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All Journal Green Medical Journal
Asyura, Muhammad Mikail Athif Zhafir
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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Potensi Inhibitor Protein Non-struktural 1 (NS1) Berbasis Peptida untuk Mengobstruksi Replikasi Virus Dengue (DENV): Sebuah Kajian Literatur Asyura, Muhammad Mikail Athif Zhafir; Fauzi, Ahmad; Ayub, Fakhru Adlan
Green Medical Journal Vol 3 No 1 April (2021): Green Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/gmj.v3i1.71

Abstract

Introduction: Dengue Virus (DENV) is the pathogen for human dengue fever and is responsible for 390 million infections per year. The viral genome produces about 10 viral protein products, one of them being NS1. The NS1 protein plays a key role in viral replication and stimulation of humoral immune cells, thus being the perfect candidate to create an effective antiviral drug or vaccine for dengue Methods: Dengue Virus (DENV) is the pathogen for human dengue fever and is responsible for 390 million infections per year. The viral genome produces about 10 viral protein products, one of them being NS1. The NS1 protein plays a key role in viral replication and stimulation of humoral immune cells, thus being the perfect candidate to create an effective antiviral drug or vaccine for dengue Conclusion: The review established promising results of using peptide-based intervention on NS1. Further in vivo and randomized controlled trials are advised to solidify the applicability and biosafety of the intervention
Co-Authors Ayub, Fakhru Adlan Fauzi Ahmad Muda