2 Diabetes Mellitus.Methods This is an analyticobservational study with a cross sectional design. Fourty patients who had beendiagnosed with diabetes mellitus was assessed by six minute walk test. Chi squareand logistic regression analysis was perform by using SPSS 25. Results Six minutewalk test correlated significantly with Ancle Brachial Index scores (p = 0.016) andBody Mass Index (p = 0.03) Conclusion Ancle Brachial Index Score and Body MassIndex are factors associated with functional capacity in Type 2 Diabetes Mellitus

Does Electroencephalography Result Affect the Success of Treatment for Epilepsy Patients ? Sri handayani Suroto; Yunni Diansari; Selly Marisdina; Nova Lestari; Sri Yani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 2 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i1.205

A B S T R A C TIntroduction: Approximately there is 50 million people with epilepsy in the world.Currently, pharmacological management is the most therapeutic option. However,about 30% of patients will develop drug-resistant epilepsy. Many factors arethought to affect the treatment success. This study was conducted to determinethe relationship between electroencephalographic results and epilepsy treatmentsuccess. Methods : This is cross sectional observational study. Inclusion criteriawas epileptic patients aged > 18 years and had received epilepsy treatment for atleast 1 year. The chi-square test is performed to see the relationship betweenresearch variables. Results: EEG results has an effect on the success of therapy(p 0.027). The most common type of epileptiform abnormality is sharp waves. Themost epileptiform amplitude and location were 80 microvolts and in the temporallobe. Conclusion: There is a significant relationship between EEG abnormalitiesand the epilepsy treatment success.

ACE2 Receptor in the skin and Cutaneous Manifestations of SARS-Cov-2: A Review of the Literature Pho, Denita Meiliani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 2 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i1.209

A B S T R A C TSevere Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a newlydiscovered coronavirus that causes Coronavirus Disease 2019 (COVID-19). Theinteraction of SARS-CoV-2 transmembrane spike (S) glycoprotein with the humanangiotensin-converting enzyme-2 (hACE2) is the primary method of virus entry tothe cell. ACE2 is a transmembrane enzyme involved in the renin-angiotensin-aldosterone system. This enzyme plays pivotal roles in blood pressure regulationsand also electrolyte homeostasis. The expression of ACE2 in various skin cells hasbeen demonstrated in previous studies. Keratinocytes in the epidermis show anexceptionally high expression of ACE2. In addition to human skin, ACE2 is alsofound in animals’ tissues and were exceptionally high in cats and dogs’ skin andeyes. This finding suggests their obscure role in COVID-19 transmission. Cutaneoussymptoms of COVID-19 in humans exist as the consequence of ACE2 presence inthe skin. The possible mechanisms of COVID-19 clinical manifestations in the skinare upregulated innate immune human response, hypercoagulable state, and non-structural proteins in SARS-CoV-2. These processes are presented as differentdermatologic manifestations, which are maculopapular rash, papulovesicular rash,and livedo reticularis. This review aims to link the theoretical framework andpublished findings to establish the connection between ACE2 expression in skin andcutaneous manifestations of COVID-19.

The Role Protein Sonic Hedgehog in Carcinoma Basal Cell Yulia Farida Yahya; Radema Maradom; Hari Darmawan; Theresia L. Toruan; Ika Kartika
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 2 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i1.210

A B S T R A C TIntroduction: Basal cell carcinoma (KSB) is a non-melanoma skin cancer (KKNM),which is most commonly found compared to other skin cancers. KSB originates fromstem cells in the bulk of hair follicles or inter-follicular epidermis, through the Sonichadgehog (SHH) activation pathway, an increase in Sonic hadgehog (SHH) proteinexpression, involving Patches protein (PTCH), smothened protein (SMO), in the formof increased protein transcription activation Glia (GLI) in the nucleus, binds to DNAto initiate tumor-aggressive growth and tissue. Objective: to determine therelationship between Sonic hadgehog (SHH) expression and non-aggressive andaggressive basal cell carcinoma. Methods: The study was carried out in anobservational laboratory with 35 primary KSB patients, the tissue was taken usingelliptic biopsy technique, made paraffin block specimens for histopathologicalexamination of the subtype of KSB consisting of 20 non-aggressive KSB patients,namely nodular and superficial KSB; 15 patients with aggressive KSB werepigmented KSB; Infiltrates KSB, micronodular KSB, metypical KSB (basosquamousKSB) and SHH immunohistochemical (CPI) examination using SHH antibodies, inthe Anatomy Pathology section, FK Unsri / RSMH Palembang. The characteristics ofKSB patients were recorded, namely sex, age, occupation based on the length ofexposure to BC, namely exposure <3 hours / day, exposure 3-6 hours / day,exposure ≥ 6 hours / day. The data were processed using the Statistical AnalysisSoftware Package (SPSS) version 20.0 (IBM Corporation), tested with Pearsoncorrelation test and chi square test and presented in the form of diagrams, andnarrative tables. Results: Pearson's test showed a significant correlation betweenthe clinical features of KSB and the histopathologic features of non-aggressive andaggressive types of KSB (p 0.020), there was a significant relationship between thesubtypes of histopathologic features of KSB with non-aggressive and aggressivetypes of KSB (p 0.000), there was a significant relationship between strong SHHexpression and BCC aggressive compared to non-aggressive KSB, p 0.000 (p <05α),and r = 732 Conclusion: There is a relationship between SHH expression and KSBaggressiveness. The increase in strong SHH expression shows the aggressiveness ofKSB, SHH expression can be used as a biological gene target both as a prognosticindicator and can be used as a target for treatment of aggressive KSB, especially inthe elderly.

