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All Journal Indonesian Journal of Urology Journal of Agromedicine and Medical Sciences Warta Pengabdian Majalah Kedokteran Andalas Jurnal Kesehatan ABDIMAYUDA: Indonesian Journal of Community Empowerment for Health
Aziz, Ayu Munawaroh
Department Of Histology, Faculty Of Medicine, University Of Jember, Indonesia
Computer Science & IT Education Health Professions Medicine & Pharmacology Public Health

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HYPERTENSION EFFECTS ON THE DECREASED KIDNEY FUNCTION PROGRESIVITY IN BENIGN PROSTATIC HYPERPLASIA PATIENTS Dhiemas Trisyuananda Eniestama; Aziz, Ayu Munawaroh; Wahyudi, Septa Surya
Indonesian Journal of Urology Vol 28 No 1 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i1.660

Abstract

Objective: A comprehensive knowledge about BPH and hypertension is needed to reduce morbidity and mortality in patients with decreased kidney function due to the two diseases. Material & Methods: This research used the observational analytics method with cross-sectional design. This research used secondary data from medical records of BPH patients in Bina Sehat Hospital and Paru Hospital from January 1st to December 1st 2019. Results: Comparative serum creatinine test results in hypertensive BPH patients with non-hypertensive BPH patients using the Mann Whitney test, obtained p= 0.000. Based on these results it can be concluded that there are significant differences in serum creatinine between hypertensive BPH patients and non-hypertensive BPH patients. Correlation test results using the Spearman test between serum creatinine with blood pressure systole and diastole all samples obtained each p= 0.000 r= 0.399 for systolic blood pressure and p= 0.000 r= 0.337 for diastole blood pressure. Based on these results it can be concluded that there is a significant correlation between serum creatinine with systolic and diastolic blood pressure of the patient. Conclusion: Hypertension will worsen the kidney function decline in BPH patients seen from an increase in serum creatinine.
In silico Test Proteolytic Potential of Papain and Zingibain Enzymes Against Protein Forming Congenital and Senilis Cataracts Gangsar Lintas Damai; Nugraha Wahyu Cahyana; Ayu Munawaroh Aziz
Journal of Agromedicine and Medical Sciences Vol 8 No 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i1.23324

Abstract

Abstract Phacoemulsification is cataract therapy’s gold standard with lowest complication rate and best visual outcome. However, phacoemulsification is expensive and difficult to use widely. Pathogenesis of cataract related to Crystalline P23T γD protein in congenital cataracts and β-amyloid protein in senile cataract. Papain enzymes and zingibain enzymes are cataract’s alternatives therapy with proteolytic effects that potentially lyse these proteins. Proteolytic injection with 30-gauge needle results in small, safe incision. Papain enzyme from Carica Papaya plant and zingibain enzyme from Zingiber Officinale plant which grows plentifully in Indonesia that becomes cheap source of proteolytic. This study’s purpose is to compare probability of binding energy based on Binding Interaction Model (BIM) between papain and zingibain enzymes against Crystalline P23T γD protein and β-amyloid protein with molecular docking. This research uses https://cluspro.bu.edu./login.php. BIM with lowest binding energy has most stable bond. Docking results show interaction probability between papain enzyme and Crystalline P23T γD protein has lowest binding energy of -730.4 kJ/mol at BIM 1. Probability of interaction between papain enzyme and β-amyloid protein has lowest binding energy of -697.2 kJ/mol at BIM 1. Probability of interaction between the enzyme zingibain and the crystalline P23T protein γD has lowest binding energy of -890.5 kJ/mol at BIM 2. Probability of interaction between the enzyme zingibain and the β-amyloid protein has lowest binding energy of -873.5 kJ/mol at BIM 0. It was concluded that the zingibain enzyme has the most stable probability of forming a stable bond to Crystalline P23T γD protein and β-amyloid protein. Keyword:In silico, papain, zingibain, cataract
The Protection Effect Of Methanol Extract From Asam Jawa Seed On Testicular Tissue Damage Induced By Aluminium Chloride (AlCL3) Rena Normasari; Muhammad Iqbal Fauzi; Ayu Munawaroh Aziz
Journal of Agromedicine and Medical Sciences Vol 7 No 1 (2021)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v7i1.19645

