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All Journal Journal of Islamic Pharmacy Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Journal Pharmasci (Journal of Pharmacy and Science)
Rakhma, Dita Nurlita
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Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Physics Public Health

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Pengaruh Rasio Karbomer dan HPMC Terhadap Karakteristik dan Stabilitas Fisik Emulgel Minyak Ikan Salmon Rakhma, Dita Nurlita; Najih, Yuli Ainun; Eka Pratiwi, Fadhilah
Journal of Pharmacy and Science Vol. 5 No. 2 (2020): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v5i2.171

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh rasio gelling agent Karbomer dan HPMC terhadap karakteristik dan stabilitas fisik emulgel minyak ikan salmon. Pada penelitian ini digunakan minyak ikan salmon sebagai bahan aktif karena mengandung Omega-3 yaitu EPA dan DHA yang berkhasiat sebagai antiiflamasi secara topikal. Rasio karbomer:HPMC yang digunakan yaitu 2:0 (FI), 0:2 (FII), 0,5 :1,5 (FIII) dan 1:1 (FIV). Pengujian yang dilakukan meliputi pH, viskositas, dan daya sebar. Pengujian stabilitas fisik yang dilakukan meliputi uji sentrifugasi dan cycling test. Pada uji pH diperoleh hasil semua formula memenuhi rentang pH kulit. Pada pengukuran viskositas dan daya sebar terdapat perbedaan bermakna pada masing-masing formula (p<0,05) dimana FI memiliki viskositas yang paling tinggi dan untuk uji daya sebar menunjukkan bahwa FII mempunyai nilai daya sebar paling tinggi. Pada uji stabilitas fisik baik uji cycling test maupun sentrifugasi menunjukkan bahwa perbedaan rasio gelling agent tidak memberikan pengaruh terhadap stabilitas fisik emulgel minyak ikan salmon pada FI, FIII, dan FIV. Namun memberikan pengaruh pada FII dengan rasio gelling agent Karbomer:HPMC (0:2) yang ditunjukkan dengan pemisahan fase pada uji sentrifugasi. Dari hasil penelitian tersebut dapat disimpulkan bahwa perbedaan rasio gelling agent karbomer:HPMC memberikan pengaruh terhadap karakter dan stabilitas fisik emulgel minyak ikan salmon.
Optimization of Skin Moisturizer Formula Based on Fixed Oil (VCO, Olive Oil, and Jojoba Oil): Optimasi Formula Pelembab Kulit Berbasis Minyak Nabati (VCO, Minyak Zaitun dan Minyak Jojoba) Rakhma, Dita Nurlita; Nailufa, Yuyun; Ainun Najih, Yuli; Wahjudi, Hery
Journal of Pharmacy and Science Vol. 6 No. 2 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i2.221

Abstract

Currently, formulations of skin moisturizers are derived from natural compounds. Fixed oils are known to have compounds that potential to be developed as skin moisturizers based on emollient mechanism. Therefore, this study aims to determine the effect of oil type on the physical characteristics of skin moisturizer creams. In this study, a skin moisturizer cream was formulated using three types of fixed oils: VCO (F1), Olive Oil (F2), and Jojoba Oil (F3). All formulas were tested for physical characteristics of pH, cream type, viscosity, spreadability, and homogeneity. The test results show that all formulas appropriate to the skin pH range, have o/w type creams and homogeneous texture. In the results of the viscosity test, there was a significant difference (p<0.05) with the highest value of viscosity for F2 (16750 ± 250 cP) > F3 (14200 ± 346cP) > F1 (5833 ± 58 cP), while for spreadability test there were also significant differences (p<0.05) with the highest diameter for F1 (5.8 ± 0.1 cm) = F3 (5.7 ± 0.2 cm) > F2 (4.3 ± 0.2 cm). Based on the results, it can be concluded that the type of oil can affect the physical characteristics of the moisturizer formula. F1 and F3 have better physical characteristics than F2.
Karakterisasi Sistem Dispersi Padat Meloksikam Dengan Matriks PEG 6000 Dan Poloxamer 188 Dibuat Dengan Menggunakan Metode Peleburan Najih, Yuli Ainun; Nailufa, Yuyun; Rakhma, Dita Nurlita; Widjaja, Bambang; Silviyah, Lailatul; Mujahida, Choirun
Journal of Islamic Pharmacy Vol 6, No 1 (2021): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v6i1.11284

