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Diagnosis and Treatment of Antisocial Personality Disorder: A Case Report Patricia Wulandari
Scientia Psychiatrica Vol. 1 No. 3 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v1i3.15

Introduction: Antisocial personality disorder (ASPD) defines patterns of behavior that are irresponsible for social, exploitative, and unproblematic issues that begin in early childhood or adolescence and are manifested by changes in the life phase. This case report aimed to describe antisocial personality disorder experienced by a girl in Aceh, Indonesia. Case presentation. A woman, 19 years old, a college student, living in a suburban area, came to consult to hospital with complaints of anxiety and difficulty sleeping. The patient claimed that she often wanted to hurt and persecute others. She often tries to hurt other people but does not get caught because she said the act was carried out accidentally. When she was a child, she liked to torture animals and she did it without guilt and pity. Lately patient felt the desire to hurt others is getting bigger. Conclusion: The management of antisocial personality disorder can be adjusted to the circumstances and background or risk factors of the disorder, and treatment is used to reduce symptoms.

Are Young Women More Potential to Commit Suicide? Patricia Wulandari; Rachmat Hidayat
Scientia Psychiatrica Vol. 1 No. 3 (2020): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v1i3.16

Introduction: Convenience in various aspects of life in fact does not guarantee people live happier. Every year around the world around one million people die from suicide. One of the most consistent findings in suicide research is that women make more suicide attempts (tentament suicide) than men. This research is the first research conducted as an effort to increase the awareness of all medical potentials of young women to commit suicide. Methods: This research was qualitative research with an in-depth interview approach to respondents. The subjects of this study were patients with a diagnosis of tentamen suicide who consulted the Cattleya Consultation Center, Palembang, Indonesia. Results: All subjects with a tendency to commit suicide were female (100%) with a young age, ie the youngest age was 16 years and the oldest was 28 years. Women at this age are classified as young and productive age. It was found that most of the patients had avoidant personality traits (43%). In addition, the factors that triggered the emergence of tentamen suicide in some respondents were social and environmental factors (44%), namely in the form of friendship factors (peer groups), and the experience of bullying. Conclusion: Young women have the potential to do tentamen suicide.

An Overlap between Depression and Anxiety- A Literature Review Patricia Wulandari
Scientia Psychiatrica Vol. 2 No. 3 (2021): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v2i3.38

Most studies show a high overlap between depression and anxiety syndromes. Relevant data come from representative studies. In clinical settings, the relative proportion of comorbid cases is even higher than that found in representative population surveys. Individuals with two concomitant disorders, suffering from a high overall burden, are more likely to seek treatment than individuals with only one disorder (Berkson’s paradox). Both depression and anxiety syndromes also co-occur with other psychiatric conditions such as substance abuse or personality disorders.

Brain Development of Attachment Experience: How Does It Affects Our Brain? Rachmat Hidayat; Patricia Wulandari
Scientia Psychiatrica Vol. 2 No. 3 (2021): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v2i3.39

Our infant experiences involve our emotions, behavior, perceptions, and our mental models of the world of others and ourselves. Implicit memories encode the early forms of our learning about the world. Implicit memories directly shape our experiences here and now with no clue as to their origins from past events. Attachment research, combined with independent findings from our modern studies of genetics and developmental neurobiology, suggests that certain types of communication in emotionally connected relationships offer an essential experience that a child's mind can develop. This literature review describes how our experience in childhood affects brain development.

Effect of Andrographis paniculata on Blood Sugar Levels Through Regulation of Alpha-Glucosidase Enzyme Expression: An In Vivo Study Rachmat Hidayat; Patricia Wulandari
Eureka Herba Indonesia Vol. 3 No. 1 (2022): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v3i1.56

Diabetes mellitus (DM) is a disease characterized by an increase in blood glucose levels caused by insulin deficiency, either absolute or relative. The α-glucosidase enzyme functions to accelerate the absorption of glucose by the small intestine by catalyzing the hydrolytic cleavage of oligosaccharides into monosaccharides. This study aims to explore the potential of AP extract in regulating blood sugar levels through inhibition of α-glucosidase activity in the intestine. This study is an in vivo experimental study. A total of 30 \ rats were divided into a control group and treated with Andrographis paniculata. Examination of blood sugar levels was carried out by spectrophotometry and examination of alpha-glucosidase enzymes by ELISA. Data analysis was performed using SPSS software with univariate and bivariate analysis. Andrographis paniculata extract was able to reduce blood sugar levels and was able to decrease the activity of the alpha-glucosidase enzyme as the dose increased. Andrographis paniculata extract is able to reduce blood sugar levels by inhibiting the activity of the alpha-glucosidase enzyme in the intestine.

Bioethical Principles of Use of Experimental Animals in Biomedical Research Rachmat Hidayat; Patricia Wulandari
Biomedical Journal of Indonesia Vol. 7 No. 1 (2021): Vol 7, No 1, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i1.267

Research is an activity carried out based on scientific principles and methods systematically to obtain information, data, and information from related subjects, with understanding the theory and proving assumptions and / or hypotheses. The resultsobtained are conclusions that can be applied or become additional knowledge for the advancement of science. However, research activities must still respect the rights and dignity of research subjects. Health research includes biomedical, epidemiological, social, and behavioral research. Some health research can be done in vitro, using mathematical models, or computer simulations.

