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All Journal Majalah Kedokteran Bandung Medula Juke Jurnal Kesehatan JURNAL ILMIAH KESEHATAN SANDI HUSADA Bioscientia Medicina : Journal of Biomedicine and Translational Research JURNAL PENELITIAN PERAWAT PROFESIONAL JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia JK Unila (Jurnal Kedokteran Universitas Lampung) Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Nursing and Health Sciences Majority
Rizki Hanriko
Universitas Lampung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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KORELASI ANTARA IMUNOEKSPRESI P53 DAN RESPONS KEMOTERAPI NEOADJUVAN REGIMEN FLUORORASIL, ADRIAMISIN, DAN SIKLOFOSFAMID PADA KARSINOMA DUKTUS PAYUDARA INVASIF Muhartono, -; Hanriko, Rizki
Majalah Kedokteran Bandung Vol 44, No 1 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (915.71 KB)

Abstract

Karsinoma duktus payudara invasif (KDPI) stadium IIIB perlu penanganan multimodalitas. Kemoterapi neoadjuvan (KN) diberikan untuk menurunkan ukuran dan stadium tumor agar dapat dilakukan operasi. Regimen KN yang biasanya digunakan yaitu fluororasil, adriamisin, dan siklofosfamid (FAS). Kemoterapi FAS bekerja dengan cara merusak deoxyribonucleic acid dan menginduksi apoptosis sel kanker. Terjadinya kelainan protein atau gen yang berhubungan dengan apoptosis (p53) diduga mempengaruhi respons kemoterapi tersebut. Tujuan penelitian ini untuk mengetahui korelasi imunoekspresi p53 dengan respons kemoterapi neoadjuvan FAS. Penelitian ini merupakan penelitian analitik potong lintang terhadap 40 kasus KDPI yang diberikan KN FAS di Rumah Sakit Dr. Hasan Sadikin Bandung periode Maret 2008?Februari 2009. Respons KN FAS dinilai berdasarkan ukuran massa tumor setelah pemberian FAS. Blok parafin penderita dibuat pulasan hematoksilin-eosin dan imunohistokimia dengan menggunakan mouse monoclonal antibody p53 protein (Novocastra), kemudian ditentukan tingkat imunoekspresi p53. Uji statistik dengan Somers?d dan Gamma untuk menguji korelasi antar variabel. Nilai p<0,05 secara statistik dianggap bermakna. Pada 40 kasus KDPI, 20 berespons dan 20 kasus tidak berespons terhadap KN FAS; 13 kasus terekspresi p53>75%, 14 kasus p53=10?75%, 7 kasus p53<10%, dan 6 kasus tidak terekspresi p53. Terdapat korelasi bermakna antara imunoekspresi p53 dan respons kemoterapi FAS (p=0,000). Simpulan, semakin tinggi ekspresi p53, semakin tidak berespons terhadap KN FAS. Imunoekspresi p53 dapat memprediksi respons KN FAS pada KDPI stadium IIIB. [MKB. 2012;44(1):13?8].Kata kunci: Karsinoma duktus payudara invasif, imunoekspresi, p53 Correlation between p53 Immunoexpression and Fluorouracyl, Adriamycin and Cyclophosphamide Regimen Neoadjuvant Chemotherapy Responses in Invasive Ductal Breast CarcinomaInvasive ductal breast carcinoma (IDBC) stage IIIB need multimodality treatment. Neoadjuvant chemotherapy (NC) is given to reduce the size and stage of tumor so that surgery can be performed. Neoadjuvant chemotherapy regimens generally used was fluorouracil, adriamycin and cyclophosphamide (FAC). FAC chemotherapy works by damaging deoxyribonucleic acid and induce apoptosis of cancer cells. Abnormalities of proteins or genes associated with apoptosis (p53) is believed to affect the chemotherapy response. This study was purpose to determine correlation between immunoexpression of p53 and response of neoadjuvant FAC chemotherapy in invasive ductal breast carcinoma. The study was a cross sectional analytic study of 40 IDBC cases given FAC NC at Dr. Hasan Sadikin Hospital Bandung between March 2008?February 2009. Response of FAC NC judged on the size of tumor mass following administration of FAC. Haematoxylin-eosin and immunohistochemistry stain using a mouse monoclonal antibody to p53 protein (Novocastra) was made from paraffin blocks of patients, then determined the immunoexpression levels of p53. Somers?d and Gamma statistical were used to test the correlation between variables. The p-value <0.05 was considered statistically significant. In 40 IDCB cases, 20 cases were responded and 20 cases did not respond to FAC NC; 13 cases expressed p53>75%, 14 cases p53 10?75%, 7 cases p53<10%, and 6 cases were not expresed p53; There was a significant correlation between immunoexpression of p53 and the response of FAC chemotherapy (p=0.000). In conclusions, the higher expression of p53, the lower response to NC FAC. Immunoexpression of p53 can predict the response of FAC NC on IDBC stage IIIB. [MKB.2012;44(1):13?8].Key words: Immunoexpression, invasive ductal breast carcinoma, p53 DOI: http://dx.doi.org/10.15395/mkb.v44n1.209
Efek Protektif Jahe Putih Besar (Zingiber Officinale Rosc. Var. Officinarum) terhadap Ulkus Gaster Tikus Jantan Galur Sprague dawley yang Diinduksi Piroksikam Hanriko, Rizki; Anggraini, Dwi Indria; Pairul, Piesta Prima Beta
Jurnal Kedokteran Universitas Lampung Vol 2, No 2 (2018): Jk Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v2i2.1947

