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NEBIVOLOL: A THIRD GENERATION BETA BLOCKER AS ANTIHYPERTENSION AGENT Ni Putu Wirantari; I Made Jawi; Bagus Komang Satriyasa
E-Jurnal Medika Udayana vol 2 no 7 (2013):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Hypertension is a silent killer because it causes complications in vital organs unwitting patients. Beta blockers are generally a choice of safe and effective drugs for initial treatment of hypertension. However, the current hypertension treatment guidelines said beta blockers were not suitable use as first-line therapy because of complications caused. On the use of atenolol found an increased incidence of cardiovascular death of 24%, 14% and cardiac complications 23% cerebrovascular complications. Nebivolol is a third-generation beta-blocker that is highly selective for ?1-adrenergic receptors and has the ability as a direct vasodilator was able to stimulate the activity of endothelial L-arginin/nitric oxide synthase, is expected nebivolol can reduce blood pressure so can achieve blood pressure that expected.
THE EXTRACT OF PURPLE SWEET POTATO DECREASE BLOOD AND LIVER MDA OF MICE AFTER INTENSE PHYSICAL ACTIVITY I Made Jawi; Dewa Ngurah Suprapta; A.A. Ngurah Subawa
Jurnal Veteriner Vol 9 No 2 (2008)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

Oxidative stress as consequence of intense physical exercises cause tissue lesions. The objective of this study was to identify the comparable antioxidant effect of water extract and syrup of Balinese purple sweet potato to the liver tissue in mice after maximal exercise, through the quantification of blood and liver malondialdehyde (MDA), and the histologic feature of liver tissue. Subjects of this study were 60 adult male Swiss mice divided into 6 groups with control group post-test only design. Blood and liver were collected after exercise protocol of exhausting swimming in ten mice without water extract, ten mice with water extract and ten mice with syrup of Balinese purple sweet potato. The MDA was quantification with TBARS method. Samples were also collected from control group of ten mice without water extract, ten mice with water extract and ten mice with syrup of Balinese purple sweet potato as sedentary mice. The results show a significant increase of MDA in the blood and liver, after swimming with and without water extract or syrup of Balinese purple sweet potato respectively (p<0,05). The increase of MDA was slightly significant in the group with water extract or syrup of Balinese purple sweet potato (p<0,05). The increase of liver cell necrosis was slightly significant in the group with water extract of Balinese purple sweet potato (p<0,05). From this finding it can be concluded that water extract or syrup of Balinese purple sweet potato has antioxidant effect in exhausting exercise in mice. Water extract of Balinese purple sweet potato has protective effect to the liver cell in exhausting exercise in mice
GLUTAMIN MEMPERCEPAT WAKTU PEMULIHAN JUMLAH SEL LIMFOSIT LIEN SETELAH AKTIVITAS FISIK MAKSIMAL PADA MENCIT (GLUTAMINE SHORTENS RECOVERY TIME OF LIEN LYMPHOCYTES AFTER EXCESSIVE PHYSICAL ACTIVITY IN MICE) I Made Jawi; Ketut Budiasa
Jurnal Veteriner Vol 8 No 2 (2007)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

The immunologic? system? of the body requires? suitable recovery time after? excessive physical? activity. The recovery? time of spleen lymphocytes after? excessive? physical activity? in one? investigation was? 3? days. The? aim? of this? research is to identify?the role of? glutamine? in shortening? the recovery time of? spleen? lymphocytes? after?excessive physical activity. The? study? was conducted? on? 70? adults? Balb/c mice which? were? divided? into? 7? groups, with? a randomized control? group post-test? only design. In this? study? an observation? was made on? spleen? lymphocytes? of control, after? excessive? physical activity(in the the? form of swimming? until? near? drowning) with glutamine,? without glutamine ?and? after? the? recovery time of 1 and 2 days? of? each of? the 10 mice. Spleen? lymphocytes? were? counted in spleen preparation by mikroskop. The data obtained were tested? by? one way Anova. The findings? showed? that the number of spleen? lymphocytes significantly decrease after? excessive? physical activity?? in the?glutamine? and? non glutamine groups ( p < 0,05).The number of spleen? lymphocytes? was? not different as compered to control group or returned? to normal after recovery? time? of 1? day? in? the? glutamine group (p > 0,05 ).?In the nonglutamine group the number of spleen lymphocytes was different from control group until 2 days (p<0,05 ). From this finding it can be concluded that glutamine? shortens the recovery time of spleen lymphocytes? after? excessive? physical activity in mice.
Ekstrak Air Umbi Ubijalar Ungu Menurunkan Total Kolesterol serta Meningkatkan Total Antioksidan Darah Kelinci I Made Jawi; Ketut Budiasa
Jurnal Veteriner Vol 12, No 2 (2011)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

