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Tjowanta, Austin Simon
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Health Professions Medicine & Pharmacology Public Health

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Hubungan 25-hydroxyvitamin D Dengan Sepsis Pada Anak Tjowanta, Austin Simon; Yoel, Chairul
Cermin Dunia Kedokteran Vol 45, No 6 (2018): Penyakit Dalam
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1069.082 KB) | DOI: 10.55175/cdk.v45i6.660

Abstract

Sepsis masih merupakan penyebab utama morbiditas dan mortalitas pada anak. Bukti terbaru menunjukkan bahwa vitamin D dapat meningkatkan respons imun bawaan dengan menginduksi peptida antimikroba. Pada anak sepsis dijumpai penurunan kadar 25-hydroxyvitamin D dan risiko sepsis meningkat pada pasien kekurangan vitamin D. Risiko mortalitas lebih tinggi pada pasien sepsis yang kekurangan vitamin D. Pemberian vitamin D pada anak dapat mengurangi keparahan penyakit dan juga menurunkan mortalitas.Sepsis is a major cause of morbidity and mortality in pediatric population, despite scientific progresses in the last decades. Recent evidences suggest that vitamin D may enhance the innate immune response by induction of antimicrobial peptides. Children with sepsis have decreased 25-hydroxyvitamin D levels and vitamin D deficiency patients have increased sepsis risk. Vitamin D-deficient sepsis patients have higher risk of mortality compared to sepsis patients with normal vitamin D levels. Vitamin D supplementation may decrease the severity of illness and also reduce mortality.
Co-Authors Chairul Yoel, Chairul