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Yudhanto, Hendy Setyo
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PERBEDAAN ANTARA EKSPRESI CD3, CD20, CD43 LIMFOMA NON-HODGKIN SEL B DAN LESI LIMFOPROLIFERATIF REAKTIF Fadli, Muhammad Luqman; Norahmawati, Eviana; Yudhanto, Hendy Setyo; Al Rasyid, Harun
Majalah Kesehatan FKUB Vol 6, No 4 (2019): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1187.202 KB) | DOI: 10.21776/ub.majalahkesehatan.2019.006.04.3

Abstract

Lesi limfoproliferatif sering menimbulkan masalah dalam penegakan diagnosis karena kemiripan morfologi dan pola pertumbuhan sel-sel limfoid yang menyusun lesi limfoproliferatif reaktif dan limfoma non-Hodgkin Sel B. Diagnosis sulit ditegakkan hanya dengan pulasan rutin Hematoksilin-Eosin, oleh karena itu diperlukan pemeriksaan imunohistokimia menggunakan panel antibodi yang tepat. Penelitian ini bertujuan untuk mengetahui perbedaan ekspresi CD3, CD20, CD43 sebagai panel antibodi dasar dalam menentukan karakter jinak atau ganas dari lesi limfoproliferatif. Karakter jinak diwakili oleh lesi limfoproliferatif reaktif, sedangkan karakter ganas diwakili oleh limfoma non-Hodgkin sel B. Total 50 sampel dibagi menjadi 2  kelompok, yakni kelompok A terdiri dari 25 sampel limfoma non-Hodgkin sel B dan kelompok B terdiri dari 25 sampel lesi limfoproliferatif reaktif. Keseluruhan sampel dipulas antibodi CD3, CD20, CD43. Hasil penelitian menunjukkan persentase imunopositif CD3 dan CD20 pada kelompok A dan B berbeda signifikan dengan nilai p < 0,001. Hal ini menunjukkan bahwa CD3 dan CD20 mampu membedakan karakter klonalitas jinak dan ganas dari sel penyusun lesi limfoproliferatif. Persentase imunopositif CD43 antara kelompok A dan B tidak berbeda signifikan dengan nilai p = 0,791. Hasil yang tidak berbeda signifikan mengindikasikan bahwa CD43 diekspresikan oleh dua jenis populasi sel yang berbeda. Pada kelompok A, CD43 diekspresikan oleh limfosit B neoplastik (ganas), sedangkan pada kelompok B diekspresikan oleh limfosit T. Berdasarkan hasil penelitian, panel antibodi CD3, CD20, CD43 dapat membedakan lesi limfoproliferatif jinak dan ganas, namun diperlukan korelasi morfologi dan kesesuaian pola ekspresi imunopositif dari sel-sel limfoid penyusunnya.   
PROFIL KLINIKOPATOLOGI KARSINOMA NASOFARING DI RUMAH SAKIT UMUM DAERAH (RSUD) DR.SAIFUL ANWAR MALANG TAHUN 2018-2020 Kusuma, Ihda Dian; Retnani, Diah Prabawati; Yudhanto, Hendy Setyo
Majalah Kesehatan FKUB Vol 8, No 3 (2021): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2021.008.03.5

