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Santri trained troops: Making new normal kits and training for the COVID-19 task force Damayanti, Meta Maulida; Yuniarti, Yuniarti; Rachmawati, Meike; Kusmiati, Mia
Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Vol 7, No 1 (2022): February 2022
Publisher : University of Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/abdimas.v7i1.6020

Abstract

Since the COVID-19 pandemic first emerged in December 2019 and was confirmed in Indonesia in March 2020, the Indonesian government has imposed a strict lockdown. The number of confirmed cases is increasing all the time. Efforts to prevent transmission must be carried out immediately, including improving health protocols. The activity aims to create trained troops Santri, by providing insight into COVID-19 which consists of training to implement health protocols and soft skills for making new normal kits, namely hand sanitizers and cloth masks. The activities were carried out at the Manarul Huda Islamic Boarding School, Bandung to 31 Santri. The new normal kit manufacturing training is accompanied by an expert. The training of Santri produces cadres with a level of knowledge about COVID-19 most highly with a fair category (51,61%). Based on the percentage of the group, age17 years, male gender, and education level graduated from school have a higher level of good knowledge than other groups. This service activity produces trained troops Santri equipped with knowledge about COVID-19 particularly good health protocols, has soft skills to make hand sanitizers and cloth masks. Towards they can produce a new normal kit and create a COVID-free Islamic boarding school area.
Osteocalcin expression of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) added with hydroxyapatite (HA) in rabbit’s post extraction tooth sockets Meta Maulida Damayanti; Bethy Suryawathy Hernowo; Susi Susanah
Padjadjaran Journal of Dentistry Vol 32, No 3 (2020): November 2020
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol32no3.24848

Abstract

Introduction: Platelets play an important role in wound healing because it is a reservoir for growth factors and cytokines which is important in bone regeneration and soft tissue healing. The purpose of this study was to compare the use of scaffolds in platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) which added with hydroxyapatite (HA) in the socket healing process after tooth extraction in the value of regenerating an alveolar bone tissue. Methods: The research was conducted at biomedical laboratory Bandung Islamic University. Eighteen rabbits (Oryctolagus cuniculus) with extracted anterior and inferior teeth were divided into 2 treatment groups and 3 observation times. The tooth socket is filled with PRF (Group 1) and PRP + HA (Group 2). The observation was conducted on Day 3, Day 7 and Day 14. Immunoexpression Osteocalcin was performed to assess the healing process of alveolar bone. Data was analyzed with the SPSS software program. Analysis of normality data by Shapiro-Wilk test, homogeneity of variance with Levene's test and comparison between treatment groups with the Chi-square test. Results: Group 1 shown the average score was higher than in Group 2 with a strong category of 72.2% for Group 1 and 56.6% for Group 2. Based on statistically,  there was no difference in osteocalcin immunoexpression between Group 1 and Group 2 with the p-value>0.05. Conclusion: Regeneration of rabbit’s alveolar bone tissue by application of PRF and PRP plus HA as scaffolds have results was similar. The use of PRF in post-extraction wound recovery is a better choice because it has an easy procedure and lower cost.
Deteksi Dini Penyakit Parkinson: Pengetahuan, Sikap, dan Perilaku Petani Desa Tanjung Wangi Cicalengka Mengenai Bahaya Pestisida bagi Kesehatan Arief Budi Yulianti; Siska Nia Irasanti; Meta Maulida; Mia Kusmiati; Adhika Putra Rahmatullah
Global Medical & Health Communication (GMHC) Vol 4, No 1 (2016)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (102.876 KB) | DOI: 10.29313/gmhc.v4i1.1730

