Claim Missing Document
Check
Articles

Found 13 Documents
Search

Plant cyanogenic glycosides: an overview Hartanti, Dwi; Cahyani, Arinda Nur
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 5, No 1 (2020)
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i1.10047

Abstract

The cyanogenic glycosides have consisted of α-hydroxy nitrile aglycone and a sugar moiety that producing hydrogen cyanide (HCN) during the hydrolysis process. This HCN-producing property underlines the toxicity of the plants commonly associated with these compounds in humans and animals. However, new evidence shows that the toxicity of these compounds is lower than those theoretically caused by the equivalent released HCN. In order to provide a deeper understanding of cyanogenic glycosides, an overview of these compounds is given in this article. It covers the chemistry, distribution, biosynthesis, toxicity, determination, as well as extraction and isolation of the compounds. 
Plant cyanogenic glycosides: an overview Dwi Hartanti; Arinda Nur Cahyani
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 1 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i1.10047

Abstract

The cyanogenic glycosides have consisted of α-hydroxy nitrile aglycone and a sugar moiety that producing hydrogen cyanide (HCN) during the hydrolysis process. This HCN-producing property underlines the toxicity of the plants commonly associated with these compounds in humans and animals. However, new evidence shows that the toxicity of these compounds is lower than those theoretically caused by the equivalent released HCN. In order to provide a deeper understanding of cyanogenic glycosides, an overview of these compounds is given in this article. It covers the chemistry, distribution, biosynthesis, toxicity, determination, as well as extraction and isolation of the compounds. 
Phytochemical analysis, FTIR fingerprint and bioactivity of crude extract and fractions of Mesua ferrea L. Dwi Hartanti; Zainur Rahman Hakim; Anna Nurlativah; Arinda Nur Cahyani; Fadhilah Zahra Nadia; Asmiyenti Djaliasrin Djalil
Research Journal of Life Science Vol 6, No 1 (2019)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.rjls.2019.006.01.7

Abstract

Mesua ferrea L. (Ceylon ironwood, Calophyllaceae) is a popular medicinal plant with a long history in South and Southeast Asia folk medicines. In this study, we report the phytochemical analysis, FTIR fingerprint, as well as antimicrobial and antioxidant activities of the crude extract of leaves of M. ferrea and its fractions. The dried leaves of M. ferrea were extracted with ethanol by the re-maceration method. The crude extract was further partitioned in ethanol-water and ethyl acetate to obtain ethanol and ethyl acetate fractions, respectively. The identification of compounds in the extract and fractions was conducted according to the standard phytochemical screening method. Fourier-transform infrared spectroscopy (FTIR) was utilized to record their metabolites fingerprint. The antimicrobial activity was evaluated with the disk diffusion method against Escherichia coli, Bacillus subtilis, Candida albicans, and Saccharomyces cerevisiae. The antioxidant activity assay was conducted with 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. The crude extract of M. ferrea leaves and it fractions contained saponins, phenolic compounds, flavonoids, and terpenoids. The FTIR data supported the presence of terpenoids and glycosides in those samples as well. The extract and fractions demonstrated considerable antimicrobial activity against all tested bacteria and fungi, with MIC values ranged 3.9-31.3 μg/ml.  The ethyl acetate fraction of M. ferrea leaves showed a moderate antioxidant activity with an IC50 value of 49.19 μg/ml. 
PHYTOCHEMICAL AND PHARMACOLOGICAL ASPECTS OF ANTHRAQUINONES OF RHEUM AUSTRALE D. DON Dwi Hartanti; Arinda Nur Cahyani
Jurnal Farmasi Sains dan Praktis Vol 6 No 2 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i2.3699

Abstract

Anthraquinones are phenolic compounds known best for their laxative activity. Rheum australe D. Don (Indian rhubarb, Polygonaceae) is a prominent medicinal plant with anthraquinones as the bioactive compounds, among a few others. The online literature search was carried out to collect data on the phytochemistry and pharmacological activity of anthraquinones, particularly those isolated from R. australe. Anthraquinones are commonly found in the genera of Rheum, Senna, Aloe, Frangula, and Rubia, which can be quantitatively and qualitatively determined using both conventional and advanced analytical methods. The anthraquinones of R. australe were found in free and glycosidic forms, which were best extracted by the microwave-assisted extraction method. Various chromatographic techniques were commonly conducted to isolate the pure compounds. In addition to its laxative activity, anthraquinones of R. australe also showed potential antibacterial, cytotoxic, and antioxidant properties.
SOSIALISASI, PENYULUHAN, DAN PELATIHAN PEMBUATAN JAMU PENINGKAT IMUNITAS TUBUH DI DESA LEDUG KABUPATEN BANYUMAS Arinda Nur Cahyani; Iva Rinia Dewi; Septiana Liaturrohmah; Anisa A
Jurnal Bakti untuk Negeri Vol 2 No 2 (2022): JBN
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.01 KB)

