<![CDATA[Background: The global percentage of contraceptive users in women of reproductive age range (15-49 years) or women who are married is 62.7%. Combined oral contraceptives represent 8.8% of the prevalence (more than 100 million women). COCs are very effective in preventing pregnancy, but like most medications, combined oral contraceptives can be associated with a variety of side effects and risks, including venous thromboembolism (VTE) and stroke. This study aims to determine the estimated effect of combined oral contraceptives on venous thromboembolism and stroke on family planning acceptors by meta-analysis.Subjects and Method: Meta-analyzes were performed by searching for articles from the Google Scholar, PubMed, Research Gate, Scopus, Springer Link, and Science direct databases. The keywords used in the search for the article included “oral contraceptive” OR “combined oral contraceptives” OR “risk factor” AND “venous thrombolism” OR “VTE” AND “stroke” AND “family planning”. The inclusion criteria in this study were full text articles, from 2000-2020, with a case-control study design. The article analysis was carried out using RevMan 5.3.Results: There are 15 articles analyzed. The results showed that combined oral contraceptives increased the incidence of venous thromboembolism and stroke in family planning acceptors (aOR 2.95; 95% CI = 1.80-4.84; p <0.001); (aOR 1.50; 95% CI = 1.30-1.74; p <0.001). The results of the meta-analysis showed a publication bias between the use of combined oral contraceptives and the incidence of stroke among family planning acceptors.Conclusion: Combined oral contraceptives affect venous thromboembolism and stroke in family planning acceptors.Keywords: COCs, venous thromboembolism, stroke, family planning acceptorsCorrespondence: Putri Yunita Sari, Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: puyunita16@gmail.com. Mobile: 08818794685.Journal of Maternal and Child Health (2021), 06(02): 131-145https://doi.org/10.26911/thejmch.2021.06.02.01]]>