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Pestisida bersifat toksik bagi manusia dan lingkungan sekitarnya. Petani adalah kelompok masyarakat berisiko tinggi terpapar pestisida. Tingkat pengetahuan, sikap, dan perilaku petani mengenai bahaya pestisida sangat diperlukan agar keputusan untuk menggunakan pestisida sesuai dengan jenis, waktu, dan cara menjadi tepat. Penelitian ini dilaksanakan selama bulan Maret–Juli 2015 dan merupakan penelitian observasional dengan subjek penelitian petani Desa Tanjung Wangi. Subjek penelitian diambil secara acak diperoleh 62 subjek penelitian yang terdiri atas 47 laki-laki dan 15 perempuan. Tingkat pengetahuan, sikap, dan perilaku diukur dengan kuesioner yang sudah divalidasi. Pengukuran gejala dini Parkinson menggunakan kuesioner PDQ39 yang sudah dimodifikasi. Diperoleh tingkat pengetahun dan sikap petani mengenai bahaya pestisida skor terendah 0,70 dan tertinggi 0,97 dengan nilai median 0,80 dan modus 0,79. Perilaku pestisida ini mengenai tata cara penggunaan pestisida skor terendah 0,64, tertinggi 1 dengan modus 0,84. Gejala dini Parkinson pada petani di Desa Tanjung Wangi skor tertendah 0,74 dan tertinggi 1 dengan nilai median 0,84 dan modus 0,91. Simpulan, pengetahuan, sikap, dan perilaku petani Desa Tanjung Wangi mengenai bahaya pestisida baik. Hasil yang diperoleh dari kuesioner tidak menggambarkan kondisi petani di lapangan. Hal ini dapat terjadi karena peneliti tidak memasukkan unsur ekonomi sebagai salah satu faktor penentu pengambilan keputusan menggunakan pestisida sehingga diperlukan upaya edukasi petani. DETECTION-EARLY OF PARKINSON'S DISEASE: KNOWLEDGE, ATTITUDES, AND BEHAVIOR FARMER IN DESA TANJUNG WANGI ABOUT PESTICIDES TOXICITIES TOWARD HEALTHPesticides are toxic for human and environment. Farmers are people at high risk of exposure to pesticides. The level of knowledge, attitudes, and behaviors of farmers about pesticides toxicity needed, so the decision to use pesticides be expected right. This research held on March–July 2015, observational method with subjects farmers in Desa Tanjung Wangi were taken randomly. Number of samples were 62 person consisted of 47 men and 15 women. The level of knowledge, attitudes, behaviors and detectionearly of Parkinson’s disease were measured with a questionnaire PDQ39 modified. The lowest score of level knowledge and attitudes about pesticides toxicities was 0.70 and the highest was 0.97 with median and modus 0.80 and 0.79, respectively. The lowest score of behavior regarding the method of pesticides used was 0.64 and the highest was 1 with modus 0.84. The lowest score of detection-early of Parkinson’s disease was 0.74 and the highest was 1 with median and modus 0.84 and 0.91, respectively. In conclusions, farmers knowledge, attitudes and behavior regarding pesticides toxicities are good. But the questionnaire wasn’t describe the really condition in field, especially in economic issues that affecting decisions about pesticides to be used, so educating to understand about pesticides toxicities needs to be done.
Folic Acid Usual Doses Decrease the Buccal Micronucleus Frequency on Smokers Yuktiana Kharisma; Meta Maulida Damayanti; Fajar Awalia Yulianto; Santun Bhekti Rahimah; Winni Maharani; Meike Rachmawati; Herri S. Sastramihardja; Muhammad Alief Abdul ‘Aziiz; Muhammad Ilham Halim
Global Medical & Health Communication (GMHC) Vol 7, No 2 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (89.007 KB) | DOI: 10.29313/gmhc.v7i2.4414