Abstract

Tujuan dari penelitian ini adalah mengetahui Efek Protektif Jahe Putih Besar (Zingiber Officinale Rosc. Var. Officinarum) terhadap Ulkus Gaster yang diinduksi oleh Piroksikam. Penelitian ini merupakan penelitian eksperimental metode acak terkontrol dengan pola post only design. 28 ekor tikus putih (Rattus Novergicus) jantan galur Sprague Dawley berumur 10-16 minggu yang dipilih secara acak dan dibagi menjadi 6 kelompok. Kelompok 1 diberikan piroksikam 40mg/200gBB, kelompok 2-5 diberikan Jahe Putih Besar dengan dosis bertingkat yaitu 40mg/200gBB, 80mg/200gBB, 120mg/200gBB dan 160mg/200gBB serta kelompok 6 diberikan Omeprazole 25,2 mg/200gBB. Persentasi penghambatan Ulkus Gaster terbesar hingga terkecil adalah Jahe Putih Besar 160mg/200gBB (77,5%), Jahe Putih Besar 120mg/200gBB (72%), Jahe Putih Besar 80mg/200gBB dan Omeprazole (58%), Jahe Putih Besar 40mg/200gBB (40%). Pada penelitian ini didapatkan hasil bila Jahe Putih Besar 80mg/200gBB dan Omeprazole memiliki efek protektif yang sebanding. Dapat disimpulkan Jahe memiliki efek protektif terhadap ulkus lambung. Kata kunci :Efek protektif, Jahe, Ulkus
Tumor Carcinoid Paru Hanriko, Rizki
Jurnal Kedokteran Universitas Lampung Vol 1, No 3 (2017): JK UNILA
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v1i3.1725

Abstract

Tumor carcinoid paru termasuk dalam tumor neuroendokrin yang terbagi atas tipe typical dan atypical yang berbeda dalam hal prognosis. Menurut data Depkes RI 2007, kasus kanker bronkus dan paru pada pasien rawat inap sebesar 5,8% dari seluruh jenis kanker. Dari semua kanker paru, 1-2% merupakan tumor carcinoid dimana yang terbanyak adalah tipe TCTumor carcinoid paru umumnya terjadi pada usia muda kurang dari 40 tahun dengan kejadian yang sama antara pria dan wanita. TC tidak mengalami mutasi p53 atau abnormalitas ekspresi BCL2 dan BAX, sedangkan AC menunjukkan adanya 20-40% mutasi p53 dan 10-20% abnormalitas ekspresi BCL2 dan BAX.Gejala klinis sebagian besar asimptomatik dan umumnya berupa gejala obstruksi bronkus. Terapi tumor adalah reseksi dengan prognosis cukup baik. terdapat empat kategori NETs yaitu typical carcinoid (TC), atypical carcinoid (AC), large cell neuroendocrine carcinoma (LCNC), dan small cell lung carcinoma (SCLC). Typical carcinoid harus dibedakan dari yang athypical karena prognosis umumnya lebih baik dari Athypical meskipun ada metastase ke KGB. Untuk membantu membedakan tumor carcinoid dengan tumor nonneuroendokrin digunakan imunohistokimia, salah satunya MAP-2 yang sensitif dan spesifik. Prognosis cukup baik setelah reseksi tumor.Kata kunci: Gejala Klinis, Terapi Tumor, Tumor Carcnoid Paru
Hubungan Antara Hipertensi dan Usia dengan Angka Kejadian Kanker Payudara Di RSUD Dr. H. Abdul Moeloek Bandar Lampung Tahun 2018 Mohamad Reihansyah Deswindra; Muhartono; Rizki Hanriko; Waluyo Rudiyanto
Medula Vol 10 No 1 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i1.12

