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All Journal Majalah Patologi Indonesia Trends in Infection and Global Health
Fitri Dewi Ismida
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Hubungan antara Ekspresi CD-10 dan Grading Histopatologi Karsinoma Payudara Invasif Fitri Dewi Ismida; Soekimin; Delyuzar
Majalah Patologi Indonesia Vol 28 No 2 (2019): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (387.905 KB)

Abstract

Latar belakangKarsinoma payudara invasif merupakan suatu keganasan epitelial payudara yang ditandai oleh invasi sel-selepitel ke dalam stroma. Secara global, insidensi karsinoma payudara invasif menduduki peringkat tertinggi danterus meningkat dari tahun ke tahun. Pada jaringan payudara normal, ekspresi CD-10 terlokalisir pada sel-selmioepitel dan tidak teridentifikasi pada stroma. Demikian juga, pada ductal carcinoma in situ (DCIS), CD-10tidak terekspresi pada stroma. Namun pada karsinoma payudara invasif CD-10 akan terekspresi pada stroma.CD-10 merupakan suatu cell-surface zinc-dependent metalloproteinase yang sering direkomendasikan sebagaimarker leukemia limfoblastik. Beberapa penelitian telah dilakukan untuk menilai hubungan antara ekspresi CD10 dan grading histopatologi karsinoma payudara invasif, namun sampai kini hasilnya masih kontroversi.Tujuan penelitian ini untuk menganalisis hubungan antara ekspresi imunohistokimia CD-10 dan gradinghistopatologi karsinoma payudara invasif.MetodePenelitian ini merupakan penelitian deskriptif analitik dengan pendekatan cross sectional. Sampel penelitianadalah blok parafin, berasal dari jaringan payudara yang didiagnosis secara histopatologi sebagai karsinomapayudara invasif. Sampel dipulas dengan teknik immunohistokimia menggunakan CD-10; dan kemudianekspresi CD-10 dianalisis dengan uji Kruskal-Wallis.HasilBerdasarkan analisa statistik Kruskal-Wallis terhadap 60 sampel kasus karsinoma payudara invasif mengujihubungan ekspresi imunohistokimia CD-10 dengan grading histopatologi karsinoma payudara invasif, diperolehp-value=0,0001 (p<0,05).KesimpulanEkspres
The pandemic of COVID-19 decreased adherence to treatment among hypertension patients at Dr. Zainoel Abidin Hospital Ghina Salsabila Rahman; Muhammad Ridwan; Hilwah Nora; Maimun Syukri; Fitri Dewi Ismida
Trends in Infection and Global Health Vol 1, No 2 (2021): December 2021
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.292 KB) | DOI: 10.24815/tigh.v1i2.22418

Abstract

Hypertension is one of the leading causes of mortality and morbidity worldwide. Treatment adherence is an essential factor in controlling blood pressure among hypertensive patients. This study aimed to evaluate the effect of the Coronavirus disease 2019 (COVID-19) pandemic on treatment adherence among hypertensive patients at Dr. Zainoel Abidin Hospital, Aceh, Indonesia, as well as to determine its associated factors. A cross-sectional study was conducted at the Cardiac Center by utilizing medical records of hypertensive patients visiting during the period of April-July 2019 and December 2020-March 2021. Bivariate analysis using the Kruskal-Wallis test was employed to examine the effect of the COVID-19 pandemic on patients’ adherence. The results showed that the number of patients adhering to treatment significantly decreased (p=0.000) by 22.7%, from 179 patients in 2019 to 64 patients in 2020. The data also suggested a significant positive association between residential and patient adherence before the pandemic (p=0.006); however, no significant difference was observed between residential and patients’ adherence after the pandemic (p=0.282). Furthermore, our study found no association between age and adherence before and after the pandemic (p=0.690 in 2019 and p=0.125 in 2020). In conclusion, the pandemic of COVID-19 significantly affected treatment adherence among patients with hypertension at Aceh provincial hospital, with a decreased number in patient visits up to 22.7%.  
Co-Authors Delyuzar, Delyuzar Ghina Salsabila Rahman Hilwah Nora Maimun Syukri Muhammad Ridwan Soekimin