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All Journal KESMAS STUDI PELAKSANAAN SELFMEDICATION PADA PENDERITA DIARE BERDASARKAN TINGKAT PENGETAHUAN MASYARAKAT PESISIR KECAMATAN SOROPIA KABUPATEN KONAWE
Hartono, Eric
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Health Professions Public Health

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EFEK EKSTRAK KULIT PISANG KEPOK TERHADAP KADAR KOLESTROL HDL TIKUS PUTIH JANTAN GALUR WISTAR YANG TELAH DIINDUKSI DIET TINGGI LEMAK Soedrajad, Stephen; Hartono, Eric
KESMAS Vol 8, No 1 (2019): Volume 8, Nomor 1, Januari 2019
Publisher : Sam Ratulangi University

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Penderita obesitas dapat mengalami dislipidemia yang merupakan kelainan metabolisme lipid yang ditandai dengan peningkatan maupun penurunan fraksi lipid dalam plasma. Kondisi ini jika dibiarkan dapat menimbulkan terjadinya plak aterosklerosis yang nantinya menimbulkan penyakit jantung koroner. Penelitian ini mengunakan sampel hewan coba sebanyak 24 ekor yang dibagi menjadi 3 kelompok, yaitu kelompok hewan coba yang diberi pakan standar, kelompok hewan coba yang diberi diet tinggi lemak, dan kelompok hewan coba yang diberi ekstrak kulit pisang kapok dan diet tinggi lemak. Pada hari ke 30, hewan coba dikorbankan dan dilakukan pemeriksaan kadar HDL. Hasilnya yaitu terdapat perbedaan bermakna (p = 0,021) rerata kadar HDL antara kelompok hewan coba yang diberi diet tinggi lemak dengan kelompok hewan coba yang diberi diet tinggi lemak dan ekstrak kulit pisang kepok. Sehingga dapat disimpulkan ekstrak kulit pisang kapok menaikkan secara bermakna kadar HDL darah.Kata Kunci: kulit pisang kepok, kadar HDL, antioksidan  ABSTRACTObese people can experience dyslipidemia which is a disorder of lipid metabolism characterized by an increase or decrease in lipid fraction in the plasma. This condition if left unchecked can lead to atherosclerotic plaques which later lead to coronary heart disease. Using 24 male Wistar rats, divided into 3 groups. The first group of rats fed with standard food, the second group of rats was given fat diet orally, and the third group of rats was given kepok banana skin extract and fat diet orally. At the end of experiment all animals were sacrificed and HDL levels were measured on the 30th day.  The result, there was also signifficant difference (p = 0,021) of HDL levels between group of rats fed with high dose fat diet and group of rats fed with high dose fat diet and kepok banana skin extract. So the conclussion is kepok banana skin extract increased significantly the HDL levels.Keywords: kepok banana skin, HDL levels, antioxidant
EFEK EKSTRAK DAUN MIMBA TERHADAP AKTIVITAS SGPT TIKUS PUTIH JANTAN GALUR WISTAR YANG TELAH DIINDUKSI PARASETAMOL DOSIS TINGGI Hartono, Eric; Prabowo, Sulistiana
KESMAS Vol 7, No 6 (2018): Volume 7, Nomor 6, November 2018
Publisher : Sam Ratulangi University

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Latar belakang: Pemberian parasetamol dosis tinggi dapat menyebabkan terjadinya stres oksidatif melalui jalur metabolisme yang menghasilkan NAPQI dalam jumlah besar dan diduga dapat menyebabkan peningkatan aktivitas SGPT.Metode: Mengunakan sampel hewan coba sebanyak 24 ekor yang dibagi menjadi 3 kelompok, yaitu kelompok hewan coba yang diberi pakan standar, kelompok hewan coba yang diberi parasetamol, dan kelompok hewan coba yang diberi ekstrak daun mimba dan parasetamol. Pada hari ke 10, hewan coba dikorbankan dan dilakukan pemeriksaan aktivitas SGPT dengan metode spektofotometri.Hasil: terdapat perbedaan bermakna (p = 0,021) rerata aktivitas SGPT antara kelompok hewan coba yang diberi parasetamol dosis tinggi (1360,94 + 1509,08 U/L) dengan kelompok hewan coba yang diberi parasetamol dosis tinggi dan ekstrak daun mimba (138,76 + 34,36 U/L).Kesimpulan: ekstrak daun mimba menurunkan secara bermakna aktivitas SGPT karena kandungan flavonoid dan limonoid yang berfungsi sebagai antioksidan. Kata Kunci: parasetamol, Azadirachta indica, SGPT ABSTRACTBackground: High dose paracetamol can cause oxidative stress through the metabolic pathway that produces NAPQI in large quantities and may cause to  increase SGPT activity. Method: Using 24 male Wistar rats, divided into 3 groups. The first group of rats fed with standard food, the second group of rats was given paracetamol orally, and the third group of rats was given neem’s leaf extract and paracetamol 1 orally. At the end of experiment all animals were sacrificed and SGPT activity were measured on the 10th day with spectrophotometric method. Result: There was also signifficant difference (p = 0,021) of SGPT activity between group of rats fed with high dose paracetamol (1360,94 + 1509,08 U/L) and group of rats fed with high dose paracetamol and meem’s leaf extract (138,76 + 34,36 U/L). Conclussion: neem’s leaf extract decreased significantly the SGPT activity because the neem leaf contains flavonoid and limonoid which act as anti oxidant. Keywords: paracetamol, Azadirachta indica, SGPT 
PENGARUH KOMPENSASI DAN LINGKUNGAN KERJA FISIK TERHADAP KINERJA KARYAWAN PADA PT. INNO WANGSA OILS AND FATS Hartono, Eric; Vincent Tristan, Radick; Liangga, David; Daniel, Daniel; Michael, Michael
Aksara Public Vol 3 No 1 (2019): Februari 2019
Publisher : EDUTECH CONSULTANT

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This study aims to examine and analyze the effect of compensation and physical work environment on employee performance at PT Inno Wangsa Oils And Fats. Data collection was used in this study in the form of questionnaires, interviews and documentation. The data sources used in this study are primary data and secondary data. The data analysis technique used by the author in the form of multiple linear regression analysis serves to determine the effect / relationship of the independent variable with the dependent variable, validity test and reliability test, Classical Assumption Test and Hypothesis Test / Goodnes of fit test. Based on the results of the research partially, it shows that only compensation variables have a positive and significant effect on the performance of employees at PT. Inno Wangsa Oils And Fats. While the results of testing simultaneously show that compensation behavior and physical work environment have a positive and significant effect on employee performance at PT. Inno Wangsa Oils And Fats.
Co-Authors Daniel Daniel Liangga, David Michael Michael Prabowo, Sulistiana Soedrajad, Stephen Vincent Tristan, Radick