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All Journal INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES JURNAL ITENAS REKAYASA REKA GEOMATIKA Pharmaceutical Journal of Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang
Sumarno -
Universitas Negeri Yogyakarta
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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CHARACTERISTICS OF PILI HEMAGLUTININ PROTEIN AND ITS ROLE IN THE PATHOGENESIS OF URINARY TRACT INFECTION WITH UROPATHOGENIC ESCHERICHIA COLI Sudhana, I Wayan; Suwitra, Ketut; -, Sumarno
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 3, No. 2 Juli 2009
Publisher : Udayana University

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Abstract

Urinary tract infection (UTI) is one of the most common infectious diseasesencountered in the community. The bacteria most frequently implicated as the causes ofUTI are the Gram-negative bacteria, especially Escherechia coli. Early phase of thepathogenesis of the infection constitutes adhesion of bacteria onto the epithelial cells ofurinary tract. SDS-PAGE examination was carried out to investigate molecule ofhemagglutinin protein and hemagglutination (HA) test continued by adhesion andinhibited adhesion tests.The observation of molecular weight of pili E. coli protein molecule byexplorative examination using SDS-PAGE showed on E. coli strip that the mostprominent molecular weights (MW) of the proteins were 61 kDa, 37 kDa, 30 kDa, and 20kDa. Purification by electro-elusion was done to proteins of the MW of 20 kDa, 37 kDaand 61 kDa. The HA test results indicated the 61 kDa, 37 kDa, and 20 kDa werehemagglutinin proteins and one which subsequently applied as sub unit proteins ofUropathogenic E. coli (UPEC) was the 37 kDa. Adhesion test of UPEC bacteria carriedout on urinary bladder epithelial cells of rabbit showed a significant correlation betweenadhesion index and various doses of subunit proteins of UPEC 37 kDa as coat of urinarybladder epithelial cells. Spearman rank correlation test and regression/non regressionanalysis confirmed an exponential decrease of UPEC adhesion to urinary tract epithelialcells as a response to the increasing doses of coating protein. This finding points out thatpili hemagglutinin protein subunit of UPEC 37 kDa was an adhesive molecule. Pilihemagglutinin protein subunit of UPEC 37 kDa is an adhesive molecule, which plays arole in adherence of UPEC to epithelial cells of urinary bladder at the early pathogenesisof urinary tract infection.
INHIBITION OF BIFIDOBACTERIUM sp ISOLATED FROM INFANTS FECES TOWARDS ADHESION OF SALMONELLA TYPHI ON BALB/c MICE ENTEROCYTE Sukrama, I D. M.; Sukardika, K.; -, Sumarno; Mantik Astawa, N.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 4, No. 1 Januari 2010
Publisher : Udayana University

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Diarrhea, up to the recent year remains a cause of high morbidity and mortalityworldwide, especially in developing countries including Indonesia. Research concerning ofmanagement, prevention, and medication of the disease have been continually improved. Theaim of this research is searching Bifidobacterium sp isolated from infants feces. ThisBifidobacterium was then applied as an anti-adhesion of Salmonella typhi in the hope to gain acure of diarrhea. This research employed two research designs, namely descriptive explorationand true experimental. Exploration was applied in order to obtain isolation and characterizationof Bifidobacterium isolated from infants feces. Adherence ability of this Bifidobacterium sptowards Salmonella typhi adhesion on mice entherocyte was then carried out by applyingRandomized Posttest-Only Control Group Design. In this research, average Bifidobacterium spadhesion index of 1950 on entherocyte was obtained. In simple word, there are 19.5Bifidobacteria adhere to any single entherocyte cell. This adhesion index value is highercompare to Salmonella typhi adhesion of 1504. Conclusions that can be drawn from this researchare the finding of Bifidobacterium sp isolated from infants feces. This Bifidobacterium sp has anability to inhibit adhesion of Salmonella typhi on BALB/c mice enterocyte. Future work that canbe carried out are further researches concerning whether these bacteria have an ability to inhibitadherence of other pathogen bacteria. More over, searching of cell wall adhesin ofBifidobacterium sp that can be used as a replacement of life probiotic bacteria is also a greatinterest of research to be carried out.
Pemanfaatan WebGIS “Petakita” untuk Dokumentasi dan Sosialisasi Objek Arkeologi -, Sumarno
JURNAL ITENAS REKAYASA Vol 18, No 1 (2014)
Publisher : Jurnal ITENAS Rekayasa

