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<![CDATA[Profil Penggunaan Obat Antiinflamasi Nonstreoid di Indonesia ]]>
<![CDATA[Maratu Soleha]]>;
<![CDATA[Ani Isnawati]]>;
<![CDATA[Nyoman Fitri]]>;
<![CDATA[Rosa Adelina]]>;
<![CDATA[Hamim Tsalis Soblia]]>;
<![CDATA[Winarsih Winarsih]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v8i2.316
<![CDATA[Nonsteroid Antiinflamation Drugs (NSAIDs) are available in drug store and be bought as a pain relief. Basic Health Research (Riskesdas) 2013 study the medicines stored in household. Basic Health Research (Riskesdas) 2013 was held in 33 provinces and 497 districts in Indonesia. The research encompasses 300.000 households in 12.000 blocks cencus. The participants were designated households and its member of the family. The study were interviewing the participants to obtain data of all drugs that are stored and used, including traditional medicines. The data including the brand, indication, the provenance (prescribed or unprescribed by doctor), the storage period and also observe drug condition. This study was further analysis of subset data in block IV of Riskesdas 2013 in households. The data were classified by its mechanism and its structure. The result showed that East Java was the highest user of AINS drugs was (15%). Non selectif COX-2 drug and partial selectif COX-2 was 38,3% bought from drug store and 14,4% from drug store. For rheumatism treatment was all used for more than a month. Widely use of NSAIDs as a pain relief indicated the necessity of a proper medicine use information to avoid side effect of NSAID drug.]]>
<![CDATA[The Pharmaceutical Availability of Gambier Leaves Bioactive Fraction Coated Tablet in Simulated Human Body Fluids ]]>
<![CDATA[Indah Sulistyowati]]>;
<![CDATA[Nanang Yunarto]]>;
<![CDATA[Nurul Aini]]>;
<![CDATA[Kelik M Arifin]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v8i2.321
<![CDATA[The widespread usage of traditional medicine either in the developed or developing countries, makes traditional medicine requirements become a major concern in terms of assuring the safety and effectiveness of treatment. WHO suggested dissolution study to support traditional medicine clinical trials. The catechins from Gambier could reduce atherosclerotic lesions case caused by elevated levels of cholesterol, LDL, and triglycerides. Catechin is hygroscopic that becoming unstable. Raising the stability, Gambier is made to a coated tablet. This study aimed to determine the condition of gambier leaves bioactive fraction coated tablet in simulated human body fluids through an in vitro testing using dissolution tester. Three formulations coated tablet with different coating percentage had been tested using dissolution tester apparatus. The test was conducted in water, acid, and buffer as dissolution medium to generate the dissolution profile. Tablet evaluation showed that the three formulations dissolved 71.25% ± 6.26 to 91.05% ±3.05 in the water, acid, and buffer dissolution medium. The gambier leaves bioactive fraction coated tablet had more than 70% pharmaceutical availability in simulated human body fluids.]]>
<![CDATA[Karakterisasi Minyak Atsiri dari Simplisia Basah Ranting dan Daun sebagai Alternatif Subtitusi Kulit Batang Cinnamomum burmannii Blume ]]>
<![CDATA[Mery Budiarti]]>;
<![CDATA[Wahyu Jokopriambodo]]>;
<![CDATA[Ani Isnawati]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v8i2.323
<![CDATA[The bark of Cinnamomum burmannii Blume is the main raw material of Cinnamomum oil because its cinnamaldehyde content is higher than in the other parts. This condition lead to the exploitation of Cinnamomum burmannii Blume bark without any cultivation effort, thus it can cause the raw material scarcity. Twigs and leaves of Cinnamomum burmannii Blume are also known to contain cinnamaldehyde therefore it provide a potential alternative source of cinnamaldehyde. The purpose of this research is to investigate the characteristic of Cinnamomum burmannii Blume essential oil which includes refractive index, profiling of chemical constituent and percentage of cinnamaldehyde as a marker compound. This research used three fresh Cinnamomum burmannii Blume simplicia of bark, twigs and leaves from two selected growing locations: Tawangmangu and Purwokerto. Simple water distillation method was conducted, together with characterization and refractive index using refractometer, followed by qualitative and quantitative analysis with Thin Layer Chromatography (TLC) and Gas Chromatography (GC). The results showed Cinnamomum burmannii Blume oil derived from bark, twig and leaf have different profiles, but all have cinnamaldehyde as the main component. The leaf produces higher essential oil yield percentage compared to the twig with a cinnamaldehyde content that is comparable to the bark by 50% of cinnamaldehyde content in cinnamomum bark oil.]]>
