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Synthesis, Characterization and Anti Mcf-7 Proliferative Acitivity of Flavonol Derivatives of 2'-Hydroxyacetophenon and 3,4,5-Dimethoxy Benzaldehid Rokim, Muhamad; Zamri, Adel; Teruna, Hilwan Yuda
Jurnal Natur Indonesia Vol 17, No 2 (2019)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (475.257 KB) | DOI: 10.31258/jnat.17.2.16-24

Abstract

Flavonols a derivatives of 2'-hydroxyacetophenon and 3,4,5-dimethoxy benzaldehid has been synthesized under basic condition (KOH). The structure of the compound was characterized based on the interpretation of spectroscopic data, including UV, FTIR, NMR and HRMS. Anticancer activity was evaluated using the MTS assay against MCF-7 cells, which showed that the flavonol 2'-hydroxycalone derivative was potentially active as an anticancer substance with IC50 values <1000 µg / mL.