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Antibacterial Activities of Perfume: Combination Flower Magnolia alba, Cananga odorata and Mimusops elengi L, Fixed with Pogostemon cablin Oil Nasution, Rosnani; Azwar, Azalia Izdhihar; Helwati, Hira; Marianne
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (787.644 KB) | DOI: 10.32734/idjpcr.v2i1.814

Abstract

Abstract: The making of perfume from the combination Magnolia alba (M. alba) flower oil, Cananga odorata (C. odorata) and Mimusops elengi L (M. elengi) fixed with Pogostemon cablin oil (P. cablin) have been done. Essential oil of M. alba and C. odorata was distilled by water distillation and extraction essential oil of M. elengi flower using n-hexane evaporated solvent method. Composition perfume through organoleptic test obtained with a ratio of 4% v/v, 4% v/v, and 2% v/v for each essential oil M. alba, C. odorata and M. elengi. Antibacterial activity of the perfume and each of the volatile oil was performed by the disc diffusion method. Antibacterial activity test showed that perfumes were able to inhibit the growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria, but less active. Antibacterial activity of the perfume was more active against E. coli with an inhibitory zone of 8.3 mm and 39.81% inhibitory power than S. aureus bacterial 7.3 mm inhibition zone with 37.55% inhibitory power. Perfumes after storage for one, and two months had better antibacterial activity than before storage with an average inhibitory zone of 11-15 mm and inhibitory power of 50- 68,18%. Keywords: Antibacterial, E. Coli, C. Odorata, M. alba, M. elengi, P. cablin, , S. aureus
Analgesic Activity of Ethanol Extract of Temu Giring Rhizome (Curcuma heyneana Val & Zijp) in Mice Marianne; Khairunnisa; Wilda
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 1 No. 2 (2018): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (800.784 KB) | DOI: 10.32734/idjpcr.v1i2.535

Abstract

Temu giring (Curcuma heyneana Val & Zijp) is a traditional medicinal plant that is believed in community as an analgesic. The objective of this research was to determine the analgesic activity of the C. heyneana rhizome by using infra red (IR) thermal induction method in mice. Mice were divided into 7 groups. Group 1 served as negative control, group 2,3,4,5 served as treatment groups which is given ethanolic extract of C. heyneana rhizome at dose of 5, 25, 125, and 625 mg/kg respectively, group 6 and 7 served as comparable groups, given antalgin 65 mg/kg and morphine sulphate 1.3 mg/kg respectively. The observation have been done, included to pain resistance of mice which exposed by infra red (IR) every 10 minutes for 80 minutes. The data were analyzed by ANOVA at the significance level of 95%. Ethanolic extract of C. heyneana at the doses of 25, 125, and 625 mg/kg had significant effect to reduce the pain compared to the negative control (p<0.05). Ethanolic extract of C. heyneana rhizome at dose of 125 mg/kg, had the same effect to antalgin 65 mg/kg (p≥0.05), while the ethanolic extract of C. heyneana at the dose of 625 mg/kg had the same effect as morphine sulfate 1.3 mg/kg (p≥0.05). It can be concluded that ethanolic extract of C. heyneana rhizome has analgesic activity. Keywords: temu giring, analgesic, Curcuma heyneana, rhizome
Hepatoprotective Activity of Curcuma mangga Extract on Paracetamol-Induced Male Mice Yuandani; Mardaliza, Silvia; Marianne
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 1 No. 2 (2018): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (715.476 KB) | DOI: 10.32734/idjpcr.v1i2.432

Abstract

This study was carried out to investigate the protective effect of ethanol extract of Curcuma mangga rhizomes on paracetamol-induced hepatotoxicity. High dose of paracetamol (1.35g/kg bw) was used to induce hepatic necrosis of mice liver. The male mice received ethanol extract of C. mangga rhizomes (100, 200 and 400 mg/kg BW) for 7 days. The hepatoprotective actvity of extract was compared to normal, positive (curcuma) and negative control. The liver function was evaluated by measuring the biochemistry parameters which include alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In addition, histophatological study on hepatic tissue section was also carried out. The C. mangga extract displayed hepatoprotective effect except at dose of 100 mg/kg bw. The increasing of serum levels of AST and ALT were inhibited after treatment with ethanol extract at doses of 200 and 400 mg/kb bw which was comparable with normal and curcuma as postive control (p>0.05). In addition, histological assessment of hepatic tissue demonstrated no liver damage, specially at dose of 400 mg/kb BW. The result indicate that ethanol extract of C. mangga rhizomes has hepatoprotective effect, especially at doses of 200 and 400 mg/kg bw . Keywords: C. mangga, rhizomes, biochemistry parameters, histopathology
STIMULASI WIRAUSAHA PADA MURID SEKOLAH MENENGAH ATAS DI TANJUNG PURA LANGKAT SUMATERA UTARA MELALUI WORKSHOP PEMBUATAN LOSION ANTI NYAMUK BERBASIS HERBAL Yuandani1; Marianne; Popi Patilaya
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 2 No. 1 (2017): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (603.86 KB) | DOI: 10.32734/abdimastalenta.v2i1.2205

