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Tanaman Obat Pada Ramuan B2P2TOOT Di Puskesmas Pejeruk Ampenan Kota Mataram Permatasari, Kartika; Aini, Siti Rahmatul; Hanifa, Nisa Isneni
Jurnal Kedokteran Vol 9 No 4 (2020): Jurnal Kedokteran volume 9 no 4 2020
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v9i4.440

Abstract

Latar belakang: Ramuan obat tradisional dari B2P2TOOT adalah ramuan paling banyak yang diresepkan oleh dokter dari 12 provinsi pada tahun 2014. Syarat Fasyankes dapat memberikan pelayanan obat tradisional khususnya ramuan B2P2TOOT adalah memiliki tenaga kesehatan yang telah mengikuti pelatihan saintifikasi jamu. B2P2TOOT terus melakukan evaluasi terhadap ramuan obat yang diberikan dengan memonitoring efek obat dari pelayanan Yankestrad yang menggunakan ramuan B2P2TOOT. Tujuan dari penelitian ini untuk mengetahui komposisi ramuan B2P2TOOT khususnya di Puskesmas Pejeruk Ampenan Kota Mataram yang memberikan pelayanan obat tradisional. Metode: Penelitian ini menggunakan metode kualitatif dengan metode pengambilan data secara cross sectional jenis purposive sampling. Hasil: Terdapat sebanyak 11 ramuan B2P2TOOT di Poli jamu Puskesmas Pejeruk Ampenan. Ramuan B2P2TOOT tersebut dalam bentuk kapsul yang sudah diracik sesuai komposisi tanaman. Komposisi tanaman obat dari tiap-tiap ramuan berbeda, namun secara keseluruhan ramuan tersebut berasal dari tanaman obat yang ada di Indonesia. Spesies tanaman yang dominan digunakan pada 3 atau lebih ramuan B2P2TOOT adalah daun salam (Syzgium polyanthum (Wight) Walp), bunga cengkeh (Syzygium aromaticum), dan temulawak (Curcuma xanthorriza Roxb.). Kesimpulan: Berdasarkan hasil penelitian yang telah dilakukan, maka dapat diambil kesimpulan bahwa komposisi ramuan obat tradisional yang diresepkan di Puskesmas Pejeruk Ampenan Kota Mataram berasal dari tanaman obat Indonesia. Tanaman obat yang paling banyak digunakan dalam ramuan yaitu daun salam, bunga cengkeh dan temulawak yang digunakan pada terapi 3 penyakit atau lebih. Setiap tanaman obat memiliki kandungan metabolit sekunder yang mampu memberikan efek terapi, akan tetapi diperlukan kandungan dari tanaman lain untuk mendukung efek terapi yang diinginkan.
GAMBARAN PERESEPAN OBAT TRADISIONAL DI POLI JAMU PUSKESMAS PEJERUK AMPENAN KOTA MATARAM PERIODE JULI-DESEMBER 2017 Permatasari, Kartika; Aini, Siti Rahmatul; Hanifa, Nisa Isneni
Jurnal Kedokteran Vol 10 No 1 (2021): volume 10 nomor 1 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i1.494

Abstract

Obat diresepkan oleh dokter dengan mempertimbangkan beberapa aspek yaitu pembuktian obat secara ilmiah, obat yang paling bermanfaat, paling aman dan paling ekonomis. Obat tradisional merupakan salah satu obat yang dapat digunakan oleh dokter dalam terapi karena memiliki efek samping yang sedikit dan aman digunakan. Ramuan B2P2TOOT (Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional) merupakan salah satu obat tradisional yang memiliki peresepan tertinggi di 12 provinsi. Penelitian ini bertujuan untuk mengetahui gambaran peresepan obat tradisional di Puskesmas Pejeruk Ampenan yang memberikan pelayanan poli Jamu (Ramuan B2P2TOOT). Penelitian ini bersifat deskriptif retrospektif, data yang diperoleh diolah menggunakan Microsoft excel. Hasil yang diperoleh, penyakit yang dominan diresepkan obat tradisional adalah penyakit degeneratif (kolesterol, hipertensi, asam urat dan diabetes melitus) dengan peresepan obat yang lebih dominan oleh dokter yaitu 2x2 caps/hari dengan jumlah obat yang diresepkan sebanyak 40 kapsul dengan lama terapi 10 hari.
Perbandingan Pelarut Etanol 96% dan Aseton pada Ekstraksi dan Isolasi Kurkumin dari Rimpang Kunyit Haryani, Fitri; Hakim, Aliefman; Hanifa, Nisa Isneni
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 2, No 2 (2021): JULI
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v2i2.5224

