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The Combination of Platelet Rich Plasma with Skin Needling or Subcision for Postacne Scaring: a Serial Case Study yustin, endra
Journal of Stem Cell Research and Tissue Engineering Vol 3, No 2 (2019): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v3i2.20131


Scaring in acne remains a common problem and became therapeutic challenges for the clinician. Several modalities were introduced, and combination therapies are required to achieve satisfactory results. Skin needling and subcision reported as effective methods for treating acne scar. The skin needling technique involves puncturing the skin multiple times with a small needle to induce collagen growth, while subcision worked by tunneling the connective tissue and scattered the fibrosis scar. Platelet-rich plasma (PRP) influences wound-healing by stimulating an intense inflammatory response and growth factors, these increase in the production of extracellular matrix and granulation tissue occurs, with vascular in-growth, fibroblastic proliferation, and collagen production also accelerated. Three male patients enrolled in the study, with grades 2-3 acne scar. There are three different methods of treatment were used to see the effect of the treatment. The first patient used the combination of topical PRP and skin needling, and the second patient received a combination of PRP injection and subcision, while the third patient obtains combination between topical PRP and skin needling continued with PRP injection and subcision. Our study revealed that PRP and skin needling or subcision is a simple technique and has the potential for improvement of acne scars. Three weeks after treatment, all three patient had smoother facial skin and reduction of acne scar severity. The combination of PRP and skin needling or and subcision is a simple, safe and rapid method for acne scars treatment.
Tatalaksana Herpes Genitalis pada Kehamilan Triana, Agung; Dyah Ayu, Ardelia; Zulfikar, Dendy; Yustin, Endra
Cermin Dunia Kedokteran Vol 47, No 12 (2020): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (113.818 KB) | DOI: 10.55175/cdk.v47i12.1236


Herpes simplex virus (HSV) adalah penyebab herpes genitalis (HG). Perubahan imunologi saat kehamilan akan meningkatkan kerentanan terhadap infeksi HSV yang merupakan penyebab morbiditas dan mortalitas ibu dan janin. Pengaruh infeksi ini pada ibu dan janin/neonatus tergantung apakah infeksi primer (inisial) atau rekuren. Penentuan episode infeksi HG penting baik untuk tatalaksana maupun edukasi pasien.Genital herpes is caused by Herpes simplex virus (HSV). Immunologic changes in pregnancy may increase susceptibility to HSV infection as one of the major cause of morbidity and mortality for both mother and fetus. The effect to the mother and fetus/ neonate depends on whether a primary infection (initial) or a recurrent infection. Determination of an episode of genital herpes is important to provide best management and education.