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Swimming Improves Memory Function and Decreases N-Methyl-D-Aspartate in Ageing Rats Hanik Badriyah Hidayati; Purwo Sri Rejeki; Lilik Herawati; Susi Wahyuning Asih; Suhartati Suhartati; Siti Khaerunnisa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16883

Abstract

A single Memory impairment substantially reduces the quality of life in the elderly. It is associated with thealteration of neurotrophic (NT) factors, such as brain-derived neurotrophic factor (BDNF) and glutamatereceptor N-methyl-D-aspartate (NMDA). Exercise is often used to reduce cognitive impairment. Previousstudies show that the benefits of aerobic exercises on such impairments are correlated with increasing BDNFand preventing the production of NMDA. However, some results remain controversial. Thus, the associationbetween exercise and Memory was addressed by examining increases in BDNF and the reduction of NMDAin ageing rats. The study used a randomized, post-test-only controlled group of 30 male one-year-old ageingRattus norvegicus divided into three groups, namely, K0 (control) and K1 and K2 (aerobic swimmingexercise). K1 and K2 animals differed in the frequency of exercise, which is three and four sessions perweek, respectively. Memory was assessed using Y-maze performance. BDNF and NMDA were analyzedusing enzyme-linked immunosorbent assays. A significant improvement in memory function and reductionin the NMDA level were observed in K1 and K2 group rats (p = 0.001; p = 0.041). No significant impact onthe BDNF levels was observed (p = 0.387). Swimming may boost Memory by reducing the NMDA levelbut not by increasing BDNF. Swimming is a promising method for preventing or delaying memory loss indegenerative brain diseases. Further investigation is needed to fully understand underlying mechanisms.
Kemampuan Siswa dalam Merencanakan Penyelesaian Masalah melalui Pendekatan Matematika Realistik yang Mengintegrasikan Nilai Islami Jannatul Alyana; Cut Morina Zubainur; Suhartati Suhartati
Jurnal Peluang Vol 8, No 1 (2020): Vol 8, No 1 (2020): Jurnal Peluang
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jp.v8i1.18778

Abstract

This study aimed to examine students' abilities in planning problem-solving through a realistic mathematical approach integrating Islamic values in one of the junior high schools in Aceh, Indonesia. This research employed a mix-method approach. The population of this study was all Year 7 students in the school studied (35 students). The sample was one group chosen randomly (7 students). The data were collected through tests of problem-solving abilities and semi-structured interviews. The data were analyzed descriptively by comparing the data from the test results and interviews to describe the ability of problem-solving planning. The results showed that the students' ability of problem-solving planning through a realistic mathematical approach developed for each lesson. In the first lesson, three out of seven students met the ability of problem-solving planning. Furthermore, in the second lesson, five out of seven, and in the third lesson, six out of seven students fulfilled the ability of problem-solving planning. This research implies that teachers can expand the application of a realistic mathematical approach integrating Islamic values to other materials to foster the ability of problem-solving planning.
Aktivitas Enzim Protease dan Dinamika Protein Cairan Rumen pada Rekayasa Pakan Aditif Secara In Vitro Agung Prastyo Nugroho; Suhartati Suhartati; Sri Rahayu; Merryafinola Ifani
Jurnal Ilmu dan Teknologi Peternakan Tropis Vol 9, No 1 (2022): JITRO, Januari 2022
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (415.217 KB) | DOI: 10.33772/jitro.v9i1.18346

