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Correlation between Obesity and Contraceptive Method on Estrogen and Progesterone Receptors and Human Epidermal Growth Factor Receptor–2 Expression among Breast Cancer Patients in Dr. Moewardi Hospital, Surakarta Agustina, Silvia Ari; Barokah, Liberty
Indonesian Journal of Medicine Vol 4, No 3 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (326.078 KB)

Abstract

Background: Breast cancer is the number 2 cancer in Indonesia after cervical cancer. Breast cancer increases every year. The formation of breast cancer is stimulated by various factors such as obesity and a history of family planning. In breast cancer, there are three important receptors, namely estrogen (ER) receptors, progesterone receptors (PR), and HER-2/Neu. The purpose of this study was to determine the association of obesity and history of family planning with the estrogen hormone receptor (ER), progesterone hormone receptor (PR), and HER-2/Neu expression in breast cancer patients in the dr. Moewardi Hospital in Surakarta, Central Java.Subjects and Method: This was an analytic observational study carried out at Dr. Moewardi Hospital, Surakarta, Central Java. A sample of 117 pre- and post-menopausal women who performed examinations at the oncology surgical clinic at Dr. Moewardi hospital, Surakarta was selected by total sampling. The dependent variables were estrogen and progesterone receptors and HER-2/Neu expressions. The independent variables were obesity and history of contraceptive method. Data were obtained from the medical record and analyzed by multiple logistic regression.Results: Obesity (OR= 0.29; 95% CI= 0.13 to 0.68; p= 0.004) reduced estrogen hormone receptors and it was statistically significant. History of contraceptive method (OR= 1.18; 95% CI= 0.55 to 2.52; p= 0.680) increased estrogen hormone receptors but it was not statistically signi­ficant. Obesity (OR=0.41; 95% CI= 0.18 to 0.96; p= 0.040) and history of contraceptive method (OR= 0.41; 95% CI= 0.19 to 0.88; p= 0.022) reduced progesterone hormone receptors. Obesity and history of contraceptive method increased Her-2/Neu expression.Conclusion: Obesity reduces estrogen hormone receptors. History of the contraceptive method increases estrogen hormone receptors. Obesity and history of contraceptive method reduce pro­gesterone hormone receptors. Obesity and history of contraceptive method increase Her-2/Neu expression.Keywords: Obesity, contraceptive method, estrogen, progesterone hormones, Her-2/neuCorrespondence: Silvia Ari Agustina. Study Program in Midwifery, School of Health Sciences Achmad Yani, Yogya­karta. Jl. Ringroad Barat Ambarketawang, Gamping, Sleman, Yogyakarta. Phone: (0274) 4342000. Email: silvia_ari99@yahoo.com. Indonesian Journal of Medicine (2019), 4(3): 259-265https://doi.org/10.26911/theijmed.2019.04.03.09
ANALISIS DETERMINAN MASALAH GIZI BALITA Agustina, Silvia Ari; Rahmadhena, Melisa Putri
Jurnal Kesehatan - Institut Kesehatan Prima Nusantara Bukittinggi Vol 11, No 1 (2020): Jurnal Kesehatan
Publisher : STIKes Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2877.301 KB) | DOI: 10.35730/jk.v11i1.466

Abstract

Balita di Indonesia mengalami permasalahan gizi ganda (double burden), di satu sisi mengalami obesitas, namun di sisi lainnya mengalami stunting, anemia, kurus, hingga gizi buruk. Masalah gizi tidak bisa dismakan dengan penyakit, karena masalah gizi prosesnya berlangsung lama Penelitian ini untuk menganalisis determinan masalah gizi balita yang meliputi status sosial ekonomi, pendidikan, kelengkapan imunisasi, riwayat ASI, BBLR, dan penyakit yang diderita balita dengan masalah gizi di Puskesmas Tempel 1 Sleman Yogyakarta. Desain penelitian menggunakan teknik lapangan (field research) dengan jenis penelitian analitik korelasi dan menggunakan pendekatan cross sectional study. Waktu penelitian pada bulan Agustus-Desember 2018. Penelitian ini dilaksanakan di Wilayah Kerja Puskesmas Tempel 1 dengan jumlah sampel minimal 97. Cara pengumpulan data secara langsung untuk pengumpulan data kuantitatif dengan menggunakan angket. Teknik sampling yang digunakan pada penelitian ini adalah jenis non probability sampling yaitu menggunakan consecutive sampling (sampling kuota). Analisis data menggunakan analisis multivariat regresi logistik ganda. Terdapat hubungan yang positif dan secara statistik signifikan antara determinan masalah gizi balita dengan beberapa variabel independen yang diteliti. Secara statistik diperoleh hasil status ekonomi (OR:2,79; CI 95%:0,004-0,93; p
PELATIHAN DAN PENDAMPINGAN PIJAT BAYI PADA KADER POSYANDU SEBAGAI STIMULASI TUMBUH KEMBANG BALITA DI TEGALREJO KOTA YOGYAKARTA Kusuma, Reni Merta; Agustina, Silvia Ari; Susanti, Dwi
Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Vol 3, No 3 (2019)
Publisher : Universitas Ahmad Dahlan, Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jp.v3i3.1168