Abstract

Breast cancer is one of the most highest incidence rate cancer in all countries. Age and Hypertension is known as risk factor for breast cancer. The purpose of this study is to know the relation between hypertension and age with breast cancer incidence rates in Dr. H. Abdul Moeloek Bandar Lampung. The method of this study is observational analytic study with case control design. The data that used are secondary data that gathered from medical records of patients in Dr. H. Abdul Moeloek Hospital and taken with consecutive sampling method. The data is analyzed using univariate and bivariate analysis using Chi-square test and Fisher test. The result is in the case group, hypertension percentage obtained was 12.5% ​​while those whose has not hypertension was 87.5%. In the control group the percentage of hypertension was 8.3% while those whose has not hypertension was 91.7%. In the case group ≥50 years of age percentage obtained was 54.2% while at age <50 years was 45.8%. In the control group ≥50 years of age percentage of 16.7% while at age <50 years at 83.3%. The results showed that age ≥50 years have a p value = 0,007 with OR = 5,909 and hypertension group have a p value = 0.500. The conclusion of this study is, there is no the relationship between hypertension and breast cancer incidence rates Lampung and there is relationship between the age of patients with breast cancer incidence rates in the Hospital of Dr. H. Abdul Moeloek Bandar Lampung.
Pengaruh Pemberian Ekstrak Etanol Rimpang Lengkuas (Alpinia galanga) terhadap Gambaran Histopatologi Testis Mencit (Mus musculus L.) jantan yang Diinduksi Monosodium Glutamat Annisa Shafira Pramono; Muhartono; Rizki Hanriko; Eca Cania
Medula Vol 10 No 1 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i1.43

Abstract

Monosodium Glutamate (MSG) may form free radicals that cause damages to the organs of the body, one of which is the male reproductive organs, i.e. testes. Galangal rhizome is one of the natural ingredients with antioxidant content that can neutralize free radicals. The purpose of this research was to determine the effect of ethanol extract of galangal rhizome on testicular histopathology of MSG-induced male mice. The design of this research was experimental research with 5 treatment groups, each group consisted of 5 mice (Mus musculus L.) DDY strain. Group K (-) was not treated; k (+) was provided with 4 mg/ grBB MSG; P1 was provided with 4 mg/ grBB MSG + 14 mg/ 20 grBB ethanol extract of galangal rhizome; P2 was provided with 4 mg/ grBB MSG + 28 mg/ 20 grBB ethanol extract of galangal rhizome; P3 was provided with 4 mg/ grBB MSG + 56 mg/ 20 grBB ethanol extract of galangal rhizome. Assessment used Johnsen score in group K(-) was 48,4, K(+) was 47,4, P1 was 47,4, P2 was 47,4, and P3 was 48. Kruskal-Wallis test result was p=0,085 (p>0,05). The conclusion was that ethanol extract of galangal rhizome did not effect significantly (p>0,05) on the testicular histopathology of monosodium glutamate-induced mice.
Efek Curcumin Sebagai Pengobatan Penyakit Jantung Koroner Anggun Elidiya; Rizki Hanriko; M. Yusran
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.264

