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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Humanism : Jurnal Pengabdian Masyarakat
Gina Noor Djalilah
Fakultas Kedokteran Universitas Muhammadiyah Surabaya
Religion Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Effect of Oral Sildenafil on the Decrease in the Degree of Pulmonary Artery Systolic Pressure in PPHN Infants at Siti Khodijah Muhammadiyah Hospital Sepanjang Afif, Muhammad; Airlangga, Muhammad Perdana; Yuliyanasari, Nurma; Djalilah, Gina Noor
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 8, No 1 (2021): February
Publisher : APKKM (Muhammadiyah Medical and Health Education Association)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1786.194 KB) | DOI: 10.26714/magnamed.8.1.2021.18-28

Abstract

Background: Persistent Pulmonary Hypertension of the Newborn (PPHN) is a condition of the failure to decrease pulmonary artery pressure, so that blood pressure in the lungs remains high, as in a fetus. PPHN cases are 2-6 of 1000 live births and responsible for 10% of confirmed deaths in the neonatal intensive care unit (NICU). Sildenafil is vasodilator that can be used to reduce pulmonary artery systolic pressure (PASP), morbidity, and mortality in PPHN infants.Objective: To analyze the effect of sildenafil on decrease the severity of pulmonary artery systolic pressure in PPHN infants.Method: This is an analytic observational study with cross-sectional design. The samples were collected using consecutive sampling on 30 PPHN infant patients in 2018. The data were collected from medical records of PPHN infant patients, then assessing the severity value of PASP which obtained from echocardiography result. The severity of PASP is classified into normal (PASP≤35 mmHg), mild (PASP36-45 mmHg), moderate (PASP 45-60 mmHg), and severe (PASP>60 mmHg)Results: This study showed that 27 PPHN infant patients have decreased PASP level to normal, previously from mild 7 infants (23.3%), moderate 16 infants (53.3%), and severe 4 infants (13%), after being given oral sildenafil. There were 1 (3.3%) infant patient remained severes, 1 (3.3%) patient was decreased from severe to moderate, and 1 patient (3.3%) was decreased from severe to mild. The p value <0.05 was obtained, so oral sildenafil significantly decreased the PASP severity in PPHN infants patients.Conclusion: There is a beneficial effect of oral sildenafil on decreasing the severity of pulmonary artery systolic pressure in PPHN infants at the NICU of Siti Khodijah Muhammadiyah Hospital Sepanjang.
Skrining Kondisi Kesehatan Masyarakat Pasca Erupsi Gunung Semeru di Desa Sumbermujur, Lumajang Yelvi Levani; Muhamad Reza Utama; Gina Noor Djalilah; Muhammad Anas; Yudith Annisa Rezkitha; Nur Mujadidah Mochtar
Humanism : Jurnal Pengabdian Masyarakat Vol 3, No 1 (2022): April
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/hm.v3i1.12598

