Muhammad Reagan
Fakultas Kedokteran Universitas Sriwijaya (Faculty Of Medicine, Universitas Sriwijaya) Indonesia

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Sleep and Bone Density: A Study on Postmenopausal Indonesian Women Shafira Irmayati; Muhammad Reagan; Legiran Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 3 No. 1 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v3i1.68

Abstract

Background: Low bone density has been known as one of the factors that increased fracture risk. Aging, estrogen deficiency, low BMI, and inadequate calcium intake are known factors that contribute to decreased bone density. Other than the known factors, some research show that sleep duration can also lower bone density. Sleep affects bone density in a way that it causes increased level of cortisol, proinflammatory cytokine, and decreased in physical activity. Method: This study is an observational analytic study with cross-sectional design. It is conducted on menopausal patients that has been examined with bone mineral densitometry at Poliklinik Reumatologi Penyakit Dalam RSUP Dr. Mohammad Hoesin Palembang in November 2017 to Oktober 2018. Samples are collected using total sampling technique. Results: From 93 subjects that participated in this study, 20,4% of them had osteopenia, and 51,6% had osteoporosis. Patients with low bone density, mainly slept for 6 to 8 hours at night per day, 30 minutes of nap per day, and has a total sleep duration for less than 8 hours each day. This study shows no significant association between night-time sleep, daytime napping, and total sleep duration with bone density (p value = 0,168, p value = 0,831, p value = 0,984). Analysis on other risk factors show significant association between body mass index and low bone density (p value = 0,002). Conclusion: There are no significant association between sleep duration and bone density in menopausal patients at Poliklinik Reumatologi RSUP Dr. Mohammad Hoesin Palembang.
Sleep and Bone Density: A Study on Postmenopausal Indonesian Women Shafira Irmayati; Muhammad Reagan; Legiran Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 3 No. 1 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v3i1.68

Abstract

Background: Low bone density has been known as one of the factors that increased fracture risk. Aging, estrogen deficiency, low BMI, and inadequate calcium intake are known factors that contribute to decreased bone density. Other than the known factors, some research show that sleep duration can also lower bone density. Sleep affects bone density in a way that it causes increased level of cortisol, proinflammatory cytokine, and decreased in physical activity. Method: This study is an observational analytic study with cross-sectional design. It is conducted on menopausal patients that has been examined with bone mineral densitometry at Poliklinik Reumatologi Penyakit Dalam RSUP Dr. Mohammad Hoesin Palembang in November 2017 to Oktober 2018. Samples are collected using total sampling technique. Results: From 93 subjects that participated in this study, 20,4% of them had osteopenia, and 51,6% had osteoporosis. Patients with low bone density, mainly slept for 6 to 8 hours at night per day, 30 minutes of nap per day, and has a total sleep duration for less than 8 hours each day. This study shows no significant association between night-time sleep, daytime napping, and total sleep duration with bone density (p value = 0,168, p value = 0,831, p value = 0,984). Analysis on other risk factors show significant association between body mass index and low bone density (p value = 0,002). Conclusion: There are no significant association between sleep duration and bone density in menopausal patients at Poliklinik Reumatologi RSUP Dr. Mohammad Hoesin Palembang.
MRNA NFATC1 EXPRESSION IN GENU OSTEOARTHRITIS WITH EFFUSION Reagan, Muhammad; Hermansyah, Hermansyah; Hidayat, Rachmat; Darma, Surya; Muthia, Putri
Biomedical Journal of Indonesia Vol 6, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.10418

Abstract

Based on a study conducted by the WHO Global Burden of Disease in 2010 stated, OA ranks 11th, the cause of disability in the world, and ranks 6th in East Asia and the Asia-Pacific countries, ranked 10th in North America, ranked 7th in Eastern Europe , and ranked 13th in Western Europe. Pathogenesis of osteoarthritis (OA) as degenerative joint disease that was once thought caused by a mechanical process. The prevalence, etiology, pathogenesis and progression of OA are still not understood until now, mainly because of the many influencing factors. This type of research is a analytic study. It was conducted in Rheumatology Polyclinic Dr. Mohammad Hoesin Palembang from February to December 2019. Affordable research population is all genu osteoarthritis sufferers with effusion who go to Dr. RSUP Mohammad Hoesin Palembang as 80 samples. Comparison of NFATC1 mRNA levels in genu osteoarthritis patients with effusion shows that there is no difference in gender and history of diabetes, whereas hypertension history and degree of osteoarthritis based on Lawrence Kalgren shows significantly different expression of NFATC1 mRNA. Age with NFATC1 mRNA expression showed no significant correlation, in contrast to BMI, Stroke Test and joint effusion volume showed a weak significant correlation, even though the direction of the correlation was negative on Stroke Test and joint effusion volume.
MRNA NFATC1 EXPRESSION IN GENU OSTEOARTHRITIS WITH EFFUSION Reagan, Muhammad; Hermansyah, Hermansyah; Hidayat, Rachmat; Darma, Surya; Muthia, Putri
Biomedical Journal of Indonesia Vol 6, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.10418

