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All Journal Jurnal Kedokteran Brawijaya Journal of Innovation and Applied Technology Jurnal Berkala Epidemiologi Berkala Ilmu Kesehatan Kulit dan Kelamin Majalah Kesehatan FKUB Indonesian Journal of Medicine ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Klinik dan Riset Kesehatan
Sinta Murlistyarini
Departemen Dermatologi Dan Venereologi, Fakultas Kedokteran, Universitas Brawijaya/ Rumah Sakit Umum Daerah Dr. Saiful Anwar, Malang, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Jurnal Kedokteran Brawijaya

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Effectiveness of 0.1% Retinol Serum and Astaxanthin Gel on Skin Photoaging Boedhy Setyanto; Sinta Murlistyarini; Dea Florensia
Jurnal Kedokteran Brawijaya Vol. 32 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.12

Abstract

Skin photoaging is cumulative skin damage due to chronic environmental exposure, especially ultraviolet (UV) light, which interferes with the keratinocyte and fibroblast syntheses by matrix metalloproteinases (MMP). Retinol can improve wrinkles, pigmentation, elasticity, firmness, brightness, and various signs of photoaging on the skin. Astaxanthin is a powerful antioxidant that protects the skin from UV rays, inhibits MMP, and stimulates collagen production. This case report presents 2 cases of women complaining about deep skin wrinkles, dullness, and looseness. Physical examination in the facial region revealed wrinkles when resting in the first patient and wrinkles during motion in the second patient. The first patient was diagnosed Glogau III photoaging, while the second patient was diagnosed Glogau II photoaging. Both patients received astaxanthin gel therapy and SPF 33 sunscreen cream every morning, as well as 0.1% retinol serum every night. There was an improvement after six weeks. Astaxanthin and retinol 0.1% can be used as photoaging therapy. Adequate use of photoprotection is also necessary to prevent the worsening of photoaging.
Co-Authors Alfonsus Rendy Laksditalia Nugroho Ayuningtyas, Vidya Hana Dwi Boedhy Setyanto Chandrawati Cahyani Citra Wahyu Rizkita Dea Florensia Diane Tantia Sari Herwinda Brahmanti Lucky Pratama Nahlia, Nurul Laili Nasution, Annio Indah Lestari Noor Hidayah Noor Hidayah Nugrahani, Aninda Fitri Nurrahma Wahyu Fitriyani Rakhmawati, Yustian Devika Safira Khanza Silfia Mandasari Silfia Mandasari Vina Listy Pramita Vivi Nurhadianty, Vivi Widiatmoko, Arif Wuriandaru Kurniasih Yuniaswan, Anggun Putri