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Anti-Inflammatory Activity of Marine Sponge Aaptos sp. to the Plasma Interleukin-1β Level in Wistar Male Rats Fristiyohadi, Adryan; Wahyuni, Wahyuni; Kalimin, Wa OIL.; Permana, La OMJ.; Saripuddin, Saripuddin; Sahidin, Idin
Pharmacology and Clinical Pharmacy Research Vol 4, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (105.584 KB) | DOI: 10.15416/pcpr.v4i2.24269

Abstract

Inflammation is the response of the body to injury and infection characterized by swelling, heat, pain, and redness. This study aimed to investigate the anti-inflammatory effect of Aaptos sp. ethanolic extract to plasma interleukin (IL)-1β level of Wistar male rats. Aaptos sp. was macerated with 96% ethanol for 3 x 24 hours. Inflammation was induced with administration of 1% carrageenan intraplantarly. Animals were divided into 5 treatment groups, i.e., positive control  (diclofenac sodium 3598 ppm); Aaptos sp extract 50 ppm; Aaptos sp extract 100 ppm Aaptos sp extract 200 ppm; and negative control (0.5% Na CMC). After 1 hour, blood was collected and assayed using enzyme-linked immunosorbent assay (ELISA) kit. The results showed that plasma IL-1β levels of animals were decreased by Aaptos sp ethanolic extract. The administration of 50 ppm of extract showed no significant difference (p>0.05)  in IL-1β level in first and second hour measurement, but indicated a statistically significant decrease after three hour (p<0.05). The administration of 100 ppm of extract showed no significant difference (p>0.05) in every hour. Significant reduction was observed in the administration of 200 ppm of extract, but the elevation of IL-1β levels was also observed at third hour measurement. In conclusion, ethanolic extract of Aaptos sp. had anti-inflammatory activity and its effective dose was 50 ppm.   
Immunomodulator Activity of Effervescent Granule of Wualae Fruit (Etlingera elatior (Jack) R.M. Smith) Based on Specific Phagocytic Activity Fristiohady, Adryan; Zubaydah, Wa Ode Siti; Wahyuni, Wahyuni; Mirda, Mirda; Saripuddin, Saripuddin; Andriani, Rina; Purnama, La Ode Muhammad Julian; Sahidin, Sahidin
Borneo Journal of Pharmacy Vol 2 No 2 (2019): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (267.039 KB) | DOI: 10.33084/bjop.v2i2.868

Abstract

The previous study reported that Etlingera elatior (Wualae) has activity as immunostimulant with dose at 300 mg/kg BW and 400 mg/kg BW. Formulating natural product into effervescent granule (GE) can increase practicality and interest to consume traditional medicine. This study aims to investigate the immunostimulant activity of Wualae ethanolic extract in the effervescent granule. Wualae was macerated with ethanol then formulated into effervescent granule at dose 300 mg/kgBW and 400 mg/kgBW. Formulations were evaluated. Animals were divided into 4 groups and treated with: group I (positive control); group II (negative control); group III (GE dose at 300mg/kgBW); and group IV (GE at dose 400mg/kgBW) for 7 days and at days 8, groups were infected by Staphylococcus aureus intraperitoneally. Immunostimulant activity was measured by calculating the Specific Phagocytic Activity (SPA) of macrophage. Data collected from the evaluation and measurement of the SPA then analyzed using SPSS. Results from the evaluation were considered good except the moisture content of effervescent granule. Results from SPA was found that effervescent granule at dose 300 mg/kgBW and at dose 400 mg/kgBW have 26.33% and 32.5% consecutively with significance 0.02 (p<0.05). Thus, effervescent granule has comparable phagocytosis activity with positive control.
Level of Cytokine Interleukin-6 and Interleukin 1-β on Infectious Rat Model Treated with Etlingera elatior (Jack) R.M. Smith Fruit Extract as Immunomodulator Fristiohady, Adryan; Wahyuni, Wahyuni; Malik, Fadhliyah; Yusuf, Muhammad Ilyas; Salma, Wa Ode; Hamsidi, Rini; Talebong, Fredy; Yuliansyah, Yuliansyah; Purnama, La Ode Muhammad Julian; Saripuddin, Saripuddin; Sahidin, Sahidin
Borneo Journal of Pharmacy Vol 3 No 2 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i2.1318