Abstract

The most effective thing in preventing the spread of COVID-19 is to increase our body's resistance from within by drinking herbs or traditional ingredients that have been trusted from ancient times. This is not a mere superstition or belief, in fact this has been done since the time of the ancestors. Maintaining health must start from the inside first. And it all starts from our stomach. The purpose of this Community Service is to provide counseling and training on how to make herbal ingredients or herbal drinks in accordance with pharmacognosy theory and ingredients originating from the Ministry of Health. The method used is lectures and discussions to provide an understanding of how to make herbal ingredients correctly as well as simulations and demonstrations by providing skills about making and storing herbal ingredients. Community service can be carried out with permission from the village with 1 counseling activity and skills provision. Counseling on the socialization of herbal ingredients from the Ministry of Health which was presented using LCD media and pamphlets and training on making herbal or herbal drinks were carried out by direct practice.
SOSIALISASI, PENYULUHAN, DAN PELATIHAN PEMBUATAN JAMU PENINGKAT IMUNITAS TUBUH DI DESA LEDUG KABUPATEN BANYUMAS Arinda Nur Cahyani; Iva Rinia Dewi; Septiana Liaturrohmah; Anisa A
Jurnal Bakti untuk Negeri Vol 2 No 2 (2022): JBN
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jbn.v2i2.950

Abstract

The most effective thing in preventing the spread of COVID-19 is to increase our body's resistance from within by drinking herbs or traditional ingredients that have been trusted from ancient times. This is not a mere superstition or belief, in fact this has been done since the time of the ancestors. Maintaining health must start from the inside first. And it all starts from our stomach. The purpose of this Community Service is to provide counseling and training on how to make herbal ingredients or herbal drinks in accordance with pharmacognosy theory and ingredients originating from the Ministry of Health. The method used is lectures and discussions to provide an understanding of how to make herbal ingredients correctly as well as simulations and demonstrations by providing skills about making and storing herbal ingredients. Community service can be carried out with permission from the village with 1 counseling activity and skills provision. Counseling on the socialization of herbal ingredients from the Ministry of Health which was presented using LCD media and pamphlets and training on making herbal or herbal drinks were carried out by direct practice.
FORMULASI TABLET PARASETAMOL DENGAN KOMBINASI PVP DAN AMILUM UMBI PORANG (Amorphopallus onchopyllus) SEBAGAI BAHAN PENGIKAT TERHADAP SIFAT FISIK TABLET Arinda Nur Cahyani; Adi Susanto; Iva Rinia Dewi; Iswatun Nurhikmah
Jurnal Ilmiah JOPHUS : Journal Of Pharmacy UMUS Vol. 4 No. 02 (2023): Februari
Publisher : Program Studi Farmasi, Universitas Muhadi Setiabudi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46772/jophus.v4i02.886

Abstract

Tablets are the most widely used preparations, this is because tablets have advantages that other pharmaceutical preparations do not have, both in terms of production, storage, distribution, and use. This study aims to determine the concentration of PVP and starch from porang tubers which can be used as a binder in the preparation of paracetamol tablets and to determine the combination of PVP and starch from porang tubers as a binder to the physical properties of paracetamol tablets. In this study, 4 paracetamol tablet formulas with PVP binder were made combined with porang tuber starch with a weight of 650 mg per tablet. The binder used was PVP in each formula, namely F1 0%, F2 1%, F3 3%, and F4 5%, and porang tuber starch in each formula was F1 5%, F2 0%, F3 6%, and F4 7%. Tablets were made using wet granulation, the granules obtained were tested for their physical properties. including moisture content, flow time, angle of repose, and compressibility. After the powder mixture was compressed with a hardness between 4-8 kg, the resulting tablets were then tested for their physical properties including weight uniformity, size uniformity, friability, hardness, and disintegration time. The tablets produced from all formulas met the uniformity of weight, uniformity of size, and friability, the hardness that met the physical properties of the tablets was only found in formula I, which was 7.30 kg, and the fastest disintegration time in formula I was 9.6 minutes.
Anti-inflammatory Activity of Taro Stem Ethanol Extract (Colocasia esculenta (L.) Schott) In Vitro Arinda Nur Cahyani; Adi Susanto; Eko Hidayaturrohman Khumaeni; Indira Pipit Miranti; Febia Citraeni; Ratih Widiyanti
Jurnal EduHealth Vol. 14 No. 02 (2023): Periode April-June, 2023
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (223.391 KB)

