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All Journal Microbiology Indonesia MATAPPA: Jurnal Pengabdian Kepada Masyarakat Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Lumbung Farmasi : Jurnal Ilmu Kefarmasian
Lina Rahmawati Rizkuloh
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology

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In Silico Study on Testing Antidiabetic Compounds Candidate from Azaphilone Mold Monascus sp. Anna Yuliana; Hilman Fitriaji S P; Khofi Siti Mukhaufillah; Lina Rahmawati Rizkuloh
Microbiology Indonesia Vol. 14 No. 2 (2020): June 2020
Publisher : Indonesian Society for microbiology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1556.808 KB) | DOI: 10.5454/mi.14.2.2

Abstract

Monascus sp. is a mold that is used for rice fermentation so that the brown rice is produced (Red Mold Rice) or Angkak. This rice has long been used on Asian food and traditional medicine. Angkak contains many bioactive compounds, including monakolin which is potentially to be used as nutraceutical. Monascus sp. produced pigments include yellow (Ankaflavin, Monaskin), Orange (Rubropunktatin, Monaskorubrin) and Red (Rubropunktamin, monaskorubramin) which have various biological activities. The purpose of the study was to know the pigments of the Monascus sp. as a compound antidiabetic candidate. This includes the Azaphilone Kapang Monascus sp. derivative compound In Silico. The test compound consists of 57 compounds of Monascus sp. Glycogen Fosforilase used as an antidiabetic receptor. Ligan preparation is drawn using ChemDraw software then with Marvin Sketch done Protonasi. Testing Drug Scan (Screening ligand based Drug likeness). The preparation of receptors by downloading antidiabetic receptors in Protein Data Bank (GDP). The ADME study was conducted with PreADMET web-based software. Validate the docking method and molecular tethering using the Autodock software 4.2.6. Drugscan test results on compounds Isolate MPs4 have qualified grades in all parameters such as molecular weight, proton donor, proton acceptor, log p and molar refractory. The results of the ADME test in the compound Isolate MPs4 have a qualified value in all parameters Caco-2, HIA (Human Intestinal Absorption), as well as in the PPB (Protein Plasma Binding). The result of the docking test in the Isolate compound MPs4 to be the best and qualified compound because it has a smaller affinity binding than the natural ligands and the comparator ligand (glibenclamide). The result of this research Isolate MPs4 is the candidate for new drugs antidiabetic. Keyword : Monascus sp., In silico, Azaphilone, Docking, Antidiabetic
Pelatihan Pembuatan Tepung Gadung di Kecamatan Salawu Kabupaten Tasikmalaya Dalam Rangka Diversifikasi Pangan Pasca Pandemi Covid-19 Susanti Susanti; Lina Rahmawati Rizkuloh; Richa Mardianingrum
MATAPPA: Jurnal Pengabdian Kepada Masyarakat Volume 4 Nomor 4 Tahun 2021
Publisher : STKIP Andi Matappa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31100/matappa.v4i4.1427

Abstract

Coronavirus Disease 2019 (Covid-19) merupakan penyakit infeksi virus yang telah menjadi pandemi di seluruh dunia termasuk Indonesia sejak awal tahun 2020. Kondisi tersebut sangat mempengaruhi banyak aspek kehidupan, terutama aspek kesehatan dan perekonomian masyarakat.. Pemanfaatan umbi gadung sebagai sumber daya alam lokal yang kaya akan manfaat dalam rangka diversfikasi pangan dapat menjadi solusi permasalahan yang disebabkan pandemi Covid-19 dengan tujuan untuk meningkatkan kesehatan dan membantu memulihkan ekonomi masyarakat. Kurangnya pengetahuan masyarakat mengenai potensi umbi gadung sebagai sumber pangan menjadi masalah, khususnya dalam pengolahan umbi gadung yang mempunyai kandungan sianida yang cukup tinggi. Oleh karena itu dilakukan pelatihan pembuatan tepung gadung yang baik dan benar agar dapat dijadikan tepung yang dapat diolah menjadi berbagai produk makanan dan layak konsumsi.  Kegiatan pelatihan ini dilakukan kepada masyarakat Kecamatan Salawu Kabupaten Tasikmalaya. Kegiatan terdiri dari sosialisasi manfaat umbi gadung sebagai sumber pangan lokal yang bergizi dan pelatihan pembuatan tepung umbi gadung yang baik dan benar. Dengan adanya kegiatan ini, pengetahuan masyarakat mengenai manfaat dan pembuatan tepung gadung meningkat dilihat dari hasil evaluasi setelah dilakukan sosialisasi dan pelatihan. Selain itu dengan adanya kegiatan ini masyarakat memiliki keterampilan baru dalam mengolah umbi gadung menjadi suatu tepung serbaguna yang bergizi sehingga bisa meningkatkan taraf kesehatan dan bisa dijadikan produk khas daerah bernilai ekonomi yang dapat meningkatkan perekonomian masyarakat setempat pasca pandemic covid-19.
Uji Aktivitas Antidiare Ekstrak Etanol Daun Katuk (Breynia androgyna (L.)) pada Mencit Putih dengan Metode Transit Intestinal Nitya Nurul Fadilah; Gina Septiani Agustien; Lina Rahmawati Rizkuloh
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 3, No 2 (2022): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v3i2.9791

