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All Journal Seminar Nasional Aplikasi Teknologi Informasi (SNATI) Jurnal Sosio Ekonomika Bisnis JURNAL ILMIAH MANAJEMEN BISNIS DAN TERAPAN Jurnal Ilmiah Mahasiswa FEB Majalah Kedokteran Sriwijaya Jurnal Ilmiah Kesehatan Jurnal Literasiologi Majalah Patologi Indonesia Journal of Applied Electrical Engineering Journal of Dehasen Educational Review Jurnal Mandala Pengabdian Masyarakat Jurnal Penelitian Geografi (JPG) KENDURI

Citra Dewi

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Author-ID : 1875132

Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Hubungan Ekspresi Interleukin-17 dan Indeks Proliferasi Ki67 pada Karsinoma Payudara Ika Kartika,; Theodorus; Citra Dewi; Nyiayu Fauziah Kurniawati
Majalah Patologi Indonesia Vol 30 No 1 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundTumor cells have the ability to change the phenotype of inflammatory cells in the tumor environment into protumoral factors. One ofthe mediators produced such as interleukin 17 (IL-17) also plays a role in increasing tumor proliferation and invasion. Similar to IL-17,Ki67 has generally been used as a marker to assess the extent of breast carcinoma proliferation. This is the first study to determinethe relationship of IL-17 expression with Ki67 proliferation index of breast carcinoma patients.MethodsThis is a case series study using 38 paraffin block samples of breast carcinoma patients. The clinicopathological characteristicsdocumented are age, histopathological subtype and grade, TILs (tumor infiltrating lymphocytes) and molecular subtypes. Interleukin17 and Ki67 expressions were assessed using immunohistochemistry examination and data were analysed using the Pearson andSpearman test to assess correlations between the two variables.ResultsGeneral characteristics of the sample in this study were breast cancer patients aged >40 years (73.7%), histopathological subtypesof non-specific invasive carcinoma (84.2%), high tumor rates (78.9%), non-dominant TILs (94.7%) and molecular subtype luminal B(55.3%). There is no relationship between IL-17 expression and Ki67 proliferation index (p 0.72 and OR of 1.417), even though lowerexpression of IL-17 showed a higher Ki67 proliferation index.ConclusionExpression of IL-17 cannot describe the Ki67 proliferation index in breast carcinoma. Studies using another analytical techniques andlarge sample size are suggested to obtain more accurate results.

Analisis Ekspresi Interleukin-17 pada Karakteristik Klinikopatologi Karsinoma Payudara Nyiayu Fauziah Kurniawati; Ika Kartika; Citra Dewi; Theodorus
Majalah Patologi Indonesia Vol 30 No 1 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundInteraction between cancer cells and tumor microenvironment plays roles in cancer proliferation and invasiveness. Many type ofcytokine produced by inflammatory cells in tumor stroma could stimulate tumor proliferation and invasiveness, such as interleukin-17.The aim of this study is to determine the correlation between IL-17 expression and clinicopathological characteristics of breast cancer.MethodsSerial cases study was performed by enrolling 40 paraffin block of breast cancer patients. Clinicopathological characteirstics werenoted, including age, histopathological subtype and grade, TILs, lymphovascular invasion and molecular subtype. TILs were scoredby denomination area of stromal tissue occupied by mononuclear cells over total stromal area. Expression of IL-17 was examined byusing immunohistochemistry with anti-IL-17 antibody and counted from stromal mononuclear cells cytoplasm staining from five areas.The average value was used as a cut-off point in determining level of expression. Data were analysed by using SPSS v.22.ResultsMajority of the patients were more than 40 years old (75%), histopathological grade III (77.5%), without lymphovascular invasion(62.5%), luminal B molecular subtype (57.5%), and non-dominant TILs (95%). IL-17 expression was not significantly correlated withclinicopathological characteristics with p value=0.079, 0.600, 0.739, 0.883 and 1.000 respectively for age, histological grade,lymphovascular invasion, molecular subtype and TILs.ConclusionInterleukin-17 expression and clinicopathological on characteristics of breast carcinoma between histopathological grade, TILs, andlymphovascular invasion showed no significant differences. There was a tendency that the higher IL-17 expression, the higherhistopathological grade, the lower TILs and positive lymphovascular invasion

