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The Higher Level of Neutrophil – Lymphocyte Ratio (NLR) and Serum Syndecan-1 Based on Timeline (First, Sixth, and Twenty-Fourth Hour) in Sepsis-Induced Acute Kidney Injury Lila Tri Harjana; Eddy Rahardjo; Windhu Purnomo; Lilik Herawati; Nancy Margarita Rehatta
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17578

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This study aims to analyze the difference between the NLR and serum syndecan-1 level at the first,sixth, and twenty-fourth hours with the incidence of acute kidney injury (AKI) and non-AKI in sepsis.We observed thirty-one adult sepsis patients who admitted to the emergency room and ICU of Dr.Soetomo General Academic Hospital, Surabaya, Indonesia from March 30, 2020, to July 5, 2020 (fourmonth),and differentiated into two groups, AKI group (n=14) and non-AKI group (n=17). All septicpatients have been given the standard treatment based on Survival Sepsis Campaign 2018. The resultsshowed that the NLR at 1st-hours, 6th-hours, and 24th-hours in the non-AKI group were lower thanthose in the AKI group (1st: 15.9±2.6 vs 33.0±11.3; 6th: 14.2±1.8 vs 19.3±3.8; and 24th: 11.6±1.3 vs19.9±3.8) (p <0.00). Almost NLR at every groups based on serial hours were decreasing, except in theAKI group, the NLR at the 24th-hour group was higher than the NLR at 6-hour group, but still lowerthan the NLR at 1st-hours. Serum syndecan-1 levels were lower in the non-AKI group than in theAKI group, at 1st, 6th, and 24th-hours, (1st: 532.5±72.0 ng/mL vs 597.2±85.8 ng/mL; 6th: 557.6±71.6ng/mL vs 612.0±73.9 ng/mL; and 24th: 548.4±76.6 ng/mL vs 586.4±84.6 ng/mL) (p <0.05). It canbe concluded that the neutrophil-lymphocyte ratio (NLR) and serum syndecan-1 levels at 1st, 6th,and 24th hours is higher in the AKI compared to non-AKI groups in sepsis. Hence, NLR and serumsyndecan-1 have a potential biomarkers for sepsis-induced AKI.
HISTOPATHOLOGICAL EXAMINATIONS PROFILE OF BLADDER DISEASES IN DR. SOETOMO GENERAL ACADEMIC HOSPITAL FROM JANUARY 2015 TO DECEMBER 2019 Krismaningrum, Veronika Intan; Rahaju, Anny Setijo; Herawati, Lilik; Soetojo
Indonesian Journal of Urology Vol 29 No 1 (2022)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v29i1.761

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Objective: This study aimed to analyze the profile of bladder disease in Soetomo General Hospital based on histopathological examination. Material & Methods: This study was using secondary data. Histopathological examination data of patients with bladder disease were evaluated based on age, gender, and histopathological types. Results: There were 419 patients with bladder abnormalities. Non-neoplasm bladder diseases were found in 62 patients consisted of 56 patients (90.32%) with cystitis and 6 patients (9.67%) with glandular cystitis. Neoplastic bladder diseases were found in 357 patients and were divided into benign and malignant neoplasm. Benign neoplasms were found in 11 patients consisted of 5 patients (45.45%) with UP and 6 patients (54.54%) with IUP. Malignant neoplasms were found in 340 patients consisted of 300 patients (88.23%) with urothelial carcinoma, 26 patients (7.64%) with adenocarcinoma, 14 patients (4.12%) with SCC. Moreover, six male patients with PUNLMP were also reported. Conclusion: Histopathological examination in patients with bladder abnormalities shows that neoplastic bladder diseases (357/419, 85.20%) were more common than non-neoplastic bladder disease (62/419, 14.80%).
Perbandingan Psikoedukasi Langsung dan Tidak Langsung terhadap Kepatuhan Terapi Pasien Hemodialisis: A Systematic Review Innani Wildania Husna; Kusnanto Kusnanto; Lilik Herawati
BRILIANT: Jurnal Riset dan Konseptual Vol 6, No 4 (2021): Volume 6 Nomor 4, November 2021
Publisher : Universitas Nahdlatul Ulama Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (445.971 KB) | DOI: 10.28926/briliant.v6i4.755