Epidermal Proliferation and Differentiation in Ichthyosis Vulgaris Nopriyati; Deddy Deddy; Rusmawardiana; Mutia Devi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 2 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i2.214

A B S T R A C TEpidermal proliferation and differentiation is a physiological process which playscrucial role in protecting human body from external environment. Ichthyosisvulgaris is a disease caused by disruption of epidermal differentiation process.Disrupted of profilaggrin conversion to filaggrin caused by mutations from thefilaggrin gene (FLG) located on chromosome 1q21. Recently, caused of ichthyosisvulgaris is mutation of the CASP14 gene on chromosome 19p13.12 which producescaspase-14, is involved in the proteolytic degradation of filaggrin. Clinicalmanifestations of ichthyosis vulgaris are hyperlinear palmar and plantar, keratosispilaris, xerosis, and localized or generalized scaling of the skin. Application ofemollients, humectants and keratolytic agents are the main treatment of ichthyosisvulgaris. Further research on caspase-14 as a therapeutic target is needed in thetreatment of ichthyosis vulgaris.

Comprehensive Obstetric and Neonatal Emergency Services (PONEK) to Reduce Infant Mortality and Improve Maternal Health Irawan Sastradinata
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 2 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i2.218

The Millennium Development Goals (Millennium Development Goal's) in2015, there are two targets and indicators that are specifically related tothe health of mothers, infants and children. The Millennium DevelopmentGoal's (MDG's) are for the hospital to implement the PONEK program(Comprehensive Obstetric Neonatal Emergency Services) for reduce infantmortality and improve maternal health. Maternal and perinatal servicesmust be organized in a teamwork and integrated between medical, nursing,midwifery and support services. The hospital as a health serviceorganization for the community needs to make continuous qualityimprovement, which continuously improves performance andservice quality in order to meet the demands of consumers and thehospital environment.

Ferning, Schimer I and Tear Break Up Time (TBUT) Accuracy Test in Post-Operative Cataract Patient with Extra Capsular Cataract Extraction (ECCE) Technique Anang Tribowo; Alie Solahuddin; Lady Kavotiner; Theodorus; Vidya Hestika
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 2 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i2.219

A B S T R A C TObjective: To determine the accuracy of the Ferning, Schimer I and TBUT test incataract patients after cataract surgery with the ECCE technique at the EyePolyclinic at Mohammad Hoesin Hospital Palembang and the Special Eye HospitalPalembang Methods: Diagnostic test was undertaken at the Eye Polyclinic atMohammad Hoesin Hospital Palembang and the Special Eye Hospital Palembangfrom May 2019 to January 2020. There were 42 postoperative cataract patients whomet the inclusion criteria. Ferning, Schimer I and TBUT tests were performed beforesurgery and one month after surgery. Data analysis using SPSS version 22.0 (SPSS,Inc Chicago, Illinois). Results: Fourty two samples of postoperative cataract surgerywith ECCE technique obtained by female sex (57,1%) with a mean age of cataractpatients of approximately 58.09 years. The accuracy of Schimer I and TBUT is 0.952with 100% sensitivity, 50% specificity, 95% positive predictive value (PPV) and 100%negative predictive value (NPV), the accuracy of TBUT and Ferning is 0.881 with90.2% sensitivity, 0% specificity , positive predictive value (PPV) 97.4% and negativepredictive value (NPV) 0% while the accuracy of Ferning and Schimer I was 0.928with a sensitivity of 97.5%, specificity of 0%, positive predictive value (PPV) of 95.1%and negative predictive value (NPV) 0%. Conclusion: Schimer I test is more accurateto use as a predictor of dry eye in postoperative cataract patients than Ferning andTBUT

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Location Kab. ogan ilir, Sumatera selatan INDONESIA

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Contact Name
Rachmat Hidayat

Contact Email
dr.rachmat.hidayat@gmail.com

Phone
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Journal Mail Official
dr.rachmat.hidayat@gmail.com

Editorial Address
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Location
Kab. ogan ilir,

Sumatera selatan

INDONESIA