High cholesterol diet can increase blood total cholesterol and the incidence of cardiovascular disease.Flavonoid from fruits and vegetables can prevent those conditions due to it’s antioxidant effect. The aimof this study was to examine hypolipidemic and antioxidant possible effects of water extract of purplesweet potato, on blood of local rabbit with high cholesterol diet. This studies used 20 female adult localrabbit which were divided into 2 groups by using randomized pre-test and post-test control group design.Before treatment blood samples were collected from auricula venous to examine the total cholesterol, LowDensity Lipoprotein(LDL), High Density Lipoprotein (HDL), triglyseride, malondialdehide (MDA), totalantioxidant, Serum Glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamic Piruvic Transaminase(SGPT), and haemoglobin concentration, as pretest data. After pre-tests, group 1 was given high cholesteroldiet without water extract of purple sweet potato. In contrast group 2 was given high cholesterol diet withwater extract of purple sweet potato. After 3 months of the treatment the blood were collected for posttestexamination. The data was analysed by using t-test. The result showed a significant increase in totalcholesterol, LDL, SGOT,SGPT, and MDA in the blood of group 1( p<0,05), whereas there was a significantdecrease in HDL at the same group (p<0,05). However, after 3 months of the treatment, all of the parametersin group 2 (except the total cholesterol) were not significantly different with the pretest result (p>0.05),although there was a significant difference compared to the control group (p<0.05). Total cholesterol wassignificantly decreased after 3 months of treatment in group 2 (p<0,05). It can be concluded that waterextract of purple sweet potato can keep the lipid profiles in normal range values, prevent the increase ofMDA, increase blood total antioxidant, decrease blood total cholesterol, and safe for the rabbit liver thatgiven high cholesterol diet.
UMBI UBI JALAR UNGU BALI (Ipomoea batatas) DI TRANSAMINASE SERUM, MALONDIALDEHIDE HEPAR DAN ALKOHOL KRONIS I Wayan Putu Sutirta-Yasa; I Made Jawi; Ida Bagus Ngurah; Anak Agung Ngurah Subawa
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 3 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i3.1170

Abstract

Oxidative stress as a consequence of chronic alcoholic intake causes lesions of liver tissue. The objective of this study was to identifythe antioxidant effect of ethanol extract derived from Balinese purple sweet potato on the liver tissue in mice after chronic consumptionof alcohol. Subjects of this study were 32 adults male Swiss mice (12–14 weeks) divided into 4 groups with control group post-testonly design. Post-treatment of blood and liver samples were collected from each group of 8 mice. The MDA liver was quantified withthiobarbituric acid reactive substances (TBARS) method. Samples were collected from control group of 8 mice without sweet potatoextract and alcohol, 8 mice with 1 mg extract of Balinese purple sweet potato, 8 mice with 0.8 gram alcohol, and 8 mice with combineof alcohol and extract of Balinese purple sweet potato, each treatment was carried out every day for 4 weeks. The results showed asignificant increase of serum SGOT, SGPT and liver MDA level, after chronic consumption of alcohol (p = 0.00). The decrease of serumSGOT, SGPT and liver level MDA was significant in the group with extract of Balinese purple sweet potato (p = 0.00). The researchersconcluded that the extract of Balinese purple sweet potato had an antioxidant effect in mice which consumed alcohol chronically. Basedon this study it is concluded that extract of Balinese purple sweet potato has a protective effect on the liver cell in mice which consumedalcohol chronically.
EKSTRAK ETANOL UMBI UBI JALAR UNGU (Ipomoea batatas L) MENINGKATKAN KETEBALAN MIOMETRIUM & JUMLAH KELENJAR ENDOMETRIUM Desak Putu Citra Udiyani; I Made Jawi; Wayan Sugiritama; I Gusti Kamasan Nyoman Arijana
E-Jurnal Medika Udayana Vol 10 No 10 (2021): Vol 10 No 10(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/10.24843.MU.2021.V10.i10.P07