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Kepatuhan terapi merupakan tantangan bagi pasien hemodialisis, perubahan kondisi fisik dan psikologis pada pasien hemodialisis berkontribusi pada ketidakmampuan pasien untuk mempertahankan kepatuhan. Melalui strategi terapi psikoedukasi, pasien hemodialisis dapat meningkatkan kepatuhan terapi. Pencarian menggunakan Scopus, ScienceDirect, ProQuest, Pubmed, dan CINAHL pada publikasi dari 2016 hingga 2021. Panduan menggunakan checklist PRISMA. 25 artikel dianalisis. 11 Quasi Experiment, 10 Randomized Control Trials, 3 artikel review, dan 1 Research and Development. Intervensi psikoedukasi secara langsung dan tidak langsung dengan berbagai metode efektif dalam meningkatkan kepatuhan terapi pada pasien hemodialisis. ditandai dengan peningkatan pengetahuan dan penurunan IDWG.
Ketogenic Diet Slows Down Weight Gain in Juvenile Mus musculus with Benzopyrene as Cancer Inducer Dita Mega Utami; Lilik Herawati; Reny I’tishom; Mohammad Anam Al-Ari; Muhammad Miftahussurur; Purwo Sri Rejeki
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14709

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Objective: This study aims to analyze the ketogenic diet that slows down weight gain in juvenile Musmusculus induced with benzopyrene (BZP). Method: Thirty-six female mice (Mus musculus), 6-8 weeks old,weighted 15-25 grams were divided into six groups randomly. K1 (negative control, standard diet) inducedwith oleum olivarum, while K2 (positive control, standard diet), P1 (ketogenic diet 1), P2 (ketogenic diet 2),P3 (ketogenic diet 3) and P4 (ketogenic diet 4) induced with BZP subcutaneously in the right breast at a doseof 0.3mg/20gBB/day for 14 days. The ketogenic diet was given for the next 28 days. Data were analyzedusing the ANOVA and post hoc LSD test. Results: After 42 days, the ketogenic diet mice experiencedslower weight gain (p=0.000) because BZP induced neurotoxicity and the administration of the ketogenicdiet in juvenile mice induced neurohormonal changes. The ketogenic diet increased ketone plasma level(p=0.000) and reduced blood glucose levels (p=0.002) due to nutritional ketosis state. Conclusions: Theketogenic diet with fat:protein ratio 60:30 slows down weight gain, increased ketone levels and decreasedblood glucose levels in juvenile mice with BZP as cancer inducer.
Calorie Restriction and Moderate-Intensity Continuous Exercise Decrease Free Fatty Acid Levels and Visceral Fat Weight on High Calorie Diet Female Mice Ahmad Rukhani Lutfi; Lilik Herawati; Widjiati; Gadis Meinar Sari
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14944

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Objective: This study aimed to analyze the effect of a combination of calorie restriction and moderateintensity continuous exercise on FFA levels and visceral fat weight in female mice exposed to a high-caloriediet.Material and Method: This research was randomized posttest used only control group design with femalemice as the sampl Balb/c mice (Mus musculus), 8 weeks old, 20-30 grams. It was randomly divided into fourgroups, namely C (control group), G1 (moderate-intensity continuous exercise group), G2 (calorie restrictiongroup), and G3 (combination group calorie restriction and moderate-intensity continuous exercise) wherein every group consisted six female mice. Providing a high-calorie diet using ad libitum plus D40 as muchas 3-5% of calories (0.0325 mL/gBB) for 4 weeks. The provision of a high-calorie diet was done usingthe sonde technique. Calorie restriction was done 3x/week in 4 weeks by limiting calorie intake to 50% ofstandard foods. The moderate-intensity continuous exercise was carried out by swimming for 15 minutesplus 6% gBB loading, it was done 3 times/week for 4 weeks. The measurement of cholesterol, visceral fatweight, and FFA level was done at the end of treatments.Results: The results found that the mean of cholesterol of C C (171.00±47.74 mg/dL), G1 (126.00±15.92 mg/dL), G2 (131.50±22.37 mg/dL), G3 (121.17±21.23 mg/dL) dan (p=0.032). The mean weight of visceral fatat C (0.68±0.23 grams), G1 (0.25±0.08 grams), G2 (0.28±0.06 grams), G3 (0.20±0.03 grams) and (p=0.000).The mean FFA levels were at C (1511.34±6.19 µmol/L), G1 (1419.31±53.61 µmol/L), G2 (1458.20±28.89µmol/L), G3 (1451.55±43.77 µmol/L) and (p=0.004).Conclusion: Based on the results of the study, it could be concluded that the provision of calorie restrictionand moderate-intensity continuous exercise significantly reduced cholesterol levels, visceral fat weight, FFAlevels and in female mice exposed to a high-calorie diet
Ascorbic Acid Drink after Submaximal Physical Activity can Maintain the Superoxide Dismutase Levels in East Java Student Regiment Junian Cahyanto Wibawa; Muhammad Zainul Arifin; Lilik Herawati
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15824