Abstract

Gunung Semeru merupakan gunung berapi yang masih aktif di wilayah Jawa Timur. Letusan Gunung Semeru pada Bulan Desember 2021 menyebabkan 51 korban jiwa dan 10.395 penduduk mengungsi. Walaupun kondisi darurat sudah berakhir, bukan berarti permasalahan masyarakat di sekitar Gunung Semeru sudah selesai. Salah satu yang terpenting adalah masalah kesehatan. Oleh karena itu, kegiatan pengabdian masyarakat ini difokuskan untuk memberikan pelayanan kesehatan sekaligus untuk skrining penyakit yang diderita oleh masyarakat di Desa Sumbermujur, Lumajang. Dari hasil kegiatan, diketahui bahwa 85% pasien adalah perempuan dengan rentang usia terbanyak pada usia 18-60 tahun. Penyakit yang ditemukan diantaranya adalah infeksi saluran pernapasan atas (35%), tekanan darah tinggi (16%), pegal linu (15%), infeksi saluran pernapasan bawah (9%), gangguan pencernaan (7%) dan penyakit lainnya (17%). Dapat disimpulkan, Infeksi saluran pernapasan atas merupakan penyakit terbanyak yang ditemui pada masyarakat di Desa Sumbermujur pasca erupsi Gunung Semeru. Infeksi saluran pernapasan atas dapat disebabkan oleh infeksi virus dan bakteri, serta disebabkan oleh menghirup abu vulkanik.Kata Kunci: erupsi, Gunung Semeru, masalah kesehatan Abstract Mount Semeru is an active volcano in East Java. The eruption of Mount Semeru in December 2021 caused 51 death and 10,395 residents were displaced. Even though the emergency situation has ended, it does not mean that the problems of the community around Mount Semeru have been resolved. One of the most important is health issues. Therefore, this community service activity is focused on providing health services as well as screening for diseases suffered by the community in Sumbermujur Village, Lumajang. From the results of the activity, it is known that 85% of patients are women with the highest age range being 18-60 years old. Diseases found included upper respiratory tract infections (35%), high blood pressure (16%), aches and pains (15%), lower respiratory tract infections (9%), digestive disorders (7%) and other diseases (17%). It can be concluded, upper respiratory tract infection is the most common disease found in the community in Sumbermujur Village after the eruption of Mount Semeru. Upper respiratory tract infections can be caused by viral and bacterial infections, as well as caused by inhalation of volcanic ash.Keywords: eruption, Mount Semeru, health problems
The difference in severity and management between children and adult's cases of COVID-19 Mohammad Husin; Gina Noor Djalilah; R A Kaniraras; Afrita Amalia Laitupa
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.6229

Abstract

AbstractCOVID-19 (Coronavirus Disease 2019) has been started in Wuhan, China, and spread worldwide and resulting in many cases of death. COVID-19 attacks the respiratory tract acutely and infected both children and adults. The number of cases in children is less than in adults. By seeing from the clinical aspect, the COVID-19 case in children is milder. There are differences in immunology responses in children and adults where children have higher immunology response of COVID-19 than adults. Meanwhile, if the immunology response is slow in adults, it may cause them infected by COVID-19 with severe symptoms. There are some relations between immunization with immunology response to SARS-CoV-2 where children who already have BCG vaccination has lower infection rates of acute respiratory tract case. This study aims to know the difference between COVID-19 cases that infected adults and children seen in various aspects.Keywords                     : COVID-19,SARS-CoV-2, children, adult, severity, managementCorrespondence         : mohammad_husin@yahoo.com
Association between gestational age and persistent pulmonary hypertension of the newborn (PPHN) severity in preterm babies at Sidoarjo Regional Hospital Aisyah Faadhilah; M. Perdana Airlangga; Nurma Yuliyanasari; Gina Noor Djalilah
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.6107

Abstract

AbstractPersistent pulmonary hypertension of the newborn (PPHN) is a condition that occurs due to increased resistance to blood vessels in the lungs that occur persistently after the baby is born. This can be attributed to congenital heart disease such as right-to-left shunts through foramen ovale (PFO) or patent ductus arteriosus (PDA) due to an error transition fetal blood circulation to the neonate. Although PPHN is always associated with births in post-term babies, PPHN cases are often found in preterm babies. Chances of babies born with PPHN are quite large, at 1.9% per 1000 live births. PPHN can be fatal, causing mortality rates ranging from 4 to 33%. The incidence of preterm births in Indonesia is estimated at 7-14%, around 459,200 - 900,000 babies per year. This study aimed to prove the relationship between premature babies and persistent pulmonary hypertension of the newborn (pphn) in Sidoarjo  Regional Hospital and to know the characteristics and analyze these variables.  This research used crossed sectional studied design; the population was all preterm babies in the NICU at Sidoarjo  regional hospital. All samples are from medical records in January-December 2018. There is a significant difference between preterm babies and PPHN (p < 0.05); besides, the results from Spearman's correlation analysis obtained a correlation coefficient (ρ) = 0.485. In the cross-tabulation analysis, the result of the proportion with the highest correlation was Late Preterm babies with severe PPHN of 46.7%. It can be concluded that there is a relationship between premature babies and PPHN in Sidoarjo  regional hospital..Keywords                      : Persistent pulmonary hypertension of the newborn, PPHN, Preterm BabiesCorrespondence            : aisyahhelmadevithalib@gmail.com
Magnetic resonance cholangiopancreatography as a diagnostic tools to diagnose biliary atresia at Dr.Soetomo hospital Gina Noor Djalilah; Reny Widayanti; Bagus Setyoboedi; Sjamsul Arief
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 3, No 2 (2019)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (652.625 KB) | DOI: 10.30651/jqm.v3i2.2131