Hubungan Ekpresi E-Cadherin dengan Invasi Limfovaskular dan Status KGB pada Karsinoma Payudara Tripel Negatif Citra Dewi; Henny Sulastri; Jusuf Fantoni; Zen Hafy
Majalah Patologi Indonesia Vol 22 No 1 (2013): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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ABSTRAK Latar belakang Karsinoma payudara tripel negatif (KPTN) memiliki karakteristik, prognosis dan terapi yang khas dan dengan angka kematian yang tinggi. Seiring dengan berkembangnya ilmu pengetahuan biomolekuler mengenai penanda tumor, telah banyak penanda prognosis yang diteliti dan salah satunya adalah E-cadherin. Penelitian ini bertujuan untuk melihat hubungan ekspresi E-cadherin dengan invasi limfovaskular dan status kelenjar getah bening (KGB) serta ekspresi E-CD berdasarkan ukuran tumor, morfologi tumor dan derajat histologi pada KPTN. Metode Penelitian ini adalah penelitian retrospektif cross sectional. Tiga puluh sampel jaringan hasil biopsi, lumpektomi dan mastektomi diambil secara acak dari arsip di Bagian Patologi Anatomik Rumah Sakit Mohammad Hoesin (RSMH) Palembang, dilakukan pulasan dengan antibodi E-cadherin dan diteliti hubungannya dengan invasi limfovaskular serta sebaran ekspresinya berdasarkan usia, morfologi tumor dan derajat histologi. Dua puluh dua sampel jaringan hasil mastektomi diteliti untuk menilai hubungan antara ekspresi E-cadherin dengan status KGB dan sebarannya berdasarkan ukuran tumor. Hasil Sebaran ekspresi E-cadherin positif terbanyak pada KPTN dengan ukuran massa tumor >2 cm, jenis karsinoma duktal invasif, derajat histologi tinggi (43,3%). Rasio prevalens hubungan ekspresi E-cadherin dengan invasi limfovaskular dan status KGB masing-masing 1,14 (Interval Kepercayaan 0,19-0,39;p>0,01) dan 1,65 (Interval Kepercayaan-0,143-0,663; p>0,05). Kesimpulan Hasil penelitian ini menunjukkan bahwa E-cadherin belum bisa digunakan sebagai bahan pertimbangan untuk menentukan invasi limfovaskular dan status KGB pada kasus KPTN sehingga E-cadherin kurang dapat memberikan informasi mengenai prognosis penderita KPTN khususnya bagi klinisi dan penderita sendiri. Kata kunci : Karsinoma payudara tripel negatif, E-cadherin, invasi limfovaskular, status KGB. ABSTRACT Background Triple negative breast carcinoma (TNBC) has some unique characteristics, prognosis and treatment, and also a high mortality rate. Prognostic markers have been widely studied and one of them is Epithelial-Cadherin (E-cadherin). This study aims to look the relationship between E-cadherin expression with lymph vascular invasion, lymph node status, tumor size, morphology and histologic grade in TNBC. Methods This was a retrospective cross sectional study. Thirty samples of biopsy, lumpectomy and mastectomy specimens were taken randomly from the archives of the Anatomical Pathology Department of Mohammad Hoesin Hospital Palembang, stained with E-cadherin antibody, were used to investigate the relationship between the expression of E-cadherin with lymph vascular invasion, age, tumor morphology and histologic grade. Twenty-two tissue samples of mastectomy specimens were used to investigate the relationship between E-cadherin expression with lymph node status and tumor size. Results Mostly, positive expression of E-cadherin was expressed in tumor mass >2cm, in invasive ductal carcinoma type (40%) and in a high histologic grade tumor (43,3%). The prevalence ratio (PR) of E-cadherin expression of lymph vascular invasion was 1.14 (Convidence Interval 0.19-0.39; p> 0.05) and the PR of E-cadherin expression of the lymph nodes status was 1.65 (Convidence Interval -0.143-0.663; p> 0.05). Conclusion This study demonstrates that E-cadherin couldâ€™nt provide information on prognosis of TNBC as E-cadherin canâ€™t be used as indicator for lympho-vascular invasion and lymphnode status. Key words: TNBC, E-cadherin, lymph vascular invasion, lymph node status

