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Ongkowijaya, Jeffrey A.
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Nursing Public Health

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Hubungan Kadar Vitamin D dan Kadar C-Reactive Protein dengan Klinis Pasien Coronavirus Disease 2019 Berhandus, Catrien; Ongkowijaya, Jeffrey A.; Pandelaki, Karel
e-CliniC Vol 9, No 2 (2021): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v9i2.33043

Abstract

Abstract: COVID-19 patients could experience many respiratory symptoms accompanied with increased inflammatory markers, such as C-reactive protein (CRP). Vitamin D is known to have a positive effect on immune system by decreasing inflammatory process. This study was aimed to evaluate the relationship between vitamin D and CRP concentration and clinical severity, and the correlation between vitamin D concentration and CRP concentration in COVID-19 patients. This was an observational and analytical study with a cross-sectional design conducted at Prof. dr. R. D. Kandou hospital. A total of 40 subjects with COVID-19 were included. Clinical severity was classified into moderate and severe. All subjects underwent vitamin D and CRP concentration examination. The results showed that there was a significant relationship between vitamin D level and clinical severity of patients with COVID-19 (p=0.0001). There was a significant relationship between CRP level and clinical severity of patients with COVID-19 (p=0.0001). Moreover, there was a negative correlation between vitamin D concentration and CRP concentration (r=-0.49, p=0.001). In conclusion, vitamin D insufficiency or deficiency is related to CRP increament and clinical severity of patients with COVID-19.Keywords: coronavirus disease 2019, vitamin D, C-reactive protein (CRP), clinical severityAbstrak: Penderita COVID-19 mengalami berbagai gejala pernapasan disertai dengan pening-katan beberapa penanda inflamasi, salah satunya C-reactive protein (CRP). Vitamin D diketahui memiliki efek positif terhadap sistem imun tubuh dengan cara meredam proses inflamasi berlebihan. Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan antara kadar vitamin D dan kadar CRP dengan klinis COVID-19, dan korelasi antara kadar vitamin D dengan kadar CRP. Jenis penelitian ini ialah studi analitik observasional dengan desain potong lintang yang dilakukan di RSUP Prof. dr. R. D. Kandou. Total sampel sebanyak 40 pasien dengan diagnosis COVID-19. Gejala klinis pasien dibagi menjadi sedang dan berat. Pemeriksaan kadar vitamin D dan kadar CRP dilakukan pada seluruh sampel. Hasil penelitian mendapatkan hubungan bermakna antara kadar vitamin D dengan klinis pasien COVID-19 (p=0,0001), dan antara kadar CRP dengan klinis pasien COVID-19 (p=0,0001). Terdapat korelasi negatif antara kadar vitamin D dengan kadar CRP (r=-0,49, p=0,001). Simpulan penelitian ini ialah insufisiensi atau defisiensi vitamin D berhubungan dengan peningkatan CRP dan klinis pasien COVID-19.Kata kunci: coronavirus disease 2019, vitamin D, C-reactive protein (CRP), gejala klinis
Gambaran Hiperurisemia pada Subyek Keturunan Hipertensi dan Tidak Keturunan Hipertensi Berhandus, Catrien; Ongkowijaya, Jeffrey A.; Kaparang, Adeodata M. C.
Medical Scope Journal Vol 3, No 1 (2021): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.3.1.2021.33044

Abstract

Abstract: Hypertension is one of the most common cardiovascular diseases worldwide. Hyperuricemia is considered if serum uric acid level >7 mg/dl in men and >6 mg/dl in women. This condition is not only associated with gout but has other associations with various diseases such as cardiovascular disease, systemic inflammation, endothelial dysfunction, and hypertension. This study was aimed to obtain the description of serum uric acid levels among people who had family history of hypertension and those who did not. This was a descriptive and observational study with a cross-sectional design. Samples were obtained at Prof. dr. R. D. Kandou Manado by using consecutive sampling, and then were divided into two groups, with and without family history of hypertension; each of 20 people. Of the group with family history of hypertension, 12 were male (60%) and 8 were female (40%), while of the other group, 10 were male (50%) and 10 were female (50%). Based on serum uric acid levels, 6 (30%) of the group with family history of hypertension had hyperuricemia, while 3 (15%) of the other group had hyperuricemia; all of them were male. In conclusion, people with family history of hypertension had hyperuricemia more frequently compared to those without family history of hypertension, with dominant male sex in both groups.Keywords: uric acid; family history of hypertension; hyperuricemia Abstrak: Hipertensi masih merupakan salah satu penyakit kardiovaskular yang paling umum di seluruh dunia. Hiperurisemia ditetapkan bila kadar serum asam urat >7 mg/dl pada laki-laki dan >6 mg/dl pada perempuan. Hiperurisemia tidak hanya berhubungan dengan gout tetapi memiliki hubungan dengan berbagai penyakit seperti penyakit kardiovaskular, inflamasi sistemik, disfungsi endotel, dan hipertensi. Penelitian ini bertujuan untuk mendapatkan gambaran asam urat pada subyek keturunan hipertensi dan tidak keturunan hipertensi. Jenis penelitian ialah observasional deskriptif dengan desain potong lintang. Sampel diperoleh di RSUP Prof. Dr. R. D. Kandou Manado menggunakan consecutive sampling dan dibagi atas dua kelompok, yaitu keturunan hipertensi dan tidak keturunan hipertensi dari hasil anamnesis; masing-masing terdiri dari 20 orang. Dari kelompok keturunan hipertensi didapatkan 12 subyek laki-laki (60%) dan 8 perempuan (40%), sedangkan dari kelompok lainnya sebanyak 10 subyek laki-laki (50%) dan 10 subyek perempuan (50%). Berdasarkan kadar asam urat, dari kelompok keturunan hipertensi sebanyak 6 orang (30%) mengalami hiperurisemia, sedangkan pada kelompok lainnya sebanyak 3 orang (15%) mengalami hiperurisemia. Semua subyek pada kedua kelompok yang mengalami hiperurisemia berjenis kelamin laki-laki. Simpulan penelitian ini ialah subyek keturunan hipertensi lebih banyak mengalami hiperurisemia dibandingkan subyek tidak keturunan hipertensi, dengan jenis kelamin laki-laki dominan pada kedua kelompok.Kata kunci: asam urat; keturunan hipertensi; hiperurisemia
Co-Authors Berhandus, Catrien Kaparang, Adeodata M. C. Karel Pandelaki