Abstract

Atherosclerosis is a chronic and progressive problem due to the inflammatory response, oxidative stress (OS), lipid deregulation, and epigenetic disorders. Curcumin is the main compound in turmeric and is responsible for turmeric yellow and contains 50% of turmeric. Curcumin has a hypolipidemic effect along with antioxidant and anti-inflammatory, it can contribute to reduce the incidence of atherosclerosis. The extraordinary antioxidant content of curcumin reduces lipid peroxidation and oxLDL formation, and consequently, reduces the inflammatory response and the development of atherosclerosis. Another study shows that curcumin can alter gene expression associated with leukocyte adhesion and transendothelial migration in aortic tissue by increasing expression of NF-κB protein inhibitors (IκB) and decreasing NF-κB bonds and transcription activity after stimulation with tumor necrosis factor-α (TNF-α). In addition, it is proven that curcumin can regulate the activation of toll-like receptor 4 (TLR4), a receptor that recognizes exogenous or endogenous molecular patterns and modulates immune and inflammatory responses. The role of other curcumin for atherosclerosis is smooth muscle cell proliferation. Curcumin is an antioxidant that can be one of the management of coronary heart disease due to be able to suppress the formation of atherosclerosis and reduce cholesterol levels in the blood. It is expected that curcumin can be the first treatment for coronary heart disease.
Hububgan Hubungan Riwayat Merokok, Konsumsi Alkohol dan Diabetes dengan Derajat Histopatologi Karsinoma Kolorektal di RSUD Dr. H. Abdul Moeloek Bandar Lampung Periode 2017-2018 Gede Ardi Saputra; Rizki Hanriko; Hendri Busman; Muhartono
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.154

Abstract

Colorectal carcinoma is a malignant neoplasm which originating or growing in the colon or rectum. Colorectal carcinoma is one of the 10 most common cancers suffered by Indonesians. Carcinomas develop much less in the duodenum, jejunum, and ileum than in the colon and rectum. The duodenum, jejunum, and ileum join the colon in the lower right abdomen. In the early stages most cancers do not show any particular clinical symptoms, however, early testing can minimize a poor prognosis. Screening or screening for colorectal carcinoma can be performed in groups of men and women over 50 years of age or patients who are at risk of developing colorectal carcinoma. Screening should also be done by people with polyps or individuals at risk of other carcinomas. The purpose of this study was to determine the frequen distribution and the relationship between smoking history, alcohol consumption history and diabetes history to the histopathological degree of colorectal carcinoma in RSUD Dr. H. Abdul Moeloek. This research was conducted in October-November 2019 at Dr. H. Abdul Moeloek Bandar Lampung using the observational method. The sample of this study consisted of 94 people with medical record data determined using total sampling techniques. Data were processed using statistical tests with a confidence level of 0.05. Chi-square test results showed that there is a  correlation between smoking history (p = 0.0008), alcohol consumption (p = 0.006) and diabetes mellitus (p = 0.015) with the histopathological degree of colorectal carcinoma. So, it can be concluded there is a correlation between smoking history, alcohol consumption and diabetes.
Pengaruh Pemberian Ekstrak Teh Hijau (Cammelia Sinensis) Terhadap Gambaran Histopatologi Silia Pada Trakea Tikus Putih Jantan Galur Sprague Dawley yang Dipapar Uap Rokok Elektronik Ahmad Syah Putra; Susianti; Rizki Hanriko
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.156

Abstract

At present, there is a shift in the use of cigarettes, from conventional cigarettes to e-cigarettes. Exposure to particulate e-cigarettes can cause damage to the airway, one of which is ciliary tracheal. Green tea (Camellia sinensis) has a source of antioxidants in the form of polyphenols which can reduce the number of organ damage through a mechanism as an anti-oxidant. The study used an experimental design using 30 Sprague Dawley strain white rats which were divided into 6 groups, namely 3 control groups and 3 treatment groups. In the control group, given regular treatment, exposure to electric cigarettes and exposure to conventional cigarettes. In the treatment group, mice were given peritoneal injection of green tea extract each of 50 mg/kg body weight, 100 mg/kg body weight, and 200 mg/kg body weight. After 14 days of treatment, the 15th day of mice was euthanized and preparations were taken. There was a change in histopathological damage in all samples where there were significant differences in the control group, but not significantly in the treatment group with a value of K1 to K2 with p = 0.005, and K1 to K3 with p = 0.007. Whereas in vape control group (K2) between treatment groups P1, P2, and P3 were p = 0.521.There is not difference between the administration of green tea extract to histological ch es in cilia’s tracheal structure of rats exposed to steam electronic cigarettes with p=0,521.
Efek Protektif Madu Terhadap Ginjal Tikus Putih Yang Diinduksi Etanol - Muhartono; Rizki Hanriko; Haryani Dwita
JUKE Unila Vol 2, No 1 (2012)
Publisher : Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (464.001 KB)