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Objective - This study aimed to analyze the effect of ascorbic acid after submaximal physical activity onreducing levels of malondialdehyde (MDA) and increasing levels of superoxide dismutase (SOD) to StudentRegiment in East Java.Methods - This study was a true experiment with a randomized control group posttest-only design used 28male subjects aged 19-23 years with body mass index (BMI) 18.5-24.9 kg/m2, and randomly divided intofour groups. Namely G1 (n=7, control without submaximal physical activity+placebo), G2 (n=7, submaximalphysical activity+placebo), G3 (n=7, submaximal physical activity+AA 500 mg), and G4 (n=7, submaximalphysical activity+AA 1,000 mg). The submaximal physical activity was 2.400 meters running in 12 minutesor when the 60-70% of HRmax achieved. The drinks containing 500 mg and 1.000 mg ascorbic acid (AA)for G3 and G4 was given after exercise test. Measurement of serum MDA and SOD used the ThiobarbituricAcid Reactive Substances (TBARs) method. The data was statistical analyzed using SPSS software with asignificant level (p<0.05).Results - The results of MDA levels showed in G1 (308.18±61.81 ng/mL), G2 (338.42±125.78 ng/mL), G3(290.54±69.18 ng/mL), G4 (279.83±39.10 ng/mL) and there was no significantly difference among groups(p=0.557). The mean levels of SOD was significant among groups ((p=0.000), and the SOD level in eachgroup was G1 (23.19±0.77 units/mL), G2 (24.81±0.87 units/mL), G3 (25.27±0.79 units/mL), G4 (25.57±0.47units/mL).Conclusion - It can be concluded that 500 mg and 1.000 mg ascorbic acid drinks after submaximal physicalactivity can increase SOD levels of students regiment in East Java. Ascorbic acid drink may maintain theSOD level by lessening the use of antioxidant endogen and it may also increase the SOD level, howeverfuther research is needed to be conducted to figure out the mechamism.
Effectiveness of Family Empowerment towards Diet Compliance and Family Independence in Caring for Family Members with Diabetes Mellitus: A Systematic Review Angga Miftakhul Nizar; Kusnanto; Lilik Herawati
Poltekita : Jurnal Ilmu Kesehatan Vol. 15 No. 1 (2021): May
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v15i1.435

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Diabetes mellitus has now become a major problem in non-communicable diseases whose prevalence continues to increase. Lack of family independence and client non-compliance with the diet program greatly affects blood sugar levels. This study needs to evaluate the effectiveness of family empowerment towards diet compliance and family independence in caring for family members with diabetes mellitus. A systematic review searched five electronic databases (Scopus, sciencedirect, pubmed, research gate, and google scholar) with the last ten years (2011-2021). The quality of the articles used in this study was assessed using the Joanna Briggs Institute Guideline. The prism protocol is also used to review each journal. We found 15 studies out of a total of 5,865 studies that discussed family empowerment in increasing family independence and dietary adherence in family members suffering from diabetes mellitus. Family empowerment is one method that is quite effective in increasing family independence and adherence to diet programs. There are six articles (40%) that state that planned behavior theory is effective in increasing family independence and dietary adherence to family members suffering from diabetes mellitus. From all the articles analyzed, there are several effective theories to empower families to change the behavior of family independence and individual diet compliance, namely the theory of planned behavior. However, this study is not strong enough to provide an assessment that family empowerment based on the theory of planned behavior and empowerment is the best way to increase independence, therefore further research is needed.
Kopi Arabika-Gayo Menurunkan MDA dan Meningkatkan SOD setelah Latihan Fisik Akut Submaksimal pada Pria Sedenter: Gayo-Arabica Coffee Decreases MDA and Increases SOD after Single Bout Submaximal Physical Exercise in Sedentary Men Mahmudin Aritanoga; Choesnan Effendi; Lilik Herawati
Jurnal Sumberdaya Hayati Vol. 5 No. 2 (2019)
Publisher : Departemen Biologi, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jsdh.5.2.58-63