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Cigarette contains toxic chemical compounds that trigger DNA instability. Initial genotoxic oral cavity characterized by the appearance of micronucleus (MN) in the buccal mucosa. Folate is needed in maintaining DNA stability. This study aimed to compare the effects of folic acid usual doses (400 mcg and 1.000 mcg) on the MN frequency of buccal mucosa in active smokers. It is a clinical trial conducted in November 2018 in the Laboratory of the Faculty of Medicine, Universitas Islam Bandung of 53 active smokers who divided into two treatment groups. Group A was administered by 400 mcg and group B 1,000 mcg folic acid supplementation within three weeks. The buccal mucosa smear stained with hematoxylin-eosin (HE) and observed through a light microscope with 100× and 400× magnification. Data were analyzed by the Wilcoxon test statistically. The results showed that there was a significant decrease (p=0.00) in MN frequency in folic acid supplementation for three weeks, namely group A=6.39±3.92 and group B=6.93±5.82 in pre-supplementation, and group A=3.80±2.66 and group B=3.31±2.71 post-supplementation of folic acid. Giving a dose of 400 mcg and 1,000 mcg for three weeks did not provide significant results (p=0.94) with Kruskal-Wallis test. In conclusion, administration of folic acid at usual dose give results to a decrease in the buccal mucosa MN frequency in active smokers. ASAM FOLAT DOSIS LAZIM MENURUNKAN FREKUENSI MIKRONUKLEUS MUKOSA BUKAL PADA PEROKOKAsap rokok mengandung senyawa kimia toksik yang memicu ketidakstabilan DNA. Deteksi genotoksik awal  rongga mulut ditandai dengan kemunculan mikronukleus (MN) pada mukosa bukal. Folat diperlukan dalam menjaga kestabilan DNA. Penelitian ini bertujuan mengetahui efek asam folat dosis lazim (400 mcg dan 1.000 mcg) terhadap frekuensi MN mukosa bukal pada perokok aktif. Penelitian ini merupakan uji klinis yang dilakukan pada bulan November 2018 di Laboratorium Fakultas Kedokteran, Universitas Islam Bandung terhadap 53 perokok aktif yang dibagi ke dalam dua kelompok perlakuan. Kelompok A mendapatkan suplementasi asam folat 400 mcg dan kelompok B mendapatkan suplementasi asam folat 1.000 mcg selama tiga pekan. Apus mukosa bukal diwarnai dengan hematoxylin-eosin (HE) dan diamati melalui mikroskop cahaya dengan pembesaran 100× dan 400x. Data dianalisis dengan uji Wilcoxon secara statistik. Hasil penelitian menunjukkan bahwa terdapat penurunan frekuensi MN yang signifikan (p=0.00) terhadap suplementasi asam folat selama tiga minggu, yaitu kelompok A=3,80±2,66 dan kelompok B=3,31±2,71 pada pre-suplementasi, serta kelompok A=6,39±3,92 dan kelompok B=6,93±5,82 pascasuplementasi asam folat. Pemberian dosis 400 mcg dan 1.000 mcg selama tiga minggu tidak memberikan hasil yang bermakna (p=0,94) berdasar atas Uji Kruskal-Wallis. Simpulan, pemberian asam folat dosis lazim memberikan hasil baik terhadap penurunan frekuensi MN mukosa bukal pada perokok aktif.
A Comparative Evaluation of Community Periodontal Index (CPI) and the Presence of Nicotine Stomatitis among Smokers after Oral Hygiene Instruction Meta Maulida Damayanti; Yuktiana Kharisma; Fajar Awalia Yulianto; Santun Bhekti Rahimah; Winni Maharani; Meike Rachmawati; Herri S. Sastramihardja; Muhammad Alief Abdul ‘Aziiz; Muhammad Ilham Halim
Global Medical & Health Communication (GMHC) Vol 8, No 1 (2020)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1150.723 KB) | DOI: 10.29313/gmhc.v8i1.5915