Abstract

ABSTRAKKunyit (Curcuma longa Linn.) secara empiris digunakan masyarakat Bima sebagai obat infeksi kulit bernanah (antibakteri) karena kandungan kurkuminnya. Kurkumin dapat diperoleh dengan cara isolasi. Penelitian ini bertujuan untuk melakukan isolasi kurkumin dengan metode yang sederhana menggunakan dua pelarut berbeda dan mengetahui rendemen isolat hasil isolasi. Langkah awal dalam proses isolasi yang dimodifikasi, yaitu proses ekstraksi selama 30 menit menggunakan sonikator dengan pelarut aseton dan etanol 96%, serta perbandingan bobot simplisia dan volume pelarut sebesar 1:10. Proses isolasi dilanjutkan dengan ekstraksi padat-cair menggunakan pelarut n-heksan, kemudian dimurnikan dengan metode kristalisasi menggunakan campuran isopropil alkohol panas : n-heksan (1 : 1,5). Isolat dianalisis secara kualitatif dengan kromatografi lapis tipis (KLT) dan dihitung rendemen isolat terhadap bobot simplisia. Hasil yang diperoleh berupa Nilai Rf untuk standar kurkumin, sampel pelarut aseton dan sampel pelarut etanol 96% adalah 0.81, 0.80 dan 0.81. Rendemen ekstrak etanol 96% dan aseton berturut-turut sebesar 27,3% dan 26,44%. Rendemen isolat etanol 96% dan aseton sebesar 0,07% dan 0,035%. Isolasi kurkumin dengan metode sederhana menggunakan pelarut etanol 96% menghasilkan rendemen isolat lebih besar dibanding pelarut aseton.Kata kunci : Modifikasi isolasi; Kurkumin; Kunyit.ABSTRACTTurmeric (Curcuma longa Linn.) is empirically used by the people of Bima as a purulent skin infection (antibacterial) drug because of its curcumin content. Curcumin can be obtained by isolation. This study aims to isolate curcumin with a simple method using two different solvents and determine the yield of isolated isolates. The first step in the isolation process is the extraction process for 30 minutes using a sonicator with acetone and 96% ethanol as solvent, and the ratio of simplicia weight and solvent volume is 1:10. The process was continued with solid-liquid extraction using n-hexane as solvent, then purified by crystallization method using a mixture of hot isopropyl alcohol: n-hexane (1 : 1.5). The isolates were analyzed qualitatively by thin layer chromatography (TLC) and the yield of the isolates was calculated against the weight of the simplicia. The results obtained in the form of Rf values for standard curcumin, acetone solvent samples and 96% ethanol solvent samples were 0.81, 0.80 and 0.81. The yield of ethanol extract 96% and acetone were 27.3% and 26.44%, respectively. The yield of 96% ethanol and acetone isolates was 0.07% and 0.035%, respectively. Isolation of curcumin with a simple method using 96% ethanol as a solvent resulted in a higher yield of isolate than acetone solvent.Keywords : Isolation modification; Curcumin; Turmeric
Penetapan Kadar Fenolik Total Ekstrak Kulit Buah Kopi Robusta (Coffea canephora L.) Di Pulau Lombok Febriyanto, Febriyanto; Hanifa, Nisa Isneni; Muliasari, Handa
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 2, No 2 (2021): JULI
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v2i2.5036