Perbandingan Ekspresi PD-L1 dan TILS pada Karsinoma Payudara Triple Negative dan HER2 Enriched Muhammad Asprianto; Krisna Murti; Citra Dewi; Erial Bahar
Majalah Patologi Indonesia Vol 30 No 3 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundTriple negative and positive HER 2 subtype breast carcinoma are aggressive subtype that have worst prognosis among othersubtype. High level of tumor infiltrating lymphocytes (TILs) is associated with longer disease free survival and overall survival.Breast cancer is also influenced by the presence of ligation between PD-1 and PD-L1, expressed by activated CD8+ T cells andtumor cells, consecutively. To analysed the comparison of PD-L1 expression levels in triple negative breast cancer and HER2enriched subtype.MethodsA cross sectional study was conducted with 35 samples, which were immunostained with an anti-PD-L1 antibody. TILs weremeasured on HE slides, and together with PD-L1 expression were calculated using image J. Clinicopathological data were obtainedfrom medical record. All data were analysed by SPSS V25.0ResultsA significant difference was observed between PD-L1 expression in HER2 enriched and triple negative samples, where the HER2enriched subtype had a possibility to express PD-L1 3.3 times higher than those of triple negative (p = 0.021; OR = 3.3). There wereno significant differences in clinopathological characteristics or TILs density in both subtypes. Likewise, no significant differenceswas found among PD-L1 expression, and intratumoral and stromal TILs expression.ConclusionMajority patient of both subtypes are mostly older than 40 years old, with positive LVI and higher histological grading. The HER2expression showed a higher level of PD-L1 than triple negative. There was no significant difference of TILs expression betweenthese two subtypes of breast cancer.

Karakteristik Klinikopatologik serta Hubungan Derajat Keganasan dengan Subtipe Molekular Luminal B pada Pasien Karsinoma Payudara di RSUP Mohammad Hoesin Palembang Tahun 2014-2016 Reihan Putri Awaliah; Citra Dewi; Riana Sari Puspita Rasyid
Majalah Patologi Indonesia Vol 31 No 1 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundBreast carcinoma is the second highest malignant disease that causes death in Indonesia with 58,256 new cases in 2018. LuminalB has more aggressive clinical behavior and is considered as having unfavorable prognosis. This study aimed to determine theclinicopathological characteristics and the relationship histological grade with breast carcinoma subtype molecular luminal B.MethodsThis is a descriptive analytic study with cross sectional design using secondary data of breast carcinoma patients registered atRSUP Mohammad Hoesin Palembang during the period of January 1st, 2014 to December 31st, 2016.ResultsFrom 903 breast carcinoma patients in Mohammad Hoesin Hospital Palembang during 2014 to 2016, 43.63% had luminal Bmolecular subtype. The highest incidence and prevalence washappened in year 2016, whichwere 4.7 and 4.4 per 10 breastcarcinoma patients, respectively. The majority of breast carcinoma of luminal B molecular subtype occurs in the group of patientsaged ≥40 years (81.7%), female (98.7%), Malay race (100%), marital status (98.8%), housewives (68.3%), histopathologicalcarcinoma of invasive non-specific type (75.9%), high grade/ grade III (63.7%), localized (60.6%), no metastases (60.0%), rightsided tumor laterality (50.8%) and with negative HER2 (65.2%). There was a significant relationship between the histopathologicalgrade and breast carcinoma luminal B molecular subtype (p=0.009).ConclusionThe incident of breast carcinoma molecular subtype luminal B at Mohammad Hoesin Hospital Palembang has increased in the lastthree years with the poor clinicopathological characteristics.

Mastitis Granulomatosa: Sebuah Tantangan Diagnosis Citra Dewi; Ella Amalia; Nyiayu Fauziah Kurniawati; Maria Ulfa, Maria Ulfa,; Eka Putra Pratama; Krisna Murti
Majalah Patologi Indonesia Vol 31 No 1 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundGranulomatous mastitis (GM) is often found in reproductive-age women. These patients are treated by the administration ofantituberculosis drugs. It is difficult to determine the exact cause of GM cytologically and histopathologically. Various etiologies i.e.,tuberculosis, sarcoidosis, foreign bodies and immunological diseases may provide granulomatous inflammation features in thetissue. High-sensitivity tests such as PCR can help to detect the presence of Mycobacterium tuberculosis (MT) as one of possibleetiologic agent. Accurate diagnosis will improve the treatment quality thus a better quality of life. The aim of this study was todetermine whether the granulomatous mastitis patients who referred to the Department of Anatomic Pathology Faculty of MedicineUniversitas Sriwijaya/Dr. Moh. Hoesin Palembang Hospital were caused by MT.MethodsA descriptive observational study was performed. Thirty paraffin blocks of GM patients during the period of 1st October 2018 to 29thSeptember 2020 were collected. DNAs were extracted from tissue scrapings of the slides. Then, PCR analysis was conducted usinga specific primer IS6110 with around 200 bp PCR product.ResultsThe mean age of the patients was 40.8 years (range: 23-67 years). There were six samples (20%) of GM produced the expectedamplicon. However, only three of six samples morphologically consistent with tuberculosis.ConclusionGranulomatous inflammatory reactions in the breast are not only caused by tuberculosis. Further study is needed to determine theexact cause of this lesion. Despite high costs, PCR examination may become an alternative approach in determining the etiology ofGM.