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Smoking can cause periodontal disease as well as lesions in the oral mucosa. Nicotine stomatitis is inflammation caused by heat stimuli injury on the hard and soft palate of the oral cavity; smokers commonly suffer from this condition. Knowledge of how oral hygiene affects the health of dental and oral cavity. The purpose of this study was to describe the differences in community periodontal index (CPI) and nicotine stomatitis in smokers after oral hygiene instruction. The study subjects were 54 men who have a history of active smoking for more than five years. The experiment was carried out in the Biomedical Laboratory of Faculty of Medicine Universitas Islam Bandung in September 2018–January 2019. Dental examination initiated before and after dental health instructions. CPI and nicotine stomatitis tests performed on all subjects by dentists using dental instruments. After six weeks of information about oral hygiene, all subjects re-examined. The results show that there is a statistically significant difference in the average CPI value in smokers before and after dental instruction with a p value<0.001 (p≤0.05). In contrast, the condition of nicotine stomatitis remains the same. CPI value influenced by oral and dental hygiene showed that dental health instruction is very effective. However, stomatitis has not healed as long as the cause is not eliminated. EVALUASI KOMPARATIF COMMUNITY PERIODONTAL INDEX (CPI) DAN STOMATITIS NIKOTIN DI KALANGAN PEROKOK SETELAH INSTRUKSI KEBERSIHAN MULUTMerokok dapat menyebabkan penyakit pada periodontal maupun lesi pada mukosa mulut. Stomatitis nikotin merupakan inflamasi yang disebabkan oleh panas yang terdapat pada palatum keras dan lunak; perokok umumnya menderita kondisi ini. Pengetahuan mengenai tata cara kebersihan mulut memengaruhi kesehatan gigi dan rongga mulut. Tujuan penelitian ini menilai perbedaan community periodontal index (CPI) dan stomatitis nikotin pada perokok setelah instruksi kebersihan mulut. Subjek penelitian adalah 54 pria yang memiliki riwayat merokok aktif selama lebih dari lima tahun. Penelitian dilakukan di Laboratorium Biomedik, Fakultas Kedokteran, Universitas Islam Bandung pada bulan September 2018–Januari 2019. Pemeriksaan dental dilakukan sebelum dan setelah instruksi kesehatan gigi. Pemeriksaan CPI dan stomatitis nikotin dilakukan kepada seluruh subjek oleh dokter gigi menggunakan instrumen gigi. Setelah enam minggu mendapatkan penyuluhan mengenai kebersihan mulut, seluruh subjek diperiksa kembali. Hasil penelitian menunjukkan bahwa terdapat perbedaan bermakna secara statistik nilai CPI rerata pada perokok sebelum dengan setelah dilakukan instruksi kesehatan gigi dengan p<0,001 (p≤0,05). Sebaliknya, kondisi stomatitis nikotin tetap sama. Nilai CPI dipengaruhi oleh kebersihan gigi dan mulut sehingga instruksi kesehatan gigi sangat efektif. Akan tetapi, stomatitis tidak dapat sembuh selama penyebabnya tidak dihentikan.
Cogongrass (Imperata cylindrica L.) Ethanol Extract on Sepsis Mice Model Body Weight and Sepsis Score Mirasari Putri; Neni Anggraeni; Raden Aliya Tresna M. D.; Ghaliby Ardhia Ramli; Mia Kusmiati; Yuke Andriane; Eka Hendryanny; Abdul Hadi Hassan; Meta Maulida Damayanti; Nugraha Sutadipura; Mas Rizky A. A. Syamsunarno
Global Medical & Health Communication (GMHC) Vol 8, No 3 (2020)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v8i3.6604