Abstract

Based on a study conducted by the WHO Global Burden of Disease in 2010 stated, OA ranks 11th, the cause of disability in the world, and ranks 6th in East Asia and the Asia-Pacific countries, ranked 10th in North America, ranked 7th in Eastern Europe , and ranked 13th in Western Europe. Pathogenesis of osteoarthritis (OA) as degenerative joint disease that was once thought caused by a mechanical process. The prevalence, etiology, pathogenesis and progression of OA are still not understood until now, mainly because of the many influencing factors. This type of research is a analytic study. It was conducted in Rheumatology Polyclinic Dr. Mohammad Hoesin Palembang from February to December 2019. Affordable research population is all genu osteoarthritis sufferers with effusion who go to Dr. RSUP Mohammad Hoesin Palembang as 80 samples. Comparison of NFATC1 mRNA levels in genu osteoarthritis patients with effusion shows that there is no difference in gender and history of diabetes, whereas hypertension history and degree of osteoarthritis based on Lawrence Kalgren shows significantly different expression of NFATC1 mRNA. Age with NFATC1 mRNA expression showed no significant correlation, in contrast to BMI, Stroke Test and joint effusion volume showed a weak significant correlation, even though the direction of the correlation was negative on Stroke Test and joint effusion volume.
Sebuah Pengetahuan Penyakit Gout Arthritis Pada Pasien Di Poliklinik Reumatologi RSUP Dr. Mohammad Hoesin Palembang Algifari, M. Ridho Novtriawan; Darma, Surya; Reagan, Muhammad
Sriwijaya Journal of Medicine Vol. 3 No. 1 (2020): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Gout is a dominant disease in adult man and found in woman before menopause period. Prevalence of gout n the United States 3.9%, Britain 2.5%, New Zealand 6.1% and in Indonesia 7%. There are 2 pillars of gout treatment, pharmacology and non pharmacology. Non-pharmacological therapy includes patient education, diet and joint rest. Lack of knowledge about lifestyle and things that can cause gout is one of the factors that can increase the incidence of gout arthritis. The aim of this study was to identify patient knowledge about gout arthritis in Rheumatology Clinic Central General Hospital Dr. Mohamma Hoesin Palembang. A total of 80 patients who fit the inclusion criteria were included in the study. The data were obtained from interview of patients at Rheumatology Clinic Central General Hospital Dr. Mohammad Hoesin Palembang on September-November 2019. The result of this study showed that from 80 patients, 21 patients suffered from gout arthritis and 59 patients suffered from non gout arthritis. Knowledge level of gout patients were enough (52,4%) and good (47,6%) meanwhile knowledge level of non gout patient are bad (52,5%), enough (45,8%) and good (1,7 %). Knowledge level of gout patients are better than non-gout patient's in Rheumatology Clinic Central General Hospital Dr. Mohammad Hoesin Palembang.
Sebuah Pengetahuan Penyakit Gout Arthritis Pada Pasien Di Poliklinik Reumatologi RSUP Dr. Mohammad Hoesin Palembang Algifari, M. Ridho Novtriawan; Darma, Surya; Reagan, Muhammad
Sriwijaya Journal of Medicine Vol. 3 No. 1 (2020): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Gout is a dominant disease in adult man and found in woman before menopause period. Prevalence of gout n the United States 3.9%, Britain 2.5%, New Zealand 6.1% and in Indonesia 7%. There are 2 pillars of gout treatment, pharmacology and non pharmacology. Non-pharmacological therapy includes patient education, diet and joint rest. Lack of knowledge about lifestyle and things that can cause gout is one of the factors that can increase the incidence of gout arthritis. The aim of this study was to identify patient knowledge about gout arthritis in Rheumatology Clinic Central General Hospital Dr. Mohamma Hoesin Palembang. A total of 80 patients who fit the inclusion criteria were included in the study. The data were obtained from interview of patients at Rheumatology Clinic Central General Hospital Dr. Mohammad Hoesin Palembang on September-November 2019. The result of this study showed that from 80 patients, 21 patients suffered from gout arthritis and 59 patients suffered from non gout arthritis. Knowledge level of gout patients were enough (52,4%) and good (47,6%) meanwhile knowledge level of non gout patient are bad (52,5%), enough (45,8%) and good (1,7 %). Knowledge level of gout patients are better than non-gout patient's in Rheumatology Clinic Central General Hospital Dr. Mohammad Hoesin Palembang.
mRNA NFATC1 Expression in Genu Osteoarthritis with Effusion Muhammad Reagan; Hermansyah; Rachmat Hidayat; Surya Darma; Putri Muthia
Biomedical Journal of Indonesia Vol. 6 No. 2 (2020): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Based on a study conducted by the WHO Global Burden of Disease in 2010 stated, OA ranks11th, the cause of disability in the world, and ranks 6th in East Asia and the Asia-Pacificcountries, ranked 10th in North America, ranked 7th in Eastern Europe , and ranked 13th inWestern Europe. Pathogenesis of osteoarthritis (OA) as degenerative joint disease that was oncethought caused by a mechanical process. The prevalence, etiology, pathogenesis and progressionof OA are still not understood until now, mainly because of the many influencing factors. Thistype of research is a analytic study. It was conducted in Rheumatology Polyclinic Dr.Mohammad Hoesin Palembang from February to December 2019. Affordable researchpopulation is all genu osteoarthritis sufferers with effusion who go to Dr. RSUP MohammadHoesin Palembang as 80 samples. Comparison of NFATC1 mRNA levels in genu osteoarthritispatients with effusion shows that there is no difference in gender and history of diabetes, whereashypertension history and degree of osteoarthritis based on Lawrence Kalgren shows significantlydifferent expression of NFATC1 mRNA. Age with NFATC1 mRNA expression showed nosignificant correlation, in contrast to BMI, Stroke Test and joint effusion volume showed a weaksignificant correlation, even though the direction of the correlation was negative on Stroke Testand joint effusion volume.
Adult-Onset Still's Disease (AOSD): A Case Report Muhammad Reagan; Radiyati Umi Partan
Indonesian Journal of Rheumatology Vol. 14 No. 1 (2022): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v14i1.196