Karakteristik Klinikopatologik Karsinoma Sel Skuamosa Serviks dan Hubungannya dengan Tumor-Associated Neutrophil Nanda Safira Alisa; Joko M; Citra Dewi; Susilawati; Ika Kartika Edi Pudjo
Majalah Patologi Indonesia Vol 31 No 2 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundCervical carcinoma is one of the most common cancers in women, according to data from World Health Organization (WHO).Cervical carcinoma ranks the fourth most deadly type of cancer. Squamous cell carcinoma is the most common type of this cervicalcancer and it is generally caused by Human Papilloma Virus (HPV) types 16 and 18. Tumor-Associated Neutrophil (TAN) are foundin various types of cancer, the density of TAN can determine the prognostic type of tumor or cancer in each individual. This studywas aimed to identify correlation between clinicopathological characteristics of cervical squamous cell carcinoma (SCC) and TAN incervical SCC patients registered at RSUP Dr. Mohammad Hoesin Palembang.MethodsThis type of research is analytic with a cross-sectional method. Data collection in this study used a 37 slides archive which werediagnosed as cervical squamous cell carcinoma in Anatomic Pathology in RSUP Dr. Mohammad Hoesin Palembang for the periodof 2017-2019.ResultsFrom 37 cervical SCC patients, the clinicopathological characteristics of the majority of cervical SCC patients occurred in the agegroup of 51 year-old (51.4%), with histopathological type of non-keratinizing SCC (75,7%) and the most frequent differentiationdegree was moderately differentiated (75,7%). The TAN density was mostly found at low TAN densities (73%). There wassignificant correlation between age and TAN density (p=0.035) and there was no significant correlation between age and TANdensity (p=0.269).ConclusionIt was explained that the higher the degree of differentiation, the lower the density value, however the neutrophils in this studycannot be ascertained whether the neutrophils of anti-tumor (N1) or pro-tumor (N2) characteristic

Socialization of the Making of Hand Sanitizer and Instant Drinks from Herbs in Maintaining the Immune System for the Prevention of COVID 19 Citra Dewi; Rismayanti Fauziah; Nikeherpianti Lolok
Jurnal Mandala Pengabdian Masyarakat Vol. 2 No. 2 (2021): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi STIKES Mandala Waluya

Corona Virus Disease of 2019 atau disebut COVID-19 merupakan wabah penyakit yang menginfeksi saluran pernafasan pada manusia yang dapat menyebabkan kematian. Wabah ini terjadi hampir di seluruh negara di Dunia. Upaya untuk mencegah penyebaran COVID-19 antara lain sering mencuci tangan atau menggunakan hand sanitizer dan meningkatkan sistem kekebalan tubuh (sistem imunitas) melalui asupan makanan yang kaya antioksidan maupun imun boost. Berdasarkan studi literatur yang telah dilakukan, tanaman lokal Indonesia diprediksi dapat menjadi kandidat penghambat COVID-19 seperti jahe (Zingiber officinale), kunyit (Curcuma longa L.), dan temulawak (Curcuma xanthorriza Roxb). Kegiatan pengabdian masyarakat ini melalui sosialisasi dilakukan di Desa Puasana, Kecamatan Moramo Utara, Kabupaten Konawe Selatan, Provinsi Sulawesi Tenggara. Tujuan sosialisasi ini adalah untuk memberikan edukasi dan mengajak masyarakat agar menjaga kesehatan dengan tetap menerapkan physical distancing dan meningkatkan sistem imun dengan mengkonsumsi makanan sehat serta menggunakan hand sanitizer pada saat keluar rumah. Metode pengabdian kepada masyarakat dilakukan dengan cara memberikan sosialisasi dengan media presentasi. Hasil dari pengabdian ini adalah meningkatnya pemahaman masyarakat khususnya di Desa Puasana tentang cara pembuatan hand sanitizer alami dan minuman herbal instan. Hal ini berdasarkan pada masyarakat yang aktif dan antusias dalam memberikan pertanyaan untuk mengetahui langkah-langkah pencegahan penyebaran Covid-19. Kata kunci: Sosialisasi, Hand Sanitizer, Minuman Instan, Sistem Imun, COVID-19

Evaluasi Pengelolaan Proyek Saluran Air Limbah Domestik dengan Aplikasi Primavera Project Planner (Studi Kasus pada Normalisasi Saluran Air di Kec. Ngampilan Yogyakarta) Hendra Hendra; Andino Maseleno; Budi Satiawan; Rika Fetricia; Citra Dewi
Seminar Nasional Aplikasi Teknologi Informasi (SNATI) 2006
Publisher : Jurusan Teknik Informatika, Fakultas Teknologi Industri, Universitas Islam Indonesia

