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Determinan Stunting Anak 6-24 Bulan di Kabupaten Timor Tengah Selatan Provinsi Nusa Tenggara Timur Koro, Suriana; Hadju, Veni; As'ad, Suryani; Bahar, Baharuddin
Health Information : Jurnal Penelitian Vol 10 No 1 (2018): Digitalisasi Versi Cetak
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (474.201 KB) | DOI: 10.36990/hijp.v10i1.1


Nutritional problems in children under five are still a public health problem if the prevalence of stunting is> 20%. The prevalence of stunting in general in the world is also a public health problem because it is still 26%. Nationally, the prevalence of stunting in children under five in Indonesia is 37.2%. This means that the problem of nutrition in Indonesia is still a serious public health problem. Meanwhile, the proportion of children under five with stunting is 48.2% in NTT Province, including a critical public health problem. Based on this background, this study aims to determine the determinants of stunting of children 6-24 months in South Central Timor District, East Nusa Tenggara Province. B This research is an observational study with a cross-sectional design. The research was carried out in nine sub-districts of Timor Tengah Selatan Regency. Baduta food consumption data were obtained through consumption recall, while other data were obtained through questionnaires by enumerators. Analysis of nutrients in food using a food processor 2 (FP2). The statistical test used is Chi-Square. The number of respondents studied was 3480 children, with stunting and severe stunting as many as 1416 children (40.7%), most of whom were boys, as many as 1870 children (53.7%), for 12-24 months there were 1916 children, (1%), where the results of the chi square test are significant p <0.05. Education of mothers and fathers, respectively 1827 people (52.5%) and 1754 people (50.4%) with basic education did not complete and graduated from junior high school, with the majority of jobs being mother farmers (83.3%) and fathers (65.0%), most of the socio-economic conditions are low (83.5%). Maternal TB was significant (p = 0.000) as well as parity and birth spacing, the results of the chi-square test were significantly significant, p <0.005, while exclusive breastfeeding was only 596 people (17.1%). Nutritional needs did not reach the Recommended dietary allowance. (RDA) <80% RDA, energy intake (90.3%), protein (82.6%), fat (97.9%) and KH (82.0%). History of diarrhea (17.4%), fever (32.6%), shortness of breath (2.3%), cough (31.0%) and runny nose (29.2%) and the results of the chi-square test were only fever. Significant with p = 0.016. The logistic regression results showed that gender and maternal height were the most associated with stunting nutritional status. The determinant factors of stunting were the child's age, sex, mother's education, maternal occupation, mother's height, parity, birth spacing, protein intake and a history of fever.
Adiponectin and Its Role in Inflammatory Process of Obesity Febriza, Ami; Ridwan, Ridwan; As'ad, Suryani; Kasim, Vivien Novarina; Idrus, Hasta Handayani
Molecular and Cellular Biomedical Sciences Vol 3, No 2 (2019)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v3i2.66


Obesity is a chronic, low degree systemic inflammatory status. Microarray examination shows a disturbance in the expression of cytokine, chemokine, complementary protein and half of the other acute phase components in obese patients. Adiponectin is the hormone that increases insulin sensitivity, while its level decreases under condition of fatty tissue enlargement that occurs in obesity. Excessive weight causes the adipocyte cells and adipose tissues produce various types of mediators. The inflammatory process is the main cause of metabolic diseases, and the main role of adipose tissue in the inflammatory process is determined by the production of pro-inflammatory mediators and anti-inflammatory mediators. Adiponectin has an important anti-inflammatory effect on obesity. Adiponectin has an important anti-inflammatory effect on obesity. Adiponectin works on macrophage and monocyte to inhibit the production of pro-inflammatory cytokine and increase the expression of interleukin (IL)-10 and IL-1 receptor antagonists. Adiponectin reduces induction of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 endothelial adhesion by TNF-α or resistin. In obese patients, it is characterized by resistance to adiponectin alongside a decrease and the possibility of adiponectin loss in the receptor population in liver and muscles, leading to low adiponectin level.Keywords: adiponectin, obesity, inflammation
The correlation between leptin and highly sensitive C-reactive protein levels in obese children aged 9-15 years Warouw, Sarah M.; Satriono, Satriono; As'ad, Suryani
Paediatrica Indonesiana Vol 51 No 1 (2011): January 2011
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi51.1.2011.47-51


