<![CDATA[Background: Tuberculosis (TB) was an infectious disease which was still a health problem worldÂwide, including in Indonesia, which only had a population of around 261 million. The purpose of this study was to analyze biological and social economic determinants of adherence and cure of TB treatment.Subjects and Method: This was an analytic observational study with a case control design. The study was conducted in Bantul, Yogyakarta, from April to May 2019. A sample of 225 TB patients was selected by random sampling. The dependent variable was adherence and cure of TB treatÂment. The independent variables were age, gender, education, family income, nutritional status, healthy behavior, complication, family support, drug taking supervisor, drug taking adherence, environment, and smoking. The data were collected by questionnaire and analyzed by path analysis.Results: Adherence and cure of TB treatÂment was directly increased with good nutritional status (b= 076; 95% CI= 0.03 to 1.49; p= 0.042), drug taking adherence (b= 3.67; 95% CI= 1.47 to 5.92; p= 0.001), drug taking supervisor (b= 3.64; 95% CI= 1.26 to 6.02; p= 0.003), strong family support (b= 2.03; 95% CI= -3.85 to -0.21; p= 0.029), and healthy physical environment (b= 4.05; 95% CI= - 0.09 to 8.20; p= 0.056). Adherence and cure of TB treatÂment was directly decreased with age ≥65 years old (b= -0.54; 95% CI= - 1.85 to 0.75; p= 0.411), female gender (b= -0.05; 95% CI= - 0.86 to 0.76; p= 0.900), unhealthy behavior (b= -3.20; 95% CI= - 5.02 to -1.36; p= 0.001), smoking (b= -1.50; 95% CI= - 2.56 to -0.43; p= 0.006), complication (b= -1.41; 95% CI= - 2.60 to -0.23; p= 0.019). It was indirectly affected by nutritional status, education, family income, and healthy environment.Conclusion: Adherence and cure of TB treatÂment is directly increased with good nutritional status, drug taking adherence, drug taking supervisor, strong family support, and healthy physical environment. Adherence and cure of TB treatÂment is directly decreased with age ≥65 years old, female gender, unhealthy behavior, smoking, complication. It is indirectly affected by nutritional status, education, family income, and healthy environment.Keywords: tuberculosis treatÂment, drug taking adherence, path analysisCorrespondence: Tri Godha Fitriani. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: trigodha@gmail.com. Mobile: +6287738200610.Journal of Epidemiology and Public Health (2019), 4(4): 270-282 https://doi.org/10.26911/jepublichealth.2019.04.04.02]]>