Abstract

Meloxicam is included in the class II Biopharmaceutical Classification System (BCS). This drug has low solubility and high permeability. The solubility is one of the factors that affect in the dissolution rate of drug. One of the effort to increase dissolution of meloxicam is by forming a solid dispersion system made using melting method. The addition of PEG 6000 and poloxamer 188 carriers determine in the solid dispersion system aims to increase the dissolution rate of meloxicam. The purpose of this study is to characterize the meloxicam solid dispersion system with PEG 6000 and poloxamer 188 matrices at a ratio of 99:1 and 98:2 made by the melting method when compared with the physical mixture and its pure compound using Powder X-Ray Diffaction, DSC and FTIR. The results of meloxicam solid dispersion with a ratio 99:1 and 98:2 showed the disappearance of the typical peak of meloxicam at an angel of 2θ 6.5° and 11.2°. The thermogram data using DSC shows a decrease in melting point of solid dispersion system with a ratio of 99:1 and 98:2 namely 64.33°C and 64.21°C. The result of the characterization of meloxicam solid dispersion with FTIR showed that the identified spectrum were in the spectrum range of meloxicam, PEG 6000, poloxamer 188 indicating there was no incteraction in the meloxicam solid dispersion system.Keywords: Meloxicam, PEG 6000, Poloxamer 188, Solid Dispersion, Melting Method, Characterization
Uji Mutu Refined Karaginan Dari Eucheuma spinosum Berdasarkan Perbedaan Konsentrasi Kalium Hidroksida arto, Yanu andhi; Rakhma, Dita Nurlita; Fahmi, Nita Yunia
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol 2 No 02 (2021): HERCLIPS VOL 02 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v2i02.2418

Abstract

Carrageenan in the pharmaceutical industry can be used as a stabilizer, thickener, gelling agent, emulsifier, and binder. Alkaline solutions such as KOH have two functions, which help extract polysaccharides to be more perfect and accelerate the elimination of 6-sulfate from the monomer unit to 3,6-anhydro-D-galactose so that it can improve the quality of carrageenan. The purpose of this study is to evaluate the effect of to determine the effect KOH of differences concentration on yield carrageenan characteristics from the extraction results Microwave-assisted extraction (MAE). The carrageenan quality parameters tested water content, ash content, sulfate content and viscosity. The Eucheuma spinosum originating from the waters of Sumenep, Madura was extracted at the Phytochemical Laboratory of Pharmacy Program, Hang Tuah University, Surabaya using different concentrations of KOH 10%, 15%, and 20% with the Microwave Assisted Extraction (MAE) method which was then filtered and neutralized with filtration and neutralized with The HCl is then precipitated with ethanol 96%, drying and grinding until to obtain a fine carrageenan is powder. The carrageenan obtained was then calculated the for yield percentage and analyzed for the water content, ash content, sulfate content and viscosity. The concentration of KOH affects % yield where an average increase in yield results along with increasing the concentration of KOH, the highest yield at 20% concentration of KOH is 37.41% ± 1.186 and an analysis of the standard carrageenan quality test is carried out where those that meet the quality requirements are water content, ash content, and sulfate content. As for viscosity, there was no significant difference in the KOH concentrations of 15% and 20%.
Co-Authors Ainun Najih, Yuli arto, Yanu andhi Bambang Widjaja Eka Pratiwi, Fadhilah Fahmi, Nita Yunia Mujahida, Choirun Nailufa, Yuyun Najih, Yuli Ainun Silviyah, Lailatul Wahjudi, Hery