Abstract

ABSTRAK Penelitian bertujuan mengkaji pengaruh penambahan pakan aditif dalam pakan ruminansia sebagai upaya meningkatkan aktivitas protease dan mengkaji pengaruhnya terhadap total protein cairan rumen pada lama inkubasi yang berbeda. Penambahan bahan aditif diharapkan dapat menjaga kondisi lingkungan mikro rumen tetap stabil dan dapat memberikan suasana yang optimal untuk kinerja bakteri rumen. Apabila kondisi lingkungan mikro rumen sesuai dan suasana rumen menjadi anaerob maka populasi bakteri rumen akan meningkat. Peningkatan populasi bakteri rumen akan berdampak pada meningkatnya aktivitas enzim yang dihasilkan. Penelitian bersifat eksperimental menggunakan metode in vitro. Perlakuan yang diuji yaitu P0 = Pakan basal (60% konsentrat : 40% hijauan); P1 = P0 + 0,5% isobutirat; P2 = P1 + 0,5% S. cerevisiae; P3 = P2 + 1% minyak kedelai. Penelitian menggunakan rancangan acak lengkap (one way classification), setiap perlakuan diulang sebanyak 5 kali sehingga terdapat 20 unit percobaan. Peubah yang diukur yaitu aktivitas protease menggunakan metode Walter dan kadar protein cairan rumen dalam pengamatan dinamika protein diukur menggunakan metode Bradford. Hasil analisis variansi menunjukan bahwa penambahan pakan aditif berpengaruh sangat nyata (p<0,01) terhadap aktivitas protease dalam cairan rumen dan hasil analisis variansi dinamika protein menunjukkan bahwa inkubasi 4 jam pada perlakuan P2 dan P3 menunjukkan perlakuan berpengaruh sangat nyata (p<0,01) terhadap kadar protein. Hasil akhir dari penelitian ini dapat disimpulkan bahwa penambahan kombinasi isobutirat, S. Cerevisiae, dan minyak kedelai pada substrat pakan merupakan perlakuan yang paling efektif dalam meningkatkan aktivitas protease dan mampu meningkatkan kadar protein cairan rumen pada jam ke 4 inkubasi secara in vitro.Kata Kunci: pakan aditif, protease, in vitro, proteinProtease Activities and Dynamics of Rument Liquid Proteins on In Vitro Feed Additives ABSTRACTThe aim of this study was to examine the effect of adding feed additives to ruminant feed as an effort to increase protease activity and to examine its effect on the total protein in rumen fluid at different incubation times. The addition of additives is expected to maintain a stable rumen microenvironment and can provide an optimal atmosphere for the performance of rumen bacteria. If the conditions of the rumen microenvironment are suitable and the rumen atmosphere becomes anaerobic, the population of rumen bacteria will increase. An increase in the population of rumen bacteria will have an impact on increasing the activity of the enzymes produced. This research is experimental using the in vitro method. The treatments tested were P0 = basal feed (60% concentrate: 40% forage); P1 = P0 + 0.5% isobutyrate; P2 = P1 + 0.5% S. cerevisiae; P3 = P2 + 1% soybean oil. This study used a completely randomized design (one way classification), each treatment was repeated 5 times so that there were 20 experimental units. The variables measured were protease activity using the Walter method and rumen fluid protein levels in the protein dynamics observations measured using the Bradford method. The results of the analysis of variance showed that the addition of feed additives had a very significant effect (p<0.01) on the protease activity in the rumen fluid and the results of the analysis of variance of protein dynamics showed that the 4-hour incubation in P2 and P3 treatments showed a very significant effect (p <0, 01) on protein content. The conclusion of this study is the addition of a combination of isobutyrate, S. cerevisiae, and soybean oil to the feed substrate is the most effective treatment in increasing protease activity and is able to increase rumen protein levels at the 4th hour of incubation in vitro.Keywords: feed additives, protease, in vitro, protein
PHARMACODYNAMICS STUDY OF ETHANOL EXTRACT OF CYCLEA BARBATA (MIERS.) LEAVES ON SRF AND COX-2 GASTRIC MICE WITH NSAID GASTROPATHY Florence Pribadi; Suhartati Suhartati; Achmad Basori
Indonesian Journal of Pharmacy Vol 28 No 3, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (880.862 KB) | DOI: 10.14499/indonesianjpharm28iss3pp131

Abstract

Epidemiology of NSAIDs gastropathy is increasing as increase number of usage. From arthritis to cardiovascular events and cancer prevention, the versatility of NSAIDs is not questioned. However, no dose of NSAIDs is safe. No matter low dose, or single use, NSAIDs will cause gastric damage upto 3-7 days after use. In inflammation and healing process of gastropathy there are various proteins involved, but treatment with COX-2 and SRF are associated with an immediate healing and better quality of gastric mucosa. Cyclea barbata (miers.) has been declared as functional food for preventing and treatment gastropathy yet, its mechanism of actions have not yet clearly discovered. Hence the aim of this study is to analyze the effects of Cyclea barbata (miers.) ethanol extract to COX-2 and SRF in gastric tissue, in time series basis. Laboratory mice was induced with aspirin to produce gastropathy and then treated with Cyclea barbata (miers.) extract for 1, 3, 7, 10 or 14 days. Gastric tissue then harvested and analysed with elisa procedure to determine tissue SRF and COX-2 level. Treatment was proven to increase COX-2 and SRF higher than control group. This concludes one of Cyclea barbata (miers.) mechanism for NSAIDs gastropathy is by increasing tissue COX-2 and SRF. 
Kecerdasan Visual-Spasial Siswa pada Soal Tes Potensi Akademik melalui Model Pembelajaran Picture and Picture di SMA Negeri 10 Banda Aceh Suciati Suciati; Suhartati Suhartati; Mukhlis Hidayat
Jurnal Ilmiah Mahasiswa Pendidikan Matematika Vol 4, No 1 (2019): Februari 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.416 KB)

