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Achmad Taher
Jurusan Kimia-FMIPA Universitas Negeri Papua Manokwari-Papua Barat
Agriculture, Biological Sciences & Forestry Chemistry Mathematics Physics Veterinary

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Karakterisasi Nukleotida Daerah Ekson 5 dan 6 Gen LDLR Penduduk Papua Hamida; Achmad Taher
Jurnal Natural Vol. 15 No. 1 (2019): Jurnal Natural
Publisher : FMIPA Universitas Papua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30862/jn.v15i1.26

Abstract

The diversity shown in tribes in Papua has the potential to produce varying genetic diversity. LDLR gene is a gene coding for LDL receptor proteins (LDL-R) that play a very important role in cholesterol homeostasis. The LDLR gene consists of 18 exons and 17 introns that stretch for 45 kilos of base (kb). . The exon 5 and 6 regions are important structural parts in encoding amino acids and are also ligand binding regions that mediate the interaction between receptors and lipoproteins containing Apo B-100 or Apo E. This study aims to characterize the nucleotides of Papuan populations with different origins. The method used is the polymorphism chain reaction method and sequencing method to find out the sequence of nucleotide bases. The results of the exon 5 and 6 regional nucleotide characterization of LDLR genes from 9 UNIPA students from Papua showed identical results because they had the same number of nucleotides and nucleotide arrangements. The number of nucleotides for exon 5 area is 123 pb, consisting of T = 22.0%, C = 24.4%, G = 30.9%, A = 22.8%, A + T = 44.8% and C + G = 55.3%. For exon 6 area with nucleotide amount of 123 pb, the nucleotide composition is T = 16.3%, C = 26.8%, G = 27.6%, A = 29.3%, A + T = 45.6% and C + G = 54.4%. The same results show that the two regions are conserved.
Variasi Kolesterol Plasma Individual Monyet Ekor Panjang (Macaca fascicularis) sebagai Respons terhadap Diet Aterogenik IPB-1 [INDIVIDUAL PLASMA CHOLESTEROL VARIATION OF CYNOMOLGUS MACAQUE (MACACA FASCICULARIS) IN RESPONSE TO IPB-1 ATHEROGENIC DIET] Achmad Taher; Dedy Duryadi Solihin; Sulistiyani Sulistiyani; Dondin Sajuthi; Dewi Apri Astuti
Jurnal Veteriner Vol 17 No 4 (2016)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (101.446 KB)

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The effectiveness of atherogenic diet in raising plasma cholesterol level of cynomolgus macaques(Macaca fascicularis) can be predicted for population, but not for individuals.This study aimed to evaluatethe individual plasma cholesterol of cynomolgus macaques in response to IPB-1 atherogenic diet. Theanimals under study were 22 adult malemonkeys from the animal facility of Primate Research CenterBogor Agricultural University (PSSP IPB). All animals were intervened with the IPB-1 atherogenic diet forthree months and individual plasma cholesterol wasevaluated in a monthly basis.The results showedthat the monkeys’ plasma cholesterol had increased significantly (P <0.05) after one month of interventionperiod and the increases were very significantly different (P <0.01) after three months. Individually, increasesin plasma cholesterol varied among animals. Based on these variations, 2 animals were categorised ashypo-response, 18 animals as hyper-response and 2 animals as extreme.This study showed the variationof individual plasma cholesterol of cynomolgus macaques in response tothe IPB-1 atherogenic diet so thatthe animals might be selected based on the their responsiveness.
Co-Authors DEWI APRI ASTUTI Dondin Sajuthi Hamida SULISTIYANI SULISTIYANI TARUNI SRI PRAWAST MIEN KAOMINI ANY ARYANI DEDY DURYADI SOLIHIN