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ABSTRAKAktivitas arkeologi lebih berfokus kepada pengkajian sejarah kebudayaan material, yang jejaknya disebut sebagai tinggalan arkeologis, atau cagar budaya. Tinggalan arkeologis tersebut tersebar luas dalam rentang ruang dan waktu yang panjang seiring dengan perjalanan sejarah umat manusia. Penemuan kembali jejak-jejak artefak fisik penanda budaya dapat menggiring kepada perjalanan sejarah untuk dikaji dan dicerna sebagai pelajaran bagi kelangsungan peradaban dan perbaikan kualitas perjalanan sejarah ke depan. Kualitas jejak budaya sebagai tinggalan arkeologis ini akan menentukan tingkat kejelasan dalam menggali makna dan keterkaitan sejarah dalam rentang ruang dan waktu. Haltersebut menyebabkan kualitas pendokumentasian cagar budaya memiliki arti penting dalam lingkup kajian arkeologi. Petakita sebagai suatu rujukan spasial dapat digunakan untuk melakukan dokumentasi terhadap semua jejak arkeologis tersebut. Petakita dapat merekam lokasi, waktu kejadian, dan dokumentasi tekstual maupun audio visual. Keterbukaan akses Petakita juga dapat menjadi wadah untuk berkomunikasi lintas komunitas. Dengan demikian, Petakita dapat menjadi “tools” untuk sosialisasi hasil penelitian jejak budaya tinggalan arkeologis.Kata kunci: arkeologi, dokumentasi, Petakita, WebGISABSTRACTArcheological activity focuses to the historical study of material culture. Archaeological products widespread in space and time span long as the history of mankind. Rediscovery of traces of physical markers of cultural artifacts can lead to the course of history to be studied and digested as a lesson for the survival of civilization and the improvement of the quality of future history. Cultural quality imprint as archaeological remains will determine the level of clarity in exploring the meaning, connection history in the span of space and time. Thus the quality of documentation artifacts are important in the scope of archaeological study. Petakita as a spatial reference can be used to perform all the documentation of the archaeological traces that can record the location, time of occurrence and the textual and audio-visual documentation. Openess of Petakita can also be a forum for cross-community communication. Petakita thus can be use as a "tools" for the socialization of archaeological cultural products.Keywords: archeology, documentation, Petakita, WebGIS
ALIROCUMAB : MECHANISM OF ACTION, PHARMACOKINETICS, SAFETY, AND CLINICAL OUTCOMES Medina, Farah; -, Sumarno
Pharmaceutical Journal of Indonesia Vol 5, No 1 (2019)
Publisher : Brawijaya University

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Abstract

Hyperlipidemia is an established risk factor for developing cardiovascular disease (CVD). The latest guideline on lipid management emphasize treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) at doses proven to reduce CVD events.  However, some of statin-treated patients have persistently elevated cardiovascular risk due to inadequate lowering of low density lipoprotein cholesterol (LDL-C) levels. In addition, adverse effects of statins may limit their tolerability and therefore the ability to attain effective doses in some patients. A new class of drugs that inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9) has been developed to treat hyperlipidemia.  PCSK9 inhibitors are monoclonal antibodies for proprotein convertase-subtilicin/kexin type 9 which significantly reduces the concentration of LDL-C in vivo by inhibiting the degradation of LDL receptors in hepatocytes. The introduction of the PCSK9 inhibitor was heralded a new era of intensive LDL-C reductions with LDL-C concentrations lowered below the rate that once thought possible with conventional treatments such as statins. On July 24, 2015, the United States Food and Drug Administration (FDA) approved Alirocumab, the first converged proprotein of the Subtilisin Kexin 9 (PCSK9) inhibitor. This review discusses the mechanisms of action, pharmacokinetics, safety and clinical outcomes of the Alirocumab.
Evaluasi Kesiapan Implementasi Infrastruktur Data Spasial untuk Manajemen Penanggulangan Bencana -, Herlina; -, Sumarno; -, Indrianawati
REKA GEOMATIKA Vol 2017, No 1
Publisher : Institut Teknologi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.013 KB) | DOI: 10.26760/jrg.v2017i1.1466