Abstract

Aluminum is known has neurotoxin effect that can lead to alzheimer's disease, dementia, and parkinson's. Metal ions such as aluminum can distract homeostasis and increase oxidative stress level, formation of reactive oxygen species (ROS) that can overwhelm antioxidant defenses and cause DNA damage, lipid peroxidase, leading to the destruction of testicular cells. Tamarindus indica’s seeds are one of the traditional plant and useful as antioxidants. Tamarindus indica’s seeds are able to protect testicular cells from damage caused by ROS. The purpose of this study to determine the effect of methanol extract from Tamarindus indica’s seeds to prevent aluminum chloride induced testicular damage to be measured from the histopathological features. This study is a quasi experimental design with a posttest design only with non-equivalent groups using thirty male Wistar rats divided into five groups, one control group and four treatment groups. The control group was given 1 mL of aquabides solution orally. Group P1 was given a dose of aluminum solution 300 mg/kgBW orally. Groups P2, P3, and P4 were each given an aluminum solution at dose of 300 mg/kgBW orally and an extract solution at a dose of 25, 50, 100 mg/kgBW orally for 10 weeks. The results of the observations showed that the scores varied between groups. Data analysis using Kruskal-Wallis test obtained p value = 0.006 (p <0.05). Post Hoc test using Mann Whitney obtained varied p values. Post Hoc analysis between K and P1 groups, P1 and P3 groups, P1 and P4 groups showed a significant difference with p value <0.05. Based on the results of this study, methanol extract from tamarind seeds (Tamarindus indica) that was given to male wistar rats had prevented histopathological damage to the testes of rats induced by aluminum chloride (AlCl3). Keywords: aluminium, testicular cell, Tamarindus indica
Pembentukan Pos UKK Industri Pembuatan Brem di Desa Kalibaru Wilayah Kerja Puskesmas Mejayan Madiun Ayu Munawaroh Aziz
Warta Pengabdian Vol 13 No 3 (2019): Warta Pengabdian
Publisher : LP2M Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/wrtp.v13i3.8574

Abstract

Kegiatan pembentukan pos UKK dilakukan pada saat menempuh internship di Madiun. Kegiatan ini dilakukan sebagai bentuk dukungan dan aktualisasi dari peraturan menteri kesehatan mengenai pos kesehatan bagi pekerja sekto informal. Kegiatan di lakukan di desa kaliabu mejayan madiun karena merupakan salah satu sentra industri pembuatan brem dan sektor informal lainnya. Kegiatan dilakukan mulai dari tahap survei identifikasi masalah kesehatan kerja, penyuluhan, pengobatan dasar dan evaluasi hasil kegiatan. Berkat kerjasama lintas sektoral yang telah dilakukan , telah terbentuk Pos UKK percontohan untuk masyarakat pekerja di sektor informal desa Kaliabu . Program pembentukan Pos UKK ini cukup berhasil dilihat dari antusiasnya pekerja dalam mengikuti kegiatan Pos UKK dan berubahnya perilaku pekerja dalam keselamatan dan kesehatan kerja.
Hubungan kualitas tidur dengan tinggi badan pada remaja usia 10-15 tahun Septa surya wahyudi; Ayu munawaroh aziz; Alfina kamelia fakhriyah
Majalah Kedokteran Andalas Vol 44, No 2 (2021): Online July 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v44.i2.p93-103.2021

Abstract

Kualitas tidur yang baik harus dicapai seseorang untuk mendapatkan manfaat dari tidur. Selama periode tidur, tubuh menyekresikan GH dalam darah. Sekresi GH mencapai puncaknya saat tidur nyenyak terutama tengah malam. Kadar GH yang disekresikan saat tidur dapat berpengaruh terhadap pertumbuhan fisik terutama tinggi badan pada masa pertumbuhan.Penelitian ini merupakan observasional analitik, menggunakan pendekatan cross sectional. Bertujuan untuk mengetahui hubungan kualitas tidur dengan tinggi badan pada remaja usia 10-15 tahun. Teknik pengambilan sampel menggunakan teknik proportional stratified random sampling dengan menggunakan kriteria inklusi dan eksklusi. Teknik pengambilan data dilakukan dengan cara wawancara, pemeriksaan tinggi badan berat badan. Analisis data dilakukan menggunakan uji Chi Square.Penelitian menunjukkan sampel yang mempunyai kualitas tidur baik yakni 26 sampel (86,7%), kualitas tidur buruk sebanyak 4 sampel (13,3%). Sebanyak 16 sampel (53,3%) mempunyai tinggi badan sesuai nilai normal menurut usia dalam pedoman WHO, Kemenkes RI, dan CDC pada tahun 2001, 14 sampel (46,7%) lainnya tidak sesuai pedoman tersebut. Hasil uji Chi Square menunjukkan hubungan yang signifikan antara kualitas tidur dengan tinggi badan (p=0,022). Hal ini menunjukkan bahwa terdapat hubungan antara kualitas tidur dengan tinggi badan pada remaja usia 10-15 tahun. Semakin baik kualitas tidur, maka tinggi badan anak akan semakin sesuai dengan nilai normal menurut usia.
Perbedaan Forced Vital Capacity (FVC) pada Wanita Menopause dan Wanita Usia Subur Pekerja Pabrik Tembakau Ayu Munawaroh Aziz; Ida Srisurani W. A.; Madha Qoyyulledy Tursina
Jurnal Kesehatan Vol 8 No 1 (2020): April
Publisher : Politeknik Negeri Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25047/j-kes.v8i1.145

