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All Journal ACTA VETERINARIA INDONESIANA Jurnal Veteriner Paediatrica Indonesiana Majalah Kedokteran Neurosains Neurologico Spinale Medico Chirurgico JURNAL KAJIAN VETERINER eJournal Kedokteran Indonesia

Setyo Widi Nugroho

Department Of Neurosurgery Faculty Of Medicine Universitas Indonesia - RSUP Nasional Dr. Cipto Mangunkusuma

Author-ID : 2048104

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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EVALUASI TAJAM PENGLIHATAN DAN INDEKS PROPTOSIS PASIEN MENINGIOMA SPHENOORBITA PASCAOPERASI KRANIEKTOMI Renindra Ananda Aman,* Ryan Rhiveldi Keswani,* Syaiful Ichwan,* Samsul Ashari, Setyo Widi Nugroho*
NEURONA Vol. 37 No. 4 September 2020
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION SPHENOORBITAL MENINGIOMA SOM IS AN EXOPHYTIC TUMOR MASS THAT INFILTRATES THE BONE AT THE SPHENOID WING LATERAL ORBITAL WALLS ORBITAL ROOFS AND EXTENDS TO SUPERIOR ORBITAL FISSURES THE CLASSIC TRIAD OF CLINICAL FEATURES ARE PROPTOSIS DECREASED VISUAL ACUITY AND OPHTHALMOPLEGIA THE OUTCOMES OF OUR POSTOPERATIVE PATIENTS HAVE NOT BEEN EVALUATED BEFORE

HUBUNGAN WAKTU TUNGGU MENUJU OPERASI PENGANGKATAN TUMOR INTRAKRANIAL DENGAN SKALA PERFORMA KARNOFSKY PASCAOPERASI Setyo Widi Nugroho,* Aryandhito Widhi Nugroho,* Renindra Ananda Aman,* Hanif Gordang Tobing*
NEURONA Vol. 37 No. 4 September 2020
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION THE WAITING TIME TO ELECTIVE INTRACRANIAL TUMOR REMOVAL SURGERY IN INDONESIA IS UNKNOWN LET ALONE ITS ASSOCIATION WITH POSTOPERATIVE FUNCTIONAL OUTCOME

LUARAN PERDARAHAN INTRAVENTRIKEL YANG DILAKUKAN OPERASI DI DEPARTEMEN BEDAH SARAF RSUPN DR CIPTO MANGUNKUSUMO Wismaji Sadewo,* Liza Amelia,* Hanif Gordang Tobing,* Setyo Widi Nugroho,* Syaiful Ichwan,* Samsul A
NEURONA Vol. 35 No. 1 Desember 2017
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION INTRAVENTRICULAR HEMORRHAGE IVH IS A SPONTANEOUS HEMORRHAGE OCCURRING WITHIN THE VENTRICULAR SYSTEM 3045 OFTEN ASSOCIATED WITH INTRACEREBRAL HEMORRHAGE ICH EVALUATING ACCURATE AND PRECISE DAILY ACTIVITY IN POSTSTROKE PATIENTS IS CRITICAL FOR THE QUALITY OF CARE AND MEASUREMENT OF POSTSTROKE OUTCOMES

Profil Tekanan Darah Normal Tikus Putih (Rattus norvegicus) Galur Wistar dan Sprague-Dawley Setyo Widi Nugroho; Kanti Rahmi Fauziyah; Dondin Sajuthi; Huda Salahudin Darusman
Acta VETERINARIA Indonesiana Vol. 6 No. 2 (2018): Juli 2018
Publisher : IPB University

Tikus putih (Rattus norvegicus) merupakan hewan coba yang digunakan untuk penelitian biomedik. Penelitian ini bertujuan untuk memberikan nilai tekanan darah normal tikus putih dengan galur (Wistar dan Sprague-Dawley) dan jenis kelamin yang berbeda melalui pengukuran tekanan darah non-invasive. Pengukuran tekanan darah dengan menggunakan instrumen CODA® pada 20 ekor tikus putih. Profil tekanan darah yang diukur meliputi tekanan darah sistolik, diastolik, tekanan arteri rata-rata, denyut jantung, dan aliran darah pada ekor. Nilai tekanan darah sistolik, diastolik, dan tekanan arteri rata-rata pada galur Sprague-Dawley lebih tinggi secara signifikan (P<0.05) dibandingkan Wistar. Tikus putih galur Sprague-Dawley jantan memiliki profil tekanan darah diastolik dan tekanan arteri rata-rata yang lebih tinggi secara signifikan (P<0.05) dibandingkan betina. Galur Wistar jantan menunjukkan profil tekanan darah yang lebih tinggi dibandingkan betina namun tidak berbeda secara signifikan (P>0.05). Sprague-Dawley jantan menunjukkan hasil tekanan darah diastolik dan tekanan arteri rata-rata yang lebih tinggi secara signifikan (P<0.05) dibandingkan Wistar jantan. Studi ini menekankan pentingnya memilih ras dan jenis kelamin hewan coba tikus dalam studi kardiovaskuler.