<![CDATA[Efek Sinergis Kombinasi Ekstrak Etanolik Kayu Secang dan Rimpang Lempuyang pada Sel Kanker Payudara MCF-7 ]]>
<![CDATA[Sari Haryanti]]>;
<![CDATA[Ika Yanti M. Sholikhah]]>;
<![CDATA[Yuli Widiyastuti]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 1, FEBRUARI 2019 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v9i1.324
<![CDATA[Cancer is one of critical, chronic, and complex disease, also becoming the high cause of death in the world. Brazilin and brazilein in sappan wood (Caesalpinia sappan L.) and zerumbone in bitter ginger rhizome (Zingiber zerumbet L.) are known having cytotoxic activity with different mechanisms. This study aimed to examine combination effect of sappan wood and bitter ginger rhizome. Sappan wood and bitter ginger rhizomes macerated with ethanol 96% for 3x24 hours, filtered, and evaporated to obtain dried extract.Cytotoxic effect on MCF-7 cells was done using MTT assay. Combination Index (CI) was determined by CompuSyn based on the result of cytotoxic combination. Cell cycle profile and apoptosis induction was analyzed by flow cytometry. Sappan wood extracts and bitter ginger rhizome exhibited cytotoxic effects on MCF-7 cells with the IC50 values of 30 and 155 μg/mL respectively. The combination of sappan wood 15 μg/mL and bitter ginger 8, 12, 24, and 60 μg/mL produced synergistic effect with the CI value of 0.57-0.85. Sappan wood 15 μg/mL combined with bitter ginger 8 and 24 μg/mL showed cell cycle inhibition at G2/M phase. The combination also increased apoptosis induction compared to untreated cells and its single treatment.The combination of sappan wood ethanolic extracts and bitter ginger rhizome showed synergistic cytotoxic effect. Its synergism effect revealed through cell cycle arrested at G2/M phase and acceleration of apoptotic induction.]]>
<![CDATA[Identifikasi Kandungan Saponin dalam Ekstrak Kamboja Merah (Plumeria rubra L.) dan Daya Surfaktan dalam Sediaan Kosmetik ]]>
<![CDATA[Fulka Nurzaman]]>;
<![CDATA[Joshita Djajadisastra]]>;
<![CDATA[Berna Elya]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v8i2.325
<![CDATA[Saponin is a group of compounds contained in natural materials that have amphiphilic properties and can reduce surface tension. The reduction of surface tension caused by a soap compound (Latin = sapo) that can disrupt hydrogen bonds in water. Red frangipani plant (Plumeria rubra) is known to have saponin content. The research objectives were to identify the saponin content of red frangipani plant extract (Plumeria rubra) which could reduce the surface tension. Part of red frangipani plant (flowers, leaves and stems) was extracted using five kinds of solvents. Each of the extracts obtained was then tested for saponin content qualitatively. Extract from each part of the plant (flower, leaf, and stem) which has the highest foam was selected then tested surface tension using surface tensionmat equipment. The result of qualitative saponin test showed that flower, stem and flower extract of red frangipani with aqua demineralisata solvent had the highest saponin content compared to extract with other solvent. The content of saponins in plumeria rubra extract either from the leaves, stems or flowers could decrease the surface tension with the best results obtained from the flower extract with 8,61% of Critical Micelle Concentration (CMC).]]>
<![CDATA[Synthesis and Characterization Molecularly Imprinted Polymers for Analysis of Dimethylamylamine Using Acrylamide as Monomer Functional ]]>
<![CDATA[Saeful Amin]]>;
<![CDATA[Sophi Damayanti]]>;
<![CDATA[Slamet Ibrahim]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v8i2.330
