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Journal : Jurnal Natur Indonesia

Pengaruh Pemberian Taurin terhadap Gambaran Histopatologi Paru Mencit (Mus musculus) yang Diinduksi Karsinogen Benzo(α)Piren secara In Vivo Roselyn, Arini Pradita; Widiastuti, Endang Linirin; Susanto, G. Nugroho; ', Sutyarso
Jurnal Natur Indonesia Vol 17, No 1 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (793.323 KB) | DOI: 10.31258/jnat.17.1.22-32

Abstract

Lung cancer is a disease that causes high mortality. Drugs used to prevent and cure cancer mostly causes intoxicity to the normal tissues due to its less effectiveness. Therefore, it is necessary to find out any agent or substance which works much more effective and safe for cancer treatment. The aim of the study was to elucidate the role of taurine on the lung tissue of mice (Mus musculus) induced by carcinogenic benzo(α)pyrene. The experiment was conducted in a completely randomized design with 5 replications. Six treatment groups were perfomed. Group I was given 0.2 mL of corn oil and given aquadest until the end of the study period, group II was induced by benzo(α)pyrene without administration of taurine, group III before induced with benzo(α)pyrene, was given taurine dosage 7.8 mg/BW/day for two weeks, group IV after induced benzo(α)pyrene, was given taurine with dosage 3.9 mg/BW/day, group V after induced benzo(α)pyrene, was given taurine with dosage7. 8 mg/BW/day, group VI after induced with benzo(α)pyrene, was given taurine with dosage 15.6 mg/BW/day. The results of the Kruskal-Wallis analysis and one way ANOVA with LSD (p>0,05) showed that taurine reduced lung tissue damage 72.73% due to the administration of benzo(α)pyrene of 0.3 mg/BW/day. In addition, the effective dose of taurine reduce lung tissue damage was 15.6 mg/BW/day.
Pengaruh Pemberian Senyawa Taurin dan Ekstrak Daun Dewa Gynura segetum (Lour) Merr terhadap Eritrosit dan Leukosit Mencit (Mus musculus) yang Diinduksi Benzo[α]Piren Marlinda, Henny; Linirin Widiastuti, Endang; Susanto, G. Nugroho; ', Sutyarso
Jurnal Natur Indonesia Vol 17, No 1 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (150.764 KB) | DOI: 10.31258/jnat.17.1.13-21

Abstract

Blood cancer (leukemia) is a cancer that occurs due to malignancy of blood cells. Treatment of leukemia generally causes damage to normal cells. Therefore, it needs a drug that has the effect of repairing cell damage and the ability to boost immunity of normal such as taurine and Gynura leaves which are expected to have anticancer and antioxidant properties. The purpose of this study was to investigate the effect of taurine and dewa leaf extract on blood tissues induced by benzo [α] pyrene in vivo, by looking at changes in body weight, the number of red blood cells (erythrocytes), the total number and differentiation of white blood cells (leukocytes) in mice (Mus musculus). Data were analyzed by One Way ANOVA test followed by LSD at 5% significance level. The treatment groups were the group I was given 0.2 mL of corn oil (negative control), group II (given benzo [α] pyrene as a positive control, Group III (given taurine 7.8 mg/BW/day starting from day 1 to 15 before the induction of benzo [α] pyrene until the end of the study), Group IV was given benzo [α] pyrene, then were given taurine 7.8 mg/BW/day were given 2 times a day, as well as the V group was given benzo [α] pyrene, then given a dose of Gynura leaf extract 277.8 mg /BW/day. The results showed taurine and Gynura leaf extract were able to obstruct leukemia by increasing body weight, erythrocyte, leukocyte, and the number of leukocyte differentiation which becomes normal again. In conclusion taurine has better ability for therapoitic than Gynura leaf extact against blood cells induced by benzo[α]piren
Respon Histopatologis Hepar Mencit (Mus musculus) yang Diinduksi Benzo(α)Piren terhadap Pemberian Taurin dan Ekstrak Daun Sirsak (Annona muricata) Agata, Annisa; Widiastuti, Endang Linirin; Susanto, G. Nugroho; ', Sutyarso
Jurnal Natur Indonesia Vol 16, No 2 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (582.872 KB) | DOI: 10.31258/jnat.16.2.54-63

Abstract

Cancer is a disease that is characterized by the existence of damage and cell abnormality in growth and differentiation. Liver cancer is a disorder of hepar tissue derivated from its tumors. Taurine is known as antioxidant but its role as anticancer needs to be explored more as well the role of Annona muricata leaf extract which is believed to have its role as anticancer substance. This research, therefore, aimed to explore the effect of taurine and Annona muricata leaf extract on the hepar histopathology of male mice (Mus musculus) induced by benzo(α)pyren in vivo. This research was carried out by using a complete randomized design, which consisted of 5 treatment groups which was repeated 5 times. Group I was given 0.2 mL corn oil for 15 days, group II was induced by benzo(α)pyren without taurin nor A. Muricata leaf extract for 10 days, group III was given 7.8 mg taurine/BW/day (twice a day) starting from the 15 th days before the induction of benzo(α)pyren, group IV, after induced with benzo(α)pyren, taurine was given with dosage of 7.8 mg/BW/day, group V, after induced with benzo(α)pyren, soursop leaf extract was given with amount of 277.8 mg/BW/day. Data analyzed by Kruskal-Wallis test and one way ANOVA with Fisher test (p>0.05). The results indicated that taurine had ability to recover the liver tissue induced by benzo(α)pyren as (carcinogenic) while, Annona muricata leaf extract had not shown any recover of tissue damage
Bird Species Based on Tree Height Perched in the Liwa Botanical Garden, West Lampung Regency Putra, Bagus Susilo; Kanedi, M.; Nurcahyani, Nuning; Susanto, G. Nugroho
Jurnal Natur Indonesia Vol 20, No 1 (2022): April 2022
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/jnat.20.1.9-14

Abstract

Birds are one of the most diverse animals in the world, especially in Indonesia. Liwa Botanical Garden located in Pekon Kubu Perahu, Balik Bukit District, West Lampung Regency, is a conservation area with the theme of conservation and development of ornamental plants, representing the flora of Southern Sumatra. This research is a continuation of the collaboration between the Department of Biology and Balitbang UPTD Liwa Botanical Garden, West Lampung Regency. The presence of birds in the Liwa Botanical Garden is also a bioindicator of biodiversity for the environment in this area. By maintaining the presence of birds in the Liwa Botanical Garden means protecting their habitat and existing plants. The purpose of this study was to determine the species of birds based on the height of the perched trees in the Liwa Botanical Garden and the abundance of their species. The method used in this research is the point count with the observation time for 9 days in the morning and evening at the height of the tree in 3 different observation stations. Birds on KRL are mostly found on perches at an altitude of 2 - 7 meters, in the category of shrubs and trees, there are 19 out of 25 bird species found. The highest Relative Abundance Index (IKR) was Collocalia esculenta at 39.91% and the lowest IKR value was 7 bird species, each with 0.14% value. The conservation status of the 25 bird species based on IUCN is Least Concern (LC) and based on CITES there is one species that is included in Appendix II, namely Ictinaetus malayensis while based on the Regulation of the Minister of Environment and Forestry of the Republic of Indonesia No. P.20 / MENLHK / SETJEN / KUM.1 / 6/2018 there is one bird species that is included in the protection, namely species Ictinaetus malayensis