Anatomy and Physiology of Animal Model Rats in Biomedical Research Rachmat Hidayat; Patricia Wulandari
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.287

A distinguishing feature of rodents, including rats, is the absence of canines and the presence of prominent incisors. Rats are monophydontic, meaning they grow one set of teeth in their lifetime. The enamel of the rodent incisor contains iron, which gives it its yellow-orange color. Rats are mammals and as such, possess many similarities with other mammals. Only the peculiarities of the rat’s anatomy are addressed. Male rats reach puberty at 40 - 60 days of age. Descent of the testes usually occurs between days 30 - 60. Sperm counts vary by strain. The male rat has an os penis. Male rats have the following accessory sexual organs: ampulla, seminal vesicles, prostate, bulbourethral glands, coagulating glands, and preputial glands. The coagulating gland and prostatic and vesicular secretions are responsible for the copulation plug, a firm plug deposited in the vagina of the female after copulation. (This plug, when found outside the female rat, is capsuleshaped and approximately 5 mm long.) The male rat has no nipples. The adult male rat has a prominent scrotum and a longer anogenital distance than the female rat.

Efficacy of Exosome Adipose-Derived Stem Cells (ACSs-Exosome) on Skin Flaps Transplantation in Plastic Surgery: A Systematic Literature Review Rachmat Hidayat; Patricia Wulandari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 11 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i11.614

Background: Exosomes are a small subset of extracellular vesicles with a size of about 50 nm – 200 nm, which are found in many body fluids. The exosome is rich in various proteins and is a cargo that carries out the process of transporting and transporting between cells in the context of cell communication. This becomes a potential new therapeutic modality in triggering the modulation and activity of target cells so that ACSs-Exosome becomes a new potential to modulate skin flap transplantation repair in plastic surgery. Methods: The literature search process was carried out in various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the use of ASCs-exosome in skin flap transplantation repair in plastic surgery cases. Results: A total of 5 studies were included in this systematic review. In general, ASCs-exosome administration was more effective in the percentage of flap survival area than in the placebo group. There are 3 studies that state that the effectiveness of flap area survival is more than 70 percent compared to the placebo group, which is only in the range of 30-40 percent. Conclusion: ASCs-exosome has the potential to be developed to improve the survival rate of skin flap transplantation in the case of plastic surgery.

Efficacy of Exosome Adipose-Derived Stem Cells (ACSs-Exosome) on Skin Flaps Transplantation in Plastic Surgery: A Systematic Literature Review Rachmat Hidayat; Patricia Wulandari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 11 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i11.614

Background: Exosomes are a small subset of extracellular vesicles with a size of about 50 nm – 200 nm, which are found in many body fluids. The exosome is rich in various proteins and is a cargo that carries out the process of transporting and transporting between cells in the context of cell communication. This becomes a potential new therapeutic modality in triggering the modulation and activity of target cells so that ACSs-Exosome becomes a new potential to modulate skin flap transplantation repair in plastic surgery. Methods: The literature search process was carried out in various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the use of ASCs-exosome in skin flap transplantation repair in plastic surgery cases. Results: A total of 5 studies were included in this systematic review. In general, ASCs-exosome administration was more effective in the percentage of flap survival area than in the placebo group. There are 3 studies that state that the effectiveness of flap area survival is more than 70 percent compared to the placebo group, which is only in the range of 30-40 percent. Conclusion: ASCs-exosome has the potential to be developed to improve the survival rate of skin flap transplantation in the case of plastic surgery.

Activated Platelet Rich Plasma as a New Treatment Modality for Cataract Disorders: In Vivo Study Rachmat Hidayat; Patricia Wulandari
Sriwijaya Journal of Ophthalmology Vol. 5 No. 2 (2022): Sriwijaya Journal of Ophthalmology
Publisher : Department of Opthalmology, Faculty of Medicine, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjo.v6i2.86

Introduction: Cataract is the main cause of visual impairment and vision loss in the world, where 33% of the world's population has decreased vision due to cataracts. This study aims to explore the role of platelet-rich plasma (PRP) in inhibiting the pro-inflammatory cytokine interleukin-1ß, thereby triggering tissue repair in cataract cases in vivo study. Methods: This study is an experimental study with a post-test-only approach with a control group design. A total of 30 rats (Rattus norvegicus) Wistar strain was included in this study (male, 150-200 g, 8-10 weeks). The rats were divided into 3 groups, P1 (the group that was not induced by cataract and not treated with platelet-rich plasma), P2 (the group that was induced by cataract and given 10 uL of intraocular saline injection), and P3 (the group that was induced by cataract and given an intraocular injection of platelet-rich plasma). Plasma 10 uL). Results: The results showed that the P3 group that received platelet-rich plasma treatment showed a significant decrease in IL-1B levels when compared to the P2 group with cataract induced but without PRP administration (p<0.05). Conclusion: Activated platelet-rich plasma has potential as a new therapeutic modality in cataract conditions through inhibition of chronic inflammatory response in vivo studies.

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