<![CDATA[A selective separation techniques with Molecularly Imprinted Polymer (MIP) for High-Performance Liquid Chromatography (HPLC) has been developed for the assay of Dimethylamylamine (DMAA) doping compounds. Molecular imprinted polymer (MIP) is a technique to produce a polymer having the cavity due to the disposal of the templates, in which the cavity serves to recognize the molecules of the same size, structure, chemical and physical properties. The selectivity and affinity of the templates itself will increase, while the concentration value is increasing. MIP is made by DMAA as template, acrylamide as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross linking, azobisisobutyronitrile (AIBN) as the initiator and chloroform as a porogen solvent; using bulk method. The aim of research are conduct the MIP for the DMAA compound analysis, then the formed MIP is characterized by using Fourier Transform Infra Red (FTIR) and Scanning Electron Microscopy (SEM) to find out the polymer complexes formed and the morphological form of the MIP. The MIP formed then was analyzed by using High-Performance Liquid Chromatography (HPLC) to know the amount of the DMAA, the adsorption capacity, and the adsorption condition found in the MIP. The result of analysis on the content of DMAA in the MIP by using UV-Vis Spectrophotometer is 1.957 mg. Scanning Electron Microscopy (SEM) shows that the MIP has irregular and rough morphological structure; while the NIP has irregular morphology structures and smooth surfaces shape]]>
<![CDATA[Hyperlipidemia Preventing Activities of Standardized Ethanolic Extract of Red Spinach (Amaranthus tricolor L.): An In Vivo Study in Male Sprague-Dawley Rats ]]>
<![CDATA[Dimas Adhi Pradana]]>;
<![CDATA[Lalily Apriani]]>;
<![CDATA[Sitarina Widyarini]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v8i2.349
<![CDATA[Lipid metabolism disorders can lead to hyperlipidemia that triggers atherosclerosis. This study aimed to identify the potential of standardized ethanolic extract of red spinach (Amaranthus tricolor L.) to prevent hyperlipidemia by referring to the reduction of triglyceride level and total cholesterols in male Sprague-Dawley rats. A total of 30 experimental animals was put into 6 groups, including normal, positive control (0.9 mg/kgBW of simvastatin), negative control, treatment I (200 mg/kgBW of extract), treatment II (400 mg/kgBW of extract), and treatment III (800 mg/kgBW of extract). Preventive therapy and positive control were administered from day 1 to day 67. Hyperlipidemia was induced by feeding pure lard and duck yolk to the rats twice daily from day 8 to day 67. Determination of triglyceride level and total cholesterols was conducted on day 0 and day 67. The findings revealed that the treatment groups with ethanolic extract of red spinach at doses of 200 mg/kgBW, 400 mg/kgBW, and 800 mg/kgBW had statistically significant differences (p]]>
<![CDATA[Uji Aktivitas Antiseptik Ekstrak Etanol Daun Sirih (Piper betle Linn.) dalam Obat Kumur terhadap Staphylococcus aureus secara in Vitro ]]>
<![CDATA[Dian Sundari]]>;
<![CDATA[Almasyhuri Almasyhuri]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 1, FEBRUARI 2019 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v9i1.351
<![CDATA[Betle leaf (Piper betle Linn.) is very popular in Indonesia. Betle leaf is useful for dental health and frequently used as mouthwash; to eliminate body and mouth odor; treats mouth ulcer, nosebleed, itching, ulceration and vaginal discharge in women. An oral cavity is a place for bacteria. If there is a bacterial immunity reduction, that was originally commensal bacteria can turn into a pathogen that cause infection. One of bacteria that commonly found in the oral cavity is Staphylococcus aureus. The bacteria have the ability to occupy and form biofilm on biomaterials that cause resistant to antimicrobials, thus making it difficult to eradicate host that is infected by S. aureus. Previous study reported a multidrug resistant of S. aureus that could cause death, that to overcome it, betle leaves extract ethanol in vitro antiseptic test to S.aureus was conducted. The test was conducted by the phenol coefficient method using S. auereus ATCC 25923 bacteria. Povidone iodine mouthwash that is circulated in the market is used as a comparison. The results showed that mouthwash containing ethanol extract of betle leaf had a phenol coefficient value of 1.87 while povidone iodine mouthwash as a comparison, had a phenol coefficient of 1.0. Mouthwash containing ethanol extract of betle leaf had higher antiseptic effectiveness than the comparative mouthwash.]]>