Abstract

Kecerdasan visual-spasial merupakan kecerdasan yang diujikan pada soal TPA ujian masuk perguruan tinggi melalui jalur Seleksi Bersama Masuk Perguruan Tinggi Negeri (SBMPTN). Namun kecerdasan visual-spasial belum terakomodir secara eksplisit dalam kurikulum sekolah. Penelitian ini bertujuan untuk mengetahui kecerdasan visual-spasial siswa pada soal tes potensi akademik melalui model pembelajaran picture and picture. Pendekatan dan jenis penelitian yang digunakan adalah pendekatan kuantitatif dengan jenis pre-test and post-test group design. Populasi pada penelitian ini adalah seluruh siswa kelas XI SMAN 10 Banda Aceh. Sampel penelitian dipilih secara acak yaitu siswa kelas XI-1 yang berjumlah 25 siswa. Instrumen penelitian yaitu tes kecerdasan visual-spasial. Data kecerdasan visual-spasial tersebut dianalisis dengan menggunakan uji t paired t-test. Hasil penelitian menunjukkan bahwa terdapat peningkatan kecerdasan visual-spasial siswa pada soal tes potensi akademik melalui model pembelajaran picture and picture. Implikasi penelitian ini yaitu guru dapat menumbuhkan kecerdasan visual-spasial siswa dengan model pembelajaran picture and picture pada materi yang relevan. Kata Kunci:     Visual-spasial, Tes potensi akademik, Picture and picture.
Budidaya Tanaman Gaharu (Aquilaria malaccensis Lamrk.) di Lahan Kebun Kelapa Sawit dengan Aplikasi Teknik Silvikultur Suhartati Suhartati
Buletin Eboni Vol 10, No 1 (2013): Info Teknis Eboni
Publisher : Balai Penelitian dan Pengembangan Lingkungan Hidup dan Kehutanan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.919 KB) | DOI: 10.20886/buleboni.5003

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Budidaya tanaman gaharu (Aquilaria malaccensis Lamrk.) pada lahan perkebunan kelapa sawit merupakan upaya optimalisasi pemanfaatan lahan. Tanaman gaharu adalah jenis tanaman yang menghasilkan produk gaharu, dan jenis ini dikenal dengan nama tanaman karas  yang telah dibudidayakan di lahan kebun sawit. Tanaman gaharu pertumbuhannya agak lambat sehingga perlu didukung teknik silvikultur untuk mempercepat pertumbuhannya.  Budidaya tanaman gaharu  di lahan  kelapa sawit dapat  ditanam dengan  jarak  4  m dari pohon kelapa sawit,  dan membutuhkan  naungan  hingga umur 12 bulan.  Teknik silvikultur yang diaplikasikan yaitu arang pelepah kelapa sawit sebanyak  5,0 kg/tanaman,  dapat meningkatkan pertumbuhan tinggi 71,0% dan diameter batang 72,2 %.  Aplikasi kapur sebanyak  1,0 kg/tanaman  dapat meningkatkan  pertumbuhan tinggi  42,5 % dan diameter batang 125 %,  serta meminimalkan kadar kemasaman  tanah  dari   pH  4,0 meningkat menjadi pH 6,0. Selanjutnya aplikasi 150 g/tanaman pupuk NPK dapat meningkatkan pertumbuhan tinggi 77,6 % dan diameter  batang  34,85 %.  Diharapkan  nilai ekonomi tanaman kehutanan khususnya tanaman penghasil gaharu dapat bersaing dengan komoditi perkebunan, sehingga masyarakat termotivasi membudidayakan tanaman gaharu  secara tanaman campuran di lahan  kalapa sawit atau di hutan rakyat.
SARI ETANOL, ETIL ASETAT ALANG-ALANG (IMPERATA CYLINDRICA) TERHADAP SUPEROXIDE DISMUTASE (SOD) St Khaerunnisa; Sutji Kuswarini; Suhartati Suhartati; Lina Lukitasari; Ira Humairah; Reza Arta BN; Gwenny IP
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 2 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i2.1080

