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EXERCISE PREVENTS AGE-RELATED MEMORY DECLINE: THE ROLE OF NEUROTROPHIC FACTORS Rivarti, Arina Windri; Herawati, Lilik; Hidayati, Hanik Badriyah
Malang Neurology Journal Vol 6, No 2 (2020): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.02.8

Increasing aging population causes an increased prevalence of neurodegenerative diseases such as dementia that is associated with memory decline. Developing strategies for the prevention and therapy of age-related dementia is important to reduce the burden of treatment costs. Physical exercise is known to prevent cognitive decline and improve cognitive abilities. Physical exercise with moderate intensity for at least 150 minutes/week or 30 minutes/day for 5 days can reduce the incidence of degenerative diseases in the elderly. Thus, physical exercise appears as a simple, inexpensive, and affordable non-pharmacological therapy for most people. The processes of neurogenesis and neuronal survival involve the role of neurotrophic factors including BDNF, IGF-1 and VEGF, which are the three main neurotrophic factors that are known to increase after exercise. Many publications discuss about these neurotrophic factors, but their mechanism of signals and changes related to aging and exercise have not been completely studied. The purpose of this review is to discuss the mechanism of signals and changes of neurotrophic factors (focuses on BDNF, IGF-1, and VEGF) related to aging and exercise.

Latihan Fisik Meningkatkan Kadar Insulin-Like Growth Factor-1 (IGF-1) Wibawa, Junian Cahyanto; Mus, Rosdiana; Gama, Noviyanty Indjar; Rivarti, Arina Windri
Journal of Sport Science and Education Vol 6, No 1 (2021)
Publisher : Fakultas Ilmu Olahraga, Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/jossae.v6n1.p46-56

This article aims to determine the effect of physical activity in increasing insulin-like growth factor 1 (IGF-1 levels. The method used is a systematic literature review with public databases, direct science, national and international journals with vulnerabilities in 2015-2020. The results showed that physical activity could increase IGF-1 levels. IGF-1 levels are closely related to muscle building, muscle mass, and muscle strength. IGF 1 levels that occur during physical activity can reduce sarcopenia, muscle weakness, and obesity. Given theimportant role physical activity plays in increasing IGF-1 levels, this article looks at how physical activity affects the increase in IGF-1 levels. It can be concluded that physical activity can increase IGF-1 levels as one of the factors associated with increased muscle mass.

Latihan Fisik Meningkatkan Kadar Insulin-Like Growth Factor-1 (IGF-1) Junian Cahyanto Wibawa; Rosdiana Mus; Noviyanty Indjar Gama; Arina Windri Rivarti
Journal of Sport Science and Education Vol 6 No 1 (2021)
Publisher : Fakultas Ilmu Olahraga, Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/jossae.v6n1.p46-56

This article aims to determine the effect of physical activity in increasing insulin-like growth factor 1 (IGF-1 levels. The method used is a systematic literature review with public databases, direct science, national and international journals with vulnerabilities in 2015-2020. The results showed that physical activity could increase IGF-1 levels. IGF-1 levels are closely related to muscle building, muscle mass, and muscle strength. IGF 1 levels that occur during physical activity can reduce sarcopenia, muscle weakness, and obesity. Given theimportant role physical activity plays in increasing IGF-1 levels, this article looks at how physical activity affects the increase in IGF-1 levels. It can be concluded that physical activity can increase IGF-1 levels as one of the factors associated with increased muscle mass.

POTENSI OMEGA-3 BULU BABI (SEA URCHIN) DALAM KONTROL PROGRESIVITAS DEMENSIA ALZHEIMER Arina Windri Rivarti
Unram Medical Journal Vol 11 No 4 (2022): volume 11 no 4
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i4.838

With the increasing prevalence of Alzheimer's dementia and the lack of effectiveness of existing drugs in inhibiting the progression of the disease, the investigation of new drug candidates will continue. Omega-3 fatty acids, especially docosahexaenoic acid (DHA), are compounds that can be used as drug candidates for this purpose. Recent scientific evidence, both from epidemiological studies and preclinical trials in experimental animals, shows the potential of these compounds in maintaining cognitive function and inhibiting the progression of Alzheimer's dementia through various mechanisms, including anti-inflammatory, anti-amyloidogenic, and brain neuroplasticity. These compounds are contained in various marine organisms, including sea urchins. Given the wide availability of marine life on the coast and its ability to biosynthesis of omega-3 fatty acids, this marine biota can be considered as the main source of omega-3 in the development of omega-3 as a drug for the protection of cognitive function in Alzheimer's disease dementia.

