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All Journal Indonesian Journal of Pharmaceutical and Clinical Research JURNAL INOVASI KESEHTAN MASYARAKAT
FAHDI, FIRDAUS
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Effect of Omeprazole on the Pharmacokinetics of Piroxicam Profiles with High Performance Liquid Chromatography (HPLC) Method Fahdi, Firdaus; Herviani Sari; Sulasmi; Wahyudi
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 1 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i1.4049

Abstract

Piroxicam is an anti-inflammatory drug of the NSAID class that is commonly used as an analgesic and anthireumatic drug. Its use is often combined with gastric drugs, one of which is omeprazole, considering the side effects of piroxicam which can irritate the stomach. Piroxicam and omeprazole work on the same enzyme, CYP-450 so that it can affect the pharmacokinetic profile especially in the metabolic and excretion phases of piroxicam. This research is an experimental study using 3 male rabbits. Measurement of plasma levels of piroxicam drug is carried out using a High Performance’s Liquid Chromatography (HPLC) tool. The validation method is used to determine LOD and LOQ values, accuracy, and precision tests. The results of data analysis using t-tables. The results showed the value of pharmacokinetic parameters in the absorption phase increased or there were differences but did not show any significant effect on each group. While the pharmacokinetic parameter values ​​in the metabolic and excretion phases decreased and showed no differences between groups. The administration of omeprazole and piroxicam together and the administration of piroxicam which was given an hour earlier by omeprazole can inhibit the enzyme that stimulates the metabolism of piroxicam so that it affects the pharmacokinetic parameters in the absorption phase and also excretion but is not significant.
ANALYSIS OF FACTORS THAT INFLUENCE THE LOW UTILIZATION OF HEALTH SERVICES IN INPATIENT ROOMS IN THE COMMUNITY IN RSUD TUAN RONDAHAIM PEMATANG RAYA KABUPATENSIMALUNGUN IN 2019 Nerdy, Nerdy; Siagian, Nurul; Fahdi, Firdaus
Jurnal Inovasi Kesehatan Masyarakat Vol 2 No 2 (2021): Jurnal Inovasi Kesehatan Masyarakat
Publisher : Fakultas Kesehatan Masyarakat, Institut Kesehatan Deli Husada Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jikm.v2i2.871

Abstract

The hospital is a center for public health services in an effort to prevent, restore and cure diseases and improve health status. The increasing level of community life is the increasing also the demands of the community on quality of health. To find out factors that effect the low utilization of health services in the hospitalization of community in RSUD Tuan Rondahaim Pamatang Raya. The number of sampel was 97 responden who get 2.777 hospitalization in that hospital in 2017.The type of research used is analytic survey research with cross secsional design,namely research conducted at the same time but with different subject. The results showed that there was a significant influence between sex and service utilization, The level of education has a significant effect on service utilization. Income has a significant influence with the utilization of health services. Hospital facilities had a significant influence with the utilization of health services. The distance to the service location had a significant influence with the utilization of health services, trust with the utilization of health services. Types of illness with utilization of health services. Trust is the most dominant factor in the utilization of health services with a value of RP = 25,260 (95% CI: 4,022-158,645), it means that the tendency of respondents to believe in a good health service place is 25,260 times greater than those who do not believe in a health service in a hospital. There was no significant influence between age, occupation and service costs with the utilization of health services (p> 0.05).It is expected that hospitals will maintain and provide the best services, and continue to make improvements regarding the availability of more complete facilities, types or variations of health services.
Co-Authors Herviani Sari Nerdy, Nerdy Siagian, Nurul Sulasmi Wahyudi