Abstract

ABSTRAKProduksi kopi robusta (Coffea canephora L.) menghasilkan limbah berupa kulit buah kopi dengan proporsi sebesar 40-45%. Kulit buah kopi dilaporkan mengandung senyawa fenolik yang berpotensi sebagai antioksidan. Kadar senyawa fenolik dapat dipengaruhi oleh faktor lingkungan. pulau Lombok memiliki perkebunan kopi yang tersebar hampir diseluruh penjuru pulau. Penelitian ini bertujuan menentukan kadar fenolik total kulit buah kopi robusta yang dikoleksi dari tiga lokasi berbeda di pulau Lombok. Sampel kulit buah kopi diekstraksi menggunakan metode sonikasi dengan pelarut etanol 70% selama 30 menit pada suhu ruang. Penentuan kadar fenolik total menggunakan metode Folin-Ciocalteu dengan standar asam galat. Kadar fenolik total dinyatakan dalam mg equivalent asam galat (GAE) per gram simplisia. Hasil analisis menunjukkan ekstrak kulit buah kopi dari lokasi desa Lamper memiliki kadar fenolik total sebesar 56.2524 ± 0.6580 mg GAE/g, kadar fenolik total ekstrak kulit buah kopi dari desa Keru sebesar 26.6262 ± 0.8921 mg GAE/g, dan kadar fenolik total kulit buah kopi dari desa Sajang sebesar 46.7573 ± 0.5280 mg GAE/g. Ekstrak dari ketiga lokasi berpotensi sebagai antioksidan dilihat dari kadar fenolik total yang berbeda. Berdasarkan hasil penelititan dapat diketahui bahwa kadar fenolik total ekstrak kulit buah kopi dari lokasi lamper lebih tinggi daripada lokasi Sajang dan Keru.Kata kunci : Kulit buah kopi; Kopi robusta (Coffea canephora L.); Kadar fenolik total.ABSTRACT Production of robusta coffee (Coffea canephora L.) produces coffee pulp waste  with proportion of 40-45%. Coffee pulp reported contain phenolic compounds that have antioxidants activity. Content of phenolic compounds can be influenced by environmental factors. Lombok Island has coffee plantations that scattered throughout the island. This study aims to determine the total phenolic content of robusta coffee pulp collected from three different locations on the island of Lombok. The coffee pulp samples extracted using the sonication method with 70% ethanol solvent for 30 minutes at room temperature. Determination of the total phenolic content of the extract using the Folin-Ciocalteu method with gallic acid standard. Total phenolic content  is expressed in mg equivalent gallic acid (GAE) per gram of simplicia. The results of the analysis showed total phenolic content coffee pulp from Lamper village was56.2524 ± 0.6580 mg GAE/g, the total phenolic content coffee pulp from Keru village was 26.6262 ± 0.8921 mg GAE/g, and the total phenolic content coffee pulp from Sajang village was 46.7573 ± 0.5280 mg GAE/g. Extract from three different location have the potential as antioxidants. Based on the results of the study, it can be seen thatcoffee pulp extract from Lamper has highest total phenolic content than coffee pulp from Sajang and Keru.Keywords : Coffee pulp; Robusta coffee (Coffea canephora L.); Total phenolic content.
Optimasi Formula Stick Balm Minyak Atsiri Daun Sereh (Cymbopogon citratus) I Komang Ary Werdhi Widnyana; Windah Anugrah Subaidah; Nisa Isneni Hanifa
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 2 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i2.1417

Abstract

The content in lemongrass leaves essential oil (Cymbopogon citratus) has a neurobehavioral effect, so lemongrass leaves essential oil can be useful as aromatherapy. The stick balm form as an innovation of aromatherapy form is required to increase the user’s comfort and ease of application of the product. The aim of this study is to determine the optimum formula and physical properties of lemongrass essential oil stick balm form with additive variations of cera alba and lanolin. Eight stick balm formula designs were determined by using SLD (Simplex Lattice Design), method with Design Expert 11 software, and made by using melting method. The stick balm forms were tested for the physical properties such as pH test, melting point test, and adhesion test. The response to the physical properties test was processed by using Design Expert 11 software to obtain optimal formula. The optimal form of stick balm was tested for physical, organoleptic, and homogeneity properties. The results of the physical properties test of optimal formula were verified by using one sample t-test method with SPSS software. The results of the optimization of the formula were 5,310% of lanolin and 11,690% of cera alba. The stick balm forms were bright yellow in color, have a characteristic smell of lemongrass essential oil, semi-solid consistency, homogeneous mixed materials, pH level of 5,63±0,06, melting point of 44,5±0,5oC, and adhesion tests of 2,437±0,106 seconds, with the result that, the optimum formula of stick balm met requirements for the physical properties. The physical properties of the optimal formula are not significantly different from the predictions in the Design Expert 11 application.
Hepatoprotective Activity of Ethanolic Extract of Sida rhombifolia L. Leaf in CCl4-induced Rats Nisa Isneni Hanifa; Wahyu Widyaningsih
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 8 No 2 (2020): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2020.8.2.2929