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Makalah ini membahas penelitian mengenai evaluasi pengelolaan proyek saluran air limbah domestik dengan aplikasi Primavera Project Planner. Untuk melakukan pengolahan data dan analisis dalam penelitian ini menggunakan metode PDM (Presedence Diagram Method) untuk menganalisis waktu. Metode untuk menganalisis anggaran biaya total proyek dan jumlah tenaga kerja menggunakan metode analisis BOW (Burgerlijke Openbare Werken). Dari hasil penelitian didapat pendekatan dengan metode PDM menghasilkan waktu penyelesaian yang sesuai dengan rencana awal proyek, jumlah tenaga kerja yang dibutuhkan untuk beberapa jenis pekerjaan normalisasi saluran air limbah domestik Kec. Ngampilan, serta jumlah total biaya rencana proyek.Kata kunci: evaluasi proyek, primavera project planner, precedence diagram method, burgerlijke openbare werken

Pengaruh Sikap, Kepercayaan, Persepsi Kegunaan, Persepsi Kemudahaan Penggunaan, dan Kualitas Sistem Terhadap Minat Masyarakat dalam Menggunakan Kartu Kredit (Studi kasus pada RSUD “Dr. H. Slamet Martodirdjo” Kabupaten Pamekasan) CITRA DEWI; Zaki Baridwan
Jurnal Ilmiah Mahasiswa FEB Vol 3, No 2: Semester Genap 2014/2015
Publisher : Fakultas Ekonomi dan Bisnis Universitas Brawijaya

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Pengaruh Sikap, Kepercayaan, Persepsi Kegunaan, Persepsi Kemudahan Penggunaan, dan Kualitas Sistem Terhadap Minat Menggunakan Kartu Kredit. Penelitian ini bertujuan untuk menguji faktor-faktor yang mempengaruhi minat dalam menggunakan kartu kredit dengan menggunakan model Technology Acceptance Model (TAM) yang dikembangkan oleh Davis pada tahun 1989. Penelitian ini dilakukan pada dokter, bidan dan karyawan pada RSUD “Dr. H. Slamet Martodirdjo” Kabupaten Pamekasan. sebanyak 88 responden dokter, bidan, dan karyawan yang telah menggunakan kartu kredit diolah dengan menggunakan Partial Least Square (PLS). Hasil analisis untuk model ini menunjukkan bahwa minat menggunakan kartu kredit dipengaruhi secara posistif oleh konstruk sikap. Sedangkan, konstruk kepercayaan, persepsi kegunaan, persepsi kemudahan penggunaan, dan kualitas sistem tidak memberikan pengaruh positif terhadap minat menggunakan kartu kredit. Implikasi dari penelitian ini relevan bagi pihak manajemen perbankan agar memperhatikan kembali faktor sikap bagi pengguna dalam penerapan dan mengembangkan sisten transaksi kartu kredit. Kata Kunci : Sikap, Kepercayaan, Persepsi Kegunaan, Persepsi Kemudahan penggunaan, dan kualitas sistem

Co-Authors Afriyadi Cahyadi, Afriyadi Alia Desmalia Andino Maseleno Budi Satiawan Cindy Kesty Dede Komarudin Desrio Windoro M. Eka Putra Pratama Ella Amalia, Ella Erial Bahar Erita Astrid Fauzan Murdapa Fendria Sativa Hendra Hendra Henny Sulastri Iche Andriyani Liberty, Iche Andriyani Ika Kartika Ika Kartika Edi Pudjo Ika Kartika, Illa Aryeni Irwanto Zarma Putra Joko M Jusuf Fantoni Juwita Juwita Krisna Murti M. Bima Zulfikar Maria Ulfa, Maria Ulfa, Martadiansyah, Abarham Muhammad Asprianto Muhammad Iqbal Adi Saputra Nanda Safira Alisa Nikeherpianti Lolok Nuswil Bernolian Nyiayu Fauziah Kurniawati Peby Maulina Lestari, Peby Maulina Putri Mirani Ratnawaty Siata Reihan Putri Awaliah Riana Sari Puspita Rasyid Ricky Maulana Rika Fetricia Rismayanti Fauziah Rita Prima Bendriyanti Siva Fauziah, Siva Susilawati Theodorus Theodorus Theodorus Velix Septra Aditya Vivin Octowinandi Yopie Manurung Zaki Baridwan Zen Hafy Zunaidah Zunaidah

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