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All Journal Pharmaciana: Jurnal Kefarmasian Soeropati: Journal of Community Service Jurnal Kedokteran Meditek
Meilinah Hidayat
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Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Pengaruh Penyuluhan Terhadap Pengetahuan Sikap Perilaku Kader PKK Kelurahan Sukagalih Kota Bandung Tentang Diabetes Mellitus Audyati Gany; Kartika Suhada; Cindra Paskaria; Meilinah Hidayat

Publisher : Institute for Research and Community Service in Universitas Yudharta Pasuruan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (582.262 KB) | DOI: 10.35891/js.v2i1.1804

Abstract

Diabetes Mellitus is a chronic metabolic disorder which is a serious problem for the health of the people of Indonesia and the world, so the International Diabetes Federation (IDF) and the World Health Organization (WHO) set November 14 as World Diabetes Day. The aim of the research is to increase public knowledge about Diabetes Mellitus, to behave and behave as they should in their daily lives, starting with lifestyle and patterns of food and drink intake. Counseling is carried out to PKK cadres as the spearhead who continue to the community members. The study design was a lecture accompanied by cross sectional pre and post test data collection. The results of the knowledge aspects of the study showed that there was a very significant difference between the pre and post test results (p = 0,000). The attitude aspect showed that there was no significant difference between the pre and post test results (p = 0.257), but overall the cadre's attitude regarding a healthy lifestyle to prevent Diabetes Mellitus was good enough. Behavioral aspects indicate that there are respondents who behave well, a maximum value of 3, but some are not good, a minimum value of 0. The results of blood sugar tests when showing as many as 69.57% of participants are not certain to have DM, while the rest are not DM. The conclusion is that there is a very significant increase in PKK cadre knowledge, but there has not been a significant change in attitude after attending counseling.
The ethanol extract of the bastard cedar (Guazuma ulmifolia L.) as antioxidants Sijani Prahastuti; Meilinah Hidayat; Stella Tinia Hasiana; Wahyu Widowati; Wahyu Setia Widodo; Rr. Anisa Siwianti Handayani; Rizal Rizal; Hanna Sari Widya Kusuma
Pharmaciana Vol 10, No 1 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (29.278 KB) | DOI: 10.12928/pharmaciana.v10i1.13636

Abstract

Guazuma ulmifolia, or commonly known as the bastard cedar, has many pharmaceutical activities and is, therefore, claimed as a source of various plant-based medicines. This reserach was purposed to identify the antioxidant activities of the ethanolic extract of G. ulmifolia (EEGU) by phytochemical screening assay, total flavonoid and total phenolic testing, and comparative analysis between the antioxidant activities of EEGU and epicatechin. The qualitative phytochemical screening assay of EEGU detected the availability of phenols, flavonoids, alkaloids, tannins, and terpenoids, but not saponins and triterpenoids. Meanwhile, the total phenolic content was 32.24 µg GAE/mg extract, and the total flavonoid content decided using aluminum chloride reagent with quercetin standard, was 6.48 µg QE/mg extract. The role of antioxidants examined by FRAP, DPPH, H2O2, and ABTS assays. These assay are proved that the IC50 values of EEGU are higher than those of epicatechin. For DPPH scavenging, H2O2 scavenging, and ABTS reduction activities, EEGU resulted IC50 45.70 μg/mL, 162.93 μg/mL, and 35.96 μg/mL, while epicatechin only yielded IC50 0.56 μg/mL, 57.91 μg/mL, and 16.74 μg/mL respectively. Otherwise, the highest reduction in FRAP activities were shown at  50 μg/mL concentration  of epicatechin and EEGU were 236.33 and 202.71 µM Fe (II)/µg respectively. Based on these results, EEGU is concluded as an active natural product because it exhibit antioxidant activities.
Pemberian Hidrolisat Protein Kacang Polong Terhadap Kadar Superoksida Dismutase dan Perbaikan Kerusakan Ginjal Tikus Laboratorium Jeanny E Ladi; David Kristiadi Herjanto; Roro Wahyudianingsih; Meilinah Hidayat
Jurnal Kedokteran Meditek Vol 28 No 1 (2022): JANUARI-APRIL
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v28i1.2282

Abstract

Antioksidan merupakan substansi yang dapat mencegah kerusakan sel akibat stres oksidatif. Hidrolisat protein dari kacang polong hijau (Pisum sativum) dengan bromelain (HPPHB) diharapkan meningkatkan kadar antioksidan superoxide dismutase (SOD) dan mampu mencegah kerusakan ginjal. Tujuan penelitian adalah mengetahui pengaruh HPPHB terhadap kadar SOD, kadar kreatinin plasma dan histopatologis ginjal tikus yang diinduksi Cisplatin. Penelitian dilakukan dalam dua tahap, pemberian HPPHB dosis 100, 200 dan 400 mg/kgBB/h selama 28 hari terhadap kadar SOD tikus jantan dan betina Sprague Dawley (SD) tanpa induksi dan tikus yang diinduksi Cisplatin dengan parameter kadar kreatinin plasma dan histopatologis ginjal dengan pewarnaan Hematoksilin Eosin (HE). Hasil menunjukkan kadar SOD kelompok tikus kontrol berbeda bermakna dan sangat bermakna dengan kelompok perlakuan. Hasil pemeriksaan kreatinin plasma menunjukkan terdapat perbedaan yang sangat bermakna (p<0,01) antara kontrol positip dengan kelompok dosis 400 mg/kgBB. Hasil analisis mikroskopis histopatologis parameter nekrosis: kelompok perlakuan dosis 200 menunjukkan paling sedikit nekrosis di antara ke tiga dosis,  berbeda signifikan dengan kontrol positip, maupun kontrol negatip (p<0,05). Parameter densitas sel mesangium, semua kelompok dosis perlakuan tidak berbeda signifikan dengan kontrol negatip maupun kontrol positip. Simpulan, HPPHB meningkatkan kadar SOD dan menunjukkan efek perbaikan kadar kreatinin plasma dan nekrosis sel tubulus ginjal tikus SD yang diinduksi Cisplatin.
Co-Authors AUDYATI GANY Cindra Paskaria David Kristiadi Herjanto Hanna Sari Widya Kusuma Jeanny E Ladi Kartika Suhada Rizal Rizal Roro Wahyudianingsih Rr. Anisa Siwianti Handayani Sijani Prahastuti Stella Tinia Hasiana Wahyu Setia Widodo Wahyu Widowati