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It is known that coffee has much phenolic components such as flavonoids and chlorogenic acids (CGAs) content for neutralizing oxidative stress. Gayo-arabica coffee is a typical arabica coffee which widely used by Gayo people in Aceh, Indonesia. The coffee plants also grow in Gayo. However, it has not clearly understood its effect for health. The study aimed is to analyze the Gayo-arabica coffee consumption on the levels of malondialdehyde (MDA) as an indicator of damage cells due to oxidative stress and superoxide dismutase (SOD) as a marker of antioxidant enzyme, after performing a single bout submaximal physical exercise. Male sedentary subjects (21-27 y.o), consisted of 36 men, divided into 3 groups: control (zero of coffee), Gayo1 (15 g coffee in 200 ml water), and Gayo2 (20 g coffee in 200 ml water). Coffee was given once, after rockport test as a single bout submaximal physical exercise. MDA serum and SOD serum were taken after 1 hour of coffee drinking. MDA serum decreased significantly in Gayo1 (8.01 uM) and Gayo2 (10.36 uM), compared to control (26.82 uM). SOD serum increased significantly in Gayo1 (114.81 ng/ ml) and Gayo2 (101.48 ng/ml), compared to control (24.024 ng/ml). Nevertheless, there was no significantly different between Gayo1 and Gayo2 on MDA and SOD serum (p≥0.05). We suggest that the Gayo-arabica coffee after single bout submaximal exercise can diminish stress oxidative in sedentary people.
Parity as failure determinants of labor induction in Bangka Belitung Dina Delvin Anggriani; Lilik Herawati; Ernawati Ernawati
Majalah Obstetri dan Ginekologi Vol. 24 No. 3 (2016): September - December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (91.823 KB) | DOI: 10.20473/mog.V24I32016.79-83

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Objectives: to identify factors affecting labor induction failure in Sungailiat General Hospital, District Bangka, Bangka Belitung.Materials and Methods: This is a case control retrospective analytic study. Population of this study was postterm delivering mother at delivery room Sungailiat General Hospital during July 1st, 2012 to July 1st, 2015. Sampling method conducted for case group was total sampling method with labor induction failure as a inclusion criteria, and no data for first trimester ultrasound, didn’t have a routine antenatal care history, and maternal complication as exclusion criterias as many as 78 samples. Whereas, control group was women whose underwent a success labor induction used random sampling method with 1:1 ratio. Data source was from medical records. Data analysis was chi square with 95% confidence interval.Results: From the 78 samples with labor induction, 19,2 % was ≥ 35 years old, 48,7% was primiparas, 62,8% with infant birth weight ≥ 3500 gram, and from 96 samples, 47,5% with ≥ 5 years pregnancy interval. Statistical analysis result showed factors that affecting induction failure were parity (P Value 0,014, odds ratio 2,970), baby’s weight (P Value 0,016, odds ratio 2,631), pregnancy interval (P Value 0,023, odds ratio 2,993), whereas mother’s age did not show significant effect (P Value 0,383, odds ratio 2,278).Conclusion: Parity has a 2,9 times risk to develop induction failure.
High-Fat Diet Increases Serum HDL, but Not for LDL and HDL/LDL Ratio in MICE Iqbal Laksana; Purwo Sri Rejeki; Lilik Herawati; Mohammad Anam Al Arif; Indrayuni Lukitra Wardhani
Folia Medica Indonesiana Vol. 57 No. 2 (2021): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (236.031 KB) | DOI: 10.20473/fmi.v57i2.16123