Abstract

ABSTRACT Cholestasis jaundice results from diminished bile flow and/or excretion, and caused by a number of disorders such as biliary atresia (BA). Magnetic resonance cholangiopancreatography (MRCP) is widely accepted as one of the modalities for biliary system imaging; however, liver biopsy still generally used for BA diagnosis, especially in developing countries. This aim study was to evaluate the diagnostic value of biliary atresia from MRCP compared to the result of a liver biopsy. A cross-sectional for diagnostic study documented of hospitalized patients from June 2014 to June 2015. All patients had MRCP and liver biopsy examination. The collection of data including age, gender, clinical manifestation and the result of MRCP and liver biopsy with ROC to evaluate the sensitivity and specificity was done. Liver biopsy revealed of biliary atresia was made based on proliferation, degeneration, and fibrosis of bile ducts. ROC to evaluate the sensitivity and specificity was done. The sensitivity, specificity, negative predictive value, positive predictive value of MRCP in diagnosing BA were calculated. There were 16 patients enrolled in this study with a median age of diagnosis was 6 months old (range 3-11). There were nine female patients out of the 16 patient. The median age of jaundice onset was 5 days (range 2-14 days). All patients had hepatomegaly and splenomegaly. Histopathology from liver biopsy revealed biliary atresia in 12 patients. From the ROC curve, the sensitivity of MRCP was 87.5% and specificity 62.5% with PPV 70% and NPV 80%. Five patients underwent a Kasai procedure and revealed biliary atresia. MRCP is sensitive but not specific for diagnosing BA, and MRCP has moderate sensitivity and specificity for BA diagnosis.Keyword: biliary atresia, magnetic resonance cholangiopancreatography, liver biopsy, diagnostic test.Correspondence: geendjk@gmail.com ABSTRAKIkterus dikarenakan kolestasis terjadi akibat berkurangnya aliran empedu dan/ atau ekskresi, dan dapat disebabkan oleh sejumlah gangguan seperti atresia biliaris (BA). Magnetic resonance cholangiopancreatography (MRCP) secara luas diterima sebagai salah satu modalitas untuk pencitraan sistem empedu, namun biopsi hati masih secara umum digunakan untuk diagnosis BA, terutama di negara berkembang. Studi ini bertujuan untuk mengevaluasi nilai diagnostik atresia biliaris dari MRCP ke hasil biopsi hati. Sebuah cross sectional untuk studi diagnostik didokumentasikan pasien rawat inap dari Juni 2014 hingga Juni 2015. Semua pasien menjalani MRCP dan pemeriksaan biopsi hati. Data usia, jenis kelamin, manifestasi klinis dan hasil MRCP dan biopsi hati dengan ROC untuk mengevaluasi sensitivitas dan spesifisitas dilakukan. Biopsi hati mengungkapkan atresia biliar dibuat berdasarkan proliferasi, degenerasi dan fibrosis saluran empedu. ROC untuk mengevaluasi sensitivitas dan spesifisitas yang dilakukan. Dilakukan perhitungan sensitivitas, spesifisitas, nilai prediktif negatif, nilai prediksi positif MRCP dalam mendiagnosis BA. Terdapat 16 pasien yang terdaftar dalam penelitian ini dengan median usia diagnosis adalah 6 (kisaran 3-11) bulan. Terdapat 9 perempuan dari 16 pasien tersebut. Usia rata-rata onset penyakit kuning adalah 5 (kisaran 2-14) hari. Semua pasien mengalami hepatomegali dan splenomegali. Histopatologi dari biopsi hati mengungkapkan atresia bilier pada 12 dari 16 pasien. Dari kurva ROC, sensitivitas MRCP adalah 87,5% dan spesifisitas 62,5% dengan PPV 70% dan NPV 80%. Lima pasien menjalani prosedur Kasai dan mengungkapkan atresia bilier. MRCP sensitif namun tidak spesifik untuk mendiagnosis BA dan MRCP memiliki sensitivitas dan spesifisitas sedang untuk diagnosis BA.Kata kunci: biliary atresia, magnetic resonance cholangiopancreatography, liver biopsy, diagnostic test.Korespondensi: geendjk@gmail.com
Identifikasi Variasi Gen yang Bersifat Missense/Nonsense Pada Dermatomyositis Dengan Memanfaatkan Database Genomik Dan Bioinformatik Lalu Muhammad Irham; Anisa Nova Puspitaningrum; Wirawan Adikusuma; Eko Mugiyanto; Ageng Brahmadhi; Gina Noor Djalilah; Rahmat Dani Satria; Firdayani; Abdi Wira Septama
Majalah Farmasi dan Farmakologi Vol. 27 No. 1 (2023): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i01.22185

