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The relationship between vitamin A and ferritin towards malondialdehyde level among Javanese male smokers Ahmad Hamim Sadewa, Ajeng Viska Icanervilia Sunarti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 01 (2012)
Publisher : Universitas Gadjah Mada

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Cigarette smokes produce a large number of oxidants and promote secretion of ferritin byalveolar macrophages which are potential to encourage the lipid peroxidation. Malondialdehyde(MDA) is used as a parameter of lipid peroxidation. The study was aimed to evaluate therelationship between blood level of vitamin A and ferritin and MDA among Javanese malesmokers. Sixty men who lived in Purworejo District, Central Java, Indonesia comprising 30smokers as case group and 30 nonsmokers as control group were involved in this study. Bloodsample was obtained from cubiti vein and then centrifuged to obtain plasma or serum. Blood levelsof vitamin A, ferritin and MDA were measured by HPLC, ELISA and spectrophotometric methods,respectively. The result showed that the blood vitamin A, ferritin, and MDA levels in smokers were25.09±9.51μg/dL, 35.50±24.17ng/dL, 1.15±0.42μg/L, respectively, whereas in non smokers, theywere 26.11±9.19 μg/dL, 38.60±15.25 ng/dL, 1.06±0.50 μg/L, respectively. Therewas no significantdifference of the blood vitamin A, ferritin, and MDA levels between smokers and the non smokers(p>0.05). The linear regression analysis indicated that there was negative relationship betweenblood vitamin A and MDA levels although it was not significant (p=0.052), while blood ferritin andMDA levels had a significantly positive relationship (p=0.010). In conclusion, the low level of bloodvitamin A among cigarette smokers does not lead to high blood MDA level, while high level of bloodferritin among smokers leads to high blood MDA level.Keywords: vitamin A - ferritin - malondialdehyde - cigarette - smokers
Effect of feeding methods of katuk (Sauropus androgynus) extract on performance and carcass quality of broiler chickens ., Sunarti; ., Heryanto; Suteky, T; Santoso, U
Indonesian Journal of Animal and Veterinary Sciences Vol 7, No 3 (2002)
Publisher : Indonesian Animal Sciences Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (156.187 KB) | DOI: 10.14334/jitv.v7i3.287


The present experiment was conducted to evaluate effect of feeding methods of katuk extract on performance and carcass quality of broilers. Sixty 20-d-old male broilers were distributed to 5 treatment groups of 4 replicates with 3 birds each. One treatment group was fed basal diet without katuk extract (P0), whereas other treatment groups were fed basal diet plus 18 g katuk extract/kg diet (P1), basal diet plus 9 g katuk extract/l drinking water (P2), basal diet plus 9 g katuk extract/kg diet plus 4.5 g katuk extract/l drinking water (P3), and basal diet plus 4.5 g katuk extract/kg diet plus 2.25 g katuk extract/l drinking water (P4). Experimental results showed that weight gain of P1 and P4 were significantly higher (P<0.05) than those of P0 and P2. Feed conversion ratio of P1 and P4 were significantly lower than those of P0 and P2 (P<0.05). Feed intake, water intake, the weights of heart, liver and gizzard were not significantly different (P>0.05), but the weight of intestine was significantly affected (P<0.05) Abdominal fat of P4 was significantly lower than that of P0, P1 and P2 (P<0.05). Carcass color of P4 was significantly better than that of P0, P1, P2 and P3 (P<0.01). Katuk extract feeding had no effect on smell and taste of meat (P>0.05). P4 had better meat color than P0, P1, dan P2 (P<0.05). Katuk extract feeding had no effect on meat bone ratio, carcaas weight and cooking loss (P>0.05). In conclusion, in order to improve performance and carcass quality, broiler chickens could be given katuk extract through diet plus drinking water at level of 4.5 g/kg diet plus 2.25 g/l drinking water.   Key words: Katuk extract, performance, carcass quality, abdominal fat
TIPOLOGI PERMUKIMAN KUMUH KAWASAN PESISIR DI KELURAHAN WOLOMARANG KOTA MAUMERE (Slum Typology In Coastal Zone of The Wolomarang District Maumere City) ., Sunarti; Hamid, Nevi Vilianty
Jurnal Pengembangan Kota Vol 1, No 1 (2013): Juli 2013
Publisher : Jurusan Perencanaan Wilayah dan Kota

