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All Journal eJurnal Kedokteran Indonesia
Meutia Ayuputeri Kumaheri
Fakultas Kedokteran Universitas Indonesia
Medicine & Pharmacology

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The Association Between Biliary Atresia and Cytomegalovirus Infection Meutia Ayuputeri Kumaheri; Hanifah Oswari
eJournal Kedokteran Indonesia Vol 5, No 2 (2017): Vol 5, No. 2 (2017): Agustus
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

Perinatal infection of cytomegalovirus (CMV) may cause cholestasis resembling biliary atresia. CMV infection is found in patients with biliary atresia. This simultaneous occurrence of biliary atresia and CMV infection prompted speculation that CMV may contribute to the progression of biliary atresia. This report has the objective to obtain the evidence regarding the association between biliary atresia and CMV infection. Two databases were searched to obtain the evidence: PubMed and Scopus. The study design which was selected for this report was case control due to its relevance to answer the clinical question. There were two case control studies which are appropriate to answer the clinical question. Both studies showed that biliary atresia is associated with CMV infection (OR>1). Biliary atresia is associated with CMV infection at the time of diagnosis, therefore the presence of CMV infection in neonatal cholestasis should not delay the investigation towards biliary atresia.
Prognosis of Peritoneal Dialysis Compared to Hemodialysis in Patient with End-Stage Renal Disease Meutia Ayuputeri Kumaheri
eJournal Kedokteran Indonesia Vol 6, No 1 (2018): Vol 6, No. 1 (2018): April
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

End-stage Renal Disease (ESRD) is the terminal stage of Chronic Kidney Disease, where the function of the failing kidney must be substituted with Renal Replacement Therapy (RRT). There are two forms of RRT; Peritoneal Dialysis (PD) and Hemodialysis (HD. However, the issue of which method provide a better survival for patient remains an interesting topic to date. This paper aims to provide evidence on whether PD provides better survival compared to HD in a patient with ESRD. Systematic search was done using two databases; Pubmed® and Scopus®. Cohort studies were selected as appropriate study design to answer a prognosis question. Two restrospective cohorts and one prospective cohort study are relevant for this report. Two studies demonstrated survival advantage of PD over HD described by Relative Risk of Mortality of 0.398 and 0.49. The last study showed worse survival of PD patients compared to HD (RR=1.82). The difference in survival in the last study may be attributed to the fact that patients undergoing PD has worse baselinecharacteristics. PDand HD bring about comparable survival in ESRD patients.
Co-Authors Hanifah Oswari