Abstract

Kanker nasofaring adalah tumor ganas dari sel-sel epitel yang melapisi nasofaring. Pada tahun 2020, kanker nasofaring menempati urutan ke-5 di dunia. Tujuan penelitian ini adalah untuk mengetahui profil klinikopatologi kasus karsinoma nasofaring di RSUD Dr. Saiful Anwar dari tahun 2018 hingga 2020.  Penelitian ini adalah penelitian deskriptif analitik dengan pendekatan cross sectional untuk mengetahui jumlah kasus karsinoma nasofaring di RSUD Dr. Saiful Anwar dari tahun 2018 hingga 2020. Data yang dikumpulkan berupa spesimen biopsi kanker nasofaring dari laboratorium patologi anatomi meliputi jenis kelamin, umur, dan tipe histopatologi. Terdapat 557 kasus dari biopsi organ nasofaring yang terdiri dari 282 kasus ganas, 21 kasus suspek ganas, dan 216 kasus non-ganas. Kasus keganasan nasofaring pada laki-laki sebesar 69,86%. Jumlah kasus tertinggi terdapat pada rentang usia lebih dari 50 tahun. Tipe histopatologi yang paling banyak adalah karsinoma tidak berdiferensiasi (undifferentiated carcinoma) sebanyak 244 kasus.  Dapat disimpulkan bahwa kasus karsinoma nasofaring masih cukup tinggi di RSUD Dr. Saiful Anwar Malang dengan profil klinikopatologi yaitu mayoritas pasiennya adalah laki-laki, usia tua, dengan tipe histopatologi karsinoma tidak berdiferensiasi. 
Immunocytochemistry as a Diagnostic Procedure of Pleural Mesothelioma Trimurtini, Asih; Astuti, Triwahju; Yudhanto, Hendy Setyo; Erawati, Dini Rachma
Malang Respiratory Journal Vol 2, No 02 (2020)
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (795.153 KB) | DOI: 10.21776/ub.mrj.2020.002.02.2

Abstract

Background: Mesothelioma is a primary malignant tumor arising from the mesothelial surface of the pleura, peritoneal, tunica vaginalis, and pericardium. Most cases of mesothelioma originate from the pleura. Most patients have a history of asbestos exposure. A common diagnostic problem is distinguishing mesothelioma from adenocarcinoma since both tumors invade the pleura. Immunocytochemistry of calretinin and TTF-1 can be used to establish the diagnosis of mesothelioma.Case: Male, 56 years old presented with chest pain, shortness of breath, cough, and weight loss since 5 months before hospitalization. The patient had a history of occupational exposure to asbestos for 30 years. The movement and breath sounds were decreased as well as dull upon percussion at the right chest. A chest X-ray revealed a right lung tumor with pleural effusion. Thorax CT scan suggested pleural mass in right hemithorax, infiltration to intercostal muscles, and destruction of the 7th right rib, right perihilar lymphadenopathy, right pleural effusion, and liver nodules according to mesothelioma T4N1M1 Stage IV. Infiltrative stenting of the right and inferior lobe of the right lung, infiltrative and obstructive stenting of the medius lobe suggestive of a chronic malignancy and inflammation were found on FOB. Cytologic examination of pleural fluid, sputum, and Washing-and-brushing of FOB were a class II (no malignant cells). USG-guided transthoracic FNAB revealed adenocarcinoma with differential diagnosis of mesothelioma. Immunocytochemistry with calretinin showed positive results and TTF-1 showed a negative result. These confirmed the diagnosis of pleural mesothelioma T4N1M1 Stage IV. The patient showed a stable response from carboplatin/gemcitabine treatment.Keyword : Mesothelioma, Immunocytochemistry, TTF-1, Calrenitin
Elderly Male Patient with Fibrotic Non Spesific Instertitial Pneumonia from Lung Biopsy by Video Assisted Thoracoscopy santony, Santony; Djajalaksana, Susanthy; Chozin, Iin Nur; Erawati, Dini Rachma; Yudhanto, Hendy Setyo
Malang Respiratory Journal Vol 2, No 02 (2020)
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (316.507 KB) | DOI: 10.21776/ub.mrj.2020.002.02.3