SKRINING DEMENSIA DAN EDUKASI POTENSI SUMBER DAYA LAUT UNTUK MENCEGAH PENYAKIT NEURODEGENERATIF PADA MASYARAKAT PESISIR DI KABUPATEN LOMBOK UTARA (KLU) Arina Windri Rivarti; Fitriannisa Faradina Zubaedi; Herpan Syafii Harahap; Nurhidayati Nurhidayati; Legis Ocktaviana Saputri
Jurnal Abdi Insani Vol 9 No 4 (2022): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v9i4.827

Improving the quality of health services has resulted in a high elderly population. The elderly are more susceptible to various degenerative diseases, including dementia. The high prevalence of dementia is a major health issue that has an impact on global socioeconomic problems. Indonesia is one of the world's largest archipelagic countries. As an archipelago-based region, West Nusa Tenggara (NTB) has numerous marine resources that could be utilized as potential dementia therapies. This program aims to conduct health screenings for dementia and educate about the potential of marine resources for dementia treatment. This program consists of two phases. The ﬁrst phase consists of a health screening to assess the risk of dementia. This phase includes measuring blood pressure, measuring blood sugar, and evaluating cognitive performance. The second phase consists of health education regarding the potential of marine resources. Based on dementia screening revealed that 96% of participants need additional evaluation. About 47.3% of the patients were diagnosed with hypertension, 61.1% required further confirmation for diabetes mellitus, and 5.6% were diagnosed with diabetes mellitus. Health education explains the importance of marine resources in preventing degenerative diseases, the nutritional value of marine resources, and the proper treatment of marine resources as food and medication. The community's enthusiasm for health education is high. The high interest of the people was evidenced by a large number of attendees and queries asked. The community participates actively, and the programs run as intended.

SOSIALISASI PRAKTIK CUCI TANGAN PAKAI SABUN (CTPS) SERTA PEMANFAATAN LIMBAH UNTUK SARANA CUCI TANGAN SEBAGAI UPAYA MENJAGA KESEHATAN DIRI DAN LINGKUNGAN Legis Ocktaviana Saputri; Arina Windri Rivarti; Mahacita Andanalusia; Lalu Auliya Akraboe Littaqwa; M. Said Ramdlan
Jurnal Abdi Insani Vol 10 No 2 (2023): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v10i2.954

Maintaining personal and environmental health can be implemented through Clean and Healthy Behavior (PHBS). One form of application is washing hands with soap (CTPS). CTPS has proven to be effective in preventing disease transmission from one individual to another. CTPS practice is an absolute necessity, while the availability of CTPS facilities is still inadequate. This activity aims to increase the knowledge of elementary and junior high school students and teachers at Pondok Pesantren Nurul Ijtihad Al-Ma'arif NU Central Lombok about CTPS as a strategy to minimize the spread of disease (Covid-19) in the school environment. This activity is carried out in the form of socialization. CTPS Practice Education refers to the procedure for washing hands properly and correctly according to the World Health Organization (WHO). Participants were also introduced to the use of solid waste as an ideal CTPS facility and how to manage the remaining CTPS liquid waste. Pre-test and post-test were given to test the success of the activities carried out. This activity was attended by 75 participants consisting of students, teachers and regular recitation participants at the Nurul Ijtihad Al-Ma'arif NU Islamic Boarding School in Central Lombok. Participants were given education by 3 (three) experts regarding good and correct CTPS practices, the use of solid waste for making CTPS facilities, and the management of liquid waste left over from CTPS practices so as not to have a negative impact on the environment. This activity ran smoothly and proved successful in increasing participants' understanding as indicated by the pre-test and post-test scores which increased from 50.5% to 61.97%. The ideal CTPS practice needs to be constantly reminded in order to prevent disease transmission. Utilization and management of waste in the practice of CTPS is a strategy to prevent environmental pollution.

DISEMINASI INFORMASI DAN DETEKSI DINI GANGGUAN KOGNITIF TERKAIT HIPERTENSI PADA PENDUDUK DI DESA PULAU MARINGKIK, KABUPATEN LOMBOK TIMUR Herpan Syafii Harahap; Yanna Indrayana; Yusra Pintaningrum; Bambang Priyanto; Arina Windri Rivarti; Dini Suryani; Nurhidayati Nurhidayati; Legis Ocktaviana Saputri; Fitriannisa Faradina Zubaidi; Muhammad Hilman Rizaldi; Anang Hermansyah; Restia Restia
Jurnal Abdi Insani Vol 10 No 3 (2023): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v10i3.1010

Hypertension-related cognitive impairment has a wide spectrum, ranging from mild cognitive impairment to severe cognitive impairment in hypertensive individuals. Hypertension is currently also known as a risk factor for Alzheimer's dementia and vascular dementia. In its severe form, cognitively impaired individuals will have a high dependence on family members to carry out their daily activities. This community service event aims to increase the understanding of the residents of Maringkik Island Village regarding the importance of prevention and early detection of hypertension-related cognitive impairment. This event was carried out in Pulau Maringkik Village, East Lombok Regency, which is a representative of a coastal area whose population generally has a high level of consumption of sodium salt. This community service activity is carried out in 3 forms of activities, including health education, screening of hypertension, and early detection of cognitive impairment in hypertensive participants. This health education event was attended by 53 participants. Of these, 29 participants (54.7%) were hypertensive. In early detection of cognitive dysfunction, of the 29 hypertensive participants, 19 of them (65.5%) were categorized as having impaired cognitive function. Thus, in this community service events, health education activity, screening of hypertension, and early detection of hypertension-related cognitive impairment are successfully done. The frequency of residents of Maringkik Island Village with hypertension and hypertension-related cognitive impairment is quite high. Promotive efforts to change high-sodium salt consumption habits need to be carried out on an ongoing basis with an educational strategy that is adjusted to the education level of the participants.

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