Abstract

Etlingera elatior (Jack) R.M Smith or locally in Southeast Sulawesi known as Wualae fruit has activity as an immunomodulator by increasing phagocytosis activity. Prior studies have been conducted to observe the effect of E. elatior as an immunomodulator, thus further study is needed to observe the production of cytokines such as IL-1β and IL-6 which are responsible for the immune responses. Etlingera elatior fruit macerated with 96% ethanol for three days and produced a total of ±74.6 g concentrated extract. Experimental animals used were divided into four groups (n=4) and treated orally once a day for seven days as follows: group I (0.5% Na CMC); group II (Stimuno®); group III (E. elatior fruit extract dose of 300 mg/kg BW); and group IV (E. elatior fruit extract dose of 400 mg/kg BW). On the eight-day, animals were infected with Staphylococcus aureus intraperitoneally and left for an hour. Thereafter, blood was collected and assayed using ELISA Kit (Elabscience rat IL-1β and Elabscience rat IL-6). Results demonstrated that group IV increased levels of IL-1β and group III and IV increased level of IL-6 (p<0.05). Increased levels of IL-1β and IL-6 are associated with phagocytosis in the immune response. In conclusion, E. elatior fruit extract at doses of 300 and 400 mg/kg BW increases levels of IL-1β and IL-6.
Pengaruh Administrasi Pendidikan dan Supervisi Akademik Terhadap Kinerja Guru pada MAN 1 Bintan Kepulauan Riau Saripuddin, Saripuddin; Hasibuan, Lias; Anwar Us, Kasful
AkMen JURNAL ILMIAH Vol 18 No 2 (2021): AkMen JURNAL ILMIAH
Publisher : Lembaga Penelitian dan Publikasi Nobel Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37476/akmen.v18i2.1719

Abstract

This study aims to determine and analyze: the effect of educational administration and academic supervision on teacher performance at MAN 1 BintanRiau Islands. This research approach uses survey research. The time of the research was carried out starting in March 2021. The research population was 30 lecturers who taught at MAN 1 Bintan Kijang, Riau Islands. The sample selection in this study was carried out using the census method where the population acted as a sample. The results showed that: 1) There was no positive and significant effect of education administration individually (partial) on teacher performance at MAN 1 BintanRiau Archipelago, with tcount = 0.258 < ttable = 1.99. 2) There is a positive and significant effect of individual (partial) academic supervision on teacher performance at MAN 1 BintanRiau Islands, with tcount = 2.397 > ttable = 1.99. 3) There is a simultaneous (simultaneous) effect of education administration and academic supervision on teacher performance at MAN 1 BintanRiau Islands, where Fcount = 15,467 > Ftable = 2.73. Based on the results of the study, the coefficient of determination (R2 ) was 0.534 or (53.4%). This
Pengaruh Gaya Kepemimpinan, Motivasi dan Disiplin Kerja Terhadap Kinerja Pegawai Pada Kantor Kecamatan Arungkeke Kabupaten Jeneponto Rusli, Rusli; Maryadi, Maryadi; Saripuddin, Saripuddin; Jannang, Abdul Rahman
Jurnal Ilmiah Wahana Pendidikan Vol 7 No 6 (2021): Jurnal Ilmiah Wahana Pendidikan
Publisher : Peneliti.net

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.5587546

Abstract

This study aims to analyze 1) partially the influence of leadership style, motivation and work discipline on employee performance at the Arungkeke District Office, Jeneponto Regency. 2) The simultaneous influence of Leadership Style, Motivation and Work Discipline on the Performance of Arungkeke District Office Employees, Jeneponto Regency. 3) The most dominant variable has an effect on the performance of Arungkeke District Office Employees, Jeneponto Regency. This research was conducted on employees of the Arungkeke District Office, Jeneponto Regency. Determination of the sample using the saturation technique by taking the entire existing population, as many as 32 employees of the Arungkeke District Office, Jeneponto Regency. Data collection methods used are questionnaires and document studies. The analytical method used is descriptive statistical analysis and multiple linear regression analysis. The results of the study concluded that: partially Leadership Style, Motivation and Work Discipline had a positive and significant effect on the Performance of Arungkeke District Office Employees, Jeneponto Regency. This means that Leadership Style, Motivation and Work Discipline are able to improve the Performance of Arungkeke District Office Employees, Jeneponto Regency. Simultaneously Leadership Style, Motivation and Work Discipline have a positive and significant effect on the Performance of Arungkeke District Office Employees, Jeneponto Regency. Partially, it shows that the leadership style variable has a dominant effect on the performance of the Arungkeke District Office Employees, Jeneponto Regency.
ISLAM DAN SAINS: ANTARA ISLAMISASI ILMU, PENGILMUAN ISLAM, DAN TRANSINTEGRASI ILMU Saripuddin, Saripuddin; syukri, ahmad; Badarussyamsi, Badarussyamsi
Refleksi: Jurnal Filsafat dan Pemikiran Islam Vol 21, No 2 (2021)
Publisher : UIN Sunan Kalijaga Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/ref.2021.%x

Abstract

This article discusses a comparative study between the Islamization of knowledge, Islamic science, and the transintegrasi of sciences. What are the similarities and differences between the three? Why do the three of them have different views about the form of the encounter between science and Islam? To answer this question, this article uses an epistemological and historical approach. This article finds that there are two similarities between the three, namely they an Islamic response to the development of science and they reject secularism. Meanwhile, the difference between the three lies in the emphasis and the details of the key concepts. The difference between the three occurs because of the different epistemological and historical backgrounds between the three.