Abstract

Sepsis causes damage for cells, behavioral phenotype regression, and will end in most patients' death. The ethanol extract of cogongrass (Imperata cylindrica L.)  acts as an antioxidant. This study aimed to observe the effect of giving ECGR to body weight (BW) and the sepsis score of the sepsis mice model by lipopolysaccharide (LPS) induction. This study was an in vivo study with a randomized post-test controlled group design at the Animal Laboratory of Universitas Padjadjaran, 2018. We used 4 (four) groups of male mice (Mus musculus) DDY strains. Group 1 as a control, group 2: LPS 10 μL/kgBW, group 3, and 4: LPS+ECGR (90 mg/kgBW, and a dose of 115 mg/kgBW, respectively). This treatment was performed for two weeks. Every three days, we measured their body weight. After two weeks, group 2, group 3, and 4 were injected with LPS for 8 hours to induce sepsis. Next, we measured body weight and sepsis score using murine sepsis score (MSS). Then statistical analysis was performed using ANOVA and the Kruskal-Wallis test. The results showed no differences in body weight were found in the treatment groups (3 and 4) compared with control, suggesting no effect of ECGR in decreasing mice body weight. The sepsis score was more than 21 in groups treated with LPS (2, 3, and 4), suggesting LPS can induce sepsis. There was a slight decrease in scores in-group 3 and 4 compared with group 2. This study concludes that the treatment of ECGR caused no harm to body weight and slightly decreased sepsis score in the sepsis mice model. EKSTRAK ETANOL ALANG-ALANG (IMPERATA CYLINDRICA L.) TERHADAP BOBOT BADAN DAN SKOR SEPSIS MENCIT MODEL SEPSISSepsis menyebabkan kerusakan sel, regresi fenotipe perilaku, dan akan berakhir kematian pada sebagian besar pasien. Ekstrak etanol akar alang-alang (Imperata cylindrica L.) (ECGR) berperan sebagai antioksidan. Penelitian ini bertujuan mengetahui pengaruh pemberian ECGR terhadap bobot badan (BB) dan skor sepsis pada mencit model sepsis yang diinduksi lipopolisakarida (LPS). Penelitian ini adalah penelitian in vivo dengan desain randomized post-test controlled group di Laboratoium Hewan Universitas Padjadjaran tahun 2018. Kami menggunakan 4 (empat) kelompok mencit jantan (Mus musculus) strain DDY. Kelompok 1 sebagai kontrol, kelompok 2 diinduksi LPS 10 μL/kgBB, kelompok 3 dan 4 diinduksi LPS+ECGR (dosis 90 mg/kgBB dan 115 mg/kgBB masing-masing). Perlakuan ini dilakukan selama 2 minggu. Setiap tiga hari dilakukan pengukuran bobot badan mencit. Setelah dua minggu, kelompok 2, kelompok 3, dan kelompok 4 diinjeksi LPS selama 8 jam untuk menginduksi sepsis. Selanjutnya, diukur bobot badan dan skor sepsis menggunakan murine sepsis score (MSS). Analisis statistik menggunakan ANOVA dan Uji Kruskal-Wallis. Hasil penelitian menunjukkan tidak terdapat perbedaan bobot badan pada kelompok perlakuan (3 dan 4) dibanding dengan kelompok kontrol yang menunjukkan ECGR tidak berpengaruh dalam menurunkan bobot badan mencit. Skor sepsis lebih dari 21 pada kelompok yang diinduksi LPS (2, 3, dan 4) menunjukkan LPS dapat menyebabkan sepsis. Terdapat sedikit penurunan skor pada kelompok 3 dan 4 dibanding dengan kelompok 2. Simpulan penelitian ini, pengobatan ECGR tidak membahayakan bobot badan dan mengakibatkan sedikit penurunan skor sepsis pada mencit model sepsis.
Perbandingan Faktor Risiko Pasien Limfadenitis Tuberkulosis antara Hasil Bakteri Tahan Asam Positif dan Negatif Naufal Fadhillah Alam; Meta Maulida Damayanti; Maya Tejasari; Ismet Muchtar Nur; Yani Triyani
Jurnal Integrasi Kesehatan dan Sains Vol 2, No 1 (2020): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v2i1.4347

