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All Journal Jurnal Kedokteran Brawijaya JMM (Jurnal Masyarakat Mandiri)
Irawan, Dwi Dianita
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Medicine & Pharmacology Other

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Effect of Chitosan on Histology of Reproductive Organs of Female Wistar Rats (Rattus norvegicus) Exposed to Acetate Lead Purwitasari, Alief Ayu; Rozifa, Annisa' Wigati; Irawan, Dwi Dianita; Kalsum, Umi; Ratnawati, Retty; Nurdiana, Nurdiana; Anita, Kenty Wantri
Jurnal Kedokteran Brawijaya Vol 30, No 4 (2019)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2019.030.04.5

Abstract

Lead is one of the pollutants widely spread in the environment because it is not easily decomposed. Lead can affect system functions such as the ovary and endometrium. Lead can trigger oxidative stress by reducing antioxidant enzymes and increasing Reactive Oxygen Species (ROS). Lead can also reduce Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) levels by disturbing the hypothalamus. Chitosan is an antioxidant compound that can reduce the toxic effects of lead. The purpose of this study was to study the effects of chitosan administration on the diameter of antral follicles, the number of endometrial arterioles, and the thickness of endometrial rats after lead acetate exposure. This study was an experimental laboratory using a posttest-only control group design approach applied on 25 female rats aged 8 weeks old, body weight 125-175 grams. Lead and chitosan were given orally with a sonde. There were 5 groups, namely, negative control group (without any treatment), positive control group (lead 175mg/kg/BW), treatment group 1 (lead 175mg/kg/BW + chitosan 16mg/kg/BW, treatment group 2 (lead 175mg/kg/BW + chitosan 32mg/kg/BW), and treatment group 3 (lead 175mg/kg/BW + chitosan 64mg/kg/BW) for 30 days. The rats were sacrificed at proestrus phase, which was proven from vaginal swab. Observations were carried out using the Hematoxylin Eosin (HE) staining method. The observations were analyzed using One Way ANOVA and followed by Least Significant Differences (LSD) test. The results showed significant results (p-value <0.05). Chitosan can increase the diameter of the antral follicle, increase the number of endometrial arterioles, and increase the thickness of endometrial rats exposed by lead acetate.
PENINGKATAN PENGETAHUAN KADER KESEHATAN MELALUI PROMOSI ASI EKSKLUSIF DIMASA PANDEMI COVID-19 Sulistiyowati, Sulistiyowati; Amalia, Amirul; Irawan, Dwi Dianita
JMM (Jurnal Masyarakat Mandiri) Vol 5, No 4 (2021): Agustus
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v5i4.5135

Abstract

Abstrak: Menurut Organisasi Kesehatan Dunia (WHO) pada tahun 2010, sekitar 1,5 juta bayi 0-6 bulan meninggal karena pemberian makanan tambahan sebelum waktunya. Pemberian ASI Eksklusif di Indonesia sekitar 52%, angka ini belum mencapai target program Kementerian Kesehatan tahun 2014 sebesar 80%. Dalam kondisi pandemi, ibu menyusui merasa minder apakah positif corona atau tidak. Hal ini menimbulkan masalah bagi ibu yang ragu atau khawatir apakah ASI ibu masih aman untuk diberikan kepada bayinya. Pengabdian kepada masyarakat ini bertujuan untuk menambah pengetahuan kader tentang cara memberikan ASI kepada ibu menyusui yang positif COVID-19 menggunakan media secara online. Ilmu yang diperoleh kader dalam kegiatan ini diharapkan dapat memberikan pengetahuan dan mengubah perilaku masyarakat tentang cara menyusui ibu yang positif Covid-19. Dari hasil kegiatan pengabdian masyarakat yang telah dilakukan, terjadi peningkatan pengetahuan yang cukup signifikan tentang ASI eksklusif bagi Kader kesehatan  setelah diberikan pendidikan kesehatan  Abstract:  According to the World Health Organization (WHO) in 2010, 1.5 million infants 0-6 months died due to premature feeding. Breastfeeding (exclusive breastfeeding) in Indonesia is around 52%, this figure has not reached the 2014 Ministry of Health program target of 80%. In a pandemic, breastfeeding mothers feel inferior whether they are positive for Corona or not. This creates problems for mothers who are unsure or worried about whether mother's milk is still safe to give to their babies. This community service aims to increase the knowledge of cadres on how to give breast milk to breastfeeding mothers who are positive for COVID-19 using online media. The knowledge gained by cadres in this activity is expected to provide knowledge and change people's behavior about how to breastfeed mothers who are positive for Covid-19. From the results of community service activities that have been carried out, there has been a significant increase in knowledge about exclusive breastfeeding for mothers with COVID-19 after being promotion. 
Co-Authors A.A. Ketut Agung Cahyawan W Amirul Amalia Annisa' Wigati Rozifa Kenty Wantri Anita, Kenty Wantri Nurdiana Nurdiana Purwitasari, Alief Ayu Retty Ratnawati sulistiyowati, sulistiyowati