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jpk.1.1.13-22


The higher the population growth is the main factor driving the increase will need space, this is experienced by most of the town of Maumere wake region located in the coastal zone. Since several  decades ago, many coastal areas visited and occupied by people from other regions one of which is Sulawesi. Bajo society known as the sailors accomplished by bringing habits/ customs of the region of origin, they occupy the coastal areas in the Wolomarang District and start doing activities around the coast such as living with inadequate infrastructure. Most of the people work as fishermen with low incomes who can only meet the needs of life in the form of clothing, food and potluck board. Settlements in the coastal area currently has problems of slum formation as seen from the physical building and environmental conditions that have no drainage and sanitation.  This study aims to identify the cause of the formation of slums typology of coastal areas in the Wolomarang District Maumere City. To achieve these objectives is necessary to identify the assessment of physical and non physical aspects, social aspects of cultural, economic, regiona characteristics, and policy aspects of coastal spatial planning. Coastal areas has also become one of the central development region of East Nusa Tenggara Province.The method used in this study is to perform quantitative data collection through field surveys (questionnaires, interviews and observations) and a survey instansional (government). Respondents in this study were in the Wolomarang District coastal communities and relevant agencies in the town of Maumere. Data and information from the public and relevant agencies will be directly assessed based on the mapping, frequency distributions and descriptive qualitative analysis.The results of some analysis has been done shows that the typology of coastal slums Wolomarang District is the settlement stage type, the type of semi-permanent and permanent type. Typology of slum formation in the coastal zone is influenced by two factors: economic factors related to location of work and low incomes, and a very strong cultural factors inherent in the society that is accustomed to living close to the sea by building a temporary condition. In its development to date in coastal settlements Wolomarang District the bay waters are carried out by reclamation, and the quality of slum settlements are included in weight. Location of residential communities that are along the road environment and spread irregularly, describe the condition of the settlement were not well ordered. The proposed recommendation is that the government needs to improve supervision and control of construction-related permits in coastal areas and the need for provision of basic infrastructure, i.e. drainage, sanitation and solid waste as well as increasing public knowledge related to the maintenance of settlements.
-429 T/C and -374 T/A Polymorphisms in Receptor Advanced Glycation Endproducts (RAGE) gene in Type 2 Diabetic Patients with Diabetic Retinopathy at the Dr. Sardjito General Hospital Yogyakarta Djuma, Agustina Welhelmina; ., Sunarti; Hastuti, Pramudji
Indonesian Journal of Biotechnology Vol 17, No 1 (2012)
Publisher : Universitas Gadjah Mada

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Receptor of advanced glycation endproduct (RAGE) plays an important role in the pathogenesis of diabetic vascular complications, such as diabetic retinopathy. The interaction between the RAGE and advanced glycation end product (AGE) leads to oxidative stress and could result in cellular activation and infl ammation. The production of AGE occurs normally during aging but it increases in hyperglycemia condition. The objective of this research was to investigate the association between -429 T/C and -374 T/A polymorphisms in RAGE gene with the risk of diabetic retinopathy (DR) of type 2 diabetic patients in Javanese population. This was a case control study which consisted of 40 type 2 diabetic patients with DR as case subjects and 40 type 2 diabetic patients without DR (NDR) as control subjects. Genotyping of polymorphism was performed by PCR-RFLP. Chi-square test and odds ratio models were used to evaluate the association of both polymorphisms and DR risk and to examine 2-SNP haplotype of -429 T/C and -374 T/A polymorphisms in RAGE gene on DR. The genotype frequencies of -429 T/C polymorphism in RAGE gene in DR subjects were TT = 72.5% and TC/CC = 27.5%; while in NDR subjects were TT = 80% and TC/ CC = 20%, with p = 0.431. The allele frequencies of -429 T/C polymorphism in DR subjects were T = 83.7% and C= 16.3%, while in NDR subjects were T = 87.5% and C = 12.5%, with p = 0.499. The genotype frequencies of -374T/A polymorphism in RAGE gene in DR subjects were TT = 67.5%, TA = 32.5% while in NDR subjects were TT =82.5%, TA = 17.5%, with p = 0.121. In DR subjects, the frequencies of T and A were 83.7% and16.3%, while in NDR subjects the frequencies of T and A were 91.2 % and 8.8%, with p = 0.151. Odds ratios of -429 T/C polymorphism were 1.52 (95% CI = 0.54 – 4.29) for TC/CC genotype and 1.358 (95% CI = 0.56 – 3.31) for C allele. Odds ratios of -374 T/A polymorphism were 2.27 (95% CI = 0.79 – 6.49) for TA genotype and 2.02 (95% CI = 0.76 – 5.37) for A allele. χ2-value for 2-SNP haplotype was p = 0.127. The -374 T/A polymorphism in RAGE gene was a stronger risk factor of DR than -429 T/C polymorphism in RAGE gene. There were not signifi cantly different of frequencies of genotypes, allele, and two-SNP haplotype of -429 T/C and -374 T/A polymorphisms in RAGE gene between DR subjects and NDR subjects.
Jurnal Humaniora Vol 2, No 3 (2015): Jurnal Humaniora
Publisher : LPPM STKIP PGRI Pacitan