Abstract

Inflammation is a complex response of vascular tissue to hazards such as pathogens, irritants, and damaged cells/tissues. Inflammation is caused by the release of chemical mediators from damaged tissue and cell migration. The purpose of this study was to determine the efficacy of ethanol extract of taro stem (Colocasia esculenta (L.) Schott) which is used as an anti-inflammatory agent and to determine the concentration of ethanol extract of taro stem (Colocasia esculenta (L.) Schott) which can provide anti-inflammatory activity. The method used in this research is the stability of the red blood cell membrane. The concentrations used were 0 ppm, 25 ppm, 75 ppm, 150 ppm and 100 ppm. The results of the percentage inhibition of hemolysis stability of the red blood cell membrane of taro stem extract concentrations of 0 ppm (00.00%), 25 ppm (82.58%), 75 ppm (83.47%), 150 ppm (47.17%), 100 ppm (24.23%). Testing the anti-inflammatory activity of the ethanol extract of taro stem (Colocasia esculenta (L.) Schott) using the red blood cell membrane stability method has efficacy as an anti-inflammatory agent. The concentration of 25 ppm (82.58%) has the highest anti-inflammatory activity and with a small concentration of extract can produce great anti-inflammatory activity, compared to 100 ppm aspirin as a positive control of 24.23%. Testing the anti-inflammatory activity of the ethanol extract of taro stem (Colocasia esculenta (L.) Schott) using the red blood cell membrane stability method has efficacy as an anti-inflammatory agent. The concentration of 25 ppm (82.58%) has the highest anti-inflammatory activity and with a small concentration of extract can produce great anti-inflammatory activity, compared to 100 ppm aspirin as a positive control of 24.23%. Testing the anti-inflammatory activity of the ethanol extract of taro stem (Colocasia esculenta (L.) Schott) using the red blood cell membrane stability method has efficacy as an anti-inflammatory agent. The concentration of 25 ppm (82.58%) has the highest anti-inflammatory activity and with a small concentration of extract can produce great anti-inflammatory activity, compared to 100 ppm aspirin as a positive control of 24.23%.
ANALISIS KUALITATIF DAN KUANTITATIF BAHAN KIMIA OBAT (BKO) ANTALGIN PADA JAMU PEGAL LINU TIDAK BPOM YANG BEREDAR DI WILAYAH AJIBARANG Pratiwi Ayu; Arinda Nur Cahyani
Jurnal Mahasiswa Ilmu Kesehatan Vol. 1 No. 1 (2023): Januari : Jurnal Mahasiswa Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jumkes.v1i1.21

Abstract

Penambahan BKO dalam jamu sangat dilarang, karena dapat mengakibatkan efek samping yang berbahaya bagi tubuh, yang sering ditambahkan BKO adalah jamu pegal linu seperti antalgin. Tujuan dari penelitian ini adalah untuk menentukan ada tidaknya kandungan antalgin di dalam jamu pegal linu yang beredar di wilayah ajibarang dan mengetahui berapa kadar antalgin yang terdapat dalam jamu pegal linu. Metode yang digunakan dalam penelitian ini adalah Reaksi Warna dan Kromatografi Lapis Tipis. Hasil Penelitian dari metode Reaksi Warna dari 5 sampel jamu pegal linu dinyatakan negatif mengandung antalgin dengan menggunakan pereaksi FeCL3 dan HCL 0,02N sesuai dengan FI III. Dilihat dari metode reaksi warna yang didapatkan hasil seluruh sampel negatif, dan dilanjutkan menggunakan metode kromatografi lapis tipis dilihat dari nilai Rf maka dinyatakan negatif mengandung bahan kimia obat antalgin.
Aktivitas Antibakteri Dan Formulasi Krim Ekstrak Etanol Daun Teh-Tehan (Acalypha Siamensis) Terhadap Propionibacterium Acnes Zainal Habib Gunawan; Novita Endang Fitriyani; Arinda Nur Cahyani
An-Najat Vol. 1 No. 1 (2023): FEBRUARI : An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v1i1.1

Abstract

Acne is a disease caused by P. acne bacteria which can cause inflammation. Acne treatment can be done by reducing the number of P. acne colonies using antibiotic. Teh- tehan leaf contain compounds that are antibacterial such as flavonoid, phenol, steroid, alkaloid and tannin. The purpose of this study was to determine the antibacterial activity of extracts and formulations of cream teh-tehan leaf extract against P. acne bacteria. This research was conducted in the laboratory of STIKes Ibnu Sina Ajibarang. This type of research is an experimental study using the disc diffusion method (Kirby and Bauer test) with different concentrations. The concentrations of extract used were 1%, 2% and 3% with a negative control (DMSO) and a positive control (Mediklin Cream) as comparison. Physical evaluation of the preparation of teh-tehan leaf extract cream consisted of: organoleptic test, homogeneity test, pH test, spreadability test, cream type test, adhesion test and cycling test. The results of this study indicate that the teh-tehan leaf extract can be formulated as an active substance in cream preparation. The results of testing the antibacterial activity of teh-tehan leaf extract cream, it can inhibit the growth of P. acne bacteria with the best concentration of 3% concentration. The teh-tehan leaf extract formulated with concentrations of 2% (FII) and 3% (FIII) and has an average inhibition zone of 4.60 mm and 9.01 mm. Furthermore, the results of the physical evaluation of the preparation of the teh-tehan leaf extract cream showed instability in the organoleptic test where there was a change in the color of the cream after the cycling test.