Background Obesity is a low level and chronic inflammatory condition predominantly affecting white adipose tissue, where macrophage infiltration is found. Leptin is one of many molecules relating obesity to cardiovascular disease. Leptin can increase cytokine production in macrophages and monocytes, and increase oxidative stress on endothelial cells. Pro-inflammatory cytokines, in turn, may trigger the release of C-reactive protein.Objective To examine the correlation between leptin and hsCRP in obese children aged 9-15 years.Methods This cross-sectional study was done in Manado from May to December 2009, on elementary and junior high school children. Subjects were obese children aged 9-15 years, with nutritional status detennined by Body Mass Index and converted into z-score. Physical examination, blood pressure, and blood examinations for  fasting blood sugar (FBS), lipid profile, leptin, and hsCRP were perfonned. Data were analyzed with appropriate statistical methods.Results The mean leptin level in obese children was 34,009.2 pgiL (SD 18,224.79), higher than that of the control, 7,760.9 pgiL (SD 8,859.55) (P<0.0001). The mean hsCRP level in obese children was 3.6 mgiL (SD 3.60), higher than that of the control, 0.7 mgiL (SD 1.32) (<0.0001). There was a significant positive correlation between leptin and hsCRP levels in obese children (r 􀀁 0.355; P<0.0001).Conclusions There is significant positive correlation between leptin and hsCRP levels in obese children aged 9-15 years. Increased leptin and hsCRP levels indicate a low degree of chronic inflammation. Thus, intervention is needed to decrease the body weight of obese children.
Nutrition Therapy on Cutaneous Lymphoma Patient with Anemia and Hypoalbuminemia: A Case Report Tyas, Fitri; As'ad, Suryani; Safitri, Asrini; Bamahry, Aryanti
Green Medical Journal Vol 2 No 2 August (2020): Green Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/gmj.v2i2.53


Nutrition is a part of cancer management during therapy, recovery, remission, and recurrence prevention. Malnutrition and cachexia often occur in cancer patients and influence morbidity, mortality, and quality of life, especially in the advanced stage of malignancy. We reported a case of cutaneous lymphoma with anemia and hypoalbuminemia in the terminal condition. This case report focuses on nutritional therapy and palliative care on nutrition. We reported a case of a 40-year-old-man with Cutaneous Lymphoma (CL) and moderate protein-energy malnutrition that was developed to severe protein-energy malnutrition due to difficulty in dietary access. He had an eating problem because of multiple tumors and ulcers on his mouth. We provided access for parenteral nutrition from Central Venous Catheter (CVC) and orogastric tube (OGT) for enteral feeding. Even though the dietary target was never accomplished, there was a slight recovery on hypoalbuminemia and renal function during hospitalization. This case showed a considerable challenge in nutritional therapy due to limited dietary access. Since death was inevitable, we have tried different dietary access to provide adequate intake.
Pelatihan dan Sekolah Lapang Terpadu Kabupaten Bulukumba Ahmad, Mardiana; As'ad, Suryani; Aminuddin, Andi Alief; Rusnawati, Rusnawati
MATAPPA: Jurnal Pengabdian Kepada Masyarakat Volume 4 Nomor 3 Tahun 2021
Publisher : STKIP Andi Matappa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31100/matappa.v4i3.1222


