Article Per Year (5 Year)
p-Index From 2019 - 2024
0.23
P-Index
This Author published in this journals
All Journal Biomedical Journal of Indonesia Majalah Patologi Indonesia
Ika Kartika
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Analisis Ekspresi Interleukin-17 pada Karakteristik Klinikopatologi Karsinoma Payudara Nyiayu Fauziah Kurniawati; Ika Kartika; Citra Dewi; Theodorus
Majalah Patologi Indonesia Vol 30 No 1 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (494.373 KB) | DOI: 10.55816/mpi.v30i1.461

Abstract

BackgroundInteraction between cancer cells and tumor microenvironment plays roles in cancer proliferation and invasiveness. Many type ofcytokine produced by inflammatory cells in tumor stroma could stimulate tumor proliferation and invasiveness, such as interleukin-17.The aim of this study is to determine the correlation between IL-17 expression and clinicopathological characteristics of breast cancer.MethodsSerial cases study was performed by enrolling 40 paraffin block of breast cancer patients. Clinicopathological characteirstics werenoted, including age, histopathological subtype and grade, TILs, lymphovascular invasion and molecular subtype. TILs were scoredby denomination area of stromal tissue occupied by mononuclear cells over total stromal area. Expression of IL-17 was examined byusing immunohistochemistry with anti-IL-17 antibody and counted from stromal mononuclear cells cytoplasm staining from five areas.The average value was used as a cut-off point in determining level of expression. Data were analysed by using SPSS v.22.ResultsMajority of the patients were more than 40 years old (75%), histopathological grade III (77.5%), without lymphovascular invasion(62.5%), luminal B molecular subtype (57.5%), and non-dominant TILs (95%). IL-17 expression was not significantly correlated withclinicopathological characteristics with p value=0.079, 0.600, 0.739, 0.883 and 1.000 respectively for age, histological grade,lymphovascular invasion, molecular subtype and TILs.ConclusionInterleukin-17 expression and clinicopathological on characteristics of breast carcinoma between histopathological grade, TILs, andlymphovascular invasion showed no significant differences. There was a tendency that the higher IL-17 expression, the higherhistopathological grade, the lower TILs and positive lymphovascular invasion
Prevalensi Penderita Leprosy Berdasarkan Pemeriksaan Histopatologi di Bagian Patologi Anatomi RSUP DR. Mohammad Hoesin Palembang Bellinda Dwi P; Ika Kartika; Indri Seta Septadina
Biomedical Journal of Indonesia Vol. 4 No. 2 (2018): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Leprosy (kusta atau Morbus Hansen) merupakan suatu infeksi granulomatosa kronis oleh M. leprae yang menyerangsaraf tepi, kulit, mukosa mulut, dan saluran nafas bagian atas. Penyakit ini menular dan menyebar di seluruh duniaterutama negara berkembang seperti Indonesia. Walaupun tidak menimbulkan kematian, leprosy dapatmenimbulkan ulserasi, mutilasi, dan deformitas. Pemeriksaan histopatologi perlu dilakukan untuk menunjangdiagnosis secara akurat. Penelitian ini bertujuan untuk mengetahui prevalensi penderita leprosy yang diperiksasecara histopatologi di RSMH Palembang. Jenis penelitian ini adalah deskriptif observasional dengan rancangan crosssectional. Dari 29.175 kasus diperoleh 35 kasus yang terdiagnosis leprosy dan memenuhi kriteria inklusi. Prevalensipenderita leprosy di Bagian Patologi Anatomi RSMH Palembang tahun 2009-2013 adalah 1,19/1000 sampel danmayoritas pasien berusia 32-41 tahun (34,3%). Mayoritas (80%) penderita leprosy adalah laki-laki. Pada pemeriksaanhistopatologi leprosy dijumpai tipe I (2,9%), TT (20%), BT (20%), BB (8,6%), BL (31,4%), dan LL (17,1%). Penelitian inimenunjukkan bahwa prevalensi leprosy di Bagian Patologi Anatomi RSMH tahun 2009-2013. Prevalensi, demografi,dan karakteristik histopatologi leprosy pada penelitian ini mungkin dapat menyediakan gambaran secara umummengenai kondisi kasus leprosy yang diperiksa secara histopatologi di Sumatera Selatan khususnya Palembang.
Co-Authors Bellinda Dwi P Citra Dewi Indri Seta Septadina Nyiayu Fauziah Kurniawati Theodorus