Abstract

Menopause merupakan proses fisiologis Wanita, namun dengan terapi Hormone Replacement Therapy (HRT) menimbulkan efek endometriosis dan tromboemboli vena. Umbi ubi jalar ungu (Ipomoea batatas L merupakan tumbuhan dengan antosianin. Antosianin mampu meningkatkan ketebalan miometrium dan jumlah kelenjar endometrium. Tujuan penelitian: penelitian ini membuktikan ekstrak etanol umbi ubi jalar ungu (Ipomoea batatas L) mampu meningkatkan ketebalan miometrium dan jumlah kelenjar endometrium uterus. Metoda penelitian: peneliaian dilakukan dengan rancangan penelitian True Experimental-Post Test Only Control Group Design dengan 28 ekor tikus betina Wistar dibagi 4 kelompok (@7 ekor tikus): kelompok kontrol (P0), esktrak etanol umbi ubi jalar ungu dosis 10 mg/kgBB (P1), 30 mg/kgBB (P2), dan 100 mg/kgBB (P3) diberikan selama 30 hari melalui sonde, hari ke 30 dilakukan pengangkatan uterus dan dan melihat ketebalan miometrium dan jumlah kelenjar endometrium uterus diamati secara histologi.Hasil penelitian menunjukkan bahwa: Rerata ketebalan miometrium uterus antar kelompok perlakuan berbeda secara statistik (signifikansi p=0,000). Ketebalan miometrium paling tinggi pada kelompok P3. Rerata jumlah kelenjar endometrium antar kelompok perlakuan berbeda secara statistik (signifikan dengan p=0,000) dengan jumlah kelenjar endometrium yang paling tinggi pada kelompok P3. Kesimpulan: hasil penelitian ini menyimpulkan ekstrak etanol umbi ubi jalar ungu dapat meningkatkan ketebalan miometrium dan jumlah kelenjar endometrium uterus tikus putih yang diovariektomi. Kata kunci: Ekstrak, ubi jalar ungu, antosianin, uterus
KOMBINASI EKSTRAK SAMBILOTO DENGAN METFORMIN LEBIH BAIK DALAM MEMPERBAIKI SEL BETA PULAU LANGERHANS DARI PADA METFORMIN TUNGGAL PADA TIKUS DIABETES Eva Dharma Yanti; , Ni Wayan Sucindra Dewi; I Made Jawi
E-Jurnal Medika Udayana Vol 8 No 2 (2019): Vol 8 No 2 (2019): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

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Abstract

Diabetes mellitus merupakan penyakit akibat gangguan insulin karena kerusakan pankreas yang ditandai dengan hiperglikemi. Obat lini pertama untuk pasien diabetes adalah metformin yang bekerja di hepar tetapi tidak memiliki efek pada sel beta sehingga pankreas tetap mengalami kerusakan akibat stress oksidatif. Saat ini banyak tanaman di Indonesia yang telah diteliti dapat memproteksi sel beta dan memperbaiki fungsi sekresi insulin, salah satunya adalah sambiloto. Penelitian ini merupakan penelitian eksperimental menggunakan 25 ekor tikus diabetes diinduksi aloksan dan dikelompokkan menjadi lima kelompok perlakuan. Kelompok P1 sebagai kontrol positif, P2 diberikan metformin 50mg/kg BB, P3 diberikan sambiloto 50mg/200g BB dan metformin 50mg/kg, P4 diberikan sambiloto 100mg/200g BB dan metformin 50mg/kg BB, P5 diberikan sambiloto 50mg/200g BB. Data dianalisis menggunakan uji ANOVA. Skor kerusakan pulau Langerhans pankreas didapatkan perbedaan rerata secara statistik bermakna sebesar 7,00 pada P1; 5,60 pada P2; 2,20 pada P3; 2,00 pada P4; dan 3,00 pada P5, namun gula darah puasa tidak bermakna secara statistik (p > 0,05). Sehingga efek kombinasi sambiloto dan metformin lebih baik dalam memperbaiki pulau Langerhans pankreas dari pada metformin tunggal. Kata Kunci: Diabetes Mellitus, Metformin, Ekstrak Sambiloto, Tikus Diabetes, Pankreas, Kadar Gula Darah