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All Journal Pharmacon Journal of Pharmaceutical Care Anwar Medika
Dianasari, Dewi
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Health Professions Medicine & Pharmacology Public Health

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POTENSI EKSTRAK ETANOL HERBA APU-APU (PISTIA STRATIOTES) DAN FRAKSI-FRAKSINYA SEBAGAI ANTIOKSIDAN DENGAN METODE DPPH Dianasari, Dewi; Firdiyansari, Irawati
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 2 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i2.9148

Abstract

Free radicals play an important role in cell damage and degenerative diseases such as coronary heart disease, stroke, premature aging and others. Compounds that can inhibit free radicals are antioxidants. One of the plants that has a high phenolic compound and can be a source of natural antioxidants, apu-apu or Pistia stratiotes. This research was conducted to scientifically prove the antioxidant activity of the apu-apu herbal extract (Pistia stratiotes) and its fractions by the DPPH method. The sample used in the form of all parts apu-apu (apu-apu herb) obtained from the Sumbersari District, Jember Regency. In this study the DPPH method was used with a DPPH concentration of 0.1 mM, incubation time of ethanol extract 40 minutes, fraction of n-hexane 50 minutes, ethyl acetate fraction 45 minutes, ethanol-water fraction 40 minutes,vitamin C 35 minutes and measured at wavelength 517 nm . The results of the average antioxidant activity (IC50) were apu-apu herbal extract 16.675 µg / mL ± 0.239, n-hexane fraction 29.915 µg / mL ± 0.156, ethyl acetate fraction 11.875 µg / mL ± 0.038, ethanol-water fraction 9.090 µg / mL ± 0.156, ethyl acetate fraction 11.875 µg / mL ± 0.038, ethanol-water fraction 9.090 µg / mL ± 0.156, ethyl acetate fraction 11.875 µg / mL ± 0.038 / mL ± 0.122, and vitamin C 3.263 µg / mL ± 0.032. Vitamin C as a positive control had the highest activity, whereas the apu-apu sample which had the highest antioxidant activity was the ethanol-water fraction, and the lowest was the n-hexane fraction. The conclusion of this study is apu-apu herbal ethanol extract and its fractions have antioxidant activity, from high to low sequentially: ethanol-water fraction, ethyl acetate fraction, apu-apu herbaceous fraction, n- fraction hexane.
POTENSI EKSTRAK ETANOL DAN FRAKSI-FRAKSINYA DARI TIGA VARIETAS JAHE SEBAGAI AGEN ANTIBAKTERI TERHADAP STAPHYLOCOCCUS AUREUS Dianasari, Dewi; Puspitasari, Endah; Ningsih, Indah Yulia; Triatmoko, Bawon; Nasititi, Fauzia Ken
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9226

Abstract

One of the natural ingredients that to be used to inhibit bacterial growth is the Zingiber officinale. In Indonesia, there are 3 types of ginger which are distinguished by morphology, namely ?emprit ginger (Zingiber officinale var. Amarum), ? gajah? ginger (Zingiber officinale var. Officinarum), and red ginger (Zingiber officinale var. Rubrum). This research was conducted to determine the activity of extracts and fractions of three ginger varieties in inhibiting the growth of Staphylococcus aureus using the disc diffusion method. The test group consisted of ethanol extract, n-hexane fraction, and ethyl acetate fraction from 3 ginger varieties, concentrations of 5, 10, 20% w / v, gentamicin 10 ?g (positive control) and 10% DMSO (negative control). The test results showed that ethanol extracts and fractions from the rhizomes of three varieties of ginger have the ability to inhibit S. aureus at concentrations of 5, 10, and 20% w / v, increasing the concentration will increase the diameter of the inhibition zone. At a concentration of 20% of all samples, the one with the greatest resistance was the n-hexane fraction (diameter of inhibitory zone of emprit ginger 9.80 mm, elephant ginger 9.78 mm, and red ginger 9.90 mm). The difference in ginger variety only affects the antibacterial activity of the ethanol extract, but not the n-hexane and ethyl acetate fractions.
Aktivitas Antibakteri Ekstrak Etanol Herba Apu-Apu (Pistia Stratiotes) Terhadap Staphylococcus Aureus Dianasari, Dewi; Iftitah, Maulidya Barikatul
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 2 No 1 (2019): Volume 2, Nomor 1, Desember 2019
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (508.197 KB) | DOI: 10.36932/jpcam.v2i1.13

Abstract

S. aureus merupakan salah satu bakteri gram positif yang dapat menyebabkan infeksi bernanah, infeksi kulit ataupun infeksi serius seperti mastitis, pneumonia dan infeksi saluran kencing. Penemuan senyawa aktif baru berasal dari tumbuhan merupakan potensi alternatif sebagai agen antibakteri. Salah satunya ialah tanaman dengan famili Araceae dari genus Pistia yaitu Pistia stratiotes atau yang biasa dikenal dengan sebutan apu-apu. Penelitian ini dilakukan untuk membuktikan secara ilmiah adanya aktivitas antibakteri dari ekstrak etanol herba apu-apu (Pistia stratiotes) terhadap Staphylococcus aureus. Uji antibakteri dengan metode difusi cakram dilakukan pada 6 kelompok, yaitu 4 kelompok perlakuan ekstrak etanol herba apu-apu dengan berbagai konsentrasi (10%; 20%; 30%; dan 40%), satu kelompok uji berisi kontrol negatif yaitu DMSO 10%, dan satu kelompok uji lainnya berisi kontrol positif yaitu gentamisin cakram 10µg. Aktivitas antibakteri ekstrak etanol herba apu-apu (Pistia stratiotes) terhadap S. aureus dari yang tinggi ke rendah secara berurutan adalah konsentrasi 40%, konsentrasi 30%, konsentrasi 20%, konsentrasi 10% dengan nilai diameter zona hambat berturut-turut sebesar 9,0 mm ± 0,30; 8,1 mm ±0,20; 7,4 mm ± 0,33; dan 6,5 mm ±0,17. Berdasarakan hasil penelitian, maka dapat disimpulkan bahwa ekstrak etanol herba apu-apu pada konsentrasi 10%; 20%; 30%; dan 40% memiliki aktivitas antibakteri terhadap S. aureus.
Co-Authors Bawon Triatmoko Endah Puspitasari Firdiyansari, Irawati Iftitah, Maulidya Barikatul Indah Yulia Ningsih Nasititi, Fauzia Ken