Abstract

SMA N 1 Tanjung Pura dan SMA Swasta Samanhudi terletak di kecamatan Tanjung Pura, Kabupaten Langkat, Provinsi Sumatera Utara. Kecamatan Tanjung Pura di Kabupaten Langkat merupakan salah satu kecamatan dengan tingkat kesejahteraan yang belum memadai. Sebahagian besar masyarakat bekerja sebagai petani dan nelayan, dan umumnya mereka belum dapat memenuhi biaya hidup yang memadai dan gagal dalam menguasai potensi produktif yang tersedia. Salah satu cara yang dapat dilakukan adalah diversifikasi pekerjaan dengan menstimulasi jiwa wirausaha generasi muda di Tanjung Pura, antara lain dengan memberikan keterampilan khusus yang nantinya bisa dimanfaatkan oleh mereka untuk membuka usaha sendiri. Salah satu cara yang akan dilakukan adalah dengan memberikan workshop pembuatan losion anti nyamuk. Hal ini mengingat kecamatan Tanjung Pura memiliki prevalensi yang tinggi terhadap penyakit malaria dan demam berdarah dengue (DBD), sehingga sangat tepat untuk mengajarkan para siswa SMA dalam pembuatan losion anti nyamuk agar dapat turut serta menurunkan angka kejadian penyakit tersebut. Oleh sebab itu,tujuan umum program pengabdian pada masyarakat ini adalah meningkatkan minat berwirausaha pada murid sekolah menengah atas, menurunkan angka pengangguran dan angka penyebaran penyakit malaria dan DBD di Kecamatan Tanjung Pura. Target utama dari program ini adalah sekelompok masyarakat yang memiliki latar pendidikan terakhir golongan menengah atau setara yang berada di Kecamatan Tanjung Pura. Secara khusus, program ini bertujuan untuk melatih siswa-siswi setingkat SMA yang ada di SMAN 1 Tanjung Pura dan SMA Swasta Samanhudi dalam berwirausaha untuk memproduksi losion anti nyamuk yang berbahan dasar minyak sereh.
Study on Acute Oral Toxicity of Ethanolic Extract of Annonasquamosa Leaves in Mice (Musmusculus) Khairunnisa; Dita Utami, Andini; Marianne
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 1 No. 1 (2018): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1025.288 KB) | DOI: 10.32734/idjpcr.v1i1.205

Abstract

Abstract. The aims of this study were to determine the potential for acute oral toxicity of ethanolic extract of A.squamosa leaves with LD50 and the histopathological changes in liver and kidney of mice.This research used experimental method as per fixed dose method. The number of animals used in this research were 20 female mice. The study was divided into 2 steps, there were sighting and main studies. The control group was given Na-CMC 0.5%, the treatment groups were given ethanolic extract of A.squamosa leaves with doses of 5, 50, 300, 2,000 and 5,000 mg/kg bw. The results showed that the ethanolic extract of A.squamosa leaves with doses of 2,000 and 5,000 mg/kg bw did not show any toxicity signs. At a dose of 5,000 mg/kg bw caused hydropic degeneration, necrosis hepatocyte, glomerular atrophy, and tubular dilatation. There was no mortality was observed.It was estimated that LD50 of ethanolic extract of A.squamosa leaves was higher than 5,000 mg/kg bw and the extract were practically non-toxic. Keywords: Acute Toxicity, Annona squamosa, Ethanolic Extract
Wash hand education and hand sanitizer preparation workshop to the community in order to prevent COVID-19 transmission Laila, Lia; Marianne; Hanum, Tengku Ismanelly; Maha, Hetty Lendora
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 2 (2020): ABDIMAS TALENTA : Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (781.671 KB) | DOI: 10.32734/abdimastalenta.v5i2.5032

Abstract

Communicable disease, COVID-19 easily spreads through the respiratory droplets. Therefore, WHO recommends the physical distancing policy to prevent the transmission. However, the transmission of SARS-CoV2 virus causing COVID-19 occurred not only by human interaction, but also the things that had been touched by the people suffered COVID-19 have potential as the media for the virus transmission. Then, it is necessary to anticipate the worries in the form of correct wash hand application or using hand sanitizer. The activities that had been done were giving an education about the communicable disease, COVID-19, how it is spread and how to prevent it; performing correct hand wash and preparation of alcohol based hand sanitizer in the form of gel to the society of Belawan I neighborhoods, Medan Belawan District, Medan City. The survey analysis results showed that the community service that had been conducted in Belawan I neighborhoods gave benefits and elevated approximately 49.5% the knowledge of the community regarding the COVID-19 and hand sanitizer preparation.