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Limfadenitis tuberkulosis merupakan tuberkulosis ekstraparu (TEBP) yang paling umum di dunia. Diagnosis pasti TEBP ditegakkan dengan pemeriksaan klinis, bakteriologis, dan atau histopatologis contoh uji yang diambil dari organ tubuh yang terkena. Pemeriksaan BTA dengan Ziehl Neelsen langsung pada jaringan mempunyai sensitivitas rendah sehingga jarang dilakukan. Penelitian ini bertujuan menganalisis perbandingan faktor risiko limfadenitis tuberkulosis dengan hasil BTA positif dan negatif dari jaringan KGB berdasar atas usia, jenis kelamin, dan riwayat TB paru di Laboratorium Rumah Sakit Al-Islam Bandung tahun 2016–2017. Terdapat 18 pasien dengan hasil BTA positif dan 17 pasien dengan BTA negatif yang memenuhi kriteria inklusi. Penelitian ini menggunakan desain penelitian potong lintang dengan analisis data univariat untuk mengetahui gambaran faktor risiko pasien dan bivariat untuk melihat hasil perbandingan faktor risiko pasien. Hasil penelitian ini menunjukkan pasien dengan BTA positif banyak diderita oleh pasien usia <20 tahun (8 dari 18) dan BTA negatif 30–39 tahun (6 dari 17). Pasien wanita mendominasi BTA positif (15 dari 18) dan BTA negatif (11 dari 17) daripada laki-laki. Pasien yang tidak mempunyai riwayat TB paru mendominasi BTA positif (14 dari 18) dan BTA negatif (14 dari 17). Perbandingan faktor risiko pasien antara hasil BTA positif dan negatif berdasar atas usia (p=0,117), jenis kelamin (p=0,264), dan riwayat TB paru (p=1,000). Walaupun mempunyai sensitivitas yang rendah, pemeriksaan BTA jaringan harus dilakukan guna memberikan informasi yang maksimal untuk klinisi. Simpulan, perbandingan faktor risiko limfadenitis tuberkulosis antara hasil BTA positif tidak berbeda. COMPARASION OF LYMPHADENITIS TUBERCULOSIS PATIENT’S RISK FACTOR BETWEEN POSITIVE AND NEGATIVE ACID-FAST BACILLUS Lymphadenitis tuberculosis is most common extrapulmonary tuberculosis (EPTB) in the world. Definitive diagnosis in EPTB is by clinical examination, bacterial examination, and histopatological examination from sample in affected organ. AFB examination by Ziehl Neelsen directly from tissue has low sensitivity and high specificity. This study aims to examine the comparion of lymphadenitis tuberculosis patient’s risk factor between positive and negative AFB from lymph node tissue based on age, sex, and previous history of pulmonary tuberculosis in Laboratory of Al-Islam Hospital Bandung during 2016–2017. There were 18 patients with positive AFB and 17 patients with negative AFB who met inclusion criteria. This study used cross sectional design with univariate data analysis to descript the risk factor of patients and bivariate to see the comparison of patient characteristics. The result of this study showed patient with positive AFB occur more at the age of <20 (8 of 18) and negative AFB occur more at the age of 30–39 (6 of 17). Woman were dominated positive AFB (15 of 18) and negative AFB (11 of 17) than man. Patients with no previous pulmonary tuberculosis history were dominated positive AFB (14 of 18) and negative AFB (14 of 17). Comparison of lymphadenitis tuberculosis patient’s risk factor between positive and negative AFB based on age (p=0.117), sex (p=0.264), and previous history of pulmonary tuberculosis (p=1.000). Despite low sensitivity, tissue AFB examination should be performed to give maximal information for clinician. Conclusion, comparison of lymphadenitis tuberculosis risk factor between positive and negative AFB is not different.
Pengaruh Fraksi Air Buah Lemon terhadap Gambaran Morfologi Jaringan Hati Mencit Tua yang Diberi Pakan Tinggi Lemak Nur Azmiati Mundiri; Meta Maulida Damayanti; Maya Tejasari; Annisa Rahmah Furqaani; R.A. Retno Ekowati
Jurnal Integrasi Kesehatan dan Sains Vol 1, No 1 (2019): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v1i1.4321

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Dislipidemia merupakan salah satu faktor risiko dari non alcoholic fatty liver disease (NAFLD). NAFLD mempunyai karakteristik steatosis hepatik, hepatocyte ballooning, inflamasi lobular, dan fibrosis.  Kandungan flavonoid pada Citrus limon dipercaya dapat mencegah steatosis hepatik. Tujuan penelitian ini mengetahui pengaruh fraksi air buah lemon terhadap gambaran morfologi jaringan hati mencit tua yang diberi pakan tinggi lemak. Penelitian ini merupakan penelitian eksperimental dengan subjek penelitian adalah mencit (Mus musculus) jantan galur DDY tua yang dibagi menjadi empat kelompok secara acak, terdiri atas kelompok kontrol dan tiga kelompok perlakuan dengan konsentrasi fraksi air buah lemon 20,6; 41,2; 82,4 mg/20 gram BB mencit. Data jumlah hepatosit dengan droplet lemak dan hepatocyte ballooning dianalisis menggunakan uji ANOVA dan Uji Kruskal Willis. Terdapat  perbedaan jumlah hepatosit dengan droplet lemak (p=0,063) dan hepatosit yang mengalami pembengkakan (p=0,109) antara kelompok kontrol dan kelompok perlakuan. Simpulan penelitian ini adalah fraksi air buah lemon dapat mencegah hepatocyte ballooning dan pembentukan droplet lemak pada hepatosit mencit tua yang diberikan pakan tinggi lemak.  PROTECTIVE EFFECT OF WATER FRACTION OF LEMON ON HIGH-FAT DIET-INDUCED LIVER INJURY IN OLD MICEDyslipidemia is one of the risk factors of non alcoholic fatty liver disease (NAFLD). NAFLD is characterized by hepatic steatosis, hepatocyte ballooning, lobular inflammation, and fibrosis. Flavonoid in Citrus limon is believed to prevent hepatic steatosis. The aim of this study is to know the protective effect of lemon’s water fraction on high-fat diet-induced liver injury in old mice. This was an experimental study with old male mice (Mus musculus) DDY strain divided into four groups randomly, consisting of control group and three groups given with water fraction of lemon at concentration 20.6; 41.2; 82.4 mg/20 gram mice body weight. Total count of hepatocytes with fat droplets and hepatocytes ballooning were analyzed using ANOVA and Kruskal Willis tests. There are differences in the amount of hepatocytes with fat droplets (p=0.063) and hepatocytes ballooning (p=0.109) between the control group and the treatment group. The conclusion of this study is lemon’s water fraction can prevent the formation of hepatocyte ballooning and fat droplet in old mice’s hepatocyte fed by high-fat diet.
Scoping Review: Pengaruh Terapi TURP terhadap Benign Prostatic Hyperplasia pada Lansia Dito Dewantoro Satriawan; Diana Wijayanti; Meta Maulida Damayanti
Jurnal Integrasi Kesehatan dan Sains Vol 3, No 1 (2021): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v3i1.7388