<![CDATA[Uji Klirens dan Uji Pirogenitas sebagai Bagian dari Penentuan Mutu Biologi Sediaan 90Y-EDTMP ]]>
<![CDATA[Sulaiman Sulaiman]]>;
<![CDATA[Sri Aguswarini]]>;
<![CDATA[Karyadi Karyadi]]>;
<![CDATA[Chairuman Chairuman]]>;
<![CDATA[Gatot Setiawan]]>;
<![CDATA[Adang HG]]>;
<![CDATA[M. Subur]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v8i2.352
<![CDATA[Cancer is one of the causes of death in Indonesia and even the world. Nuclear medicine techniques with radiopharmaceuticals and SPECT are one of the ways to treat cancer, but their use in Indonesia is not yet popular. Radiopharmaceuticals marked with radionuclide emitting beta (β) radiation are proven to be used for cancer therapy, one that has been developed in PTRR-BATAN is 90Y-EDTMP. Yttrium-90 is used in nuclear medicine by utilizing β radiation (E max 2.28 MeV). The β energy which is produced from the decay process of 90Y radionuclides to 90Zr can kill cancer cells. This study aimed to provide information about the substances biological effects so that preventive measures can be taken to protect humans. This study conducted evaluation of the 90Y-marked radiopharmaceutical (90Y produced from a 90Sr / 90Y generator which is 90Y-EDTMP) encompasses clearance test, pyrogen test, and dose safety test in experimental animals. The clearance test utilized mice, the pyrogen test utilized rabbits, and the dose safety test utilized mice. The results of the clearance test showed that 90Y-EDTMP compound which was excreted in 192 hour was 49.70% through urine and 14.59% through feces. The total excretion of 90Y-EDTMP within 192 hours was 64.57%. Based on the results of clearance tests with calculations, 90Y of 90Sr / 90Y generators in 90Y-EDTMP dosage form had 84.2 hours of half-life, 36.5 hours of an effective half-life and 52.7 hours of a residence time. Pyrogen test results showed pyrogen-free. The 90Y-EDTMP dose safety test showed that the dose is safe and not deadly. The development of 90Y-EDTMP is expected to be improved to produce radiopharmaceuticals for cancer therapy in order to make a real contribution in public health services.]]>
<![CDATA[Analisis Pelayanan Kefarmasian Berdasarkan Indikator Pelayanan Pasien WHO pada Puskesmas Kecamatan yang Belum dan Sudah Terakreditasi di Kota Depok ]]>
<![CDATA[Makhdalena Makhdalena]]>;
<![CDATA[Mahdi Jufri]]>;
<![CDATA[Retnosari Andrajati]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v8i2.355
<![CDATA[Pharmaceutical care based on WHO patient care indicators in various developing countries, including Indonesia, have not met the requirements. Puskesmas accreditation is expected to improve pharmaceutical care that has an impact on rational drug use. The purpose of the study was to analyze pharmacy care based on WHO patient care indicators in all sub-district health centers (9 health centers not yet accredited and 2 health centers already accredited) in Depok City. This study used a cross-sectional design and was carried out in December 2016-February 2017. The sample was adult patients from general poly and accompanying patients from integrated management of sick toddlers who met the inclusion criteria, as well as all prescription drugs taken. There were 30 respondents and 30 prescriptions for each sub-district health center. Data collection was done through interviews and observation of respondents and analysis of the recipe sheets. Data analysis used Mann-Whitney and Chi-square tests. The results show that the sub-district health centers have not been accredited which meets WHO recommendations for preparation time and delivery of drugs (> 3 minutes) of 77.8% and those who are 100% accredited. None of the sub-district health centers in Depok City meet WHO recommendations for the suitability of drug delivery, adequate drug labeling and patients with correct drug knowledge (= 100%). The time of preparation and delivery of drugs at the subdistrict health centers has been accredited significantly longer than those not yet accredited (p]]>
