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All Journal Medula Indian Journal of Forensic Medicine & Toxicology Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek)
Muhartono
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Biochemistry, Genetics & Molecular Biology Education Environmental Science Medicine & Pharmacology Neuroscience Public Health

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Hubungan Antara Hipertensi dan Usia dengan Angka Kejadian Kanker Payudara Di RSUD Dr. H. Abdul Moeloek Bandar Lampung Tahun 2018 Mohamad Reihansyah Deswindra; Muhartono; Rizki Hanriko; Waluyo Rudiyanto
Medula Vol 10 No 1 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i1.12

Abstract

Breast cancer is one of the most highest incidence rate cancer in all countries. Age and Hypertension is known as risk factor for breast cancer. The purpose of this study is to know the relation between hypertension and age with breast cancer incidence rates in Dr. H. Abdul Moeloek Bandar Lampung. The method of this study is observational analytic study with case control design. The data that used are secondary data that gathered from medical records of patients in Dr. H. Abdul Moeloek Hospital and taken with consecutive sampling method. The data is analyzed using univariate and bivariate analysis using Chi-square test and Fisher test. The result is in the case group, hypertension percentage obtained was 12.5% ​​while those whose has not hypertension was 87.5%. In the control group the percentage of hypertension was 8.3% while those whose has not hypertension was 91.7%. In the case group ≥50 years of age percentage obtained was 54.2% while at age <50 years was 45.8%. In the control group ≥50 years of age percentage of 16.7% while at age <50 years at 83.3%. The results showed that age ≥50 years have a p value = 0,007 with OR = 5,909 and hypertension group have a p value = 0.500. The conclusion of this study is, there is no the relationship between hypertension and breast cancer incidence rates Lampung and there is relationship between the age of patients with breast cancer incidence rates in the Hospital of Dr. H. Abdul Moeloek Bandar Lampung.
Pengaruh Pemberian Ekstrak Etanol Rimpang Lengkuas (Alpinia galanga) terhadap Gambaran Histopatologi Testis Mencit (Mus musculus L.) jantan yang Diinduksi Monosodium Glutamat Annisa Shafira Pramono; Muhartono; Rizki Hanriko; Eca Cania
Medula Vol 10 No 1 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i1.43

Abstract

Monosodium Glutamate (MSG) may form free radicals that cause damages to the organs of the body, one of which is the male reproductive organs, i.e. testes. Galangal rhizome is one of the natural ingredients with antioxidant content that can neutralize free radicals. The purpose of this research was to determine the effect of ethanol extract of galangal rhizome on testicular histopathology of MSG-induced male mice. The design of this research was experimental research with 5 treatment groups, each group consisted of 5 mice (Mus musculus L.) DDY strain. Group K (-) was not treated; k (+) was provided with 4 mg/ grBB MSG; P1 was provided with 4 mg/ grBB MSG + 14 mg/ 20 grBB ethanol extract of galangal rhizome; P2 was provided with 4 mg/ grBB MSG + 28 mg/ 20 grBB ethanol extract of galangal rhizome; P3 was provided with 4 mg/ grBB MSG + 56 mg/ 20 grBB ethanol extract of galangal rhizome. Assessment used Johnsen score in group K(-) was 48,4, K(+) was 47,4, P1 was 47,4, P2 was 47,4, and P3 was 48. Kruskal-Wallis test result was p=0,085 (p>0,05). The conclusion was that ethanol extract of galangal rhizome did not effect significantly (p>0,05) on the testicular histopathology of monosodium glutamate-induced mice.
Biomarker Tumor pada Kanker Paru Dimas; Muhartono
Medula Vol 11 No 1 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i1.187

Abstract

Tumor markers play an important role in cancer detection and guide patient management. In healthy asymptomatic individuals, biological markers can be used to identify sufferers at high risk of developing malignancy and in screening for early cancer. After diagnosis of malignancy, biomarkers can be used in determining prognosis, prediction of advance therapy, postoperative surveillance and monitoring response to ongoing therapy. Biomarkers are simply defined as components that can be used to distinguish abnormal and normal images, making for better diagnostic measures for lung cancer that facilitate early detection of disease, therefore enabling effective interventions, are needed to reduce lung cancer mortality. in both men and women, lung cancer is the most frequently diagnosed cancer and the leading cause of cancer death. In addition, the incidence rate is increasing in many countries. Many lung cancer patients have a poor prognosis because it is usually diagnosed at an advanced stage. Therefore, there is an urgent need to develop effective methods for early diagnosis of lung cancer. Several systematic reviews have evaluated the value of biomarkers for diagnosing lung cancer. However, it is still unclear which biomarkers have superior performance for early and accurate detection of lung cancer. This literature review presents the potential of biomarker detection which in the future can be developed into major biomarkers that are more beneficial for patients.
Potensi Metformin sebagai Agen Anti-Kanker Ni Made Dewi Puspita Sari; Muhartono; M. Yusran
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.271

Abstract

Metformin is one of the often prescribed anti-diabetic drugs. As an anti-diabetes effect, metformin also becomes anti-cancer. The mechanism of metformin as an anti-cancer through direct and indirect effects. Indirect sugar with loss of glucose levels, effects of hyperinsulinemia, levels of Insulin Growth Factor-1 (IGF-1), and immune responses to cancer cells. A direct effect on AMPK activation stimulation which works molecularly on cancer cells. This makes the metformation is potential as an anti-cancer agent alone or in combination with other chemotherapy agents or radiation.
Hubungan Antara Lama Menderita Diabetes Melitus Tipe 2 Dengan Kejadian Peripheral Arterial Disease Pada Pasien Diabetes Melitus Tipe 2 Di Puskesmas Kedaton Kota Bandar Lampung Adinda Ayu Lintang S; Hanna Mutiara; Merry Indah Sari; Muhartono; Ryan Falami
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.286