Teknik Penanganan Kendali Hewan Sesuai Kaidah Kesejahteraan Hewan Meningkatkan Akurasi Pengukuran Profil Hemodinamika Tikus Laboratorium Huda Shalahudin Darusman; Setyo Widi Nugroho; Fauzi Abdurrahman Munggaran; Dondin Sajuthi
Jurnal Veteriner Vol 19 No 2 (2018)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Chronic discomfort potentially occurred during a hemodynamic measurements in a rat-tail blood pressure chamber due to the animal is restrained in restricted space for a long period – it took 10 repetitions each at approximately 1.5 minutes for a session of hemodynamic measure. Procedures related to the animal welfare methods are required to improve the accuracy of the measurement which would altered from the discomfort to comfort state of the animal. Welfare procedures are represented by humane handling and habituation of the subject (rats) to the operator and the hemodynamic apparatus. Seven rats were subjected in this study and measured for hemodynamic value in three times point: before (T0), after humane handling (T1) and after human handling and habituation to the measurement apparatus (T2), respectively. Six out of seven subjects showed a significant lowering deviation for all variables of hemodynamic measurements, and that deviation followed by a declining trend from T0 to T2, i.e T0>T1>T2. The results indicated that welfare-based approach would benefit the animals from feeling discomfort and yet improving the accuracy and quality of the outcomes.

Perubahan Patologi Seluler Kelenjar Adrenal Tikus Hipertensi dengan Terapi Sel Punca Mesenkimal Sumsum Tulang (CELLULER STUDY OF ADRENAL GLAND IN HYPERTENSIVE RATS WITH IMPACT OF BONE MARROW MESENCHYMAL STEM CELLS THERAPY) Yanse Yanne Rumlaklak; Erni Sulistiawati; Dondin Sajuthi; Sus Derthi Widhyari; Setyo Widi Nugroho
Jurnal Veteriner Vol 19 No 2 (2018)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

The purpose of this study was to investigate changes in cellular pathology of adrenal gland as impact of bone marrow mesenchymal stem cells (BMMSC) therapy in hypertensive rats. The research used ten male wistar rats with age ± 10-12 weeks with body weight ± 200-250 grams which is devided into two different groups ie BMMSc(-) hyprtention and BMMSc(+) hypertension. Rats are conditioned with hypertention using Hasbinoto et al method. Right nephrectomy and left carotid communic artery ligation are performed on all rats. Rats are injected with deoxycorticosterone acetate (DOCA), then 0.12 % of âaminopropionitrile fumarate (BAPN) is added into drinking water. 1% NaCl solution was administered as drinking water during the study. Rats were evaluated for particular indicator ie blood pressure then were euthanized for adrenal organs collections. The data that obtained then analysed using qualitative descriptive. The result of the study indicate hypertention therapy using BMMSC can repair cell damaged of the adrenal gland such as hyperplasia, nodules, cysts and cytoplasm vacuolization.

Studi Histologi Tubulus Ginjal Tikus Model Hipertensi yang Diterapi Menggunakan Bone Marrow Mesenchymal Stem Cell Tiara Widyaputri; Erni Sulistiawati; Dondin Sajuthi; Anita Esfandiari; Setyo Widi Nugroho
Jurnal Veteriner Vol 22 No 3 (2021)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Akhir-akhir ini banyak peneliti yang mempelajari terapi berbasis sel sebagai terapi regeneratif untuk melindungi atau memperbaiki jaringan yang rusak. Bone marrow mesenchymal stem cell (BMMSC) memiliki kemampuan yang menjanjikan dalam memperbaiki ginjal. Tujuan penelitian ini adalah untuk mengetahui apakah induksi yang dilakukan dapat menyebabkan kerusakan tubulus ginjal dan BMMSC mampu melindungi atau memperbaiki kerusakan yang terjadi. Penelitian ini menggunakan dua belas tikus jantan umur 10-12 minggu dengan rata-rata tekanan darah sistolik minimum mencapai 140-150 mmHg yang dibagi menjadi kelompok kontrol dan kelompok terapi. Tekanan darah yang tinggi diinduksi dengan mengangkat ginjal kanan, mengikat arteri karotis komunis kiri, serta memberikan NaCl 1%, DOCA 2,5 mg/100gBB, dan BAPN 0,12%. Bone marrow mesenchymal stem cell disuntikkan setelah 16 minggu induksi. Evaluasi histopatologi ginjal yang didukung dengan evaluasi darah dilakukan dua minggu setelah injeksi BMMSC. Berdasarkan evaluasi histopatologi, kerusakan tubulus ginjal pada dua kelompok tidak menunjukkan hasil yang berbeda. Demikian juga regenerasi pada kedua kelompok menunjukkan hasil sama. Kadar blood urea nitrogen (BUN) dan kreatinin pada kedua kelompok berada dalam kisaran kadar normal. Hasil yang didapat menunjukkan bahwa kerusakan yang terjadi tidak parah dan BMMSC memperbaiki tubulus ginjal akan tetapi belum dapat melindungi tubulus ginjal dari kerusakan.