Taccorong Village in Ujung Bulu Subdistrict is one of the villages with the highest death toll in the Bulukumba Regency. There were 33 cases of neonatal deaths in 2015. In anticipation of this event, Training and integrated Field Schools activities through Clean and Healthy Lifestyle Counseling (PHBS), Balanced Nutrition Counseling, Early Breastfeeding Initiation Counseling (IMD), and Examination and Gymnastics of Pregnant Women. The approach method used in this devotional program is participatory education and training or educational and participatory approach both to health workers in Community Health Centers (Puskesmas) and Integrated Service Post (Posyandu) and for Village Health Worker of Integrated Service Post. This method positions the target audience as recipients of knowledge, understanding, and skills on how to change the lifestyle to be healthier, where the mother cadre group is involved in all activities ranging from planning, implementation, monitoring, and evaluation. In addition, participatory counseling is conducted by conducting learning activities. The activity was held for 2 (two) days, namely, on Saturday-Sunday, August 11-12-2018, with many workshop participants as many as 30 people. Workshop participants consisted of 3 health workers, Community Health Centers (Puskesmas), 12 cadres, and 15 citizens. The results of this devotion get participants have implemented the practice of Clean and Healthy Living Behavior, practiced the preparation of a balanced nutrition menu, especially at 1000 HPK, and has implemented early breastfeeding initiation (IMD)practices in the postpartum period. It is expected that this activity can be replicated throughout the village and can continue to support the improvement of public health
Correlation Between Adiponectin, Tumor Necrosis Factor-alpha, Insulin Resistance and Atherogenic Dyslipidemia in Non Diabetic Central Obese Males Ninghayu, Candra; Wijaya, Andi; As'ad, Suryani
The Indonesian Biomedical Journal Vol 2, No 1 (2010)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v2i1.113


BACKGROUND: Obesity raises the risk for atherosclerotic cardiovascular disease (ASCVD) through many risk factors including atherogenic dyslipidemia. Atherogenic dyslipidemia is characterized by high levels of triglyceride, increased small dense low density lipoprotein particles, and reduced levels of high density lipoprotein cholesterol. The exact mechanisms of central obesity and this atherogenic lipoprotein phenotype (ALP) is not clearly understood. Central obesity is characterized by a state of systemic low grade inflammation and insulin resistance. Adipose tissue has recently been shown to secrete a variety of bioactive peptides, called adipocytokines, that can potentially affect glucose and lipid metabolism. The aim of this study was to observe the role of adiponectin, tumor necrosis factor-α (TNF- α) and insulin resistance in atherogenic dyslipidemia in nondiabetic central obese males.METHODS: This was a cross-sectional study on 75 non-diabetic central obese male subjects (waist circumferences > 90 cm). Adiponectin and TNF-α testing were performed by ELISA; insulin resistance was assessed by the Homeostasis Model Assessment (HOMA) index, triglyceride was assessed by GPO-PAP, HDL cholesterol and small dense LDL were measured by homogenous method. Statistical analysis was done by SPSS for Windows v. 11.5 with a significance level at p < 0.05. The Pearson and Spearman’s Rho correlation coefficient was used to assess the correlation between various anthropometric and biochemical parameters.RESULTS: There were 75 patients aged 38.0±6.3 years, Adiponectin concentration was 3.55±1.38 μg/ml, HOMA index was 2.28±1.63, TNF-α was 12.42±11.25 pg/ml, triglyceride was 185.17±109.00, HDL-cholesterol was 44.15±9.23 mg/dL, small dense LDL 23.22±12.26 mg/dL. This study revealed that there were correlations between adiponectin and triglyceride (r=-0.236, p=0.042), adiponectin and HDL cholesterol (r=0.300, p=0.009), adiponectin and atherogenic dyslipidemia (r=-0.256, p=0.027), whereas there was no correlation between insulin resistance and TNF-α with the atherogenic dyslipidemia.CONCLUSION: Adiponectin might contribute to atherogenic dyslipidemia in central obese non-diabetic males. Advancing our understanding of the function and measurement of adiponectin serum concentration will be useful in clinical diagnosis of obesity related atherogenic dyslipidemia.KEYWORDS: obesity, waist circumference, adiponectin, insulin resistance, TNF-α, atherogenic dyslipidemia
C-Reactive Protein and Matrix Metalloproteinase-9 are Associated with Outcome of Ischemic Stroke Surjawan, Yenny; Ranakusuma, Teguh A S; Wijaya, Andi; As'ad, Suryani
The Indonesian Biomedical Journal Vol 4, No 3 (2012)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v4i3.176