Abstract

ABSTRAK Akses data spasial yang cepat dan akurat mempunyai peranan yang penting dalam pengambilan keputusan untuk manajemen penanggulangan bencana. Infrastruktur Data Spasial (IDS) merupakan suatu cara untuk memudahkan pengguna untuk mengakses data spasial secara konsisten, mudah, dan aman. Dengan kata lain, IDS dapat meningkatkan ketersediaan data, kemudahan dalam akses, dan implementasi data spasial dalam pengambilan keputusan. Dalam hal manajemen penanggulangan bencana, BPBD dan stakeholder kebencanaan Kabupaten Bandung belum mengimplementasikan IDS kebencanaan. Tujuan penelitian ini adalah menentukan model IDS kebencanaan dan mengevaluasi kesiapan implementasi dalam manajemen penanggulangan bencana di Kabupaten Bandung. Metode yang digunakan dalam penelitian adalah penentuan model IDS kebencanaan yang mengacu pada model IDS yang dirumuskan oleh Rajabifard kemudian didetailkan dengan indikator penilaian IDS yang dikeluarkan Badan Informasi Geospasial tahun 2016. Pengambilan data dilakukan pada 18 stakeholder kebencanaan Kabupaten Bandung dengan wawancara, kuesioner, dan penilaian melalui website. Hasil evaluasi dari kesiapan implementasi IDS kebencanaan Kabupaten Bandung adalah 45,8%. Kata kunci: Infrastruktur Data Spasial, Manajemen Penanggulangan Bencana, Kabupaten Bandung ABSTRACT Fast and accurate spatial data access has an important role in decision making for disaster management. Spatial Data Infrastructure (SDI) is a way to facilitate the users to access spatial data consistently, easily, and safety. In the case, SDI can improve data availability, ease of access and implementation of spatial data for decision making. In disaster management, BPBD and disaster stakeholders in Bandung District have not implemented SDI of disaster. The objective of this study is to determine the SDI model of disaster and evaluate the readiness of implementation in disaster management in Bandung District. The method used in this study is determining SDI model of disaster, referred to IDS model which is formulated by Rajabifard, and then the SDI model of disaster is detailed by SDI assessment indicator issued by Geospatial Information Agency (2016). The data collection has been taken on 18 disaster stakeholders in Bandung District with interview, questionnaire, and assessment through the website. The evaluation result of the readiness of implementation the SDI of disaster in Bandung District is 45.8%. Keywords: Spatial Data Infrastructure, Disaster Management, Bandung District
ALIROCUMAB : MECHANISM OF ACTION, PHARMACOKINETICS, SAFETY, AND CLINICAL OUTCOMES Medina, Farah; -, Sumarno
Pharmaceutical Journal of Indonesia Vol 5, No 1 (2019)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hyperlipidemia is an established risk factor for developing cardiovascular disease (CVD). The latest guideline on lipid management emphasize treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) at doses proven to reduce CVD events.  However, some of statin-treated patients have persistently elevated cardiovascular risk due to inadequate lowering of low density lipoprotein cholesterol (LDL-C) levels. In addition, adverse effects of statins may limit their tolerability and therefore the ability to attain effective doses in some patients. A new class of drugs that inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9) has been developed to treat hyperlipidemia.  PCSK9 inhibitors are monoclonal antibodies for proprotein convertase-subtilicin/kexin type 9 which significantly reduces the concentration of LDL-C in vivo by inhibiting the degradation of LDL receptors in hepatocytes. The introduction of the PCSK9 inhibitor was heralded a new era of intensive LDL-C reductions with LDL-C concentrations lowered below the rate that once thought possible with conventional treatments such as statins. On July 24, 2015, the United States Food and Drug Administration (FDA) approved Alirocumab, the first converged proprotein of the Subtilisin Kexin 9 (PCSK9) inhibitor. This review discusses the mechanisms of action, pharmacokinetics, safety and clinical outcomes of the Alirocumab.
Co-Authors - Indrianawati Herlina Herlina I Dewa Made Sukrama I NYOMAN MANTIK ASTAWA I Wayan Sudhana K. Sukardika Ketut Suwitra Medina, Farah Purwo Subekti