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All Journal Makara Journal of Health Research
Taher, Muhammad
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In vitro evaluation of the effect of Pluchea indica extracts in promoting glucose consumption activity on a liver cell line Suriyah, Wastuti H; Ichwan, Solachuddin J A; Kasmuri, Abdul R; Taher, Muhammad
Makara Journal of Health Research
Publisher : UI Scholars Hub

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Background: Type 2 diabetes mellitus is a chronic metabolic disorder that is associated with mortality and morbidity. Recently, several plant-based agents have been used in the management of diabetes. Pluchea indica has been traditionally consumed as a medicinal plant in Southeast Asia, and its leaves have demonstrated induction of hypoglycemic effect in normal rats. This in vitro study aimed to evaluate the potency of P. indica extracts in stimulating glucose consumption in human liver CCL-13 cell line model. Methods: P. indica leaves were dried and extracted using a series of organic solvents and water. The effect of the extracts on cell viability was determined by MTT assay. The glucose consumption was analyzed using glucose oxidase method. Results: Our results revealed that the methanol extract of P. indica could significantly increase glucose consumption of cells in a concentration-dependent manner, which suggests the usefulness of the extract as an antidiabetic candidate via stimulation of glucose uptake into the liver cells. Conclusion: Our study suggests that P. indica is a potential natural candidate for diabetes mellitus management.
Cytotoxic and Anti-Inflammatory Activities of Garcinia xanthochymus Extracts on Cell Lines Hamidon, Hanisuhana; Taher, Muhammad; Jaffri, Juliana M; Tg Zakaria, Tg M; Sulaiman, Wan MAW; Susanti, Deny; Ichwan, Solachuddin JA; Zakaria, Zainul A
Makara Journal of Health Research Vol. 20, No. 1
Publisher : UI Scholars Hub

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Background: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines. Methods: The roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane and methanol, successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. The nitric oxide production in LPS-stimulated cells was measured using Griess reagent. Results: The results of cytotoxic and anti-inflammatory study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. Conclusions: This finding indicated that G. xanthochymus extracts might become interesting candidate for treatment of cancer and inflammation.
Co-Authors Hamidon, Hanisuhana Ichwan, Solachuddin J A Ichwan, Solachuddin JA Jaffri, Juliana M Kasmuri, Abdul R Sulaiman, Wan MAW Suriyah, Wastuti H Susanti, Deny Tg Zakaria, Tg M Zakaria, Zainul A