Abstract

Oxidative stress has been considered as a mechanism involved in the pathogenesis and progression of many diseases such as:hypercholesterolemia and atherosclerosis. The objective of this current study was to know the potential antioxidant role of ethanol andethyl acetate extract of reeds (Imperata cylindrica) by investigation in rats fed with a high-cholesterol diet. Imperata cylindrica is richin antioxidants and has a cholesterol-reducing effect. A group of twenty four male albino Wistar rats was divided into four subgroups: anormal diet group (K0), a high-cholesterol diet group (K1), the same diet with ethanol extract of Imperata cylindrica group (K2), and thesimilar diet with ethyl acetate fraction of Imperata cylindrica group (K3),. After the treatment period, the hepatic antioxidant enzymeactivity (Superoxide dismutase/SOD) was determined. The rats fed on high-cholesterol diet with supplementation exhibited a significantelevation in SOD activity (p<0. 05), 61.6±12.4% inhibition, compared to normal animals 37.44±12.2%. The treated animals withethanol and ethyl acetate extract of Imperata cylindrica showed a significantly reduced the level of SOD activity (p<0.05, 29.90±5.6%as well as a 33.49±7.4% inhibition). The level of SOD activity when restored was closer to that in normal animals, signifying reversalof the oxidative stress. The study results showed that the treatment with Imperata cylindrica positively changed the hepatic antioxidantenzyme activities in high fat-diet rats, and thus had potential hypocholesterolemic and antioxidant effects. Imperata cylindrica couldprotect against oxidative stress linked to atherosclerosis and also decrease the atherogenic index.
KATEKIN DAUN TEH HIJAU (Camelia sinensis) TERHADAP MALONDIALDEHYDE DAN SUPER OXIDE DISMUTASE Sukina B; Gwenny I.P; Suhartati Suhartati; Harianto N
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 2 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i2.1063

Abstract

Recent studies have shown that Plumbum could disrupt tissue prooxidant/antioxidant balance. The green tea leaves (Camelliasinensis) is an antioxidant scavenger of free radicals and chelator of heavy metals. This study was designed to know and investigate theefficacy of Katekin from green tea leaves malondialdehid (MDA) and superoxide dismutase (SOD) activity in erythrocytes caused by oralPb administration in Wistar rats. Thirty adult male rats were divided into six (6) groups (each groups: 5 rats): K+ group (oral 33.75mg/bw Katekin), K group as a normal control, K- group (oral 15.82 mg/day lead acetate), P1 group (oral 22.5 mg/bw Katekin and 15.82mg/day lead acetate, P2 group (oral 33.75 mg/bw Katekin and 15.82 mg/day lead acetate for), and P3 group (oral 45 mg/bw/Katekinand 15.82 mg/day lead acetate) for 4 weeks. The results showed that Pb exposure induced the raised of MDA levels and decrease SODactivity in erythrocytes of rats. The administration of Katekin from green tea leaves significantly reduced MDA levels and increased SODactivity in Pb exposed erythrocytes of rats. The optimal dose of Katekin from green tea leaves as a scavenger of free radicals and chelatorof heavy metals was 22.5 mg/bw/day (P1). These results indicated that the administration of Katekin from green tea leaves may havean important role in modulating oxidative stress in Pb exposed erythrocytes, but at a higher concentration of Katekin from green tealeaves showed prooxidant activity.
PENGARUH RETURN ON ASSET (ROA) DAN UKURAN PERUSAHAAN TERHADAP FINANCIAL DISTRESS PADA PERUSAHAAN SUB SEKTOR KIMIA YANG TERDAFTAR DI BURSA EFEK INDONESIA Jaka Maulana; Suhartati Suhartati
LAND JOURNAL Vol. 3 No. 1 (2022): Januari 2022
Publisher : Universitas Logistik dan Bisnis Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47491/landjournal.v3i1.1764