Abstract

Benign prostatic hyperplasia (BPH) merupakan istilah histopatologis, yaitu hiperplasia sel stroma dan sel epitel kelenjar prostat,dan bersifat jinak. Prevalensi BPH terjadi sekitar 70% pada pria di atas usia 60 tahun. Tujuan terapi pada pasien BPH adalah memperbaiki kualitas hidup pasien. Salah satu pilihan terapi untuk BPH yaitu transurethral resection of prostate (TURP) yang merupakan metode paling banyak digunakan untuk mengatasi pembesaran prostat. Tujuan penelitian ini adalah melihat gambaran pengaruh terapi TURP terhadap BPH pada lansia. Penelitian ini merupakan Scoping Review, yang diambil dari database PubMed, Springer Link, dan Science Direct dengan metode original research articles (observasional). Penelitian ini dinilai secara PICOS untuk ditentukan sebagai kriteria eligible pada prisma flow chart yang sesuai yaitu population (pasien BPH, lansia), intervention (terapi TURP), comparison (terapi lain), outcome (kesembuhan pasien BPH) terdapat 10.025 artikel, dan hasil uji berdasar atas PICOS sebanyak 10 artikel. Hasil analisis dan review dari 10 artikel ini, yaitu terapi TURP memiliki banyak fungsi serta manfaat untuk perbaikan kondisi pasien. Indikator tersebut dapat dinilai dari penurunan risiko perdarahan, waktu operasi, waktu irigasi kandung kemih, durasi kateterisasi, durasi rawat inap, perbaikan pada IPSS, QoL, Qmax, PVR, Na+ serum, K+ serum, kadar hematokrit, volume cairan irigasi, kadar hemoglobin, kreatinin serum, volume prostat dasar, IIEF-5, CTCAE, SHIM, MSHQ-EjD, dan ISI. Pasien BPH juga dapat mengalami risiko komplikasi intraoperatif ataupun pascaoperatif. Kesimpulan penelitian ini menunjukkan bahwa pengaruh terapi TURP terhadap BPH pada lansia mempunyai hasil yang cukup baik, efisien, dan efektif. Scoping Review: the Effect of TURP Therapy on Benign Prostatic Hyperplasia in the ElderlyBenign prostatic hyperplasia (BPH) is a histopathological term, which is hyperplasia of stromal cells and epithelial cells of the prostate gland, and is benign. The prevalence of BPH occurs in about 70% in men over the age of 60. The goal of therapy in BPH patients is to improve the patient's quality of life. One of the treatment options for BPH is the transurethral resection of prostate (TURP) which is the most widely used method to treat an enlarged prostate. The purpose of this study was to describe the effect of TURP therapy on BPH in the elderly. This research is a Scoping Review, which is taken from the PubMed, Springer Link, and Science Direct databases using the original research articles (observational) method. This study was assessed by PICOS to be determined as eligible criteria on the appropriate prism flow chart, namely population (BPH patients, the elderly), intervention (TURP therapy), comparison (other therapies), 10,025 articles of outcome (recovery of BPH patients), and test results. based on PICOS as many as 10 articles. The results of the analysis and review of these 10 articles are: TURP therapy has many functions and benefits for improving the patient's condition. These indicators can be assessed from the decreased risk of bleeding, time of operation, time of bladder irrigation, duration of catheterization, duration of hospitalization, improvement in IPSS, QoL, Qmax, PVR, serum Na +, serum K +, levels of hematocrit, volume of irrigation fluid, hemoglobin levels, serum creatinine, baseline prostate volume, IIEF-5, CTCAE, SHIM, MSHQ-EjD, and ISI. Patients with BPH may also be at risk of intraoperative or postoperative complications. The conclusion of this study shows that the effect of TURP therapy on BPH in the elderly has good, efficient and effective results.
Karakteristik Pasien dengan Nodul Tiroid di Rumah Sakit Al-Ihsan Bandung Yuyun Saputri; Meta Maulida Damayanti; Ismet Muchtar Nur
Jurnal Integrasi Kesehatan dan Sains Vol 3, No 2 (2021): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v3i2.7412