Abstract

Background: Adult-Onset Still's Disease (AOSD) is a rare multisystemic autoinflammatory disorder with an unknown etiology, and the diagnosis is difficult due to various differential diagnoses. AOSD diagnosis is getting better because medical developments and therapeutic strategies from various studies have benefited from advances in understanding autoinflammatory and autoimmune diseases. Case presentation. A woman patient has a complaint of periodic high fever with joint pain for more than 1 month and reddish spots on the skin, fatigue, and menstrual disorders. Patients had been treated several times and performed a blood transfusion, but complaints still occur frequently. The patient is diagnosed with Adult-Onset Still’s Disease with secondary amenorrhoea. Conclusion: This case is rarely found, so it requires quite difficult therapy and diagnostics. Therefore, this case was presented as a case report in order to get better therapy.
Enhancing cognitive function of healthy Wistar rats with aqueous extract of Centella asiatica Ayeshah A Rosdah; Evi Lusiana; Muhammad Reagan; Abdurrahman Akib; Fadhila Khairunnisa; Afkara Husna
Acta Biochimica Indonesiana Vol. 1 No. 2 (2018): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.v1i2.15

Abstract

Background: Centella asiatica (L.) Urb is a native herb from Asian countries such as India, China, and Indonesia. This herb has been widely used as a cure for various diseases. However, studies investigating the aqueous extract of Centella asiatica as a nootropic in healthy individuals are still very limited. Objective: This study aims to investigate the potential of aqueous extract of Centella asiatica in enhancing cognitive function of healthy male Wistar rats. Methods: Rats were randomly allocated to four treatment groups, i.e. without treatment and aqueous Centella asiatica extract at doses of 200, 400 and 800 mg/kg. To determine enhancement of cognitive function, novel object recognition (NOR) test was conducted after the course of treatment. Acetylcholine content was assessed by enzyme-linked immunosorbent assay. Results: There was a significantly high preference index towards the novel object in the NOR test in groups treated with 200 mg/kg and 800 mg/kg of the aqueous extract compared to control. This was further confirmed by a significant increase of brain acetylcholine content in rats treated with 200 mg/kg of the extract. Conclusion: Therefore, this study confirms that the aqueous extract is effective in enhancing cognitive performance of healthy Wistar rats.
Potential of Sriwijaya Thermal Cycler Smart Controlling-Based as a Tool for DNA Sequence Polymerase Chain Reaction Msy Rulan Adnindya; Indri Seta Septadina; Muhammad Reagan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 4 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i4.208

Abstract

Introduction. Along with the COVID-19 pandemic, the need for a thermal cyclerdevice for examining COVID-19 is getting bigger. Many laboratories have overusedthe use of thermal cyclers due to the limited availability of this tool. This study aimsto test the effectiveness of the Sriwijaya thermal cycler based on a smart controllerin conducting PCR DNA sequences. Methods. The research design was anexperimental study with a posttest control group approach, in order to see anoverview of the results of the polymerase chain reaction (PCR) in the form ofintermediate DNA bands using Sriwijaya Thermal Cycler compared to groups usingfactory-made Thermal cyclers. Results. The PCR results showed precise results fromthe image and band separation, and there was a clear separation of the bands onthe marker. The PCR results from the ACE I / D gene showed quite good and optimalresults in the separation of the PCR results band. Conclusion. Sriwijaya thermalcycler is effective in DNA polymerase chain reaction (PCR) sequences comparable tothat of the manufacturer's Thermal Cycler.