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Secara umum penelitian ini mempunyai tujuan adalah untuk mengetahui peningkatan prestasi belajar matematika siswa dengan metode Problem Based Learning pada siswa kelas XII AK-1 SMK Negeri 2 Pacitan dan sekaligus untuk mengetahui perkembangan kemampuan belajar setelah diterapkannya Problem Based Learning. Salah satu model pembelajaran yang sesuai dengan kurikulum 2006 yang dikembangkan sekarang adalah Pembelajaran Berbasis masalah (Problem Based Learning). Pembelajaran ini berfungsi untuk merangsang siswa untuk berfikir kritis dan keterampilan pemecahan masalah baik yang dihadapi secara nyata maupun telaah kasus sehingga hasil belajar yang diharapkan dapat tercapai.Pelaksanaan tindakan dilakukan pada semester 1 pada bulan Agustus sampai dengan Oktober 2011 pada tahun pelajaran 2011/2012. Penelitian Tindakan Kelas (PTK) ini dilaksanakan di SMK Negeri 2 Pacitan pada siswa kelas XII AK-1. Objek penelitian ini adalah siswa kelas XII AK-1 dengan jumlah 32 siswa.Hasil evaluasi yang dilakukan diperoleh data sekian permasalahan tersebut diatas pada kegiatan pembelajaran siklus 1 masih berkisar 58,38 % siswa yang mampu dalam proses belajar mengajar dan hasil evaluasi 59% sedangkan pada siklus 2 Dalam aktifitas kegiatan pembelajaran pada siklus 2 telah diketahui bahwa hasil yang dicapai berkisar 73 % hal ini menunjukkan adanya peningkatan, sedangkan kegiatan evaluasi 78 % siswa yang tuntas dalam pembelajaran. Dengan demikian pembelajaran matemtika dengan kompetensi dasar statistik dengan metode Problem Based Learning dapat ditingkatkan.Kata Kunci ; Peningkatan, prestasi belajar matematika, metode
Efek asupan vitamin D terhadap tekanan darah sistolik tikus putih (Rattus norvegicus) Hermawan, Dessy; Kadarsih, Sri; ., Sunarti; Astuti, Indwiani; Agus, Zaenal Arifin Nang
Jurnal Gizi Klinik Indonesia Vol 9, No 1 (2012): Juli
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (216.68 KB) | DOI: 10.22146/ijcn.15363


Background: Hypertension still became potential life threatening disease for human life. The prevalence of hypertension was high and tends to increase. Previous study suggested that there was a linier rise in blood pressure at increasing distances from the equator. More recent study indicated that vitamin D insuffi ciency may be associated with elevated blood pressure.Objective: To investigate the effect of vitamin D intake on blood pressure.Method: This was an experimental study with pre-post test group design. The subjects were 20 male Rattus norvegicus aged 8 weeks. Subjects were divided into 5 groups and each groups received treatment as follow: lived in dark cage and consumed vitamin D free diet for 1 – 13 days, then moved to normal cage (dark-light period) and given vitamin D per-oral of 0.25 μg/kg BW for 1 – 5 days. Data of systolic blood pressure was collected and analyzed with paired t test.Results: The absence of vitamin D in diet caused a signifi cant increase in systolic blood pressure (p=0.01) after 7 days of treatment in dark cage. While oral vitamin D supplementation of 0.25 μg/kg BW caused a signifi cant decline of systolic blood pressure since the fi rst day of vitamin D supplementation and the result appeared stronger after 4 days of treatment (p=0.001).Conclusion: Vitamin D intake had a strong infl uence on systolic blood pressure