Abstract

Nodul tiroid merupakan kasus yang dapat disebabkan oleh berbagai jenis gangguan kelenjar tiroid dan masih sering ditemukan. Sekitar 90% nodul tiroid bersifat jinak dan 10% bersifat ganas. Di Indonesia data statistik mengenai nodul tiroid masih sangat kurang. Penelitian ini bertujuan mengetahui karakteristik pasien dengan nodul tiroid. Penelitian ini menggunakan metode deskriptif observasional dengan pendekatan potong lintang yang dilaksanakan selama bulan September 2020. Teknik pengambilan sampel dalam penelitian ini adalah total sampling. Data didapatkan melalui rekam medis tahun 2018–2019 di Rumah Sakit Al-Ihsan Bandung dan didapatkan 72 rekam medis yang memenuhi kriteria inklusi. Hasil penelitian menunjukkan frekuensi tertinggi berdasar atas usia terdapat pada kelompok usia 40–49 tahun (32%). Frekuensi tertinggi berdasar atas jenis kelamin terdapat pada pasien perempuan (90%). Frekuensi tertinggi berdasar atas ukuran nodul tiroid terdapat pada kelompok >4 cm (72%). Frekuensi tertinggi berdasar atas gambaran histopatologi berupa adenomatoid goiter (74%). Simpulan penelitian ini menunjukkan frekuensi tertinggi nodul tiroid terdapat pada usia 40–49 tahun, perempuan, ukuran nodul tiroid >4 cm dan jenis adenomatoid goiter. Hal ini terjadi karena imunitas dan daya tahan tubuh seseorang menjadi menurun seiring dengan usia yang bertambah. Pada perempuan risiko penyakit nodul tiroid dapat meningkat dengan penggunaan hormon estrogen pada kontrasepsi oral, pada kehamilan, serta perubahan siklus menstruasi. CHARACTERISTICS OF  PATIENTS WITH THYROID NODULE AT THE AL-IHSAN HOSPITAL BANDUNGThyroid nodules are a disease caused by various types of thyroid gland disorders and are still often found. Approximately 90% of thyroid nodules are benign, and 10% are malignant. In Indonesia, statistical data for thyroid nodules are still limited. The purpose of this study was to determine the characteristics of patients with thyroid nodules. This study used a descriptive observational method with the cross-sectional approach was carried out during September 2020. The sampling technique in this research is total sampling. Data were obtained through medical records for January 2018–December 2019 at Al-Ihsan Hospital Bandung and obtained 72 medical records that met the inclusion criteria. The results showed that the highest frequency according to age was found in the 40–49 years group (32%). The highest frequency according to gender was found in female patients (90%). The highest frequency according to thyroid nodules size was in the >4 cm (72%). The highest frequency according to the histopathological features was found in adenomatoid goiter (74%). The conclusions in this study indicate that the highest frequency of thyroid nodules occurs at the age of 40–49 years, women, thyroid nodule size >4 cm, and adenomatoid goiter type. These happen because a person’s immunity and body resistance decrease with age. In women, the risk of thyroid nodule disease can increase cause using the hormone estrogen in oral contraceptives, in pregnancy, and changes in the menstrual cycle.