Abstract

Diabetes mellitus is a metabolic disease with characteristics of hyperglycemia occurs due to abnormalities of insulin secretion, insulin function, or both. Diabetes mellitus causes various kinds of complications, one of which is peripheral arterial disease (PAD). PAD is is a condition characterized by atherosclerotic occlusive disease of the lower extremities. The purpose of this study to knowing the relationship between the length of suffering type 2 diabetes mellitus and the incidence of peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus in Puskesmas Kedaton Kota Bandar Lampung. This research is correlative analytic with cross sectional approach. The study was conducted November 2017. The population in this study were all patients with DM type 2 who joined prolanis activities at Puskesmas Kedaton of Bandar Lampung city. The number of research samples are 40 respondents with consecutive sampling technique. This results has 17 male and 23 women respondents. The average duration of DM is 9.8 years. Respondents with normal were 52.5%, mild PAD 12.5%, moderate 32.5% and severe 2.5%. Spearman test results of both variables obtained p value of 0.001 and correlation value 0.651. The conclusion is there are relationship between length of suffering type 2 diabetes mellitus and the incidence of peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus in Puskesmas Kedaton of Bandar Lampung city.
The SNP rs13118928, rs1828591 and rs10519717 in the HHIP Gene are not Associated on COPD Susceptibility in Male Javanese Smokers Syazili Mustofa; Sutyarso; Muhartono; Yandri; Retno Ariza Soeprihatini Soemarwoto; Hendri Busman; Wawan Abdullah Setiawan
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17108

Abstract

Background: Hedgehog Interacting Protein (HHIP) gene polymorphisms have an association on COPDhas been carried out in Europe and Asia but in Indonesia there is still very limited study on this type andthe largest ethnic group in Indonesia is the Javanese. Objective: To analyze the association between theHHIP gene polymorphism and the incidence of COPD in male Javanese smokers in Lampung, Indonesia.Method: In a case-control study in Javanese male smokers, three single nucleotide polymorphism (SNPs)in the HHIP gene were analyzed by Sanger sequencing method. There were 110 participants in this studywhich were divided into 2 groups, such as COPD group (55 participants) and control group (55 participants).Three SNPs in the gene (rs13118928, rs1828591 and rs10519717) were selected for genotyping. Genotypedistributions were compared between patients and controls. The statistical analysis was carried out with theSPSS program with a chi-square test. Result: The genotypic frequency of the HHIP gene sequence at theSNP position rs1828591, such as AA (52.72%), GG (3.63%) and AG (43.63%) in COPD group, while inthe control group such as AA (38.18%), GG (9.09%) and GG (52.72%; p > 0.05). The genotypic frequencyof the HHIP gene sequence at the SNP position rs13118928 consisted of AA (47.27%) and AG (53.72%)in the control group, while the COPD group consisted of AA (52.72%), GG (1.81%) and AG (45.45%; p> 0.05). The genotypic frequency of the HHIP gene sequence at the SNP position rs10519717 consistedof TT (34.54%), CC (14.56%) and CT (50.90%) in COPD group, while controls group consisted of TT(23.63%), CC (16.37%) and CT (60.00%; p > 0.05). The genotypic analysis of Three SNPs in HHIP genewere observed but showed no significant difference between case and control groups. Conclusion: Singlenucleotidevariants in the HHIP gene are not associated with COPD susceptibility in Javanese male smokers.
Analisis Hubungan Variabel Lingkungan terhadap Kejadian Metastase Kanker Payudara di Rsud Dr. H. Abdul Moeloek Bandar Lampung Tahun 2018 Deby Mipa Salam; Muhartono; Asep Sukohar; Samsul Bakri
Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) 2019: Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (216.587 KB)

Abstract

Banyak faktor-faktor yang dapat menyebabkan seorang wanita menderita kanker payudara dan menyebar ke jaringan lain, terutama faktor lingkungan yang 90% berpengaruh terhadap kejadian kanker payudara. Tujuan dari penelitian ini untuk mengetahui hubungan antara variabel lingkungan terhadap kejadian metastase kanker payudara di RSUD Dr. H. Abdul Moeloek Bandar Lampung tahun 2018. Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional. Sampel terdiri dari 26 orang pasien kanker payudara wanita yang ditentukan dengan teknik purposive sampling. Metode pengukuran berupa hasil wawancara untuk variabel bebas dan rekam medis dan/atau hasil pemeriksaan patologi anatomi untuk variabel terikat. Penelitian dilakukan pada bulan Mei sampai dengan Juli 2018. Teknik analisis pada penelitian ini menggunakan uji Chi-square dan uji Fisher. Hasil penelitian menunjukkan bahwa genetik (p=0,046), paparan asap rokok (p=0,009) dan pestisida (p= 0,028) berhubungan dengan kejadian metastase pada kanker payudara. Dengan demikian dapat disimpulkan bahwa variabel lingkungan berhubungan dengan kejadian metastase kanker payudara.
Co-Authors Adinda Ayu Lintang S Annisa Shafira Pramono Asep Sukohar Deby Mipa Salam Dimas Eca Cania Hanna Mutiara Hendri Busman M. Yusran Merry Indah Sari Mohamad Reihansyah Deswindra Ni Made Dewi Puspita Sari Retno Ariza Soeprihatini Soemarwoto Rizki Hanriko Ryan Falami Samsul Bakri Sutyarso Syazili Mustofa Waluyo Rudiyanto Wawan Abdullah Setiawan Yandri