Abstract

Honey  already used as natural food sources since long time ago.  Honey has been shown contained active chemical compounds that are antioxidants, yet there is still only a few experimental studies about the protective effect of honey against ethanol-induced renal damage. This study aims to prove the protective effect of honey against renal damage and determine the relationship of increasing doses of honey against renal damage in male rat (Rattus norvegicus). Research subjects were used 25 Sprageu dawley strain male rat.  Rat weredivided into 5 groups that was negative control were given only distilled, positif control (only given ethanol 0,01 ml/gBW/day), treatment group I (given honey 0,0018 ml/gBW/day dan ethanol 0,01 ml/gBW/day), treatment group II (given honey 0,0054 ml/gBW/day dan ethanol 0,01 ml/gBW/day), treatment group III (given honey 0,0162 ml/gBW/day dan ethanol 0,01 ml/gBW/day) for 14 days. Based on result of the Kruskal wallis test performed on this data p<0,05, which mean there were protective effect of giving the honey treatment to renal damage male rat.  Mann whitney test result p <0,05, which  means that there were significant differences proximal tubulus on rat almost found between each groups except positif control group with treatment group I and treatment group II with treatment group III. Honey shown to have protective effects against ethanol-induced renal damage of Sprageu dawley strain male rat. Increasing doses of honey can increase the protective effects against the renal damage of Sprageu dawley strain male rat at certain dose, on dose 0,0018 ml/gBW/day and 0,0054 ml/gBW/day
Correlation of Lymphocyte-Monocyte Ratio with Grading of Breast Cancer Malignancy Muhartono Muhartono; Rizki Hanriko; Suharyani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 3 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i3.139

Abstract

Introduction: Breast cancer cases are increase and fast becoming the leading cause of oncologic mortality among women worldwide. Delay in management will worsen the prognosis of breast cancer patients. The poor prognosis is correlate with high grade of breast cancer malignancy. Histology can be used as an indicator to assess the grade of breast cancer malignancy. In addition, a high predictive value of lymphocyte-monocyte ratio (LMR) has been suggested to indicate favorable prognosis of various cancer, and used as parameters for assessing breast cancer prognosis. Method: This study is a quantitative research, using an observational approach. Laboratory examination results are collected from 43 breast cancer patients who will conduct treatment at Urip Sumoharjo Hospital from June to September 2019. Data are processed by the Spearman rank test using SPSS 22.0. Results: Correlation test results between lymphocyte-monocyte ratio with histological grading of breast cancer obtained a P value of 0.376. Conclusions: Lymphocytes to monocytes ratio (LMR) value cannot be utilize as a parameter for evaluating prognosis of breast cancer.
Co-Authors - Muhartono - Muhartono Ahmad Syah Putra Alif Fernanda Putra Anggun Elidiya Annisa Shafira Pramono ari wahyuni Ari Wahyuni Dian Isti Angraini Dian Isti Angraini Dwi Indria Anggraini Eca Cania Ety Apriliana Ety Apriliana Fauziyyah Nuur Al azizah Gede Ardi Saputra Hanna Mutiara Haryani Dwita Haula Rizqiyah Helsa Apty Tamara Hendri Busman KHAIRUNNISA SALSABILA M. Yusran Mohamad Reihansyah Deswindra Muhammad Iz Zuddin Adha Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Nabil Abdurrahman Naufal Rasyid Aswan Nisa Karima Okki Muhammad Fajar Muthahhari Oktadoni Saputra Pairul, Piesta Prima Beta Putu Devie Sri Astari Rani Himayani Ratna Dewi PS Retno Ariza Soeprihatini Rodiani Siti Raqiya Rasyid Suharmanto Suharmanto Suharyani Susianti Susianti Tasya Khalis Ilmiani Tri Umiana Soleha Trixie Almira Veny Anisya Waluyo Rudiyanto Yovani Rehuel Br Sitepu