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Dalam mendirikan suatu perusahaan tentunya mempunyai tujuan untuk mendapatkan keuntungan, tetapi juga akan mengalami penurunan kondisi keuangan. Sehingga banyak berbagai perusahaan yang mengalami kebangkrutan dikarenakan perusahaan tersebut kurang efektif dan efisien dalam mengelola laporan keuangan. Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh return on asset (ROA) dan ukuran perusahaan terhadap financial distress. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif dengan data sekunder dan jenis perumusan masalah asosiatif yang memiliki hubungan sebab akibat. Populasi dalam penelitian ini adalah perusahaan Sub Sektor Kimia yang terdaftar di Bursa Efek Indonesia tahun 2016-2019. Berdasarkan kriteria yang ada, pengambilan sampel dilakukan dengan teknik purposive sampling, sampel yang diperoleh 8 perusahaan dengan total sampel 32 data. Pengujian hipotesis dalam penelitian ini menggunakan uji normalitas data, analisis korelasi product moment, analisis korelasi berganda, analisis regresi linier berganda, analisis koefisien determinasi, uji t-test, dan uji f-test. Hasil penelitian ini menunjukkan bahwa secara parsial return on asset (ROA) tidak memiliki pengaruh terhadap financial distress dan ukuran perusahaan memiliki pengaruh positif yang signifikan terhadap financial distress. Secara simultan return on asset (ROA) dan ukuran perusahaan memiliki pengaruh positif yang signifikan terhadap financial distress.
ANALISIS DISKRIMINAN UNTUK MENCARI TINGGI RENDAHNYA RATA-RATA HASIL BELAJAR MAHASISWA MATEMATIKA BERDASARKAN TEMPAT TINGGAL M Hasbi; Suhartati Suhartati; Suryawati Suryawati; Mukhlis Hidayat
Jurnal Geuthèë: Penelitian Multidisiplin Vol 1, No 1 (2018): Jurnal Geuthee : Penelitian Multidisiplin
Publisher : Geuthèë Institute, Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (344.678 KB) | DOI: 10.52626/jg.v1i1.7

Abstract

Penelitian ini merupakan penelitian tentang hasil belajar mahasiswa matematika berdasarkan tempat tinggal. Pengumpulan data dilakukan dengan cara mengedarkan angket kepada setiap mahasiswa matematika di empat universitas yang berbeda. Data mentah yang telah dikumpulkan terlebih dahulu dinormalkan menggunakan log kemudian dianalisis menggunakan discriminan fisher melalui aplikasi SPSS. Variabel dependen dalam penelitan ini adalah tinggi rendahnya hasil belajar mahasiswa matematika, sedangkan variabel independen terdapat 10 faktor yang dapat mempengaruhi tinggi rendahnya hasil belajar mahasiswa matematika berdasarkan tempat tinggalnya. Hasil yang diperoleh dalam penelitian ini dari 100 sampel yaitu 14 dari 30 sampel yang bertempat tinggal di rumah, 11 dari 30 sampel di kos, dan 20 dari 40 sampel di dayah mendapatkan hasil belajar yang tinggi. Artinya, 45 sampel yang memiliki hasil belajar yang tinggi berdasarkan tiga tempat tinggal. Sedangkan 55 sampel lainnya memiliki nilai yang rendah. Fungsi diskriminan fisher yang terbentuk adalah: P1 = (-0.325)X1 + (3.192)X2 + (6.199)X3 + (1.429)X4 + (3.448)X5 + (7.559)X6 + (1.251)X7 + (2.612)X8 + (1.823)X9 + (35.362)X10 P2 = (-0.308)Y1 + (2.899)Y2 + (6.071)Y3 + (0.567)Y4 + (3.187)Y5 + (6.411)Y6 + (0.560)Y7 + (2.088)Y8 + (2.025)Y9 + (33.879)Y10 P3 = (-0.684)Z1 + (2.623)Z2 + (4.809)Z3 + (1.983)Z4 + (4.961)Z5 + (5.609)Z6 + (-0.344)Z7 + (2.745)Z8 + (1.925)Z9 + (34.731)Z10 Discriminant Analysis To Calculate High Low Average of Learning Mathematical Students Based on Residence This research is a research about the result of student learning mathematics based on residence. Data collection was done by circulating questionnaires to each mathematics student at four different universities. The raw data that has been collected is normalized using logs and then analyzed using discriminant fisher through SPSS application. The dependent variable in this research is the high of the mathematics student learning result, while the independent variable there are 10 factors that can influence the high of the mathematics student learning result based on their place of residence. The results obtained in this study from 100 samples are 14 out of 30 samples residing at home, 11 out of 30 samples in boarding house, and 20 out of 40 samples in dayah get high learning result. That is, 45 samples that have high learning outcomes based on three dwellings. While 55 other samples have low value. The function of the fisher discriminant formed is: P1 = (-0.325)X1 + (3.192)X2 + (6.199)X3 + (1.429)X4 + (3.448)X5 + (7.559)X6 + (1.251)X7 + (2.612)X8 + (1.823)X9 + (35.362)X10 P2 = (-0.308)Y1 + (2.899)Y2 + (6.071)Y3 + (0.567)Y4 + (3.187)Y5 + (6.411)Y6 + (0.560)Y7 + (2.088)Y8 + (2.025)Y9 + (33.879)Y10 P3 = (-0.684)Z1 + (2.623)Z2 + (4.809)Z3 + (1.983)Z4 + (4.961)Z5 + (5.609)Z6 + (-0.344)Z7 + (2.745)Z8 + (1.925)Z9 + (34.731)Z10