Abstract

Streptococcus mutans is responsible for cause the dental caries. The purpose of this research was to test antibacterial activity of Ganitrus leaves. The bacterial activity of methanol and aquadest by disc difusion method with 10%; 20%; 30%; 40%; 50% and 100%. The extracts showed that methanol extract had activity with susceptible category at concentration of 10%, 30%, 50% and 100% against Streptococcus mutans with inhibition zone 15.74mm, 16.68 mm, 16.70 mm and 17.68 mm, respectively. Aquadest extract showed activity with intermediet category of 30% and 100% with inhibition zone 11,04 mm and 11,39 mm. The methanol extract showed that activity of antibacterial better than the aqueous Elaeocarpus ganitrus Roxb leaves.
Skrining fitokimia pada tanaman penyembuh luka di Lombok Timur Fidrus Affandy; Dyke Gita Wirasisya; Nisa Isneni Hanifa
Sasambo Journal of Pharmacy Vol. 2 No. 1 (2021): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (317.078 KB) | DOI: 10.29303/sjp.v2i1.84

Abstract

The ethnomedicinal study which conducted in East Lombok revealed 5 potentially plants that have wound healing properties (Jatropha multifida L., Stachytarpheta jamaicensis (L.) Vahl, Centella asiatica (L.) Urban, Euphorbia pulcherrima Willd, and Angelica keiskei). The five plants have been no further research related to the presence of compounds that have activity in wound healing. This study aims to screen the plants secondary metabolites from above plants. The sample was maserated with 96% solvent methanol. The viscous extract was determined by physical characterization including consistency and color as well as chemical characterization, namely the phytochemical screening test. The results showed that the five plants contained flavonoids, phenolics, saponins, and steroids, except for Stachytarpheta jamaicensis (L.) Vahl showed negative results for saponins and Angelica keiskei showed negative results for steroid compounds. Keywords: phytochemical screening, total phenolic content, wound healing herbs, East Lombok
Sosialisasi Pencegahan Penyakit Infeksi Kecacingan Di Wilayah Mataram Ni Made Amelia Ratnata Dewi; Candra Eka Puspitasari; Nisa Isneni Hanifa
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 1 No. 1 (2020): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (390.173 KB) | DOI: 10.29303/indra.v1i1.18

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Abstract: Helminthiasis is an infection that often attacks children and could result in decreased health, nutrition, intelligence and productivity of the patient. The purpose of this community service activity is to organize a socialization that can improve the understanding of helminthiasis dangers and how to prevent it. The socialization method that used are presentation of the material by the speakers, discussions session and brochures distribution for the audition. The socialization was held in the South Batu Ringgit area. As many as 30 residents participated in this activity. The socialization went well and has produced the expected outcomes. Pre and post assesment to evaluate resident knowledge about helminthiasis were done by written multiple choice quiz. The difference between the pre-test and post-test score was carried out using the Wilcoxon test. Wilcoxon test results showed that there were significant differences between the pre-test and post-test with p values= 0.03 Keywords: infection, helminthiasis, socialization
Optimasi Formula Krim Ekstrak Daun Katuk (Sauropus Androgynus) Variasi Konsentrasi Asam Stearat, Trietanolamin, dan Gliserin Febia Arien Lestari; Wahida Hajrin; Nisa Isneni Hanifa
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 2, AGUSTUS 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i2.2496