Abstract

Background: NSIP is a rare disease, the incidence rate ranges from 1 to 9 per 100,000 population, where most cases of NSIP are idiopathic. NSIP definitive diagnosis is very difficult because it must be with a multidisciplinary approach and confirm from a pulmonary biopsy. On the course of his illnesses the possibility of Connective tissue diseases (CTDs) arising in NSIP during follow up period was about 10% of cases.Case Report: We reported one case at RS Dr. Saiful Anwar, an old adult male smoker, age 64 with fibrotic type Non Spesific Instertitial Pneumonia (NSIP). From clinical patients including anamnesis, physical examination and laboratory results and X-Ray chest, ILD suspicion was found. Bodypletstimography results show a corresponding decrease in DLCO with ILD. CT-Scan results obtained by crazy paving with pulmonary bronchiectasis traction in accordance with ILD susp Sussection NSIP and enforced from VATS biopsy results with conclusions according to NSIP description. Patients received corticosteroid therapy for 4 weeks and showed clinical improvement.Conclusion: In these patients the diagnosis of fibrotic NSIP has gone through a multidisciplinary approach including the pulmonology, radiologist and pathologist sections. Corticosteroid therapy in these patients gives good results and the patient is in stable condition. Periodic monitoring is necessary because of the risk of exacerbations and the incidence of CTD complications..
Sarcomatoid Carcinoma Of The Mediastinal : A Rare Case of Giant Mass Thymic Carcinoma Subtype Santoso, Agus Andreas; Parsama Putra, Ngakan Putu; Setiawan, Ungky Agus; Isharanto, Artono; Erawati, Dini Rachma; Yudhanto, Hendy Setyo
Malang Respiratory Journal Vol 3, No 1 (2021): Vol. 3 No. 1
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (12695.27 KB) | DOI: 10.21776/ub.mrj.2021.003.01.4

Abstract

ABSTRACTTitle: Sarcomatoid Carcinoma Of The Mediastinum: A Rare Case of Giant Mass Thymic Carcinoma SubtypeAuthor: Agus Andreas Santoso, MD. Pulmonology and Respiratory Medicine Department, Brawijaya University, Malang, Indonesia. Supervisor: Ngakan Putu Persama Putra, MD, Pulmonologist Consultant, Ungky Agus Setiawan, MD, Pulmonologist Consultant, Artono I, MD, Cardiovascular and Thorax Surgeon, Dini Rachma Erawati, MD, Radiologist Consultant, Hendy Setyo Yudhanto, MD, Pathology Anatomy Specialist.Introduction: Sarcomatoid carcinoma is a type of thymus carcinoma that contains partial or complete spindle cells. Incidence of Sarcomatoid Carcinoma 5-10% of all patients with thymic carcinoma. Carcinoma Sarcomatoid is a highly progressive tumor, most patients will die after 3 years of diagnosis despite aggressive multimodality therapy.Case Description: A 47-year-old woman with chest pain, shortness of breath, coughing, weight loss, enlarging lump in the neck and chest was felt for 1 month. Physical and supporting examination showed anterior superior mediastinal tumors and soft mass tissue in the right region of the Colli. Based on the Transthoracal FNAB Guiding ultrasound and FNAB the anterior colli region concluded that Thymoma, thyroid oncocytic adenoma and Nodular colloid goiter with azkanasy cell proliferation. The patient had Partial Sternotomy (Hemiclamshell), thymectomy with the final diagnosis of Sarcomatoid Carcinoma. Discussion: Sarcomatoid carcinoma is a type of thymic carcinoma that has both malignant epithelium (carcinomatous) and spindle cells (sarcomatous/sarcomatoid), generally with a transition between the two. This case was interesting because of the rare occurrence of Sarcomatoid Carcinoma plus the large size of tumor mass in this patient. 
Co-Authors Chozin, Iin Nur Djajalaksana, Susanthy Erawati, Dini Rachma Eviana Norahmawati Fadli, Muhammad Luqman Harun Al Rasyid Ihda Dian Kusuma Isharanto, Artono Parsama Putra, Ngakan Putu Retnani, Diah Prabawati santony, Santony Santoso, Agus Andreas Setiawan, Ungky Agus Trimurtini, Asih Triwahju Astuti