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The use of a ketogenic diet with an increased proportion of fat is rampant lately, both as a therapy or even lifestyle. The use of a ketogenic diet is feared to cause dyslipidemia. It will also lead to atherosclerosis and thrombosis. This study aimed to determine the effect of a high-fat diet on HDL, LDL, and HDL/LDL ratio in mice. Thirty male Mus Musculus, 2-3 mo, 15-25 g divided into five groups diet. K1 (12% fat, 20% protein, 62% carb), K2 (30% fat, 60%protein), K3 (45% fat, 45% protein), K4 (60% fat, 30% protein) and K5 (75% fat, 15% protein) for 4 weeks. Feed and water by adlibitum. Blood for serum was taken from the ventricle, while in the measurement of HDL serum level, the LDL used ELISA. Normality of data analyzed by Shapiro Wilk, and homogeneity by Levene test. HDL serum was analyzed using equality test followed by Games Howell, LDL serum and ratio of HDL/LDL was tested by ANOVA followed by LSD with significance 0,05. HDL serum in K1 (62,50±9.94) mg/dL, K2 (78,40±18,76) mg/dL, K3 (79,00±3,81) mg/dL, K4 (80,00±2,16) mg/dL, and K5 (83,50±5,62) mg/dL with p<0,05 in K1, K2 to K3, K4 and K5. LDL serum in K1 (21,67± 4,80) mg/dL, K2 (23,00±12,70) mg/dL, K3 (18,40±4,34) mg/dL, K4 (24,00 ±1,83) mg/dL and K5 (22,00 ± 4,08) mg/dL with p>0,05. Ratio HDL/LDL K1 (3,01±0,91), K2 (4,10±1,86), K3 (4,53±1,5), K4 (3,35±0,34), and K5 (3,96 ± 1,25) with p>0,05.
Co-Authors Adek Ardiansyah Aditiawarman - Ahmad Rukhani Lutfi Ahmad Rukhani Lutfi Angga Miftakhul Nizar Angga Miftakhul Nizar Anggis Putri Wijayanti Anggraeni Dyah Kumalasari Anissa Maulina Rinjani Annas, Jimmy Yanuar Anny Setijo Rahaju, Anny Setijo Ario Imandiri Ashon Sa’adi Ashon Sa’adi Bambang Harijono Bambang Purwanto Cantika Putri Melyana Chiquita Febby Pragitara Choesnan Effendi Citrawati Dyah Kencono Wungu Damayanti Tinduh David Wicaksono Dede Gantini Desi Rianti Rahmadhani Dicha Niswansyah Auliyah Dina Delvin Anggriani Dita Mega Utami Dwi Putri Rahayu Tampubolon Dwikora Novembri Utomo Eddy Rahardjo Eka Arum Cahyaning Putri Ema Qurnianingsih Endyka Erye Frety Ernawati Ernawati Ernawati Ernawati Faizah, Zakiyatul Fajar Shamsudin Fajar Syamsudin Farah Yusrania Gadis Meinar Sari Gantini, Dede Gebyar Catur Wahyuning Rohmawati Giwang Yayi Retnosari Gosy Endra Vigriawan Hanik Badriyah Hidayati, Hanik Badriyah HariSetijono Hayuris Kinandita Setiawan Herdy Sulistyono Hermina Novida Hidayat Arifin I Ketut Sudiana I'tishom, Reny Indira Syahraya Indriani, Aliza Umar Innani Wildania Husna Iqbal Laksana Irwanto, Irwanto Jimmy Yanuar Annas Junian Cahyanto Wibawa Krismaningrum, Veronika Intan Kusnanto Kusnanto Kusnanto Kusnanto Kusnanto Kusnanto Laylatul Fitriah Mukarromah Lila Tri Harjana Lina Lukitasari, M.Si M. Ali Machfud Maharani Ayuputeri Wijaya Mahmudin Aritanoga Maulana Arif Murtadho Maya Septriana Misbah Abdul Haris Nasution Alhanif Mohammad Anam Al-Ari Mohammad Anam Al-Arif Muchammad Rif’at Fawaid As’ad Muchammad Rif’at Fawaid As’ad Mufarrihul Ihsan Mufidah Sheena Andani Prastini Muhammad Miftahussurur Muhammad Zainul Arifin Nancy M. Rehatta, Nancy M. Ningrum, Astika Gita Niwanda Yogiswara Nugroho, Ardi Setyo Nuniek Nugraheni Sulistiawaty Nurcholis Majid Paulus Liben Paulus Liben Pradika Gita Baskara Prananda Surya Airlangga Purwo Sri Rejeki Purwo Sri Rejeki Purwo Sri Rejeki Purwo Sri Rejeki Purwo Sri Rezeki Putri Lisdiana Rahmawati Putri Rizkiya Raden Argarini Rehatta, Nancy Margarita Rezy Ramawan Melbiarta Rias Gesang Kinanti Rifka Kurniati Risa Etika, Risa Rivarti, Arina Windri Senja Himaya Senja Himaya Silvia Maya Ananta Siti Khaerunnisa Siti Khaerunnisa Soetojo Soetojo Sony Wibisono Sri Ratna Dwiningsih Suhartati Suhartati Sundari Indah Wiyasihati Susi Wahyuning Asih Tato Nuryanto Viskasari P. Kalanjati Wardhani, Indrayuni Lukitra Wibi Riawan Widati Fatmaningrum Widayana, Maeril Kirana Widjiati Wigati, Kristanti Wanito Windhu Purnomo Winna Adelia Amru Yudi Her Oktaviano Yusuf Salim Zulhabri Othman Zulhabri Othman