Abstract

ABSTRAKDiare merupakan suatu masalah gangguan pada saluran pencernaan yang ditandai dengan pengeluaran feses cair berulang kali atau lebih dari 3 (tiga) kali sehari atau diare adalah frekuensi terjadinya defekasi lebih sering dari keadaan normal. Tanaman katuk mengandung senyawa-senyawa kimia meliputi flavonoid, saponin dan tanin. Tanin merupakan salah satu zat yang berkhasiat sebagai adstringensia sehingga diduga mampu memberikan efek antidiare.Tujuan penelitian ini adalah untuk melihat aktivitas antidiare dari tanaman katuk (Breynia androgyna).   Metode yang digunakan untuk menguji efek antidiare ekstrak etanol daun katuk yakni menggunakan metode transit intestinal. Dosis yang digunakan berturut-turut adalah (dosis I) 40 mg (dosis II) 80 mg dan (dosis III) 160 mg/20g BB. Berdasarkan hasil yang didapatkan pada uji aktivitas antidiare ekstrak etanol daun katuk dapat diketahui bahwa ekstrak daun katuk memiliki efek sebagai antidiare yang ditunjukkan dengan nilai rasio transit intestinal terbaik sebesar 0.39 pada dosis III sebesar 160mg/20gBB dan secara statistik siginifikan (p<0.05)   terhadap kontrol negatif. Kata kunci : Diare; Daun Katuk; Transit Intestinal; Tanin.ABSTRACTDiarrhea is a problem in the digestive tract, which is characterized by repeated discharge of liquid stools or more than 3 (three) times a day or diarrhea is the frequency of defecation more often than normal. Katuk plant contains chemical compounds including flavonoids, saponins and tannins. Tannins are one of the substances that are efficacious as an adstringensia so that they are thought to have an antidiarrheal effect. The purpose of this study was to see the antidiarrheal activity of the katuk (Breynia androgyna) plant. The method used to test the antidiarrheal effect of the ethanolic extract of katuk leaves is using the intestinal transit method. The doses used were (dose I) 40 mg (dose II) 80 mg and (dose III) 160 mg/20g BW. Based on the results obtained in the antidiarrheal activity test of the ethanol extract of katuk leaves, it can be seen that the katuk leaf extract has an antidiarrheal effect as indicated by the best intestinal transit ratio value of 0.39 at dose III of 160mg/20gBW and statistically significant (p<0.05) against the control negative. Keywords : Diarrhea; Katuk Leaves; Intestinal Transit; Tannins
UJI SPF DAN AKTIVITAS ANTIBAKTERI SEDIAAN SUNSCREEN POWDER EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava L.) TERHADAP Propionibacterium acnes Nurul Halimah Amimi; Lina Rahmawati Rizkuloh; Susanti
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 2 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i2.5767

Abstract

Every human being has different skin problems. Skin problems caused by sun exposure and acne-causing bacteria can be overcome by using a sunscreen powder that contains anti-acne. Natural ingredients that can overcome these problems are guava leaves (Psidium guajava L.) because they contain flavonoid compounds that can absorb ultraviolet light and have antibacterial activity. This study aims to determine the ability of guava leaves as a sunscreen by determining the value of SPF (Sun Protection Factor) using a UV-Vis spectrophotometer and as an anti-acne by calculating the inhibition of Propionibacterium acnes bacteria using the well diffusion method. The preparation formulation uses a variation in the concentration of guava leaf extract of 2.5%, 5%, and 7.5%. The results showed that guava leaf extract can be formulated into a sunscreen powder that meets the requirements. Based on the data obtained, the SPF value and inhibition zone diameter increased according to the high concentration of guava leaf extract used. All three formulas have an SPF value in the maximum protection category. Formula 3 (7.5%) has the highest SPF value of 15.00. The results of bacterial inhibition zone activity in formulas 1 (2.5%) and 2 (5%) were included in the strong category, while formula 3 (7.5%) had an inhibition of 21.33 mm, which was included in the very strong category.
Co-Authors Anna Yuliana, Anna Gina Septiani Agustien Hilman Fitriaji S P Khofi Siti Mukhaufillah Nitya Nurul Fadilah Nurul Halimah Amimi Richa Mardianingrum Susanti Susanti Susanti