Abstract

Permasalahan tumbuh kembang bayi dan balita terjadi di wilayah Tegalrejo. Tujuan pengabdian kepada masyarakat ini untuk memecahkan masalah tumbuh kembang bayi di Kelurahan Bener dan Kelurahan Kricak, Kecamatan Tegalrejo, Kota Yogyakarta. Masalah yang ditemukan banyaknya anak yang mengalami sulit makan yang merupakan awal masalah terjadinya gizi buruk bagi anak. Masalah gizi buruk dapat diantisipasi sejak masih bayi. Salah satunya dengan memberikan stimulasi dengan terapi sentuhan yaitu pijat bayi. Pijat bayi yang dilakukan secara berkala dan berkelanjutan akan merangsang nervus vagus bayi dan menimbulkan nafsu makan. Agar bayi dapat dipijat secara berkala dan bersinambungan, maka tenaga kesehatan membutuhkan perpanjangan tangan yaitu mengoptimalkan peran kader. Kader dibekali dengan pelatihan dan pendampingan pijat bayi selama 3 bulan. Kemampuan kader dalam melakukan pijat bayi dapat meningkat dari sebelum pelatihan dan pendampingan. Pengetahuan kader posyandu balita juga bertambah sehingga persepsi dan perlakukan terhadap bayi menjadi lebih baik. Hasil dari pengabdian kepada masyarakat ini kemampuan kader melakukan pijat semakin meningkat, beberapa bayi yang mengalami masalah pertumbuhan dan perkembangan dapat diketahui lebih awal, bayi semakin sehat, tenaga kesehatan dan tokoh masyarakat menyambut baik karena ada salah satu langkah yang dapat dilakukan untuk mengatasi masalah gizi pada balita. Growth problems for infants and toddlers occur in the Tegalrejo region. The purpose of community service is to solve the problem of growth and development of infants in the Village of Bener and Village Kricak, District Tegalrejo, Yogyakarta City. The problem found by many children who have difficulty eating is the beginning of the problem of malnutrition for children.Malnutrition problems can be anticipated since I was a baby. One of them by providing stimulation with touch therapy is baby massage. A regular and ongoing baby massage will stimulate the baby's vagus nerve and cause appetite. So that the baby can be massaged regularly and continuously, then health workers need an extension of the hand that is optimizing the role of cadres.Cadres are equipped with training and assistance for infant massage for 3 months. The ability of cadres to do baby massage can improve from before training and mentoring. The knowledge of posyandu toddlers is also increasing so that the perception and treatment of babies is better.The results of community service have increased the ability of cadres to do massage, some babies who experience growth and development problems can be known earlier, babies are healthier, health workers and community leaders are welcomed because there is one step that can be done to overcome nutritional problems in toddler.
Faktor Internal Kejadian Ketuban Pecah Dini di Kabupaten Kulonprogo Barokah, Liberty; Agustina, Silvia Ari
Window of Health : Jurnal Kesehatan Vol 4 No 2 (April 2021 )
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33368/woh.v0iNo 2.314

Abstract

Premature rupture of membranes (PROM) is a rupture of the membranes before labor. PROM is still a Disease of Theory because it is not yet known the exact cause, but there are several internal or external conditions thought to be related to premature rupture of membranes. Internal factors include maternal age, parity, polyhydramnios, cervical incompetence and fetal presentation. Complications due to PROM are infections in labor and childbirth, prolonged labor, increased of caesarean section deliveries. The purpose of this study was to determine the internal factors of the incidence Premature rupture of membranes (PROM) in Kulonprogo, Yogyakarta. This study uses analytic surveys with a retrospective approach. Univariate data analysis uses percentage forms and multivariate uses binomial logistic regression analysis. The results showed that internal factors such as parity, gestational age, disporpotion Chepalo Pelvic and c diseases in pregnant had p values (0.031, 0.035, 0,008 dan 0.000) < 0.005. the variable has a significant influence on the incidence of PROM. While the variable location of the fetus and uterine enlargement does not have a partial effect on PROM with a p value (0.816 and 0.857) > 0.005 here is a relationship between internal factors (parity, gestational age, PROM and diseases in pregnant) with the incidence of PROM