Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya
Suryanto, Tjahyo
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Environmental Science Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation Suryanto, Tjahyo; Tjahjono, Harjoedi Adji; Widjajanto, Edi
Journal of Tropical Life Science Vol 8, No 1 (2018)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.08.01.06

Abstract

Type 1 Diabetes Mellitus (T1DM) has become a health problem in many countries. T1DM is the consequence of autoimmune destruction process of β cells. There was relationship between vitamin D deficiency with T1DM. The destruction process was caused by an imbalance of pro-inflammatory and anti-inflammatory cytokines. One of the pro-inflammatory cytokines is IL-2. C-peptide examination to see the function of beta cells due to destruction of pancreatic beta cell. Administration of vitamin D3 supplementation still cause controversy and give varying results. This randomized clinical trial was conducted to determine the levels of 25(OH)D3, IL-2, and C-peptide in people with T1DM who received vitamin D3 supplementation. The subjects were 26 children with T1DM, divided into K1 group (received vitamin D3 supplementation) and K2 group (received placebo). The results showed higher levels of 25(OH)D3 in the K1 group and statistically found a significant difference (p = 0.00). Higher levels of IL-2 and lower C-peptide were obtained in the K1 group and no statistically significant differences were found (p = 0.76 and p= 0.26). The insignificant relationship and the negative correlation were found between 25(OH)D3 and IL-2 (p = 0.71; r = - 0.12), 25(OH)D3 and C-peptide (p = 0.59; r = -0.16), also levels of IL-2 and C-peptide (p = 0.13; r = -0.44) in children with type 1 diabetes who received vitamin D3 supplementation. From this study can be concluded that administration vitamin D3 supplementation in patients with T1DM can increase levels 25(OH)D3 significantly. This increase has not significantly lowered levels of IL-2 and increased levels of C-peptide. However, there was an absolute decrease in the rate of slower C-peptide in the supplemented group than in the placebo group.
Hubungan antara Kadar 25(OH)D3 dan C-Peptida Berdasarkan Lama Sakit pada Anak dengan Diabetes Melitus Tipe 1 Suryanto, Tjahyo; Tjahjono, Harjoedi Adji
Jurnal Kedokteran Brawijaya Vol 30, No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2018.030.01.6

Abstract

Diabetes melitus (DM) tipe 1 menjadi masalah kesehatan di banyak negara, dengan keseluruhan peningkatan per tahun diperkirakan sebesar 3%. DM tipe 1 merupakan konsekuensi dari proses destruksi autoimun sel β pankreas. Ditemukan hubungan antara defisiensi vitamin D dengan DM tipe 1. Penelitian cross sectional ini dilakukan untuk melihat hubungan antara kadar 25(OH)D3 dan C-peptida berdasarkan lama sakit pada anak dengan DM tipe 1. Subjek penelitian adalah 26 anak dengan DM  tipe 1, status vitamin D pada sampel penelitian didominasi dengan status vitamin D yang tidak normal sebanyak 16 orang (61,5%). Hasil penelitian menunjukkan kadar 25(OH)D3 yang lebih rendah pada kelompok dengan lama sakit ≤ 5 tahun dan secara statistik tidak didapatkan perbedaan kadar 25(OH)D3 yang bermakna antara kedua kelompok (p=0,403). Didapatkan kadar C-peptida yang lebih tinggi pada kelompok dengan lama sakit ≤ 5 tahun dan secara statistik tidak didapatkan perbedaan kadar C-peptida yang bermakna antara kedua kelompok (p=0,137). Hubungan yang tidak signifikan didapatkan antara kadar vitamin D dan kadar C-peptida pada anak DM tipe 1, dengan keeratan hubungan yang lemah dan dengan korelasi bernilai positif (p=0,069; r=0,363). Dari penelitian ini dapat disimpulkan bahwa pada anak dengan DM tipe 1 didapatkan kadar 25(OH)D3 dan kadar C-peptida yang rendah. Semakin lama anak menderita DM tipe 1 dan tidak mendapatkan terapi yang adekuat, maka akan semakin rendah kadar 25(OH)D3 dan kadar C-peptida.
Co-Authors Edi Widjajanto Harjoedi Adji Tjahjono, Harjoedi Adji