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Samara, Tjam Diana
Faculty of Medicine, Trisakti University
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Cullin 1 is not associated with late-onset preeclampsia Samara, Tjam Diana; Liem, Isabella Kurnia; Prijanti, Ani Retno; Andrijono, Andrijono
Universa Medicina Vol 38, No 1 (2019)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (653.458 KB) | DOI: 10.18051/UnivMed.2019.v38.4-9

Abstract

BackgroundLate-onset preeclampsia (PE) is preeclampsia occurring after 34 weeks of gestational age or later.  Cullin 1 (CUL1), a proangiogenic protein, is expressed in the placenta, where an imbalance between proangiogenic and antiangiogenic proteins during gestation can cause disturbance of trophoblast invasion. This defect results in vascular ischemia that may produce preeclampsia. The objective of this study was to determine the correlation between CUL1 as proangiogenic factor and late-onset preeclampsia. MethodsThis study was of analytical observational cross-sectional design and involved 44 preeclampsia patients with ³34 weeks of gestational age (late-onset PE). The CUL1 level in the subjects’ sera, taken before they gave birth, and in homogenates of their placenta, obtained per vaginam or by cesarean section, were examined by the ELISA technique.  Statistical analysis was performed with the Spearman correlation test with significant p value of <0.05.ResultsMedian maternal age was 31 years and median gestational age was 37 weeks.  Median serum CUL1 was 41.78 pg/mL and median placental homogenate CUL1 was 32.24 pg per milligram of total placental tissue protein. There was no significant correlation between serum CUL1 level and late-onset preeclampsia (r=-0.281; p=0.065). There was also no significant correlation between placental CUL1 level and late-onset preeclampsia (r=-0.166; p=0.281).ConclusionSerum CUL1 and placental CUL1 were not correlated with late-onset preeclampsia. However, this study indicated that low serum CUL1 tends to prolong gestational age in preeclampsia.
Mesothelioma akibat inhalasi debu asbes Samara, Tjam Diana; Fitriyani, Meylan; Safitri, Paluvi; Shahnaz, Puti; Sabrina, Isra; Maisarah, Syadza
Jurnal Biomedika dan Kesehatan Vol 3 No 4 (2020)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2020.v3.193-201

Abstract

Mesothelioma adalah kanker yang berkembang mengenai lapisan paru-paru, adomen, atau jantung. Risiko mesothelioma tidak turun dari waktu kewaktu setelah paparan asbes berhenti. Sebanyak 80% mesothelioma disebabkan oleh inhalasi debu asbes. Masa laten mesothelioma dapat terjadi 10 sampai 50 tahun. Mesothelioma pleura adalah mesothelioma yang paling sering ditemukan dengan gejala sesak nafas, batuk kering, nyeri dada, hemoptoe, mudah lelah, demam disertai keringat terutama malam hari, berat badan menurun, dan efusi pleura. Standar penegakan diagnosis mesothelioma pleura dapat dilakukan dengan beberapa pilihan pemeriksaan antara lain rontgen thoraks, Computed Tomography (CT) Scan, Positron-Emission Tomography (PET) Scan, atau Magnetic Resonance Imaging (MRI). Terapi mesothelioma terutama pada mesothelioma pleural dapat dilakukan pembedahan, kemoterapi, radioterapi atau kombinasi dari keduanya atau lebih atau yang disebut sebagai terapi multimodal. Prognosis untuk kanker mesothelioma umumnya buruk dan banyak pasien yang hidup kurang dari satu tahun.
Comparison of matrix metalloproteinase-9 and E-cadherin expression in early- and late-onset preeclampsia Samara, Tjam Diana; Wibowo, Heri; Liem, Isabella Kurnia; Prijanti, Ani Retno; Andrijono, Andrijono
Universa Medicina Vol. 40 No. 3 (2021)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2021.v40.200-206

Abstract

BACKGROUNDPreeclampsia (PE) is one of the most common pregnancy complications worldwide. Turnover of villous trophoblast is affected by impaired placental perfusion in preeclampsia. Among the various factors that influence pro and antiangiogenic factors in trophoblast invasion of PE are E-cadherin and matrix metalloproteinase-9 (MMP-9). The current classification scheme differentiates PE into two variants early-onset (EO) and late-onset (LO) PE. The aim of this study was to compare MMP-9 and E-cadherin expression between early- (EO) and late-onset (LO) PE. METHODSThis study used a cross-sectional design involving 26 women with gestational age <34 weeks (EO) and 38 women with gestational age ≥34 weeks (LO) from PE patients. Placentas born to preeclamptic mothers were taken in the form of small pieces of the maternal side to measure the levels of MMP-9 and E-cadherin by the ELISA method. Statistical analysis was assessed using the Mann Whitney and independent t-test with a significant p value <0.05. RESULTSSemiquantitative proteinuria levels were significantly higher in EO-PE group compared to LO-PE group (p=0.000). Mean E-cadherin levels were significant lower in the EO-PE group (125.94 ± 54.22 pg/mg) compared to LO-PE group (157.95 ± 54.12 pg/mg) (p=0.024). However, there was no significance difference in median MMP-9 levels between EO-PE group and LO-PE group (p=0.376). CONCLUSIONThis study demonstrate that E-cadherin had lower levels in preeclampsia patients who gave birth <34 weeks. This study indicated that lower levels of e-cadherin can lead to early delivery in preeclampsia patients.
Co-Authors Andrijono Andrijono Ani Retno Prijanti Briliant, Permaisonya Fitriyani, Meylan Hairunisa, Nany Liem, Isabella Kurnia Liem, Isabella Kurnia Luh Putu Ratna Sundari Magdalena Wartono, Magdalena Maisarah, Syadza Purnamawati Tjhin, Purnamawati Sabrina, Isra Safitri, Paluvi Shahnaz, Puti