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All Journal Indian Journal of Forensic Medicine & Toxicology
Tutik Kusmiati
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Public Health

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A Woman with Tuberculosis Multidrug Resistance and QTc Prolongation Repetitive Interval: A Case Report Tutik Kusmiati; Ni Made Mertaniasih; Johanes Nugroho Eko Putranto; Budi Suprapti; Soedarsono; Abdul Rahman Bahmid
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17119

Abstract

Background : Prolonged QTc interval is one of the side effects of the short-regimen MDR-TB. QTcprolongation is a risk factor for Torsades de pointes and is influenced by many factors. Case : 47-year-oldwoman who was diagnosed with MDR-TB through GeneXpert examination and received short-regimenMDR-TB. This patient experienced repeated QTc prolongation, with peak QTc interval 600 msec occurringat 4th month with mild hypokalemia without clinical symptoms. The patient completed 9 months of shortregimentherapy with improve chest x ray followed by negative sputum culture. Conclusion : Short-regimenMDR-TB contains several drugs that cause QTc prolongation. Clinical evaluation is required in patientswith QTc prolongation before changing the regiment.
Co-Authors Abdul Rahman Bahmid Budi Suprapti Ni Made Mertaniasih Putranto, J. Nugroho Eko Soedarsono