Abstract

Pekerja pabrik tembakau dikelilingi oleh berbagai bahaya kesehatan kerja. Debu tembakau yang terhirup terus menerus menyebabkan akumulasi di saluran pernapasan yang menyebabkan peradangan dan menghasilkan jaringan fibrotik yang dapat mengurangi ekspansi paru-paru (restriction). Forced Vital Capacity (FVC) dalam hasil spirometri digunakan sebagai parameter untuk pola gangguan restriksi paru-paru. Penelitian ini bertujuan untuk mengetahui perbedaan FVC pada wanita menopause dan wanita pekerja pabrik tembakau usia subur. Jenis penelitian ini adalah observasional analitik dengan rancangan studi cross-sectional. Sampel penelitian ini adalah pekerja wanita menopause dan wanita usia subur yang bekerja di produksi pabrik tembakau. Pengumpulan data dilakukan wawancara dengan kuesioner, dan data FVC diperoleh dari hasil pemeriksaan spirometri. Penelitian ini menggunakan desain penelitian observasional analitik cross-sectional dan Unpaired T-test. Pengumpulan data tentang karakteristik individu dilakukan dengan kuesioner, sedangkan data FVC diperoleh dari spirometri. Hasil penelitian menunjukkan bahwa mayoritas pekerja pabrik tembakau perempuan mengalami penurunan nilai FVC dalam bentuk pembatasan paru-paru dan ada perbedaan nilai FVC yang signifikan antara wanita menopause dan wanita usia subur pada pekerja pabrik tembakau.
Screening for Non-Communicable Diseases and Cardiopulmonary Resucitation Education in Kranjingan Village, Sumbersari District, Jember Regency Lirista Dyah Ayu Oktafiani; Arina Mufida Ersanti; Ayu Munawaroh Aziz
ABDIMAYUDA: Indonesia Journal of Community Empowerment for Health Vol 1 No 2 (2022)
Publisher : Faculty of Public Health, University of Jember in collaboration with PERSAKMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.557 KB) | DOI: 10.19184/abdimayuda.v1i2.28536

Abstract

Non-communicable diseases (NCDs) are catastrophic diseases that can cause an increase in the socio-economic burden for sufferers, their families and the government, because their treatment takes a long time, costs a lot and requires high technology. Cardiovascular disease is one of the PTM diseases in Jember Regency which has a high prevalence of cases. Screening activities through posbindu are one of the efforts that can be done to prevent and control PTM. This activity aimed to screen NCDs and improve Cardiopulmonary Resuscitation (CPR) skills in the Kranjingan Village community, Sumbersari District, Jember Regency. This activity was carried out through several stages, starting with counseling, examining early detection of PTM risk factors, counseling and CPR training. Screening activities were important to be carried out to increase public awareness of non-communicable diseases through early detection, early treatment and controlling risk factors so as to reduce morbidity and mortality rates. After this activity, it was known that there has been an increase in participants' knowledge related to Cardiopulmonary Resuscitation (CPR) skills in the community in Kranjingan Village, Sumbersari District, Jember Regency.
Co-Authors Alfina kamelia fakhriyah Arina Mufida Ersanti Desie Dwi Wisudanti, Desie Dwi Dhiemas Trisyuananda Eniestama Gangsar Lintas Damai Ida Srisurani Wiji Astuti Lirista Dyah Ayu Oktafiani Madha Qoyyulledy Tursina Muhammad Iqbal Fauzi Nugraha Wahyu Cahyana Nugraha Wahyu Cahyana Rena Normasari septa surya wahyudi, septa surya Tegar Syaiful Qodar