Is there any benefit from surgery for giant-dumbbell spinal tumors with prolonged paraplegia and joints contractures? a rare case report Mohamad Saekhu; Eka Susanto; Samsul Ashari; Setyowidi Nugroho
Neurologico Spinale Medico Chirurgico Vol 5 No 1 (2022)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v5i1.174

The lack of clarity about the opportunities for significant neurologic improvement, coupled with the risk of severe postoperative complications, decompression surgery for patients with giant tumors in the cervical spine accompanied by long-lasting advanced neurological deficits places a heavy moral burden on surgeons. Here we report a three-year follow-up after surgery for an immense spinal neurofibroma in which the patient was bedridden for the past fifteen years. Our findings suggest surgery remains beneficial for patients without major postoperative complications.

Cervical Myelopathy as the Most Common Symptoms in Patients Undergoing C-Spine Surgery in the Spine Division, Department of Neurosurgery, Cipto Mangunkusumo General Hospital, from January 2012 to December 2016 Mohamad Saekhu; Jeremia Prasetya Pardede; Renindra Ananda Aman; Syaiful Ichwan; Wismaji Sadewo; Samsul Ashari; Setyowidi Nugroho
Neurologico Spinale Medico Chirurgico Vol 1 No 1 (2018)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (310.507 KB)

Background: Cervical spine disease has the potential to reduce productivity in aﬀected patients because of myelopathy and mood disorder (e.g. depression) which lead to decreasing of the patient’s quality of life.Objective: This study aims to elaborate on the most frequent symptoms and pathology of C-spine disease in patients who underwent a surgical procedure over the period time from January 2012 to December 2016.Method: This study is a retrospective. All patients who underwent surgery for the C-spine disease are included. The data was obtained from the records in our spine database.Result: The total number of surgical procedures for spine disease over the 5 years was 345 procedures, with 127 procedures in the C-spine which are the second most common procedures of spine surgery in Department of Neurosurgery FMUI. The C-spine diseases were more common in males, aged more than 50 years old. The most frequent disease or pathology is a degenerative disease, and yet, tumour cases show an increasing number and became the most common pathology in the year of 2016. The most common procedure is anterior cervicaldiscectomy and fusion (ACDF).Conclusion: Our study showed that the most common symptoms and pathology are myelopathies and degenerative disease respectively, which has similarity with another study in the term of the mostfrequent pathology and surgical procedure. The finding of the more advanced neurological condition by the time of surgery as the most common symptom is found to be contradictory with other studies in western countries.

THE TREND AND PROFILE OF THE THORACIC SPINE SURGERY IN NEUROSURGERY DEPARTMENT FACULTY OF MEDICINE UNIVERSITAS INDONESIA – RSUP NASIONAL DR. CIPTO MANGUNKUSUMO 2012 – 2016 Muhammad Saekhu; Bismo Nugroho; Samsul Ashari; Renindra A Aman; Hanif G Tobing; Setyowidi Nugroho
Neurologico Spinale Medico Chirurgico Vol 1 No 2 (2018)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (245.667 KB)

Background: Spinal surgery, in general, is increasing in number. The most frequent pathology is degenerative disease, and the most common segment is cervical and lumbar. However, there is limited information concerning the thoracic spine surgeries.Objective: The aim of this study is to describe the trend and profle of the thoracic spine (T-spine) surgeries in the Department of Neurosurgery Faculty of Medicine Universitas Indonesia – RSUP Dr.Cipto Mangunkusumo from 2012 to 2016.Method: This is a retrospective study including all patients who were undergoing T-spine surgery during the period of study from January 2012 to December 2016. The number of T-spine procedureswas recorded and plotted in the trend graph. The data consisting age, gender, indication and procedure of T-spine surgery, and duration of hospital stay were recorded from medical records.Result: In the last fve years, there was an increasing trend of T-spine surgery. A total of 68 surgeries for T-spine performed with 35 female and 33 male subjects. Majority of subjects were aged 41 to 50 years old (28%), with an indication of surgery due to tumours (68%). As many as 76% T-spine surgery was carried out non-instrumented. Duration of hospital stay was 9-13 days.Conclusion: Productive age is the most common age undergoing T-spine surgeries. A spinal tumour is the most frequent indication of the T-spine surgeries

Co-Authors Anita Esfandiari Aryandhito Widhi Nugroho Bismo Nugroho David Tandian David Tandian David Tandian Dondin Sajuthi Eka Susanto Eka Susanto Eka Susanto Erni Sulistiawati Fabianto Santoso Fauzi Abdurrahman Munggaran Hanif G. Tobing Harris Istianggoro Hilman Mahyuddin Huda Salahudin Darusman Huda Shalahudin Darusman Jeremia Prasetya Pardede Kanti Rahmi Fauziyah Mohamad Saekhu Padmo Santjojo Renindra A Aman Renindra A. Aman Renindra Ananda Aman Renindra Ananda Aman Renindra Ananda Aman Rumlaklak, Yanse Yane Samsul Ashari Setyo Handryastuti Sus Derthi Widhyari Syaiful Ichwan Tiara Widyaputri Wismaji Sadewo Yanse Yanne Rumlaklak Yulius Seno Nugroho

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