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All Journal eJurnal Kedokteran Indonesia
Widya Artini
Departemen Medik Mata, Fakultas Kedokteran Universitas Indonesia- RSUPN Dr. Cipto Mangunkusumo, Jakarta, Indonesia
Medicine & Pharmacology

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Influence of Mesenchymal Stem Cell Transplantation in Retaining Ganglion Cell of End Stage Glaucoma Patients Widya Artini
eJournal Kedokteran Indonesia Vol 6, No 2 (2018): Vol 6, No. 2 (2018): Agustus
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

Mesenchymal stem cells transplantation enhances nerve growth factor synthesis, brain derived nerve factor, glial cell line-derived neurotropic factor, and neurotrophin-3.. We report four end-stage primary open angle glaucoma patients, consisting of three males and one female with a median age of 68 years old, treated at RSCM on September 2017. Visual acuity ranged between 1/300 to 2/60 and intraocular pressure (IOP) between 10-14 mmHg. All patients underwent allogeneic mesenchymal stem cells transplantation derived from umbilical cord by subtenon injection and evaluated the results of the potential evoked retinograph and average thickness of ganglion cell-inner plexiform layer (GC-IPL). Three months later, two patients admitted their vision was improved. with, no significant anatomical structure changes were observed. While two other patients did not report any significant effects.
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