Abstract

Dermatomyositis merupakan penyakit autoimun yang termasuk jenis idiopatik inflamasi miopati (IIM), penyakit ini dapat mempengaruhi kulit dan otot manusia. Gejala klinis Dermatomyositis pada sebagian besar pasien adalah kelemahan otot tubuh, ruam kulit dan kulit bersisik. Salah satu faktor penyebab Dermatomyositis yang sering dilaporkan adalah faktor genetik. Hingga kini,  penelitian terkait Dermatomyositis masih terbatas pada identifikasi jenis variasi gen yang mempengaruhi, namun tidak melaporkan variasi gen mana yang paling berkontribusi pada Dermatomyositis khususnya yang bersifat missense/nonsense. Sehingga pada penelitian ini kami memanfaatkan database genomik dan analisis bioinformatik  untuk mengidentifikasi variasi gen yang paling berhubungan dengan penyakit Dermatomyositis. Penelitian ini menggunakan beberapa database, termasuk GWAS catalog, PheWAS catalog, HaploReg (v41.), dan GTEx portal. Hasil dari penelitian ini ditemukan bahwa gen ZBP1 berkaitan erat dengan penyakit Dermatomyositis dan menunjukkan ekpresi yang tinggi pada beberapa jaringan seperti paru-paru, lambung, esophagus, kulit, jantung dan otot. Variasi gen berdasarkan frekuensi varian alel (rs59626664, rs60542959, rs2066807, rs1048661, rs745400, rs2305480, rs2305479) terkait Dermatomyositis menunjukkan ekspresi jaringan tertinggi di kulit suprapubic, kulit dibawah lengan, otot rangka, dan esofagus. Penelitian ini menekankan bahwa integrasi database genomik dan analisis bioinformatik menunjukkan variasi gen yang berperan dalam patogenesis Dermatomyositis khususnya yang bersifat missense/nonsense. Kami menyarankan untuk peneliti selanjutnya untuk fokus pada variasi gen tersebut untuk divalidasi di fase klinis khusunya di populasi Indonesia.
Co-Authors Abdi Wira Septama Afrita Amalia Laitupa Ageng Brahmadhi Aisyah Faadhilah Anisa Nova Puspitaningrum Bagus Setyoboedi Eko Mugiyanto Firdayani Lalu Muhammad Irham M. Perdana Airlangga Mohammad Husin Muhamad Reza Utama Muhammad Afif Muhammad Anas Muhammad Perdana Airlangga, Muhammad Perdana Nur Mujadidah Mochtar Nurma Yuliyanasari, Nurma R A Kaniraras Rahmat Dani Satria Reny Widayanti Sjamsul Arief Wirawan Adikusuma Yelvi Levani