BACKGROUND: C-Reactive protein (CRP) and matrix metalloproteinase (MMP)-9 are inflammatory mediators that are often associated with the evolution of stroke. In this study, we aimed to find out whether concentration of these biomarkers were associated with the severity of discharge National Institute of Health Stroke Scale (NIHSS) in ischemic stroke patient.METHODS: In prospective stody, we involved 143 ischemic stroke patient who were admitted to hospital not more than 72 hours after the onset and who met the criteria. The concentration of CRP was assessed by High Sensitivity CRP reagent from Siemens and the concentration of MMP-9 was measure with Quantikine Human MMP-9 (total) Immunoassay from R&D. The outcome of stroke was determined by NIHSS score at discharge.RESULTS: There was a significant correlation between the CRP level and the severity of NIHSS at discharge (r = 0.288, p = 0.000). Subjects with intermediate/high level of CRP had a higher probability to have a moderate or even severe NIHSS (OR = 1.7, p = 0.004). Subjects with high MMP level showed a higher probability to have a severe NIHSS. CONCLUSION: The measurement of CRP and MMP-9 at 48-72 hours after stroke onset were associated with the severity of ischemic stroke based on NIHSS score at discharge.  KEYWORDS: inflammation, CRP, MMP-9, discharged NIHSS
Nurse and Health: Jurnal Keperawatan Vol 10 No 2 (2021): Nurse and Health: Jurnal Keperawatan July-December 2021
Publisher : Institute for Research and Community Service of Health Polytechnic of Kerta Cendekia, Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36720/nhjk.v10i2.295


Background: According to 2018 World Health Organization (WHO) data globally, an estimated 17.3% of the population has inadequate zinc intake, with estimates ranging from 5.7% in Oceania to 7.6% in Europe, 9.6% in America and the Caribbean, highest in Africa (23.9%) and Asia (19.6%). Zinc is important for the function of a number of enzymes and growth hormones during pregnancy. In pregnant women, the relative zinc concentration decreases up to 35% due to the influence of hormonal changes and the transport of nutrients from mother to baby. Objectives: The purpose of this study was to identify the effect of giving zinc tablets to pregnant women with zinc deficiency in the third trimester on body weight and length of babies born at the Makassar City Health Center. Methods: This type of research is True Experimental with a pretest-posttest design with a control group. The sample in this study was 62 samples of third trimester pregnant women, and the sampling technique used was purposive sampling. Measurement of zinc levels in third trimester pregnant women using the Elisa reader kit at the Research Laboratory of the Hasanuddin University Teaching Hospital. The research instruments were in the form of a research explanation sheet, respondent's consent sheet, respondent's checklist sheet, and the mother's zinc tablet consumption control sheet for 14 days. Results: Judging from the average value of newborns in pregnant women who did not have zinc deficiency, the average value of birth weight in pregnant women with zinc deficiency was 15.70 g/dL and 18.95 g/dL. zinc deficiency with a value (p < 0.05), while pregnant women with zinc deficiency have an average birth length of 10.00 g/dL and mothers who do not have a deficiency of 19.87 g/dL with a value (p < 0.05). So, it can be concluded that giving zinc tablets to pregnant women in the third trimester has an effect on Birth Weight (BBL) and Birth Length (PBL). Conclusion: Giving zinc tablets has an effect on increasing zinc levels in third trimester zinc deficiency pregnant women and increasing birth weight and length of the baby.