Abstract

Sauropus androgynus (L.) Merr.) contain secondary metabolite compounds: flavonoids and polyphenols which has bioactivity as antioxidants. Antioxidants act as photoprotector, so it can be formulated into sun protection product. The selection of cream base is very important due to it’s not only as vehicle of active ingredients but also affecting cream’s physical properties and effectiveness. This study aims to determine the composition of the optimum base formula and evaluation formula cream of extract katuk leaves with variations concentration of stearic acid, TEA, and glycerin. Formula optimization was conducted through the Simplex Lattice Design methode with 13 formulas. The results of evaluation were processed with Design Expert software. The optimum formula was respectively at 13.16% stearic acid, 12% glycerin, and 3.84% TEA. The optimum formula cream evaluation was spreadability in 4.89 cm, 0.56 s stickiness power, and pH 6,1. Acceptability test results showed that the cream could accepted by society very well.
Penetapan Kadar Fenolik Total Ekstrak Kulit Buah Kopi Robusta (Coffea canephora L.) Di Pulau Lombok Febriyanto Febriyanto; Nisa Isneni Hanifa; Handa Muliasari
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 2, No 2 (2021): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v2i2.5489

Abstract

ABSTRAKProduksi kopi robusta (Coffea canephora L.) menghasilkan limbah berupa kulit buah kopi dengan proporsi sebesar 40-45%. Kulit buah kopi dilaporkan mengandung senyawa fenolik yang berpotensi sebagai antioksidan. Kadar senyawa fenolik dapat dipengaruhi oleh faktor lingkungan. pulau Lombok memiliki perkebunan kopi yang tersebar hampir diseluruh penjuru pulau. Penelitian ini bertujuan menentukan kadar fenolik total kulit buah kopi robusta yang dikoleksi dari tiga lokasi berbeda di pulau Lombok. Sampel kulit buah kopi diekstraksi menggunakan metode sonikasi dengan pelarut etanol 70% selama 30 menit pada suhu ruang. Penentuan kadar fenolik total menggunakan metode Folin-Ciocalteu dengan standar asam galat. Kadar fenolik total dinyatakan dalam mg equivalent asam galat (GAE) per gram simplisia. Hasil analisis menunjukkan ekstrak kulit buah kopi dari lokasi desa Lamper memiliki kadar fenolik total sebesar 5.6252 ± 0.0658 mg GAE/g, kadar fenolik total ekstrak kulit buah kopi dari desa Keru sebesar 2.6626 ± 0.0892 mg GAE/g, dan kadar fenolik total kulit buah kopi dari desa Sajang sebesar 4.6757 ± 0.0528 mg GAE/g. Ekstrak dari ketiga lokasi berpotensi sebagai antioksidan dilihat dari kadar fenolik total yang berbeda. Berdasarkan hasil penelititan dapat diketahui bahwa kadar fenolik total ekstrak kulit buah kopi dari lokasi lamper lebih tinggi daripada lokasi Sajang dan Keru. Kata kunci: Kulit buah kopi; Kopi robusta (Coffea canephora L.); Kadar fenolik total.ABSTRACT Production of robusta coffee (Coffea canephora L.) produces coffee pulp waste  with proportion of 40-45%. Coffee pulp reported contain phenolic compounds that have antioxidants activity. Content of phenolic compounds can be influenced by environmental factors. Lombok Island has coffee plantations that scattered throughout the island. This study aims to determine the total phenolic content of robusta coffee pulp collected from three different locations on the island of Lombok. The coffee pulp samples extracted using the sonication method with 70% ethanol solvent for 30 minutes at room temperature. Determination of the total phenolic content of the extract using the Folin-Ciocalteu method with gallic acid standard. Total phenolic content  is expressed in mg equivalent gallic acid (GAE) per gram of simplicia. The results of the analysis showed total phenolic content coffee pulp from Lamper village was 5.6252 ± 0.0658 mg GAE/g, the total phenolic content coffee pulp from Keru village was 2.6626 ± 0.0892 mg GAE/g, and the total phenolic content coffee pulp from Sajang village was 4.6757 ± 0.0528 mg GAE/g. Extract from three different location have the potential as antioxidants. Based on the results of the study, it can be seen thatcoffee pulp extract from Lamper has highest total phenolic content than coffee pulp from Sajang and Keru.Keyword: Coffee pulp; Robusta coffee (Coffea canephora L.); Total phenolic content.